Amino acid dipepetide frequency for Nematocida displodere

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.338AlaAla: 5.338 ± 0.101	1.262AlaCys: 1.262 ± 0.034	2.563AlaAsp: 2.563 ± 0.053	4.638AlaGlu: 4.638 ± 0.097	2.853AlaPhe: 2.853 ± 0.059	3.526AlaGly: 3.526 ± 0.076	1.565AlaHis: 1.565 ± 0.041	4.569AlaIle: 4.569 ± 0.083	4.477AlaLys: 4.477 ± 0.088	8.383AlaLeu: 8.383 ± 0.127	1.568AlaMet: 1.568 ± 0.046	2.065AlaAsn: 2.065 ± 0.046	3.938AlaPro: 3.938 ± 0.102	2.941AlaGln: 2.941 ± 0.063	3.446AlaArg: 3.446 ± 0.075	5.531AlaSer: 5.531 ± 0.104	4.164AlaThr: 4.164 ± 0.077	4.72AlaVal: 4.72 ± 0.087	0.649AlaTrp: 0.649 ± 0.028	2.206AlaTyr: 2.206 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.312CysAla: 1.312 ± 0.043	0.328CysCys: 0.328 ± 0.019	0.597CysAsp: 0.597 ± 0.027	0.751CysGlu: 0.751 ± 0.031	0.931CysPhe: 0.931 ± 0.031	1.08CysGly: 1.08 ± 0.045	0.326CysHis: 0.326 ± 0.02	1.284CysIle: 1.284 ± 0.036	1.084CysLys: 1.084 ± 0.039	2.216CysLeu: 2.216 ± 0.053	0.392CysMet: 0.392 ± 0.022	0.612CysAsn: 0.612 ± 0.027	0.866CysPro: 0.866 ± 0.039	0.569CysGln: 0.569 ± 0.026	0.834CysArg: 0.834 ± 0.033	1.382CysSer: 1.382 ± 0.05	1.303CysThr: 1.303 ± 0.041	1.134CysVal: 1.134 ± 0.039	0.121CysTrp: 0.121 ± 0.011	0.478CysTyr: 0.478 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	3.191AspAla: 3.191 ± 0.059	0.74AspCys: 0.74 ± 0.032	1.647AspAsp: 1.647 ± 0.044	2.758AspGlu: 2.758 ± 0.07	1.851AspPhe: 1.851 ± 0.05	2.498AspGly: 2.498 ± 0.058	0.79AspHis: 0.79 ± 0.033	3.219AspIle: 3.219 ± 0.064	2.644AspLys: 2.644 ± 0.066	4.978AspLeu: 4.978 ± 0.08	1.049AspMet: 1.049 ± 0.035	1.463AspAsn: 1.463 ± 0.048	1.985AspPro: 1.985 ± 0.05	1.357AspGln: 1.357 ± 0.048	2.177AspArg: 2.177 ± 0.051	3.163AspSer: 3.163 ± 0.084	3.114AspThr: 3.114 ± 0.069	2.913AspVal: 2.913 ± 0.061	0.439AspTrp: 0.439 ± 0.025	1.296AspTyr: 1.296 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.214GluAla: 5.214 ± 0.114	1.299GluCys: 1.299 ± 0.041	3.534GluAsp: 3.534 ± 0.063	7.522GluGlu: 7.522 ± 0.142	2.134GluPhe: 2.134 ± 0.054	3.827GluGly: 3.827 ± 0.085	1.896GluHis: 1.896 ± 0.044	5.08GluIle: 5.08 ± 0.089	6.095GluLys: 6.095 ± 0.108	5.923GluLeu: 5.923 ± 0.091	1.977GluMet: 1.977 ± 0.048	2.851GluAsn: 2.851 ± 0.06	2.098GluPro: 2.098 ± 0.071	2.418GluGln: 2.418 ± 0.062	4.112GluArg: 4.112 ± 0.074	4.505GluSer: 4.505 ± 0.076	4.796GluThr: 4.796 ± 0.077	4.739GluVal: 4.739 ± 0.075	0.673GluTrp: 0.673 ± 0.03	2.53GluTyr: 2.53 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	2.443PheAla: 2.443 ± 0.054	0.838PheCys: 0.838 ± 0.035	1.746PheAsp: 1.746 ± 0.046	2.357PheGlu: 2.357 ± 0.054	2.552PhePhe: 2.552 ± 0.064	2.769PheGly: 2.769 ± 0.066	0.728PheHis: 0.728 ± 0.029	2.678PheIle: 2.678 ± 0.058	2.506PheLys: 2.506 ± 0.054	4.662PheLeu: 4.662 ± 0.074	0.866PheMet: 0.866 ± 0.032	1.454PheAsn: 1.454 ± 0.046	1.553PhePro: 1.553 ± 0.048	1.288PheGln: 1.288 ± 0.037	1.931PheArg: 1.931 ± 0.048	3.979PheSer: 3.979 ± 0.066	2.304PheThr: 2.304 ± 0.052	2.725PheVal: 2.725 ± 0.059	0.427PheTrp: 0.427 ± 0.022	1.491PheTyr: 1.491 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.086GlyAla: 4.086 ± 0.077	1.153GlyCys: 1.153 ± 0.046	2.185GlyAsp: 2.185 ± 0.062	3.573GlyGlu: 3.573 ± 0.075	2.275GlyPhe: 2.275 ± 0.052	3.669GlyGly: 3.669 ± 0.092	1.274GlyHis: 1.274 ± 0.043	3.787GlyIle: 3.787 ± 0.073	3.72GlyLys: 3.72 ± 0.067	5.732GlyLeu: 5.732 ± 0.096	1.632GlyMet: 1.632 ± 0.062	1.65GlyAsn: 1.65 ± 0.046	1.941GlyPro: 1.941 ± 0.066	1.692GlyGln: 1.692 ± 0.063	3.006GlyArg: 3.006 ± 0.063	4.373GlySer: 4.373 ± 0.104	3.486GlyThr: 3.486 ± 0.067	4.521GlyVal: 4.521 ± 0.09	0.567GlyTrp: 0.567 ± 0.026	1.775GlyTyr: 1.775 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.488HisAla: 1.488 ± 0.045	0.444HisCys: 0.444 ± 0.025	0.58HisAsp: 0.58 ± 0.025	1.01HisGlu: 1.01 ± 0.039	0.862HisPhe: 0.862 ± 0.035	1.172HisGly: 1.172 ± 0.035	0.595HisHis: 0.595 ± 0.029	1.594HisIle: 1.594 ± 0.044	1.252HisLys: 1.252 ± 0.041	2.889HisLeu: 2.889 ± 0.059	0.582HisMet: 0.582 ± 0.025	0.784HisAsn: 0.784 ± 0.036	1.625HisPro: 1.625 ± 0.047	0.96HisGln: 0.96 ± 0.033	1.336HisArg: 1.336 ± 0.042	1.816HisSer: 1.816 ± 0.055	1.753HisThr: 1.753 ± 0.055	1.133HisVal: 1.133 ± 0.034	0.241HisTrp: 0.241 ± 0.018	0.664HisTyr: 0.664 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.292IleAla: 4.292 ± 0.074	1.379IleCys: 1.379 ± 0.044	3.832IleAsp: 3.832 ± 0.07	5.069IleGlu: 5.069 ± 0.087	2.709IlePhe: 2.709 ± 0.061	3.393IleGly: 3.393 ± 0.062	1.545IleHis: 1.545 ± 0.039	3.318IleIle: 3.318 ± 0.07	4.272IleLys: 4.272 ± 0.08	6.585IleLeu: 6.585 ± 0.106	0.991IleMet: 0.991 ± 0.034	2.433IleAsn: 2.433 ± 0.051	2.752IlePro: 2.752 ± 0.051	2.148IleGln: 2.148 ± 0.051	3.274IleArg: 3.274 ± 0.058	5.094IleSer: 5.094 ± 0.084	3.795IleThr: 3.795 ± 0.068	4.12IleVal: 4.12 ± 0.081	0.584IleTrp: 0.584 ± 0.027	2.373IleTyr: 2.373 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	4.486LysAla: 4.486 ± 0.085	0.88LysCys: 0.88 ± 0.037	3.49LysAsp: 3.49 ± 0.081	6.701LysGlu: 6.701 ± 0.113	1.458LysPhe: 1.458 ± 0.041	3.249LysGly: 3.249 ± 0.071	1.957LysHis: 1.957 ± 0.049	4.535LysIle: 4.535 ± 0.081	6.474LysLys: 6.474 ± 0.138	5.326LysLeu: 5.326 ± 0.081	1.67LysMet: 1.67 ± 0.039	3.166LysAsn: 3.166 ± 0.066	2.505LysPro: 2.505 ± 0.073	2.345LysGln: 2.345 ± 0.056	3.96LysArg: 3.96 ± 0.071	3.994LysSer: 3.994 ± 0.079	5.152LysThr: 5.152 ± 0.093	3.951LysVal: 3.951 ± 0.069	0.493LysTrp: 0.493 ± 0.027	2.27LysTyr: 2.27 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	7.935LeuAla: 7.935 ± 0.108	2.19LeuCys: 2.19 ± 0.056	4.783LeuAsp: 4.783 ± 0.086	7.501LeuGlu: 7.501 ± 0.09	5.058LeuPhe: 5.058 ± 0.078	6.291LeuGly: 6.291 ± 0.104	2.124LeuHis: 2.124 ± 0.05	5.218LeuIle: 5.218 ± 0.076	6.886LeuLys: 6.886 ± 0.082	10.956LeuLeu: 10.956 ± 0.139	1.87LeuMet: 1.87 ± 0.048	3.512LeuAsn: 3.512 ± 0.06	5.051LeuPro: 5.051 ± 0.095	3.58LeuGln: 3.58 ± 0.073	4.79LeuArg: 4.79 ± 0.078	9.723LeuSer: 9.723 ± 0.115	5.883LeuThr: 5.883 ± 0.092	7.019LeuVal: 7.019 ± 0.108	0.99LeuTrp: 0.99 ± 0.035	2.974LeuTyr: 2.974 ± 0.065	0.0LeuXaa: 0.0 ± 0.0
Met	1.641MetAla: 1.641 ± 0.043	0.426MetCys: 0.426 ± 0.025	1.128MetAsp: 1.128 ± 0.039	1.728MetGlu: 1.728 ± 0.048	1.06MetPhe: 1.06 ± 0.032	1.393MetGly: 1.393 ± 0.052	0.703MetHis: 0.703 ± 0.026	1.107MetIle: 1.107 ± 0.036	1.712MetLys: 1.712 ± 0.043	2.347MetLeu: 2.347 ± 0.057	0.382MetMet: 0.382 ± 0.019	0.938MetAsn: 0.938 ± 0.031	1.024MetPro: 1.024 ± 0.04	0.82MetGln: 0.82 ± 0.032	0.976MetArg: 0.976 ± 0.033	1.491MetSer: 1.491 ± 0.039	0.901MetThr: 0.901 ± 0.032	1.749MetVal: 1.749 ± 0.048	0.175MetTrp: 0.175 ± 0.014	0.696MetTyr: 0.696 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.369AsnAla: 2.369 ± 0.049	0.495AsnCys: 0.495 ± 0.026	1.474AsnAsp: 1.474 ± 0.044	2.129AsnGlu: 2.129 ± 0.055	1.191AsnPhe: 1.191 ± 0.036	2.044AsnGly: 2.044 ± 0.059	0.884AsnHis: 0.884 ± 0.032	2.811AsnIle: 2.811 ± 0.055	2.265AsnLys: 2.265 ± 0.058	3.94AsnLeu: 3.94 ± 0.081	0.901AsnMet: 0.901 ± 0.032	1.585AsnAsn: 1.585 ± 0.053	2.451AsnPro: 2.451 ± 0.078	1.373AsnGln: 1.373 ± 0.04	1.981AsnArg: 1.981 ± 0.05	2.326AsnSer: 2.326 ± 0.06	3.279AsnThr: 3.279 ± 0.077	1.978AsnVal: 1.978 ± 0.051	0.289AsnTrp: 0.289 ± 0.019	1.096AsnTyr: 1.096 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	3.284ProAla: 3.284 ± 0.08	0.588ProCys: 0.588 ± 0.037	1.846ProAsp: 1.846 ± 0.049	4.715ProGlu: 4.715 ± 0.101	1.725ProPhe: 1.725 ± 0.049	2.776ProGly: 2.776 ± 0.075	1.02ProHis: 1.02 ± 0.04	2.477ProIle: 2.477 ± 0.056	3.298ProLys: 3.298 ± 0.083	3.932ProLeu: 3.932 ± 0.083	0.943ProMet: 0.943 ± 0.042	2.29ProAsn: 2.29 ± 0.077	2.624ProPro: 2.624 ± 0.092	1.667ProGln: 1.667 ± 0.056	2.26ProArg: 2.26 ± 0.058	3.94ProSer: 3.94 ± 0.092	3.127ProThr: 3.127 ± 0.082	2.718ProVal: 2.718 ± 0.067	0.347ProTrp: 0.347 ± 0.021	1.303ProTyr: 1.303 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	2.798GlnAla: 2.798 ± 0.063	0.564GlnCys: 0.564 ± 0.027	1.317GlnAsp: 1.317 ± 0.048	2.724GlnGlu: 2.724 ± 0.061	0.923GlnPhe: 0.923 ± 0.032	1.854GlnGly: 1.854 ± 0.055	0.727GlnHis: 0.727 ± 0.03	2.326GlnIle: 2.326 ± 0.057	3.03GlnLys: 3.03 ± 0.067	2.577GlnLeu: 2.577 ± 0.063	1.191GlnMet: 1.191 ± 0.041	1.502GlnAsn: 1.502 ± 0.046	1.612GlnPro: 1.612 ± 0.052	1.184GlnGln: 1.184 ± 0.048	2.006GlnArg: 2.006 ± 0.051	2.324GlnSer: 2.324 ± 0.065	2.7GlnThr: 2.7 ± 0.073	2.106GlnVal: 2.106 ± 0.055	0.318GlnTrp: 0.318 ± 0.02	0.913GlnTyr: 0.913 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.633ArgAla: 3.633 ± 0.082	0.944ArgCys: 0.944 ± 0.031	2.116ArgAsp: 2.116 ± 0.051	4.078ArgGlu: 4.078 ± 0.078	1.83ArgPhe: 1.83 ± 0.048	2.841ArgGly: 2.841 ± 0.064	1.182ArgHis: 1.182 ± 0.035	3.38ArgIle: 3.38 ± 0.069	3.693ArgLys: 3.693 ± 0.078	4.883ArgLeu: 4.883 ± 0.071	1.346ArgMet: 1.346 ± 0.039	1.811ArgAsn: 1.811 ± 0.053	1.984ArgPro: 1.984 ± 0.056	1.577ArgGln: 1.577 ± 0.045	2.749ArgArg: 2.749 ± 0.067	3.231ArgSer: 3.231 ± 0.068	3.074ArgThr: 3.074 ± 0.06	3.917ArgVal: 3.917 ± 0.071	0.464ArgTrp: 0.464 ± 0.024	1.669ArgTyr: 1.669 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.047SerAla: 5.047 ± 0.085	1.031SerCys: 1.031 ± 0.044	2.914SerAsp: 2.914 ± 0.065	5.011SerGlu: 5.011 ± 0.085	3.581SerPhe: 3.581 ± 0.061	4.768SerGly: 4.768 ± 0.095	1.489SerHis: 1.489 ± 0.045	5.37SerIle: 5.37 ± 0.082	4.55SerLys: 4.55 ± 0.081	9.092SerLeu: 9.092 ± 0.12	1.64SerMet: 1.64 ± 0.047	2.6SerAsn: 2.6 ± 0.062	3.925SerPro: 3.925 ± 0.088	2.653SerGln: 2.653 ± 0.06	3.35SerArg: 3.35 ± 0.062	6.518SerSer: 6.518 ± 0.118	5.321SerThr: 5.321 ± 0.098	5.249SerVal: 5.249 ± 0.087	0.522SerTrp: 0.522 ± 0.025	1.873SerTyr: 1.873 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.607ThrAla: 4.607 ± 0.08	0.855ThrCys: 0.855 ± 0.027	2.825ThrAsp: 2.825 ± 0.053	4.675ThrGlu: 4.675 ± 0.082	2.236ThrPhe: 2.236 ± 0.056	3.381ThrGly: 3.381 ± 0.067	1.615ThrHis: 1.615 ± 0.046	4.3ThrIle: 4.3 ± 0.076	4.086ThrLys: 4.086 ± 0.076	7.144ThrLeu: 7.144 ± 0.087	1.211ThrMet: 1.211 ± 0.039	2.533ThrAsn: 2.533 ± 0.062	4.428ThrPro: 4.428 ± 0.106	2.526ThrGln: 2.526 ± 0.059	3.116ThrArg: 3.116 ± 0.06	4.454ThrSer: 4.454 ± 0.077	4.635ThrThr: 4.635 ± 0.133	4.139ThrVal: 4.139 ± 0.085	0.42ThrTrp: 0.42 ± 0.022	1.807ThrTyr: 1.807 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	4.409ValAla: 4.409 ± 0.078	1.569ValCys: 1.569 ± 0.046	3.122ValAsp: 3.122 ± 0.058	4.258ValGlu: 4.258 ± 0.068	4.11ValPhe: 4.11 ± 0.084	3.502ValGly: 3.502 ± 0.07	1.491ValHis: 1.491 ± 0.041	3.799ValIle: 3.799 ± 0.07	3.638ValLys: 3.638 ± 0.067	8.094ValLeu: 8.094 ± 0.093	1.211ValMet: 1.211 ± 0.039	1.908ValAsn: 1.908 ± 0.049	3.043ValPro: 3.043 ± 0.06	2.177ValGln: 2.177 ± 0.053	3.149ValArg: 3.149 ± 0.058	5.861ValSer: 5.861 ± 0.097	3.125ValThr: 3.125 ± 0.069	5.164ValVal: 5.164 ± 0.099	0.691ValTrp: 0.691 ± 0.03	2.275ValTyr: 2.275 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.623TrpAla: 0.623 ± 0.029	0.192TrpCys: 0.192 ± 0.016	0.355TrpAsp: 0.355 ± 0.022	0.552TrpGlu: 0.552 ± 0.025	0.368TrpPhe: 0.368 ± 0.022	0.51TrpGly: 0.51 ± 0.025	0.135TrpHis: 0.135 ± 0.012	0.662TrpIle: 0.662 ± 0.03	0.598TrpLys: 0.598 ± 0.026	0.842TrpLeu: 0.842 ± 0.032	0.305TrpMet: 0.305 ± 0.02	0.385TrpAsn: 0.385 ± 0.022	0.277TrpPro: 0.277 ± 0.018	0.228TrpGln: 0.228 ± 0.018	0.445TrpArg: 0.445 ± 0.023	0.655TrpSer: 0.655 ± 0.025	0.46TrpThr: 0.46 ± 0.023	0.787TrpVal: 0.787 ± 0.033	0.085TrpTrp: 0.085 ± 0.01	0.224TrpTyr: 0.224 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.207TyrAla: 2.207 ± 0.055	0.424TyrCys: 0.424 ± 0.023	1.216TyrAsp: 1.216 ± 0.042	1.472TyrGlu: 1.472 ± 0.047	1.593TyrPhe: 1.593 ± 0.045	1.553TyrGly: 1.553 ± 0.043	0.734TyrHis: 0.734 ± 0.032	2.442TyrIle: 2.442 ± 0.052	1.782TyrLys: 1.782 ± 0.044	3.836TyrLeu: 3.836 ± 0.076	0.668TyrMet: 0.668 ± 0.028	1.318TyrAsn: 1.318 ± 0.044	1.201TyrPro: 1.201 ± 0.049	1.192TyrGln: 1.192 ± 0.038	1.505TyrArg: 1.505 ± 0.04	2.144TyrSer: 2.144 ± 0.047	2.618TyrThr: 2.618 ± 0.057	1.811TyrVal: 1.811 ± 0.044	0.195TyrTrp: 0.195 ± 0.018	1.046TyrTyr: 1.046 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2241 proteins (862370 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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