Amino acid dipepetide frequency for Mycoplasma agassizii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.034AlaAla: 4.034 ± 0.148
0.328AlaCys: 0.328 ± 0.03
2.974AlaAsp: 2.974 ± 0.095
3.302AlaGlu: 3.302 ± 0.109
2.775AlaPhe: 2.775 ± 0.1
3.198AlaGly: 3.198 ± 0.117
0.774AlaHis: 0.774 ± 0.051
5.631AlaIle: 5.631 ± 0.153
5.434AlaLys: 5.434 ± 0.13
5.72AlaLeu: 5.72 ± 0.132
1.046AlaMet: 1.046 ± 0.057
4.376AlaAsn: 4.376 ± 0.142
1.568AlaPro: 1.568 ± 0.083
2.017AlaGln: 2.017 ± 0.087
2.07AlaArg: 2.07 ± 0.086
4.379AlaSer: 4.379 ± 0.144
4.343AlaThr: 4.343 ± 0.174
3.641AlaVal: 3.641 ± 0.125
0.511AlaTrp: 0.511 ± 0.037
2.017AlaTyr: 2.017 ± 0.075
0.0AlaXaa: 0.0 ± 0.0
Cys
0.149CysAla: 0.149 ± 0.02
0.008CysCys: 0.008 ± 0.005
0.101CysAsp: 0.101 ± 0.017
0.137CysGlu: 0.137 ± 0.021
0.118CysPhe: 0.118 ± 0.02
0.146CysGly: 0.146 ± 0.019
0.048CysHis: 0.048 ± 0.012
0.121CysIle: 0.121 ± 0.017
0.16CysLys: 0.16 ± 0.023
0.18CysLeu: 0.18 ± 0.023
0.036CysMet: 0.036 ± 0.011
0.126CysAsn: 0.126 ± 0.018
0.098CysPro: 0.098 ± 0.016
0.081CysGln: 0.081 ± 0.017
0.084CysArg: 0.084 ± 0.014
0.365CysSer: 0.365 ± 0.037
0.14CysThr: 0.14 ± 0.019
0.101CysVal: 0.101 ± 0.017
0.017CysTrp: 0.017 ± 0.006
0.067CysTyr: 0.067 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
2.993AspAla: 2.993 ± 0.109
0.095AspCys: 0.095 ± 0.015
3.17AspAsp: 3.17 ± 0.115
4.449AspGlu: 4.449 ± 0.14
3.731AspPhe: 3.731 ± 0.121
2.693AspGly: 2.693 ± 0.104
0.892AspHis: 0.892 ± 0.052
3.975AspIle: 3.975 ± 0.106
5.297AspLys: 5.297 ± 0.127
6.035AspLeu: 6.035 ± 0.147
0.682AspMet: 0.682 ± 0.043
3.748AspAsn: 3.748 ± 0.115
1.65AspPro: 1.65 ± 0.07
2.079AspGln: 2.079 ± 0.078
1.551AspArg: 1.551 ± 0.064
3.748AspSer: 3.748 ± 0.111
2.752AspThr: 2.752 ± 0.113
3.288AspVal: 3.288 ± 0.096
0.687AspTrp: 0.687 ± 0.047
2.761AspTyr: 2.761 ± 0.093
0.0AspXaa: 0.0 ± 0.0
Glu
3.526GluAla: 3.526 ± 0.123
0.09GluCys: 0.09 ± 0.017
3.148GluAsp: 3.148 ± 0.106
4.402GluGlu: 4.402 ± 0.162
3.271GluPhe: 3.271 ± 0.11
2.379GluGly: 2.379 ± 0.085
0.929GluHis: 0.929 ± 0.058
6.727GluIle: 6.727 ± 0.176
7.308GluLys: 7.308 ± 0.199
6.065GluLeu: 6.065 ± 0.16
1.195GluMet: 1.195 ± 0.06
5.816GluAsn: 5.816 ± 0.142
1.335GluPro: 1.335 ± 0.07
2.57GluGln: 2.57 ± 0.101
2.208GluArg: 2.208 ± 0.09
3.574GluSer: 3.574 ± 0.093
3.838GluThr: 3.838 ± 0.112
3.947GluVal: 3.947 ± 0.107
0.668GluTrp: 0.668 ± 0.051
2.401GluTyr: 2.401 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
3.487PheAla: 3.487 ± 0.11
0.121PheCys: 0.121 ± 0.018
3.381PheAsp: 3.381 ± 0.102
3.633PheGlu: 3.633 ± 0.113
2.934PhePhe: 2.934 ± 0.122
2.382PheGly: 2.382 ± 0.102
0.62PheHis: 0.62 ± 0.046
4.584PheIle: 4.584 ± 0.15
5.232PheLys: 5.232 ± 0.132
5.215PheLeu: 5.215 ± 0.161
0.903PheMet: 0.903 ± 0.054
4.062PheAsn: 4.062 ± 0.132
1.153PhePro: 1.153 ± 0.061
1.386PheGln: 1.386 ± 0.062
1.38PheArg: 1.38 ± 0.064
4.41PheSer: 4.41 ± 0.116
3.089PheThr: 3.089 ± 0.108
3.232PheVal: 3.232 ± 0.112
0.561PheTrp: 0.561 ± 0.043
2.244PheTyr: 2.244 ± 0.077
0.0PheXaa: 0.0 ± 0.0
Gly
2.974GlyAla: 2.974 ± 0.127
0.079GlyCys: 0.079 ± 0.017
2.564GlyAsp: 2.564 ± 0.097
2.665GlyGlu: 2.665 ± 0.079
2.993GlyPhe: 2.993 ± 0.106
2.775GlyGly: 2.775 ± 0.123
0.727GlyHis: 0.727 ± 0.05
4.16GlyIle: 4.16 ± 0.138
3.93GlyLys: 3.93 ± 0.119
4.205GlyLeu: 4.205 ± 0.132
0.701GlyMet: 0.701 ± 0.047
2.528GlyAsn: 2.528 ± 0.098
0.985GlyPro: 0.985 ± 0.06
1.554GlyGln: 1.554 ± 0.071
1.523GlyArg: 1.523 ± 0.073
3.504GlySer: 3.504 ± 0.111
2.963GlyThr: 2.963 ± 0.118
3.288GlyVal: 3.288 ± 0.119
0.527GlyTrp: 0.527 ± 0.037
2.191GlyTyr: 2.191 ± 0.089
0.0GlyXaa: 0.0 ± 0.0
His
0.783HisAla: 0.783 ± 0.046
0.039HisCys: 0.039 ± 0.011
0.85HisAsp: 0.85 ± 0.054
0.985HisGlu: 0.985 ± 0.055
0.853HisPhe: 0.853 ± 0.05
0.788HisGly: 0.788 ± 0.054
0.328HisHis: 0.328 ± 0.031
1.058HisIle: 1.058 ± 0.063
1.159HisLys: 1.159 ± 0.068
1.579HisLeu: 1.579 ± 0.068
0.177HisMet: 0.177 ± 0.023
0.892HisAsn: 0.892 ± 0.058
0.533HisPro: 0.533 ± 0.041
0.564HisGln: 0.564 ± 0.045
0.46HisArg: 0.46 ± 0.038
0.943HisSer: 0.943 ± 0.053
0.62HisThr: 0.62 ± 0.047
0.87HisVal: 0.87 ± 0.053
0.154HisTrp: 0.154 ± 0.02
0.668HisTyr: 0.668 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
5.81IleAla: 5.81 ± 0.141
0.261IleCys: 0.261 ± 0.027
5.322IleAsp: 5.322 ± 0.119
5.28IleGlu: 5.28 ± 0.149
4.747IlePhe: 4.747 ± 0.166
3.678IleGly: 3.678 ± 0.116
1.187IleHis: 1.187 ± 0.063
7.269IleIle: 7.269 ± 0.216
8.371IleLys: 8.371 ± 0.16
7.404IleLeu: 7.404 ± 0.19
1.349IleMet: 1.349 ± 0.073
6.576IleAsn: 6.576 ± 0.159
2.415IlePro: 2.415 ± 0.091
2.141IleGln: 2.141 ± 0.085
2.528IleArg: 2.528 ± 0.092
7.0IleSer: 7.0 ± 0.165
5.215IleThr: 5.215 ± 0.137
5.117IleVal: 5.117 ± 0.153
0.797IleTrp: 0.797 ± 0.056
3.223IleTyr: 3.223 ± 0.103
0.0IleXaa: 0.0 ± 0.0
Lys
5.041LysAla: 5.041 ± 0.14
0.109LysCys: 0.109 ± 0.019
5.821LysAsp: 5.821 ± 0.15
6.626LysGlu: 6.626 ± 0.175
4.074LysPhe: 4.074 ± 0.117
3.554LysGly: 3.554 ± 0.117
1.464LysHis: 1.464 ± 0.063
9.048LysIle: 9.048 ± 0.222
9.09LysLys: 9.09 ± 0.242
8.47LysLeu: 8.47 ± 0.184
2.174LysMet: 2.174 ± 0.087
7.878LysAsn: 7.878 ± 0.19
2.547LysPro: 2.547 ± 0.11
3.308LysGln: 3.308 ± 0.116
2.92LysArg: 2.92 ± 0.101
6.049LysSer: 6.049 ± 0.125
6.225LysThr: 6.225 ± 0.149
5.597LysVal: 5.597 ± 0.161
1.052LysTrp: 1.052 ± 0.055
4.247LysTyr: 4.247 ± 0.109
0.0LysXaa: 0.0 ± 0.0
Leu
5.953LeuAla: 5.953 ± 0.132
0.18LeuCys: 0.18 ± 0.019
5.42LeuAsp: 5.42 ± 0.134
6.697LeuGlu: 6.697 ± 0.17
4.842LeuPhe: 4.842 ± 0.124
4.304LeuGly: 4.304 ± 0.129
1.246LeuHis: 1.246 ± 0.064
8.582LeuIle: 8.582 ± 0.211
10.088LeuLys: 10.088 ± 0.193
8.296LeuLeu: 8.296 ± 0.186
1.501LeuMet: 1.501 ± 0.071
7.345LeuAsn: 7.345 ± 0.158
2.704LeuPro: 2.704 ± 0.099
2.578LeuGln: 2.578 ± 0.088
2.926LeuArg: 2.926 ± 0.082
6.803LeuSer: 6.803 ± 0.141
6.063LeuThr: 6.063 ± 0.186
5.729LeuVal: 5.729 ± 0.135
0.802LeuTrp: 0.802 ± 0.056
2.87LeuTyr: 2.87 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
1.066MetAla: 1.066 ± 0.061
0.036MetCys: 0.036 ± 0.009
0.746MetAsp: 0.746 ± 0.049
0.774MetGlu: 0.774 ± 0.055
0.864MetPhe: 0.864 ± 0.054
0.685MetGly: 0.685 ± 0.049
0.317MetHis: 0.317 ± 0.035
1.42MetIle: 1.42 ± 0.075
1.939MetLys: 1.939 ± 0.066
1.473MetLeu: 1.473 ± 0.071
0.345MetMet: 0.345 ± 0.033
1.156MetAsn: 1.156 ± 0.056
0.536MetPro: 0.536 ± 0.038
0.693MetGln: 0.693 ± 0.044
0.511MetArg: 0.511 ± 0.042
1.344MetSer: 1.344 ± 0.059
0.786MetThr: 0.786 ± 0.045
0.976MetVal: 0.976 ± 0.057
0.154MetTrp: 0.154 ± 0.023
0.469MetTyr: 0.469 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.911AsnAla: 3.911 ± 0.124
0.132AsnCys: 0.132 ± 0.02
3.888AsnAsp: 3.888 ± 0.107
4.635AsnGlu: 4.635 ± 0.129
4.376AsnPhe: 4.376 ± 0.126
3.299AsnGly: 3.299 ± 0.121
1.293AsnHis: 1.293 ± 0.069
5.549AsnIle: 5.549 ± 0.154
7.019AsnLys: 7.019 ± 0.169
8.04AsnLeu: 8.04 ± 0.168
1.03AsnMet: 1.03 ± 0.051
5.973AsnAsn: 5.973 ± 0.162
2.609AsnPro: 2.609 ± 0.103
3.019AsnGln: 3.019 ± 0.118
2.062AsnArg: 2.062 ± 0.079
5.574AsnSer: 5.574 ± 0.147
3.392AsnThr: 3.392 ± 0.107
3.973AsnVal: 3.973 ± 0.101
0.912AsnTrp: 0.912 ± 0.051
3.613AsnTyr: 3.613 ± 0.106
0.0AsnXaa: 0.0 ± 0.0
Pro
1.478ProAla: 1.478 ± 0.071
0.076ProCys: 0.076 ± 0.016
1.476ProAsp: 1.476 ± 0.073
2.056ProGlu: 2.056 ± 0.082
1.38ProPhe: 1.38 ± 0.067
1.42ProGly: 1.42 ± 0.07
0.398ProHis: 0.398 ± 0.038
2.152ProIle: 2.152 ± 0.087
2.093ProLys: 2.093 ± 0.097
2.435ProLeu: 2.435 ± 0.084
0.356ProMet: 0.356 ± 0.03
1.849ProAsn: 1.849 ± 0.091
0.735ProPro: 0.735 ± 0.097
0.858ProGln: 0.858 ± 0.05
0.771ProArg: 0.771 ± 0.057
2.138ProSer: 2.138 ± 0.088
1.784ProThr: 1.784 ± 0.084
1.807ProVal: 1.807 ± 0.077
0.368ProTrp: 0.368 ± 0.035
1.26ProTyr: 1.26 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
2.127GlnAla: 2.127 ± 0.091
0.031GlnCys: 0.031 ± 0.011
1.664GlnAsp: 1.664 ± 0.069
2.275GlnGlu: 2.275 ± 0.096
1.481GlnPhe: 1.481 ± 0.074
1.574GlnGly: 1.574 ± 0.08
0.449GlnHis: 0.449 ± 0.036
3.035GlnIle: 3.035 ± 0.101
3.364GlnLys: 3.364 ± 0.12
3.041GlnLeu: 3.041 ± 0.099
0.634GlnMet: 0.634 ± 0.046
2.747GlnAsn: 2.747 ± 0.112
0.808GlnPro: 0.808 ± 0.058
1.276GlnGln: 1.276 ± 0.078
1.069GlnArg: 1.069 ± 0.069
1.944GlnSer: 1.944 ± 0.08
1.983GlnThr: 1.983 ± 0.082
1.911GlnVal: 1.911 ± 0.067
0.309GlnTrp: 0.309 ± 0.03
1.251GlnTyr: 1.251 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
1.795ArgAla: 1.795 ± 0.079
0.07ArgCys: 0.07 ± 0.014
1.669ArgAsp: 1.669 ± 0.071
2.146ArgGlu: 2.146 ± 0.096
1.636ArgPhe: 1.636 ± 0.068
1.363ArgGly: 1.363 ± 0.065
0.471ArgHis: 0.471 ± 0.04
2.688ArgIle: 2.688 ± 0.094
2.878ArgLys: 2.878 ± 0.1
2.876ArgLeu: 2.876 ± 0.097
0.617ArgMet: 0.617 ± 0.048
2.275ArgAsn: 2.275 ± 0.094
0.755ArgPro: 0.755 ± 0.048
1.06ArgGln: 1.06 ± 0.055
1.279ArgArg: 1.279 ± 0.067
2.093ArgSer: 2.093 ± 0.083
1.638ArgThr: 1.638 ± 0.069
1.829ArgVal: 1.829 ± 0.084
0.348ArgTrp: 0.348 ± 0.034
1.305ArgTyr: 1.305 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
4.334SerAla: 4.334 ± 0.133
0.213SerCys: 0.213 ± 0.025
4.343SerAsp: 4.343 ± 0.128
5.022SerGlu: 5.022 ± 0.127
4.267SerPhe: 4.267 ± 0.133
4.09SerGly: 4.09 ± 0.12
0.895SerHis: 0.895 ± 0.047
5.476SerIle: 5.476 ± 0.144
6.927SerLys: 6.927 ± 0.15
7.432SerLeu: 7.432 ± 0.178
1.032SerMet: 1.032 ± 0.056
4.893SerAsn: 4.893 ± 0.125
1.546SerPro: 1.546 ± 0.064
2.547SerGln: 2.547 ± 0.089
2.239SerArg: 2.239 ± 0.073
5.664SerSer: 5.664 ± 0.192
4.006SerThr: 4.006 ± 0.156
4.233SerVal: 4.233 ± 0.104
0.875SerTrp: 0.875 ± 0.048
2.923SerTyr: 2.923 ± 0.087
0.0SerXaa: 0.0 ± 0.0
Thr
3.526ThrAla: 3.526 ± 0.17
0.115ThrCys: 0.115 ± 0.019
3.047ThrAsp: 3.047 ± 0.112
3.052ThrGlu: 3.052 ± 0.1
3.344ThrPhe: 3.344 ± 0.116
3.165ThrGly: 3.165 ± 0.104
0.752ThrHis: 0.752 ± 0.043
5.308ThrIle: 5.308 ± 0.155
4.898ThrLys: 4.898 ± 0.155
5.636ThrLeu: 5.636 ± 0.149
0.749ThrMet: 0.749 ± 0.048
4.346ThrAsn: 4.346 ± 0.174
2.096ThrPro: 2.096 ± 0.101
1.728ThrGln: 1.728 ± 0.076
1.781ThrArg: 1.781 ± 0.074
4.963ThrSer: 4.963 ± 0.152
4.233ThrThr: 4.233 ± 0.218
3.863ThrVal: 3.863 ± 0.171
0.654ThrTrp: 0.654 ± 0.04
2.39ThrTyr: 2.39 ± 0.096
0.0ThrXaa: 0.0 ± 0.0
Val
4.32ValAla: 4.32 ± 0.122
0.121ValCys: 0.121 ± 0.018
3.706ValAsp: 3.706 ± 0.117
3.916ValGlu: 3.916 ± 0.115
3.159ValPhe: 3.159 ± 0.1
2.974ValGly: 2.974 ± 0.111
0.777ValHis: 0.777 ± 0.047
5.097ValIle: 5.097 ± 0.147
5.518ValLys: 5.518 ± 0.127
5.344ValLeu: 5.344 ± 0.122
0.979ValMet: 0.979 ± 0.047
4.18ValAsn: 4.18 ± 0.128
1.431ValPro: 1.431 ± 0.068
1.579ValGln: 1.579 ± 0.063
1.731ValArg: 1.731 ± 0.065
4.786ValSer: 4.786 ± 0.129
3.933ValThr: 3.933 ± 0.197
4.071ValVal: 4.071 ± 0.111
0.452ValTrp: 0.452 ± 0.039
2.09ValTyr: 2.09 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.477TrpAla: 0.477 ± 0.029
0.031TrpCys: 0.031 ± 0.009
0.575TrpAsp: 0.575 ± 0.039
0.572TrpGlu: 0.572 ± 0.044
0.612TrpPhe: 0.612 ± 0.047
0.426TrpGly: 0.426 ± 0.031
0.168TrpHis: 0.168 ± 0.023
0.971TrpIle: 0.971 ± 0.062
1.038TrpLys: 1.038 ± 0.058
1.024TrpLeu: 1.024 ± 0.056
0.233TrpMet: 0.233 ± 0.019
0.864TrpAsn: 0.864 ± 0.052
0.21TrpPro: 0.21 ± 0.024
0.314TrpGln: 0.314 ± 0.027
0.345TrpArg: 0.345 ± 0.029
0.699TrpSer: 0.699 ± 0.046
0.645TrpThr: 0.645 ± 0.042
0.609TrpVal: 0.609 ± 0.037
0.185TrpTrp: 0.185 ± 0.024
0.581TrpTyr: 0.581 ± 0.043
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.354TyrAla: 2.354 ± 0.082
0.149TyrCys: 0.149 ± 0.023
2.413TyrAsp: 2.413 ± 0.096
2.772TyrGlu: 2.772 ± 0.093
2.553TyrPhe: 2.553 ± 0.105
1.944TyrGly: 1.944 ± 0.077
0.567TyrHis: 0.567 ± 0.044
2.839TyrIle: 2.839 ± 0.088
3.552TyrLys: 3.552 ± 0.11
4.458TyrLeu: 4.458 ± 0.127
0.547TyrMet: 0.547 ± 0.046
2.671TyrAsn: 2.671 ± 0.102
1.175TyrPro: 1.175 ± 0.065
1.619TyrGln: 1.619 ± 0.068
1.352TyrArg: 1.352 ± 0.067
2.979TyrSer: 2.979 ± 0.093
1.997TyrThr: 1.997 ± 0.09
2.084TyrVal: 2.084 ± 0.077
0.547TyrTrp: 0.547 ± 0.041
1.675TyrTyr: 1.675 ± 0.078
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 955 proteins (356451 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski