Amino acid dipepetide frequency for Echinostoma caproni

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.259AlaAla: 6.259 ± 0.063	1.291AlaCys: 1.291 ± 0.018	3.874AlaAsp: 3.874 ± 0.042	4.09AlaGlu: 4.09 ± 0.038	2.401AlaPhe: 2.401 ± 0.024	3.702AlaGly: 3.702 ± 0.037	1.774AlaHis: 1.774 ± 0.018	3.164AlaIle: 3.164 ± 0.025	2.952AlaLys: 2.952 ± 0.029	6.303AlaLeu: 6.303 ± 0.04	1.559AlaMet: 1.559 ± 0.017	2.813AlaAsn: 2.813 ± 0.023	3.563AlaPro: 3.563 ± 0.032	2.919AlaGln: 2.919 ± 0.025	4.017AlaArg: 4.017 ± 0.031	6.088AlaSer: 6.088 ± 0.045	4.352AlaThr: 4.352 ± 0.034	4.544AlaVal: 4.544 ± 0.031	0.702AlaTrp: 0.702 ± 0.011	1.811AlaTyr: 1.811 ± 0.02	0.015AlaXaa: 0.015 ± 0.002
Cys	1.32CysAla: 1.32 ± 0.016	0.489CysCys: 0.489 ± 0.011	1.046CysAsp: 1.046 ± 0.015	1.017CysGlu: 1.017 ± 0.016	0.803CysPhe: 0.803 ± 0.013	1.19CysGly: 1.19 ± 0.016	0.568CysHis: 0.568 ± 0.011	0.933CysIle: 0.933 ± 0.014	0.681CysLys: 0.681 ± 0.012	2.126CysLeu: 2.126 ± 0.023	0.448CysMet: 0.448 ± 0.014	0.666CysAsn: 0.666 ± 0.01	1.205CysPro: 1.205 ± 0.019	0.752CysGln: 0.752 ± 0.014	1.226CysArg: 1.226 ± 0.015	1.737CysSer: 1.737 ± 0.02	1.148CysThr: 1.148 ± 0.013	1.32CysVal: 1.32 ± 0.015	0.244CysTrp: 0.244 ± 0.006	0.522CysTyr: 0.522 ± 0.01	0.005CysXaa: 0.005 ± 0.001
Asp	3.78AspAla: 3.78 ± 0.037	1.029AspCys: 1.029 ± 0.016	14.359AspAsp: 14.359 ± 0.828	4.652AspGlu: 4.652 ± 0.132	1.806AspPhe: 1.806 ± 0.019	3.55AspGly: 3.55 ± 0.057	1.585AspHis: 1.585 ± 0.032	2.23AspIle: 2.23 ± 0.021	2.02AspLys: 2.02 ± 0.023	5.089AspLeu: 5.089 ± 0.032	1.118AspMet: 1.118 ± 0.014	2.202AspAsn: 2.202 ± 0.041	3.236AspPro: 3.236 ± 0.027	2.307AspGln: 2.307 ± 0.022	3.442AspArg: 3.442 ± 0.03	5.29AspSer: 5.29 ± 0.063	2.909AspThr: 2.909 ± 0.022	3.76AspVal: 3.76 ± 0.066	0.761AspTrp: 0.761 ± 0.012	1.731AspTyr: 1.731 ± 0.033	0.014AspXaa: 0.014 ± 0.002
