Amino acid dipepetide frequency for Anaplasma phagocytophilum (strain HZ)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.113AlaAla: 7.113 ± 0.195
1.688AlaCys: 1.688 ± 0.073
3.502AlaAsp: 3.502 ± 0.102
4.379AlaGlu: 4.379 ± 0.161
3.085AlaPhe: 3.085 ± 0.103
5.675AlaGly: 5.675 ± 0.139
1.754AlaHis: 1.754 ± 0.061
5.345AlaIle: 5.345 ± 0.159
5.123AlaLys: 5.123 ± 0.171
8.496AlaLeu: 8.496 ± 0.215
2.303AlaMet: 2.303 ± 0.099
2.47AlaAsn: 2.47 ± 0.091
2.188AlaPro: 2.188 ± 0.093
2.432AlaGln: 2.432 ± 0.102
4.036AlaArg: 4.036 ± 0.132
6.115AlaSer: 6.115 ± 0.156
3.476AlaThr: 3.476 ± 0.116
6.791AlaVal: 6.791 ± 0.161
0.497AlaTrp: 0.497 ± 0.041
2.622AlaTyr: 2.622 ± 0.106
0.0AlaXaa: 0.0 ± 0.0
Cys
1.469CysAla: 1.469 ± 0.088
0.428CysCys: 0.428 ± 0.038
0.972CysAsp: 0.972 ± 0.057
0.966CysGlu: 0.966 ± 0.054
0.782CysPhe: 0.782 ± 0.054
1.567CysGly: 1.567 ± 0.073
0.356CysHis: 0.356 ± 0.031
1.414CysIle: 1.414 ± 0.068
0.957CysLys: 0.957 ± 0.051
1.4CysLeu: 1.4 ± 0.071
0.563CysMet: 0.563 ± 0.044
0.972CysAsn: 0.972 ± 0.054
0.44CysPro: 0.44 ± 0.04
0.339CysGln: 0.339 ± 0.03
0.825CysArg: 0.825 ± 0.049
1.667CysSer: 1.667 ± 0.074
0.868CysThr: 0.868 ± 0.054
1.688CysVal: 1.688 ± 0.078
0.161CysTrp: 0.161 ± 0.022
0.77CysTyr: 0.77 ± 0.063
0.0CysXaa: 0.0 ± 0.0
Asp
4.226AspAla: 4.226 ± 0.15
0.765AspCys: 0.765 ± 0.056
2.932AspAsp: 2.932 ± 0.116
3.188AspGlu: 3.188 ± 0.107
2.573AspPhe: 2.573 ± 0.098
3.921AspGly: 3.921 ± 0.132
0.888AspHis: 0.888 ± 0.047
4.534AspIle: 4.534 ± 0.117
2.84AspLys: 2.84 ± 0.088
5.261AspLeu: 5.261 ± 0.124
1.363AspMet: 1.363 ± 0.065
2.329AspAsn: 2.329 ± 0.09
1.797AspPro: 1.797 ± 0.082
1.044AspGln: 1.044 ± 0.07
2.168AspArg: 2.168 ± 0.093
3.97AspSer: 3.97 ± 0.128
2.743AspThr: 2.743 ± 0.107
4.816AspVal: 4.816 ± 0.133
0.451AspTrp: 0.451 ± 0.041
1.627AspTyr: 1.627 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.425GluAla: 4.425 ± 0.131
0.995GluCys: 0.995 ± 0.054
3.341GluAsp: 3.341 ± 0.099
4.985GluGlu: 4.985 ± 0.175
2.277GluPhe: 2.277 ± 0.088
4.456GluGly: 4.456 ± 0.137
1.578GluHis: 1.578 ± 0.068
4.666GluIle: 4.666 ± 0.123
4.442GluLys: 4.442 ± 0.13
5.48GluLeu: 5.48 ± 0.123
1.492GluMet: 1.492 ± 0.069
2.654GluAsn: 2.654 ± 0.107
1.331GluPro: 1.331 ± 0.066
1.906GluGln: 1.906 ± 0.099
3.361GluArg: 3.361 ± 0.105
4.402GluSer: 4.402 ± 0.124
2.409GluThr: 2.409 ± 0.089
5.276GluVal: 5.276 ± 0.142
0.394GluTrp: 0.394 ± 0.034
2.196GluTyr: 2.196 ± 0.093
0.0GluXaa: 0.0 ± 0.0
Phe
3.367PheAla: 3.367 ± 0.1
0.891PheCys: 0.891 ± 0.052
2.122PheAsp: 2.122 ± 0.085
1.88PheGlu: 1.88 ± 0.088
2.079PhePhe: 2.079 ± 0.086
2.705PheGly: 2.705 ± 0.096
0.773PheHis: 0.773 ± 0.051
2.412PheIle: 2.412 ± 0.089
1.78PheLys: 1.78 ± 0.075
4.356PheLeu: 4.356 ± 0.136
1.069PheMet: 1.069 ± 0.049
1.368PheAsn: 1.368 ± 0.068
1.389PhePro: 1.389 ± 0.065
0.906PheGln: 0.906 ± 0.056
1.67PheArg: 1.67 ± 0.072
4.22PheSer: 4.22 ± 0.118
1.992PheThr: 1.992 ± 0.091
3.415PheVal: 3.415 ± 0.105
0.342PheTrp: 0.342 ± 0.034
1.665PheTyr: 1.665 ± 0.076
0.0PheXaa: 0.0 ± 0.0
Gly
5.175GlyAla: 5.175 ± 0.129
1.366GlyCys: 1.366 ± 0.066
3.99GlyAsp: 3.99 ± 0.143
4.232GlyGlu: 4.232 ± 0.118
3.099GlyPhe: 3.099 ± 0.095
5.497GlyGly: 5.497 ± 0.184
1.538GlyHis: 1.538 ± 0.061
5.583GlyIle: 5.583 ± 0.134
4.936GlyLys: 4.936 ± 0.13
6.098GlyLeu: 6.098 ± 0.21
2.018GlyMet: 2.018 ± 0.095
2.901GlyAsn: 2.901 ± 0.1
1.389GlyPro: 1.389 ± 0.071
1.874GlyGln: 1.874 ± 0.068
3.326GlyArg: 3.326 ± 0.1
5.592GlySer: 5.592 ± 0.16
3.375GlyThr: 3.375 ± 0.094
6.296GlyVal: 6.296 ± 0.17
0.563GlyTrp: 0.563 ± 0.043
2.651GlyTyr: 2.651 ± 0.095
0.0GlyXaa: 0.0 ± 0.0
His
1.811HisAla: 1.811 ± 0.078
0.405HisCys: 0.405 ± 0.033
1.251HisAsp: 1.251 ± 0.057
1.147HisGlu: 1.147 ± 0.061
0.756HisPhe: 0.756 ± 0.051
1.65HisGly: 1.65 ± 0.062
0.469HisHis: 0.469 ± 0.039
1.662HisIle: 1.662 ± 0.065
1.38HisLys: 1.38 ± 0.066
1.886HisLeu: 1.886 ± 0.08
0.561HisMet: 0.561 ± 0.043
1.018HisAsn: 1.018 ± 0.059
1.009HisPro: 1.009 ± 0.058
0.454HisGln: 0.454 ± 0.036
1.202HisArg: 1.202 ± 0.058
1.699HisSer: 1.699 ± 0.071
1.058HisThr: 1.058 ± 0.059
1.65HisVal: 1.65 ± 0.083
0.175HisTrp: 0.175 ± 0.022
0.791HisTyr: 0.791 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
5.779IleAla: 5.779 ± 0.151
1.271IleCys: 1.271 ± 0.068
3.824IleAsp: 3.824 ± 0.107
4.537IleGlu: 4.537 ± 0.138
2.51IlePhe: 2.51 ± 0.098
4.715IleGly: 4.715 ± 0.134
1.202IleHis: 1.202 ± 0.073
4.036IleIle: 4.036 ± 0.125
3.545IleLys: 3.545 ± 0.108
5.807IleLeu: 5.807 ± 0.133
1.63IleMet: 1.63 ± 0.074
2.504IleAsn: 2.504 ± 0.093
2.708IlePro: 2.708 ± 0.108
1.535IleGln: 1.535 ± 0.073
3.875IleArg: 3.875 ± 0.118
6.118IleSer: 6.118 ± 0.114
3.444IleThr: 3.444 ± 0.091
5.667IleVal: 5.667 ± 0.156
0.411IleTrp: 0.411 ± 0.038
1.797IleTyr: 1.797 ± 0.07
0.0IleXaa: 0.0 ± 0.0
Lys
4.356LysAla: 4.356 ± 0.127
0.871LysCys: 0.871 ± 0.056
3.507LysAsp: 3.507 ± 0.109
3.976LysGlu: 3.976 ± 0.106
2.208LysPhe: 2.208 ± 0.088
3.749LysGly: 3.749 ± 0.115
1.345LysHis: 1.345 ± 0.067
4.068LysIle: 4.068 ± 0.096
4.016LysLys: 4.016 ± 0.127
5.247LysLeu: 5.247 ± 0.132
1.371LysMet: 1.371 ± 0.056
2.82LysAsn: 2.82 ± 0.114
1.469LysPro: 1.469 ± 0.066
1.699LysGln: 1.699 ± 0.078
2.978LysArg: 2.978 ± 0.099
4.338LysSer: 4.338 ± 0.129
3.519LysThr: 3.519 ± 0.157
4.821LysVal: 4.821 ± 0.134
0.371LysTrp: 0.371 ± 0.033
1.915LysTyr: 1.915 ± 0.08
0.0LysXaa: 0.0 ± 0.0
Leu
7.567LeuAla: 7.567 ± 0.162
2.145LeuCys: 2.145 ± 0.091
4.522LeuAsp: 4.522 ± 0.101
5.922LeuGlu: 5.922 ± 0.145
3.556LeuPhe: 3.556 ± 0.121
6.431LeuGly: 6.431 ± 0.137
2.412LeuHis: 2.412 ± 0.085
4.839LeuIle: 4.839 ± 0.145
5.382LeuLys: 5.382 ± 0.151
10.652LeuLeu: 10.652 ± 0.231
2.357LeuMet: 2.357 ± 0.089
3.381LeuAsn: 3.381 ± 0.111
3.746LeuPro: 3.746 ± 0.108
3.243LeuGln: 3.243 ± 0.1
5.465LeuArg: 5.465 ± 0.119
9.056LeuSer: 9.056 ± 0.223
4.128LeuThr: 4.128 ± 0.111
6.641LeuVal: 6.641 ± 0.163
0.747LeuTrp: 0.747 ± 0.053
2.987LeuTyr: 2.987 ± 0.102
0.0LeuXaa: 0.0 ± 0.0
Met
1.866MetAla: 1.866 ± 0.086
0.474MetCys: 0.474 ± 0.067
1.078MetAsp: 1.078 ± 0.052
1.472MetGlu: 1.472 ± 0.065
1.09MetPhe: 1.09 ± 0.06
1.834MetGly: 1.834 ± 0.082
0.814MetHis: 0.814 ± 0.044
1.305MetIle: 1.305 ± 0.07
1.276MetLys: 1.276 ± 0.067
3.332MetLeu: 3.332 ± 0.106
0.816MetMet: 0.816 ± 0.055
0.883MetAsn: 0.883 ± 0.051
1.075MetPro: 1.075 ± 0.067
1.228MetGln: 1.228 ± 0.06
1.55MetArg: 1.55 ± 0.065
2.205MetSer: 2.205 ± 0.075
0.9MetThr: 0.9 ± 0.052
2.09MetVal: 2.09 ± 0.078
0.195MetTrp: 0.195 ± 0.023
0.825MetTyr: 0.825 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
3.588AsnAla: 3.588 ± 0.122
0.624AsnCys: 0.624 ± 0.044
1.978AsnAsp: 1.978 ± 0.088
1.828AsnGlu: 1.828 ± 0.074
1.719AsnPhe: 1.719 ± 0.078
2.363AsnGly: 2.363 ± 0.087
0.632AsnHis: 0.632 ± 0.043
3.119AsnIle: 3.119 ± 0.113
2.205AsnLys: 2.205 ± 0.089
3.62AsnLeu: 3.62 ± 0.124
1.113AsnMet: 1.113 ± 0.054
1.782AsnAsn: 1.782 ± 0.079
1.524AsnPro: 1.524 ± 0.067
0.773AsnGln: 0.773 ± 0.054
1.981AsnArg: 1.981 ± 0.076
3.338AsnSer: 3.338 ± 0.122
2.429AsnThr: 2.429 ± 0.098
3.01AsnVal: 3.01 ± 0.092
0.492AsnTrp: 0.492 ± 0.036
1.144AsnTyr: 1.144 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.291ProAla: 2.291 ± 0.092
0.451ProCys: 0.451 ± 0.041
1.8ProAsp: 1.8 ± 0.071
2.855ProGlu: 2.855 ± 0.111
1.297ProPhe: 1.297 ± 0.09
2.274ProGly: 2.274 ± 0.081
0.745ProHis: 0.745 ± 0.056
2.056ProIle: 2.056 ± 0.098
1.869ProLys: 1.869 ± 0.085
2.691ProLeu: 2.691 ± 0.095
0.788ProMet: 0.788 ± 0.048
1.207ProAsn: 1.207 ± 0.057
0.94ProPro: 0.94 ± 0.061
0.995ProGln: 0.995 ± 0.053
1.489ProArg: 1.489 ± 0.067
2.654ProSer: 2.654 ± 0.139
1.851ProThr: 1.851 ± 0.089
2.832ProVal: 2.832 ± 0.093
0.313ProTrp: 0.313 ± 0.032
1.437ProTyr: 1.437 ± 0.078
0.0ProXaa: 0.0 ± 0.0
Gln
1.972GlnAla: 1.972 ± 0.081
0.664GlnCys: 0.664 ± 0.045
1.584GlnAsp: 1.584 ± 0.116
2.355GlnGlu: 2.355 ± 0.115
1.087GlnPhe: 1.087 ± 0.055
1.8GlnGly: 1.8 ± 0.074
0.831GlnHis: 0.831 ± 0.056
1.541GlnIle: 1.541 ± 0.078
1.713GlnLys: 1.713 ± 0.068
2.343GlnLeu: 2.343 ± 0.078
0.632GlnMet: 0.632 ± 0.046
1.288GlnAsn: 1.288 ± 0.07
0.903GlnPro: 0.903 ± 0.078
1.055GlnGln: 1.055 ± 0.061
1.521GlnArg: 1.521 ± 0.062
1.969GlnSer: 1.969 ± 0.105
1.144GlnThr: 1.144 ± 0.053
1.987GlnVal: 1.987 ± 0.091
0.204GlnTrp: 0.204 ± 0.023
1.029GlnTyr: 1.029 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
3.893ArgAla: 3.893 ± 0.106
0.885ArgCys: 0.885 ± 0.051
3.318ArgAsp: 3.318 ± 0.098
3.582ArgGlu: 3.582 ± 0.091
2.225ArgPhe: 2.225 ± 0.09
3.407ArgGly: 3.407 ± 0.119
0.957ArgHis: 0.957 ± 0.059
3.548ArgIle: 3.548 ± 0.1
2.996ArgLys: 2.996 ± 0.09
4.471ArgLeu: 4.471 ± 0.127
1.343ArgMet: 1.343 ± 0.067
2.102ArgAsn: 2.102 ± 0.073
1.348ArgPro: 1.348 ± 0.057
1.225ArgGln: 1.225 ± 0.057
2.829ArgArg: 2.829 ± 0.124
3.815ArgSer: 3.815 ± 0.112
2.093ArgThr: 2.093 ± 0.09
4.35ArgVal: 4.35 ± 0.114
0.391ArgTrp: 0.391 ± 0.038
1.866ArgTyr: 1.866 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
6.38SerAla: 6.38 ± 0.151
1.351SerCys: 1.351 ± 0.057
4.146SerAsp: 4.146 ± 0.127
4.709SerGlu: 4.709 ± 0.124
3.142SerPhe: 3.142 ± 0.082
6.831SerGly: 6.831 ± 0.219
1.889SerHis: 1.889 ± 0.081
5.744SerIle: 5.744 ± 0.13
4.611SerLys: 4.611 ± 0.124
7.242SerLeu: 7.242 ± 0.141
2.467SerMet: 2.467 ± 0.086
3.306SerAsn: 3.306 ± 0.119
2.723SerPro: 2.723 ± 0.12
2.188SerGln: 2.188 ± 0.099
4.045SerArg: 4.045 ± 0.114
7.86SerSer: 7.86 ± 0.218
4.692SerThr: 4.692 ± 0.151
6.874SerVal: 6.874 ± 0.147
0.546SerTrp: 0.546 ± 0.044
2.631SerTyr: 2.631 ± 0.097
0.0SerXaa: 0.0 ± 0.0
Thr
4.068ThrAla: 4.068 ± 0.124
0.857ThrCys: 0.857 ± 0.064
2.521ThrAsp: 2.521 ± 0.09
2.889ThrGlu: 2.889 ± 0.104
1.814ThrPhe: 1.814 ± 0.067
3.801ThrGly: 3.801 ± 0.117
1.104ThrHis: 1.104 ± 0.058
3.272ThrIle: 3.272 ± 0.109
2.984ThrLys: 2.984 ± 0.113
4.43ThrLeu: 4.43 ± 0.127
0.963ThrMet: 0.963 ± 0.048
1.722ThrAsn: 1.722 ± 0.081
2.234ThrPro: 2.234 ± 0.102
1.288ThrGln: 1.288 ± 0.077
2.061ThrArg: 2.061 ± 0.079
4.482ThrSer: 4.482 ± 0.142
2.421ThrThr: 2.421 ± 0.095
3.815ThrVal: 3.815 ± 0.105
0.336ThrTrp: 0.336 ± 0.035
1.271ThrTyr: 1.271 ± 0.061
0.0ThrXaa: 0.0 ± 0.0
Val
6.65ValAla: 6.65 ± 0.154
1.734ValCys: 1.734 ± 0.078
4.422ValAsp: 4.422 ± 0.132
4.977ValGlu: 4.977 ± 0.141
3.407ValPhe: 3.407 ± 0.111
5.756ValGly: 5.756 ± 0.157
1.702ValHis: 1.702 ± 0.082
5.08ValIle: 5.08 ± 0.147
4.295ValLys: 4.295 ± 0.137
8.49ValLeu: 8.49 ± 0.172
2.527ValMet: 2.527 ± 0.087
2.915ValAsn: 2.915 ± 0.095
3.027ValPro: 3.027 ± 0.103
2.291ValGln: 2.291 ± 0.087
4.065ValArg: 4.065 ± 0.122
6.612ValSer: 6.612 ± 0.146
3.907ValThr: 3.907 ± 0.109
7.8ValVal: 7.8 ± 0.194
0.535ValTrp: 0.535 ± 0.042
2.786ValTyr: 2.786 ± 0.089
0.0ValXaa: 0.0 ± 0.0
Trp
0.385TrpAla: 0.385 ± 0.035
0.158TrpCys: 0.158 ± 0.022
0.397TrpAsp: 0.397 ± 0.047
0.4TrpGlu: 0.4 ± 0.035
0.374TrpPhe: 0.374 ± 0.035
0.471TrpGly: 0.471 ± 0.036
0.213TrpHis: 0.213 ± 0.026
0.477TrpIle: 0.477 ± 0.037
0.509TrpLys: 0.509 ± 0.035
0.756TrpLeu: 0.756 ± 0.057
0.175TrpMet: 0.175 ± 0.021
0.385TrpAsn: 0.385 ± 0.036
0.509TrpPro: 0.509 ± 0.037
0.256TrpGln: 0.256 ± 0.026
0.391TrpArg: 0.391 ± 0.034
0.463TrpSer: 0.463 ± 0.037
0.236TrpThr: 0.236 ± 0.028
0.497TrpVal: 0.497 ± 0.035
0.095TrpTrp: 0.095 ± 0.018
0.299TrpTyr: 0.299 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.708TyrAla: 2.708 ± 0.101
0.584TyrCys: 0.584 ± 0.039
2.231TyrAsp: 2.231 ± 0.09
1.785TyrGlu: 1.785 ± 0.078
1.322TyrPhe: 1.322 ± 0.053
2.596TyrGly: 2.596 ± 0.097
0.831TyrHis: 0.831 ± 0.045
2.214TyrIle: 2.214 ± 0.075
1.782TyrLys: 1.782 ± 0.073
3.125TyrLeu: 3.125 ± 0.08
0.756TyrMet: 0.756 ± 0.048
1.256TyrAsn: 1.256 ± 0.068
1.087TyrPro: 1.087 ± 0.053
0.891TyrGln: 0.891 ± 0.051
1.803TyrArg: 1.803 ± 0.075
2.8TyrSer: 2.8 ± 0.108
1.647TyrThr: 1.647 ± 0.076
2.665TyrVal: 2.665 ± 0.112
0.224TyrTrp: 0.224 ± 0.025
1.006TyrTyr: 1.006 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1330 proteins (347830 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski