Amino acid dipepetide frequency for Coastal Plains virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.667AlaAla: 1.667 ± 0.542
0.953AlaCys: 0.953 ± 0.337
2.859AlaAsp: 2.859 ± 0.951
0.715AlaGlu: 0.715 ± 0.373
1.429AlaPhe: 1.429 ± 0.86
1.191AlaGly: 1.191 ± 0.565
0.715AlaHis: 0.715 ± 0.271
4.05AlaIle: 4.05 ± 0.907
3.335AlaLys: 3.335 ± 0.91
4.526AlaLeu: 4.526 ± 0.704
1.191AlaMet: 1.191 ± 0.314
1.906AlaAsn: 1.906 ± 0.466
0.715AlaPro: 0.715 ± 0.344
0.476AlaGln: 0.476 ± 0.25
1.906AlaArg: 1.906 ± 0.85
2.144AlaSer: 2.144 ± 0.515
1.667AlaThr: 1.667 ± 0.712
1.667AlaVal: 1.667 ± 0.754
0.476AlaTrp: 0.476 ± 0.287
2.382AlaTyr: 2.382 ± 0.746
0.0AlaXaa: 0.0 ± 0.0
Cys
0.476CysAla: 0.476 ± 0.287
0.715CysCys: 0.715 ± 0.348
0.715CysAsp: 0.715 ± 0.356
1.906CysGlu: 1.906 ± 0.595
0.953CysPhe: 0.953 ± 0.387
0.715CysGly: 0.715 ± 0.297
0.715CysHis: 0.715 ± 0.356
1.191CysIle: 1.191 ± 0.552
1.667CysLys: 1.667 ± 0.893
2.382CysLeu: 2.382 ± 0.5
0.238CysMet: 0.238 ± 0.143
1.191CysAsn: 1.191 ± 0.446
0.715CysPro: 0.715 ± 0.271
1.429CysGln: 1.429 ± 0.667
0.476CysArg: 0.476 ± 0.381
2.144CysSer: 2.144 ± 0.824
0.953CysThr: 0.953 ± 0.42
0.476CysVal: 0.476 ± 0.222
0.238CysTrp: 0.238 ± 0.143
0.953CysTyr: 0.953 ± 0.697
0.0CysXaa: 0.0 ± 0.0
Asp
2.62AspAla: 2.62 ± 0.914
0.953AspCys: 0.953 ± 0.553
5.241AspAsp: 5.241 ± 1.542
3.335AspGlu: 3.335 ± 0.578
3.335AspPhe: 3.335 ± 0.614
2.144AspGly: 2.144 ± 0.896
2.62AspHis: 2.62 ± 0.635
5.479AspIle: 5.479 ± 0.845
4.288AspLys: 4.288 ± 1.345
10.958AspLeu: 10.958 ± 0.946
1.429AspMet: 1.429 ± 0.376
3.573AspAsn: 3.573 ± 0.284
3.573AspPro: 3.573 ± 0.689
2.144AspGln: 2.144 ± 0.617
2.859AspArg: 2.859 ± 0.587
3.097AspSer: 3.097 ± 0.793
1.906AspThr: 1.906 ± 0.7
1.191AspVal: 1.191 ± 0.479
1.667AspTrp: 1.667 ± 0.874
3.811AspTyr: 3.811 ± 0.479
0.0AspXaa: 0.0 ± 0.0
Glu
1.906GluAla: 1.906 ± 0.508
1.191GluCys: 1.191 ± 0.441
5.241GluAsp: 5.241 ± 0.902
4.526GluGlu: 4.526 ± 1.082
1.667GluPhe: 1.667 ± 1.004
2.62GluGly: 2.62 ± 0.758
1.191GluHis: 1.191 ± 0.735
5.241GluIle: 5.241 ± 0.565
2.62GluLys: 2.62 ± 0.656
5.241GluLeu: 5.241 ± 1.705
1.906GluMet: 1.906 ± 0.486
2.62GluAsn: 2.62 ± 0.84
2.144GluPro: 2.144 ± 1.101
1.906GluGln: 1.906 ± 0.525
1.191GluArg: 1.191 ± 0.496
3.335GluSer: 3.335 ± 0.534
3.811GluThr: 3.811 ± 0.825
2.382GluVal: 2.382 ± 1.652
0.715GluTrp: 0.715 ± 0.432
1.429GluTyr: 1.429 ± 0.86
0.0GluXaa: 0.0 ± 0.0
Phe
0.953PheAla: 0.953 ± 0.27
1.191PheCys: 1.191 ± 0.475
2.144PheAsp: 2.144 ± 0.777
1.906PheGlu: 1.906 ± 0.457
2.62PhePhe: 2.62 ± 0.883
2.62PheGly: 2.62 ± 0.668
0.476PheHis: 0.476 ± 0.222
1.429PheIle: 1.429 ± 0.491
4.288PheLys: 4.288 ± 0.731
3.811PheLeu: 3.811 ± 0.972
1.906PheMet: 1.906 ± 0.995
3.097PheAsn: 3.097 ± 0.449
1.906PhePro: 1.906 ± 0.889
1.191PheGln: 1.191 ± 0.496
2.144PheArg: 2.144 ± 0.791
4.526PheSer: 4.526 ± 1.001
1.906PheThr: 1.906 ± 0.531
3.335PheVal: 3.335 ± 0.583
0.476PheTrp: 0.476 ± 0.287
1.191PheTyr: 1.191 ± 0.717
0.0PheXaa: 0.0 ± 0.0
Gly
1.191GlyAla: 1.191 ± 0.522
0.238GlyCys: 0.238 ± 0.441
3.335GlyAsp: 3.335 ± 0.591
1.667GlyGlu: 1.667 ± 0.836
2.382GlyPhe: 2.382 ± 0.541
2.382GlyGly: 2.382 ± 1.003
1.191GlyHis: 1.191 ± 0.475
4.05GlyIle: 4.05 ± 0.681
4.288GlyLys: 4.288 ± 1.647
7.384GlyLeu: 7.384 ± 1.693
0.238GlyMet: 0.238 ± 0.143
2.859GlyAsn: 2.859 ± 0.628
1.906GlyPro: 1.906 ± 0.46
2.859GlyGln: 2.859 ± 0.634
1.667GlyArg: 1.667 ± 0.587
5.241GlySer: 5.241 ± 1.507
3.573GlyThr: 3.573 ± 0.811
1.667GlyVal: 1.667 ± 0.567
0.715GlyTrp: 0.715 ± 0.271
2.382GlyTyr: 2.382 ± 0.515
0.0GlyXaa: 0.0 ± 0.0
His
0.715HisAla: 0.715 ± 0.43
0.238HisCys: 0.238 ± 0.143
1.429HisAsp: 1.429 ± 0.64
1.906HisGlu: 1.906 ± 1.011
1.191HisPhe: 1.191 ± 0.475
1.191HisGly: 1.191 ± 0.669
0.238HisHis: 0.238 ± 0.355
1.667HisIle: 1.667 ± 0.769
2.382HisLys: 2.382 ± 1.397
1.191HisLeu: 1.191 ± 0.569
0.476HisMet: 0.476 ± 0.291
0.953HisAsn: 0.953 ± 0.533
1.667HisPro: 1.667 ± 0.64
0.715HisGln: 0.715 ± 0.459
1.906HisArg: 1.906 ± 0.46
1.191HisSer: 1.191 ± 0.359
0.953HisThr: 0.953 ± 0.373
1.191HisVal: 1.191 ± 0.314
0.953HisTrp: 0.953 ± 0.541
1.667HisTyr: 1.667 ± 0.511
0.0HisXaa: 0.0 ± 0.0
Ile
1.906IleAla: 1.906 ± 1.055
1.429IleCys: 1.429 ± 0.498
3.335IleAsp: 3.335 ± 0.66
4.764IleGlu: 4.764 ± 0.89
3.097IlePhe: 3.097 ± 0.816
6.67IleGly: 6.67 ± 1.131
1.906IleHis: 1.906 ± 0.368
5.241IleIle: 5.241 ± 2.034
10.719IleLys: 10.719 ± 1.345
7.146IleLeu: 7.146 ± 1.879
0.715IleMet: 0.715 ± 0.501
6.908IleAsn: 6.908 ± 1.088
4.288IlePro: 4.288 ± 1.004
3.097IleGln: 3.097 ± 0.809
2.382IleArg: 2.382 ± 0.737
7.146IleSer: 7.146 ± 1.137
4.764IleThr: 4.764 ± 0.994
3.811IleVal: 3.811 ± 1.654
0.715IleTrp: 0.715 ± 0.43
4.288IleTyr: 4.288 ± 0.922