Glu	4.242GluAla: 4.242 ± 0.036	1.008GluCys: 1.008 ± 0.014	3.979GluAsp: 3.979 ± 0.117	4.419GluGlu: 4.419 ± 0.054	2.033GluPhe: 2.033 ± 0.022	2.251GluGly: 2.251 ± 0.025	1.488GluHis: 1.488 ± 0.019	2.571GluIle: 2.571 ± 0.025	2.953GluLys: 2.953 ± 0.034	5.967GluLeu: 5.967 ± 0.051	1.4GluMet: 1.4 ± 0.019	2.52GluAsn: 2.52 ± 0.025	2.83GluPro: 2.83 ± 0.031	2.796GluGln: 2.796 ± 0.034	3.71GluArg: 3.71 ± 0.035	4.54GluSer: 4.54 ± 0.031	3.419GluThr: 3.419 ± 0.03	3.388GluVal: 3.388 ± 0.029	0.613GluTrp: 0.613 ± 0.011	1.434GluTyr: 1.434 ± 0.02	0.011GluXaa: 0.011 ± 0.002
Phe	2.274PheAla: 2.274 ± 0.022	0.82PheCys: 0.82 ± 0.015	2.018PheAsp: 2.018 ± 0.019	1.899PheGlu: 1.899 ± 0.019	1.306PhePhe: 1.306 ± 0.017	2.222PheGly: 2.222 ± 0.022	1.046PheHis: 1.046 ± 0.015	1.75PheIle: 1.75 ± 0.02	1.304PheLys: 1.304 ± 0.017	3.378PheLeu: 3.378 ± 0.031	0.794PheMet: 0.794 ± 0.013	1.349PheAsn: 1.349 ± 0.02	1.798PhePro: 1.798 ± 0.019	1.337PheGln: 1.337 ± 0.016	2.248PheArg: 2.248 ± 0.022	2.942PheSer: 2.942 ± 0.024	2.226PheThr: 2.226 ± 0.02	2.431PheVal: 2.431 ± 0.023	0.42PheTrp: 0.42 ± 0.01	1.064PheTyr: 1.064 ± 0.017	0.009PheXaa: 0.009 ± 0.001
Gly	3.48GlyAla: 3.48 ± 0.033	1.054GlyCys: 1.054 ± 0.015	3.352GlyAsp: 3.352 ± 0.054	2.852GlyGlu: 2.852 ± 0.036	2.007GlyPhe: 2.007 ± 0.022	3.885GlyGly: 3.885 ± 0.051	1.489GlyHis: 1.489 ± 0.018	2.545GlyIle: 2.545 ± 0.025	2.428GlyLys: 2.428 ± 0.023	5.245GlyLeu: 5.245 ± 0.036	1.302GlyMet: 1.302 ± 0.016	2.048GlyAsn: 2.048 ± 0.021	3.221GlyPro: 3.221 ± 0.067	2.301GlyGln: 2.301 ± 0.025	3.46GlyArg: 3.46 ± 0.028	5.55GlySer: 5.55 ± 0.051	3.687GlyThr: 3.687 ± 0.028	3.299GlyVal: 3.299 ± 0.028	0.628GlyTrp: 0.628 ± 0.012	1.551GlyTyr: 1.551 ± 0.023	0.017GlyXaa: 0.017 ± 0.002
His	1.674HisAla: 1.674 ± 0.016	0.609HisCys: 0.609 ± 0.011	1.368HisAsp: 1.368 ± 0.033	1.354HisGlu: 1.354 ± 0.017	1.022HisPhe: 1.022 ± 0.016	1.512HisGly: 1.512 ± 0.018	0.985HisHis: 0.985 ± 0.019	1.205HisIle: 1.205 ± 0.016	0.934HisLys: 0.934 ± 0.014	2.856HisLeu: 2.856 ± 0.026	0.647HisMet: 0.647 ± 0.01	0.956HisAsn: 0.956 ± 0.012	1.822HisPro: 1.822 ± 0.024	1.217HisGln: 1.217 ± 0.016	1.827HisArg: 1.827 ± 0.02	2.636HisSer: 2.636 ± 0.025	1.613HisThr: 1.613 ± 0.018	1.756HisVal: 1.756 ± 0.02	0.375HisTrp: 0.375 ± 0.008	0.758HisTyr: 0.758 ± 0.012	0.006HisXaa: 0.006 ± 0.001
Ile	3.018IleAla: 3.018 ± 0.023	1.035IleCys: 1.035 ± 0.015	2.51IleAsp: 2.51 ± 0.024	2.592IleGlu: 2.592 ± 0.025	1.576IlePhe: 1.576 ± 0.018	2.586IleGly: 2.586 ± 0.026	1.366IleHis: 1.366 ± 0.016	2.072IleIle: 2.072 ± 0.037	1.919IleLys: 1.919 ± 0.02	4.272IleLeu: 4.272 ± 0.033	1.197IleMet: 1.197 ± 0.025	1.902IleAsn: 1.902 ± 0.018	3.052IlePro: 3.052 ± 0.026	2.137IleGln: 2.137 ± 0.021	3.533IleArg: 3.533 ± 0.032	3.853IleSer: 3.853 ± 0.029	2.847IleThr: 2.847 ± 0.026	2.919IleVal: 2.919 ± 0.023	0.538IleTrp: 0.538 ± 0.009	1.329IleTyr: 1.329 ± 0.017	0.011IleXaa: 0.011 ± 0.002
Lys	2.773LysAla: 2.773 ± 0.029	0.815LysCys: 0.815 ± 0.013	1.966LysAsp: 1.966 ± 0.02	2.526LysGlu: 2.526 ± 0.034	1.333LysPhe: 1.333 ± 0.016	1.707LysGly: 1.707 ± 0.037	1.184LysHis: 1.184 ± 0.016	1.881LysIle: 1.881 ± 0.021	2.34LysLys: 2.34 ± 0.038	4.292LysLeu: 4.292 ± 0.034	1.108LysMet: 1.108 ± 0.017	1.589LysAsn: 1.589 ± 0.019	2.729LysPro: 2.729 ± 0.025	2.079LysGln: 2.079 ± 0.025	3.262LysArg: 3.262 ± 0.032	3.657LysSer: 3.657 ± 0.032	2.536LysThr: 2.536 ± 0.025	2.34LysVal: 2.34 ± 0.021	0.465LysTrp: 0.465 ± 0.01	1.083LysTyr: 1.083 ± 0.014	0.013LysXaa: 0.013 ± 0.001
Leu	6.607LeuAla: 6.607 ± 0.047	2.02LeuCys: 2.02 ± 0.022	5.259LeuAsp: 5.259 ± 0.035	5.291LeuGlu: 5.291 ± 0.047	3.702LeuPhe: 3.702 ± 0.033	4.724LeuGly: 4.724 ± 0.034	2.638LeuHis: 2.638 ± 0.024	4.949LeuIle: 4.949 ± 0.033	4.079LeuLys: 4.079 ± 0.033	9.443LeuLeu: 9.443 ± 0.07	2.319LeuMet: 2.319 ± 0.035	4.137LeuAsn: 4.137 ± 0.029	5.374LeuPro: 5.374 ± 0.04	3.95LeuGln: 3.95 ± 0.037	6.288LeuArg: 6.288 ± 0.044	8.338LeuSer: 8.338 ± 0.053	5.977LeuThr: 5.977 ± 0.039	5.796LeuVal: 5.796 ± 0.039	1.023LeuTrp: 1.023 ± 0.015	2.253LeuTyr: 2.253 ± 0.02	0.026LeuXaa: 0.026 ± 0.002
Met	1.558MetAla: 1.558 ± 0.016	0.412MetCys: 0.412 ± 0.008	1.397MetAsp: 1.397 ± 0.016	1.489MetGlu: 1.489 ± 0.019	0.832MetPhe: 0.832 ± 0.013	1.169MetGly: 1.169 ± 0.017	0.661MetHis: 0.661 ± 0.01	1.55MetIle: 1.55 ± 0.041	1.16MetLys: 1.16 ± 0.018	2.255MetLeu: 2.255 ± 0.031	4.726MetMet: 4.726 ± 0.271	1.127MetAsn: 1.127 ± 0.015	1.156MetPro: 1.156 ± 0.015	0.957MetGln: 0.957 ± 0.012	1.525MetArg: 1.525 ± 0.021	1.771MetSer: 1.771 ± 0.017	1.553MetThr: 1.553 ± 0.028	1.389MetVal: 1.389 ± 0.021	0.241MetTrp: 0.241 ± 0.007	0.559MetTyr: 0.559 ± 0.014	0.006MetXaa: 0.006 ± 0.001
Asn	2.954AsnAla: 2.954 ± 0.024	0.775AsnCys: 0.775 ± 0.013	2.343AsnAsp: 2.343 ± 0.045	2.456AsnGlu: 2.456 ± 0.024	1.336AsnPhe: 1.336 ± 0.017	2.651AsnGly: 2.651 ± 0.025	1.042AsnHis: 1.042 ± 0.014	1.654AsnIle: 1.654 ± 0.018	1.631AsnLys: 1.631 ± 0.018	3.837AsnLeu: 3.837 ± 0.029	0.902AsnMet: 0.902 ± 0.013	1.75AsnAsn: 1.75 ± 0.021	2.73AsnPro: 2.73 ± 0.021	1.929AsnGln: 1.929 ± 0.02	2.684AsnArg: 2.684 ± 0.025	3.689AsnSer: 3.689 ± 0.03	2.578AsnThr: 2.578 ± 0.023	2.535AsnVal: 2.535 ± 0.023	0.513AsnTrp: 0.513 ± 0.009	1.13AsnTyr: 1.13 ± 0.016	0.008AsnXaa: 0.008 ± 0.001
Pro	3.7ProAla: 3.7 ± 0.031	0.953ProCys: 0.953 ± 0.016	3.322ProAsp: 3.322 ± 0.027	3.362ProGlu: 3.362 ± 0.028	1.852ProPhe: 1.852 ± 0.02	3.823ProGly: 3.823 ± 0.073	1.48ProHis: 1.48 ± 0.019	2.965ProIle: 2.965 ± 0.028	2.389ProLys: 2.389 ± 0.027	4.661ProLeu: 4.661 ± 0.032	1.227ProMet: 1.227 ± 0.015	2.765ProAsn: 2.765 ± 0.027	4.633ProPro: 4.633 ± 0.056	2.207ProGln: 2.207 ± 0.023	3.197ProArg: 3.197 ± 0.026	5.799ProSer: 5.799 ± 0.048	4.234ProThr: 4.234 ± 0.034	4.436ProVal: 4.436 ± 0.042	0.579ProTrp: 0.579 ± 0.011	1.405ProTyr: 1.405 ± 0.015	0.016ProXaa: 0.016 ± 0.002
Gln	2.863GlnAla: 2.863 ± 0.026	0.825GlnCys: 0.825 ± 0.015	1.534GlnAsp: 1.534 ± 0.016	1.94GlnGlu: 1.94 ± 0.024	1.606GlnPhe: 1.606 ± 0.019	1.596GlnGly: 1.596 ± 0.024	1.166GlnHis: 1.166 ± 0.016	2.066GlnIle: 2.066 ± 0.02	1.78GlnLys: 1.78 ± 0.021	5.14GlnLeu: 5.14 ± 0.041	1.112GlnMet: 1.112 ± 0.016	1.736GlnAsn: 1.736 ± 0.017	2.779GlnPro: 2.779 ± 0.031	2.824GlnGln: 2.824 ± 0.056	2.697GlnArg: 2.697 ± 0.027	4.116GlnSer: 4.116 ± 0.039	2.982GlnThr: 2.982 ± 0.029	2.283GlnVal: 2.283 ± 0.018	0.546GlnTrp: 0.546 ± 0.01	1.04GlnTyr: 1.04 ± 0.013	0.011GlnXaa: 0.011 ± 0.001
Arg	4.12ArgAla: 4.12 ± 0.031	1.248ArgCys: 1.248 ± 0.019	2.97ArgAsp: 2.97 ± 0.025	3.348ArgGlu: 3.348 ± 0.035	2.488ArgPhe: 2.488 ± 0.026	3.098ArgGly: 3.098 ± 0.033	1.747ArgHis: 1.747 ± 0.019	3.308ArgIle: 3.308 ± 0.024	2.988ArgLys: 2.988 ± 0.027	7.158ArgLeu: 7.158 ± 0.046	1.841ArgMet: 1.841 ± 0.031	2.426ArgAsn: 2.426 ± 0.019	3.52ArgPro: 3.52 ± 0.031	2.745ArgGln: 2.745 ± 0.027	5.156ArgArg: 5.156 ± 0.047	5.574ArgSer: 5.574 ± 0.044	3.666ArgThr: 3.666 ± 0.027	3.749ArgVal: 3.749 ± 0.033	0.815ArgTrp: 0.815 ± 0.014	1.671ArgTyr: 1.671 ± 0.017	0.02ArgXaa: 0.02 ± 0.002
Ser	6.306SerAla: 6.306 ± 0.047	1.594SerCys: 1.594 ± 0.02	5.519SerAsp: 5.519 ± 0.065	4.8SerGlu: 4.8 ± 0.035	2.774SerPhe: 2.774 ± 0.024	5.999SerGly: 5.999 ± 0.049	2.352SerHis: 2.352 ± 0.025	3.795SerIle: 3.795 ± 0.028	3.499SerLys: 3.499 ± 0.026	7.618SerLeu: 7.618 ± 0.046	1.907SerMet: 1.907 ± 0.018	3.9SerAsn: 3.9 ± 0.03	5.568SerPro: 5.568 ± 0.053	3.506SerGln: 3.506 ± 0.028	5.314SerArg: 5.314 ± 0.044	10.32SerSer: 10.32 ± 0.098	6.632SerThr: 6.632 ± 0.053	6.162SerVal: 6.162 ± 0.043	0.882SerTrp: 0.882 ± 0.013	1.927SerTyr: 1.927 ± 0.019	0.025SerXaa: 0.025 ± 0.002
Thr	4.635ThrAla: 4.635 ± 0.034	1.159ThrCys: 1.159 ± 0.017	3.626ThrAsp: 3.626 ± 0.029	3.921ThrGlu: 3.921 ± 0.034	1.93ThrPhe: 1.93 ± 0.02	4.37ThrGly: 4.37 ± 0.037	1.581ThrHis: 1.581 ± 0.018	2.776ThrIle: 2.776 ± 0.023	2.595ThrLys: 2.595 ± 0.025	5.106ThrLeu: 5.106 ± 0.033	1.562ThrMet: 1.562 ± 0.024	2.947ThrAsn: 2.947 ± 0.025	3.879ThrPro: 3.879 ± 0.032	2.529ThrGln: 2.529 ± 0.024	3.568ThrArg: 3.568 ± 0.028	5.813ThrSer: 5.813 ± 0.044	4.958ThrThr: 4.958 ± 0.054	4.526ThrVal: 4.526 ± 0.032	0.628ThrTrp: 0.628 ± 0.012	1.458ThrTyr: 1.458 ± 0.017	0.02ThrXaa: 0.02 ± 0.002
Val	4.172ValAla: 4.172 ± 0.03	1.461ValCys: 1.461 ± 0.021	4.201ValAsp: 4.201 ± 0.06	3.607ValGlu: 3.607 ± 0.027	2.24ValPhe: 2.24 ± 0.022	3.393ValGly: 3.393 ± 0.025	1.874ValHis: 1.874 ± 0.02	3.058ValIle: 3.058 ± 0.027	2.55ValLys: 2.55 ± 0.022	5.636ValLeu: 5.636 ± 0.037	1.406ValMet: 1.406 ± 0.02	2.749ValAsn: 2.749 ± 0.022	3.825ValPro: 3.825 ± 0.031	2.673ValGln: 2.673 ± 0.031	3.927ValArg: 3.927 ± 0.03	5.61ValSer: 5.61 ± 0.046	4.031ValThr: 4.031 ± 0.03	4.142ValVal: 4.142 ± 0.037	0.673ValTrp: 0.673 ± 0.011	1.754ValTyr: 1.754 ± 0.02	0.019ValXaa: 0.019 ± 0.002
Trp	0.657TrpAla: 0.657 ± 0.011	0.257TrpCys: 0.257 ± 0.008	0.617TrpAsp: 0.617 ± 0.012	0.523TrpGlu: 0.523 ± 0.01	0.487TrpPhe: 0.487 ± 0.009	0.412TrpGly: 0.412 ± 0.011	0.324TrpHis: 0.324 ± 0.008	0.696TrpIle: 0.696 ± 0.011	0.54TrpLys: 0.54 ± 0.011	1.208TrpLeu: 1.208 ± 0.015	0.303TrpMet: 0.303 ± 0.008	0.564TrpAsn: 0.564 ± 0.01	0.603TrpPro: 0.603 ± 0.012	0.403TrpGln: 0.403 ± 0.009	0.731TrpArg: 0.731 ± 0.011	1.039TrpSer: 1.039 ± 0.013	0.735TrpThr: 0.735 ± 0.014	0.56TrpVal: 0.56 ± 0.012	0.168TrpTrp: 0.168 ± 0.006	0.329TrpTyr: 0.329 ± 0.007	0.003TrpXaa: 0.003 ± 0.001
Tyr	1.787TyrAla: 1.787 ± 0.017	0.588TyrCys: 0.588 ± 0.011	1.597TyrAsp: 1.597 ± 0.035	1.425TyrGlu: 1.425 ± 0.019	1.095TyrPhe: 1.095 ± 0.015	1.546TyrGly: 1.546 ± 0.02	0.778TyrHis: 0.778 ± 0.012	1.08TyrIle: 1.08 ± 0.015	0.93TyrLys: 0.93 ± 0.014	2.578TyrLeu: 2.578 ± 0.024	0.603TyrMet: 0.603 ± 0.011	0.969TyrAsn: 0.969 ± 0.015	1.456TyrPro: 1.456 ± 0.016	1.064TyrGln: 1.064 ± 0.014	1.826TyrArg: 1.826 ± 0.02	2.009TyrSer: 2.009 ± 0.017	1.487TyrThr: 1.487 ± 0.018	1.649TyrVal: 1.649 ± 0.02	0.342TyrTrp: 0.342 ± 0.008	1.027TyrTyr: 1.027 ± 0.034	0.006TyrXaa: 0.006 ± 0.001
Xaa	0.017XaaAla: 0.017 ± 0.001	0.005XaaCys: 0.005 ± 0.001	0.011XaaAsp: 0.011 ± 0.001	0.01XaaGlu: 0.01 ± 0.001	0.009XaaPhe: 0.009 ± 0.001	0.016XaaGly: 0.016 ± 0.002	0.007XaaHis: 0.007 ± 0.001	0.012XaaIle: 0.012 ± 0.001	0.009XaaLys: 0.009 ± 0.001	0.026XaaLeu: 0.026 ± 0.002	0.01XaaMet: 0.01 ± 0.001	0.01XaaAsn: 0.01 ± 0.001	0.024XaaPro: 0.024 ± 0.002	0.01XaaGln: 0.01 ± 0.001	0.019XaaArg: 0.019 ± 0.002	0.027XaaSer: 0.027 ± 0.002	0.016XaaThr: 0.016 ± 0.001	0.014XaaVal: 0.014 ± 0.002	0.003XaaTrp: 0.003 ± 0.001	0.008XaaTyr: 0.008 ± 0.001	0.443XaaXaa: 0.443 ± 0.126

Statistics based on 18535 proteins (5728309 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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