0.0IleXaa: 0.0 ± 0.0
Lys
2.382LysAla: 2.382 ± 0.843
1.191LysCys: 1.191 ± 0.531
4.05LysAsp: 4.05 ± 1.33
3.335LysGlu: 3.335 ± 0.686
2.859LysPhe: 2.859 ± 1.356
3.097LysGly: 3.097 ± 0.864
0.953LysHis: 0.953 ± 0.445
7.623LysIle: 7.623 ± 1.47
4.764LysLys: 4.764 ± 0.849
7.384LysLeu: 7.384 ± 2.47
2.382LysMet: 2.382 ± 0.553
4.526LysAsn: 4.526 ± 1.353
3.573LysPro: 3.573 ± 1.226
2.859LysGln: 2.859 ± 0.583
5.479LysArg: 5.479 ± 2.313
5.479LysSer: 5.479 ± 0.99
4.526LysThr: 4.526 ± 1.399
5.002LysVal: 5.002 ± 1.966
1.667LysTrp: 1.667 ± 0.676
1.191LysTyr: 1.191 ± 0.421
0.0LysXaa: 0.0 ± 0.0
Leu
4.288LeuAla: 4.288 ± 0.973
2.859LeuCys: 2.859 ± 0.647
7.146LeuAsp: 7.146 ± 1.185
5.241LeuGlu: 5.241 ± 1.373
3.811LeuPhe: 3.811 ± 0.964
5.955LeuGly: 5.955 ± 1.99
3.335LeuHis: 3.335 ± 0.904
9.29LeuIle: 9.29 ± 1.466
5.955LeuLys: 5.955 ± 1.056
7.861LeuLeu: 7.861 ± 1.867
2.859LeuMet: 2.859 ± 0.582
7.861LeuAsn: 7.861 ± 1.457
3.811LeuPro: 3.811 ± 0.86
2.859LeuGln: 2.859 ± 1.041
6.432LeuArg: 6.432 ± 0.645
6.908LeuSer: 6.908 ± 1.343
6.908LeuThr: 6.908 ± 1.386
5.479LeuVal: 5.479 ± 1.08
0.715LeuTrp: 0.715 ± 0.356
2.859LeuTyr: 2.859 ± 0.808
0.0LeuXaa: 0.0 ± 0.0
Met
1.429MetAla: 1.429 ± 0.609
0.715MetCys: 0.715 ± 0.772
1.667MetAsp: 1.667 ± 0.402
0.953MetGlu: 0.953 ± 0.902
0.953MetPhe: 0.953 ± 0.27
0.953MetGly: 0.953 ± 0.328
0.953MetHis: 0.953 ± 0.455
2.382MetIle: 2.382 ± 0.704
1.429MetLys: 1.429 ± 0.425
1.429MetLeu: 1.429 ± 0.881
0.715MetMet: 0.715 ± 0.501
1.191MetAsn: 1.191 ± 0.499
0.953MetPro: 0.953 ± 0.397
0.238MetGln: 0.238 ± 0.143
1.191MetArg: 1.191 ± 0.733
2.859MetSer: 2.859 ± 0.805
1.191MetThr: 1.191 ± 0.314
1.191MetVal: 1.191 ± 0.514
0.0MetTrp: 0.0 ± 0.0
0.953MetTyr: 0.953 ± 0.949
0.0MetXaa: 0.0 ± 0.0
Asn
3.097AsnAla: 3.097 ± 1.024
1.191AsnCys: 1.191 ± 0.475
4.05AsnAsp: 4.05 ± 1.509
2.859AsnGlu: 2.859 ± 1.17
1.906AsnPhe: 1.906 ± 0.407
3.097AsnGly: 3.097 ± 0.891
1.191AsnHis: 1.191 ± 0.468
6.432AsnIle: 6.432 ± 1.122
3.811AsnLys: 3.811 ± 1.148
7.384AsnLeu: 7.384 ± 1.17
1.191AsnMet: 1.191 ± 0.764
3.573AsnAsn: 3.573 ± 0.971
3.573AsnPro: 3.573 ± 0.625
1.906AsnGln: 1.906 ± 0.388
2.62AsnArg: 2.62 ± 0.692
3.097AsnSer: 3.097 ± 0.605
3.335AsnThr: 3.335 ± 0.665
1.667AsnVal: 1.667 ± 0.657
1.191AsnTrp: 1.191 ± 0.454
2.382AsnTyr: 2.382 ± 0.674
0.0AsnXaa: 0.0 ± 0.0
Pro
0.953ProAla: 0.953 ± 0.488
0.715ProCys: 0.715 ± 0.334
3.335ProAsp: 3.335 ± 1.192
2.144ProGlu: 2.144 ± 0.8
1.191ProPhe: 1.191 ± 0.965
1.667ProGly: 1.667 ± 0.991
1.429ProHis: 1.429 ± 0.491
4.05ProIle: 4.05 ± 1.103
3.811ProLys: 3.811 ± 0.702
4.526ProLeu: 4.526 ± 1.345
0.476ProMet: 0.476 ± 0.438
2.382ProAsn: 2.382 ± 0.531
1.906ProPro: 1.906 ± 1.163
0.715ProGln: 0.715 ± 0.55
0.953ProArg: 0.953 ± 0.42
4.288ProSer: 4.288 ± 0.521
3.573ProThr: 3.573 ± 0.657
1.191ProVal: 1.191 ± 0.475
0.476ProTrp: 0.476 ± 0.291
1.906ProTyr: 1.906 ± 0.858
0.0ProXaa: 0.0 ± 0.0
Gln
1.191GlnAla: 1.191 ± 0.468
0.715GlnCys: 0.715 ± 0.271
2.859GlnAsp: 2.859 ± 0.683
2.62GlnGlu: 2.62 ± 0.692
2.144GlnPhe: 2.144 ± 1.034
0.953GlnGly: 0.953 ± 0.655
0.953GlnHis: 0.953 ± 0.539
4.526GlnIle: 4.526 ± 0.798
2.62GlnLys: 2.62 ± 0.917
1.667GlnLeu: 1.667 ± 0.402
0.476GlnMet: 0.476 ± 0.291
2.859GlnAsn: 2.859 ± 0.69
1.429GlnPro: 1.429 ± 0.609
0.953GlnGln: 0.953 ± 0.497
1.429GlnArg: 1.429 ± 0.267
2.382GlnSer: 2.382 ± 0.649
1.906GlnThr: 1.906 ± 0.949
0.953GlnVal: 0.953 ± 0.373
0.715GlnTrp: 0.715 ± 0.501
1.906GlnTyr: 1.906 ± 0.741
0.0GlnXaa: 0.0 ± 0.0
Arg
1.191ArgAla: 1.191 ± 0.314
1.429ArgCys: 1.429 ± 0.756
1.429ArgAsp: 1.429 ± 0.704
1.906ArgGlu: 1.906 ± 0.641
3.335ArgPhe: 3.335 ± 1.278
3.811ArgGly: 3.811 ± 1.026
0.953ArgHis: 0.953 ± 0.439
4.05ArgIle: 4.05 ± 0.851
1.667ArgLys: 1.667 ± 0.61
4.288ArgLeu: 4.288 ± 1.815
1.191ArgMet: 1.191 ± 0.53
2.859ArgAsn: 2.859 ± 0.744
2.144ArgPro: 2.144 ± 0.613
1.906ArgGln: 1.906 ± 0.716
1.667ArgArg: 1.667 ± 0.588
4.526ArgSer: 4.526 ± 1.13
2.859ArgThr: 2.859 ± 0.905
2.144ArgVal: 2.144 ± 0.617
1.429ArgTrp: 1.429 ± 0.377
0.953ArgTyr: 0.953 ± 0.431
0.0ArgXaa: 0.0 ± 0.0
Ser
4.288SerAla: 4.288 ± 1.552
1.191SerCys: 1.191 ± 0.443
5.955SerAsp: 5.955 ± 1.134
4.288SerGlu: 4.288 ± 0.646
3.335SerPhe: 3.335 ± 0.738
4.526SerGly: 4.526 ± 1.125
1.191SerHis: 1.191 ± 0.441
6.908SerIle: 6.908 ± 1.209
3.097SerLys: 3.097 ± 1.43
7.861SerLeu: 7.861 ± 1.621
1.429SerMet: 1.429 ± 0.428
4.764SerAsn: 4.764 ± 1.194
2.144SerPro: 2.144 ± 0.9
3.097SerGln: 3.097 ± 1.378
3.335SerArg: 3.335 ± 0.939
6.67SerSer: 6.67 ± 0.794
5.002SerThr: 5.002 ± 1.36
5.241SerVal: 5.241 ± 1.754
1.429SerTrp: 1.429 ± 0.749
2.62SerTyr: 2.62 ± 0.466
0.0SerXaa: 0.0 ± 0.0
Thr
1.906ThrAla: 1.906 ± 0.454
1.191ThrCys: 1.191 ± 0.475
3.811ThrAsp: 3.811 ± 1.318
2.144ThrGlu: 2.144 ± 0.728
2.382ThrPhe: 2.382 ± 0.706
2.859ThrGly: 2.859 ± 0.471
1.429ThrHis: 1.429 ± 0.877
3.573ThrIle: 3.573 ± 0.839
5.479ThrLys: 5.479 ± 0.943
5.717ThrLeu: 5.717 ± 1.137
2.382ThrMet: 2.382 ± 1.033
2.62ThrAsn: 2.62 ± 0.347
0.715ThrPro: 0.715 ± 0.55
2.62ThrGln: 2.62 ± 0.435
3.335ThrArg: 3.335 ± 1.183
4.764ThrSer: 4.764 ± 0.897
1.191ThrThr: 1.191 ± 0.348
4.526ThrVal: 4.526 ± 0.485
1.191ThrTrp: 1.191 ± 0.348
2.144ThrTyr: 2.144 ± 0.436
0.0ThrXaa: 0.0 ± 0.0
Val
1.667ValAla: 1.667 ± 0.948
0.953ValCys: 0.953 ± 0.494
4.05ValAsp: 4.05 ± 1.725
4.05ValGlu: 4.05 ± 1.608
2.144ValPhe: 2.144 ± 0.656
2.144ValGly: 2.144 ± 1.192
1.191ValHis: 1.191 ± 0.595
3.573ValIle: 3.573 ± 0.893
4.526ValLys: 4.526 ± 1.857
3.811ValLeu: 3.811 ± 0.662
0.715ValMet: 0.715 ± 0.41
1.906ValAsn: 1.906 ± 0.407
2.144ValPro: 2.144 ± 0.883
1.906ValGln: 1.906 ± 0.694
1.906ValArg: 1.906 ± 0.523
4.288ValSer: 4.288 ± 0.905
4.05ValThr: 4.05 ± 1.387
1.906ValVal: 1.906 ± 0.987
0.715ValTrp: 0.715 ± 0.374
1.667ValTyr: 1.667 ± 0.593
0.0ValXaa: 0.0 ± 0.0
Trp
0.953TrpAla: 0.953 ± 0.387
0.0TrpCys: 0.0 ± 0.0
0.715TrpAsp: 0.715 ± 0.271
1.191TrpGlu: 1.191 ± 0.348
0.476TrpPhe: 0.476 ± 0.25
1.429TrpGly: 1.429 ± 0.64
0.476TrpHis: 0.476 ± 0.412
0.715TrpIle: 0.715 ± 0.451
1.191TrpLys: 1.191 ± 0.541
2.144TrpLeu: 2.144 ± 0.543
0.953TrpMet: 0.953 ± 0.716
0.476TrpAsn: 0.476 ± 0.287
0.715TrpPro: 0.715 ± 0.43
0.238TrpGln: 0.238 ± 0.257
0.953TrpArg: 0.953 ± 0.373
0.953TrpSer: 0.953 ± 0.311
0.238TrpThr: 0.238 ± 0.257
1.667TrpVal: 1.667 ± 1.171
0.476TrpTrp: 0.476 ± 0.491
0.476TrpTyr: 0.476 ± 0.222
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.191TyrAla: 1.191 ± 0.717
1.191TyrCys: 1.191 ± 0.868
2.859TyrAsp: 2.859 ± 0.815
1.429TyrGlu: 1.429 ± 0.425
1.906TyrPhe: 1.906 ± 0.69
1.191TyrGly: 1.191 ± 0.496
0.715TyrHis: 0.715 ± 0.944
2.859TyrIle: 2.859 ± 0.865
2.382TyrLys: 2.382 ± 0.986
5.955TyrLeu: 5.955 ± 1.108
0.238TyrMet: 0.238 ± 0.257
1.429TyrAsn: 1.429 ± 0.446
1.667TyrPro: 1.667 ± 0.619
2.144TyrGln: 2.144 ± 0.513
1.906TyrArg: 1.906 ± 1.012
3.335TyrSer: 3.335 ± 0.651
1.667TyrThr: 1.667 ± 0.728
2.62TyrVal: 2.62 ± 0.79
0.476TyrTrp: 0.476 ± 0.222
2.62TyrTyr: 2.62 ± 0.541
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (4199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski