Amino acid dipepetide frequency for Butyrivibrio sp. YAB3001

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.927AlaAla: 5.927 ± 0.106
0.964AlaCys: 0.964 ± 0.025
4.699AlaAsp: 4.699 ± 0.069
4.961AlaGlu: 4.961 ± 0.077
3.183AlaPhe: 3.183 ± 0.051
5.15AlaGly: 5.15 ± 0.081
0.976AlaHis: 0.976 ± 0.028
5.52AlaIle: 5.52 ± 0.057
4.831AlaLys: 4.831 ± 0.083
6.351AlaLeu: 6.351 ± 0.081
2.115AlaMet: 2.115 ± 0.048
2.874AlaAsn: 2.874 ± 0.056
1.87AlaPro: 1.87 ± 0.048
2.024AlaGln: 2.024 ± 0.041
2.558AlaArg: 2.558 ± 0.05
4.213AlaSer: 4.213 ± 0.076
3.384AlaThr: 3.384 ± 0.073
5.247AlaVal: 5.247 ± 0.073
0.581AlaTrp: 0.581 ± 0.024
2.697AlaTyr: 2.697 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.956CysAla: 0.956 ± 0.028
0.262CysCys: 0.262 ± 0.015
0.926CysAsp: 0.926 ± 0.027
0.88CysGlu: 0.88 ± 0.029
0.666CysPhe: 0.666 ± 0.023
1.348CysGly: 1.348 ± 0.036
0.271CysHis: 0.271 ± 0.016
1.118CysIle: 1.118 ± 0.031
0.915CysLys: 0.915 ± 0.028
1.085CysLeu: 1.085 ± 0.025
0.421CysMet: 0.421 ± 0.017
0.636CysAsn: 0.636 ± 0.023
0.507CysPro: 0.507 ± 0.022
0.325CysGln: 0.325 ± 0.015
0.536CysArg: 0.536 ± 0.023
0.878CysSer: 0.878 ± 0.027
0.636CysThr: 0.636 ± 0.022
0.91CysVal: 0.91 ± 0.027
0.125CysTrp: 0.125 ± 0.009
0.605CysTyr: 0.605 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
4.382AspAla: 4.382 ± 0.067
0.769AspCys: 0.769 ± 0.024
4.034AspAsp: 4.034 ± 0.073
5.789AspGlu: 5.789 ± 0.076
3.097AspPhe: 3.097 ± 0.051
4.572AspGly: 4.572 ± 0.076
0.866AspHis: 0.866 ± 0.026
5.396AspIle: 5.396 ± 0.069
4.779AspLys: 4.779 ± 0.07
4.486AspLeu: 4.486 ± 0.062
1.903AspMet: 1.903 ± 0.033
3.234AspAsn: 3.234 ± 0.061
1.801AspPro: 1.801 ± 0.042
1.244AspGln: 1.244 ± 0.028
2.445AspArg: 2.445 ± 0.048
3.924AspSer: 3.924 ± 0.061
3.142AspThr: 3.142 ± 0.049
4.202AspVal: 4.202 ± 0.062
0.645AspTrp: 0.645 ± 0.022
3.467AspTyr: 3.467 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.181GluAla: 5.181 ± 0.088
0.878GluCys: 0.878 ± 0.027
4.506GluAsp: 4.506 ± 0.076
6.312GluGlu: 6.312 ± 0.086
2.805GluPhe: 2.805 ± 0.046
4.147GluGly: 4.147 ± 0.057
1.27GluHis: 1.27 ± 0.033
5.788GluIle: 5.788 ± 0.07
7.052GluLys: 7.052 ± 0.087
6.618GluLeu: 6.618 ± 0.083
2.241GluMet: 2.241 ± 0.049
4.707GluAsn: 4.707 ± 0.057
1.647GluPro: 1.647 ± 0.043
2.282GluGln: 2.282 ± 0.049
2.869GluArg: 2.869 ± 0.049
3.777GluSer: 3.777 ± 0.063
3.581GluThr: 3.581 ± 0.062
4.31GluVal: 4.31 ± 0.066
0.653GluTrp: 0.653 ± 0.023
3.456GluTyr: 3.456 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.01PheAla: 3.01 ± 0.053
0.736PheCys: 0.736 ± 0.025
3.179PheAsp: 3.179 ± 0.048
2.949PheGlu: 2.949 ± 0.046
2.288PhePhe: 2.288 ± 0.053
3.096PheGly: 3.096 ± 0.053
0.716PheHis: 0.716 ± 0.025
3.438PheIle: 3.438 ± 0.058
2.571PheLys: 2.571 ± 0.046
3.896PheLeu: 3.896 ± 0.059
1.315PheMet: 1.315 ± 0.029
1.977PheAsn: 1.977 ± 0.039
1.294PhePro: 1.294 ± 0.039
0.986PheGln: 0.986 ± 0.025
1.583PheArg: 1.583 ± 0.028
3.111PheSer: 3.111 ± 0.05
2.411PheThr: 2.411 ± 0.048
3.139PheVal: 3.139 ± 0.056
0.501PheTrp: 0.501 ± 0.019
2.031PheTyr: 2.031 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
4.579GlyAla: 4.579 ± 0.08
1.132GlyCys: 1.132 ± 0.032
3.748GlyAsp: 3.748 ± 0.054
4.286GlyGlu: 4.286 ± 0.068
3.19GlyPhe: 3.19 ± 0.051
4.251GlyGly: 4.251 ± 0.064
1.163GlyHis: 1.163 ± 0.029
6.17GlyIle: 6.17 ± 0.072
5.54GlyLys: 5.54 ± 0.078
5.312GlyLeu: 5.312 ± 0.074
2.238GlyMet: 2.238 ± 0.048
3.492GlyAsn: 3.492 ± 0.064
1.176GlyPro: 1.176 ± 0.038
1.774GlyGln: 1.774 ± 0.045
2.582GlyArg: 2.582 ± 0.048
3.974GlySer: 3.974 ± 0.076
3.958GlyThr: 3.958 ± 0.111
4.533GlyVal: 4.533 ± 0.067
0.69GlyTrp: 0.69 ± 0.023
3.301GlyTyr: 3.301 ± 0.055
0.001GlyXaa: 0.001 ± 0.001
His
0.929HisAla: 0.929 ± 0.028
0.265HisCys: 0.265 ± 0.016
1.007HisAsp: 1.007 ± 0.025
1.101HisGlu: 1.101 ± 0.03
0.817HisPhe: 0.817 ± 0.022
1.176HisGly: 1.176 ± 0.032
0.376HisHis: 0.376 ± 0.034
1.288HisIle: 1.288 ± 0.034
0.975HisLys: 0.975 ± 0.032
1.281HisLeu: 1.281 ± 0.032
0.524HisMet: 0.524 ± 0.02
0.824HisAsn: 0.824 ± 0.025
0.684HisPro: 0.684 ± 0.024
0.39HisGln: 0.39 ± 0.018
0.646HisArg: 0.646 ± 0.023
0.963HisSer: 0.963 ± 0.027
0.797HisThr: 0.797 ± 0.025
1.053HisVal: 1.053 ± 0.027
0.149HisTrp: 0.149 ± 0.011
0.776HisTyr: 0.776 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
5.844IleAla: 5.844 ± 0.079
1.389IleCys: 1.389 ± 0.037
5.176IleAsp: 5.176 ± 0.066
5.19IleGlu: 5.19 ± 0.066
3.233IlePhe: 3.233 ± 0.06
5.144IleGly: 5.144 ± 0.067
1.255IleHis: 1.255 ± 0.034
6.217IleIle: 6.217 ± 0.087
5.252IleLys: 5.252 ± 0.062
6.739IleLeu: 6.739 ± 0.068
2.128IleMet: 2.128 ± 0.043
3.675IleAsn: 3.675 ± 0.052
3.025IlePro: 3.025 ± 0.059
1.895IleGln: 1.895 ± 0.041
3.359IleArg: 3.359 ± 0.058
5.846IleSer: 5.846 ± 0.076
4.596IleThr: 4.596 ± 0.072
5.475IleVal: 5.475 ± 0.072
0.702IleTrp: 0.702 ± 0.025
3.201IleTyr: 3.201 ± 0.056
0.0IleXaa: 0.0 ± 0.0
Lys
5.321LysAla: 5.321 ± 0.089
0.837LysCys: 0.837 ± 0.028
4.853LysAsp: 4.853 ± 0.068
6.944LysGlu: 6.944 ± 0.077
2.204LysPhe: 2.204 ± 0.042
4.21LysGly: 4.21 ± 0.063
1.123LysHis: 1.123 ± 0.03
5.253LysIle: 5.253 ± 0.075
6.783LysLys: 6.783 ± 0.082
5.771LysLeu: 5.771 ± 0.068
2.215LysMet: 2.215 ± 0.039
4.297LysAsn: 4.297 ± 0.062
1.905LysPro: 1.905 ± 0.039
2.07LysGln: 2.07 ± 0.041
3.062LysArg: 3.062 ± 0.056
3.853LysSer: 3.853 ± 0.066
3.719LysThr: 3.719 ± 0.061
4.639LysVal: 4.639 ± 0.061
0.698LysTrp: 0.698 ± 0.023
3.536LysTyr: 3.536 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
5.829LeuAla: 5.829 ± 0.08
1.305LeuCys: 1.305 ± 0.035
5.178LeuAsp: 5.178 ± 0.074
5.564LeuGlu: 5.564 ± 0.068
4.14LeuPhe: 4.14 ± 0.072
5.505LeuGly: 5.505 ± 0.076
1.324LeuHis: 1.324 ± 0.035
6.3LeuIle: 6.3 ± 0.07
6.065LeuLys: 6.065 ± 0.078
7.862LeuLeu: 7.862 ± 0.09
2.487LeuMet: 2.487 ± 0.045
4.064LeuAsn: 4.064 ± 0.055
2.887LeuPro: 2.887 ± 0.05
2.348LeuGln: 2.348 ± 0.042
3.289LeuArg: 3.289 ± 0.049
6.562LeuSer: 6.562 ± 0.082
4.466LeuThr: 4.466 ± 0.064
5.308LeuVal: 5.308 ± 0.069
0.734LeuTrp: 0.734 ± 0.025
3.394LeuTyr: 3.394 ± 0.06
0.0LeuXaa: 0.0 ± 0.0
Met
2.218MetAla: 2.218 ± 0.042
0.348MetCys: 0.348 ± 0.017
1.905MetAsp: 1.905 ± 0.039
2.03MetGlu: 2.03 ± 0.04
1.041MetPhe: 1.041 ± 0.029
1.905MetGly: 1.905 ± 0.036
0.5MetHis: 0.5 ± 0.023
2.382MetIle: 2.382 ± 0.041
2.287MetLys: 2.287 ± 0.039
2.63MetLeu: 2.63 ± 0.043
0.959MetMet: 0.959 ± 0.028
1.701MetAsn: 1.701 ± 0.044
1.107MetPro: 1.107 ± 0.041
0.959MetGln: 0.959 ± 0.027
1.183MetArg: 1.183 ± 0.029
1.92MetSer: 1.92 ± 0.038
1.628MetThr: 1.628 ± 0.039
1.891MetVal: 1.891 ± 0.044
0.237MetTrp: 0.237 ± 0.014
1.016MetTyr: 1.016 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.63AsnAla: 3.63 ± 0.059
0.647AsnCys: 0.647 ± 0.021
3.007AsnAsp: 3.007 ± 0.049
3.54AsnGlu: 3.54 ± 0.057
1.833AsnPhe: 1.833 ± 0.045
3.82AsnGly: 3.82 ± 0.059
0.832AsnHis: 0.832 ± 0.026
4.066AsnIle: 4.066 ± 0.063
3.372AsnLys: 3.372 ± 0.055
4.035AsnLeu: 4.035 ± 0.053
1.587AsnMet: 1.587 ± 0.029
2.756AsnAsn: 2.756 ± 0.058
2.042AsnPro: 2.042 ± 0.042
1.34AsnGln: 1.34 ± 0.032
1.943AsnArg: 1.943 ± 0.037
3.163AsnSer: 3.163 ± 0.053
2.668AsnThr: 2.668 ± 0.052
3.401AsnVal: 3.401 ± 0.049
0.477AsnTrp: 0.477 ± 0.021
2.295AsnTyr: 2.295 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
1.962ProAla: 1.962 ± 0.044
0.366ProCys: 0.366 ± 0.019
2.266ProAsp: 2.266 ± 0.041
2.996ProGlu: 2.996 ± 0.077
1.465ProPhe: 1.465 ± 0.032
1.948ProGly: 1.948 ± 0.038
0.477ProHis: 0.477 ± 0.022
2.133ProIle: 2.133 ± 0.042
1.793ProLys: 1.793 ± 0.041
2.33ProLeu: 2.33 ± 0.045
0.814ProMet: 0.814 ± 0.028
1.214ProAsn: 1.214 ± 0.03
0.526ProPro: 0.526 ± 0.02
0.903ProGln: 0.903 ± 0.031
0.888ProArg: 0.888 ± 0.024
1.819ProSer: 1.819 ± 0.04
1.447ProThr: 1.447 ± 0.034
2.528ProVal: 2.528 ± 0.051
0.309ProTrp: 0.309 ± 0.014
1.392ProTyr: 1.392 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
1.879GlnAla: 1.879 ± 0.04
0.286GlnCys: 0.286 ± 0.013
1.485GlnAsp: 1.485 ± 0.032
2.015GlnGlu: 2.015 ± 0.041
1.124GlnPhe: 1.124 ± 0.027
1.637GlnGly: 1.637 ± 0.037
0.419GlnHis: 0.419 ± 0.019
2.313GlnIle: 2.313 ± 0.045
2.278GlnLys: 2.278 ± 0.046
2.304GlnLeu: 2.304 ± 0.041
0.965GlnMet: 0.965 ± 0.027
1.579GlnAsn: 1.579 ± 0.035
0.694GlnPro: 0.694 ± 0.024
0.983GlnGln: 0.983 ± 0.034
1.119GlnArg: 1.119 ± 0.034
1.486GlnSer: 1.486 ± 0.037
1.436GlnThr: 1.436 ± 0.038
1.566GlnVal: 1.566 ± 0.033
0.256GlnTrp: 0.256 ± 0.016
1.266GlnTyr: 1.266 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.431ArgAla: 2.431 ± 0.044
0.507ArgCys: 0.507 ± 0.019
2.216ArgAsp: 2.216 ± 0.044
3.011ArgGlu: 3.011 ± 0.047
1.856ArgPhe: 1.856 ± 0.038
2.043ArgGly: 2.043 ± 0.042
0.691ArgHis: 0.691 ± 0.024
3.405ArgIle: 3.405 ± 0.055
3.165ArgLys: 3.165 ± 0.049
3.409ArgLeu: 3.409 ± 0.053
1.268ArgMet: 1.268 ± 0.028
2.195ArgAsn: 2.195 ± 0.043
1.114ArgPro: 1.114 ± 0.032
1.306ArgGln: 1.306 ± 0.034
1.734ArgArg: 1.734 ± 0.04
1.998ArgSer: 1.998 ± 0.036
1.921ArgThr: 1.921 ± 0.033
2.397ArgVal: 2.397 ± 0.044
0.355ArgTrp: 0.355 ± 0.018
1.773ArgTyr: 1.773 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
4.308SerAla: 4.308 ± 0.074
0.792SerCys: 0.792 ± 0.022
4.503SerAsp: 4.503 ± 0.072
4.772SerGlu: 4.772 ± 0.077
3.396SerPhe: 3.396 ± 0.052
4.974SerGly: 4.974 ± 0.076
1.0SerHis: 1.0 ± 0.032
4.828SerIle: 4.828 ± 0.065
4.251SerLys: 4.251 ± 0.066
5.16SerLeu: 5.16 ± 0.062
1.797SerMet: 1.797 ± 0.04
2.827SerAsn: 2.827 ± 0.06
1.559SerPro: 1.559 ± 0.035
1.764SerGln: 1.764 ± 0.043
2.415SerArg: 2.415 ± 0.046
4.366SerSer: 4.366 ± 0.081
3.053SerThr: 3.053 ± 0.062
4.415SerVal: 4.415 ± 0.073
0.559SerTrp: 0.559 ± 0.022
2.761SerTyr: 2.761 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
3.866ThrAla: 3.866 ± 0.09
0.604ThrCys: 0.604 ± 0.023
3.518ThrAsp: 3.518 ± 0.058
3.571ThrGlu: 3.571 ± 0.061
2.232ThrPhe: 2.232 ± 0.041
4.294ThrGly: 4.294 ± 0.095
0.768ThrHis: 0.768 ± 0.022
4.256ThrIle: 4.256 ± 0.078
3.174ThrLys: 3.174 ± 0.05
4.438ThrLeu: 4.438 ± 0.061
1.391ThrMet: 1.391 ± 0.032
2.306ThrAsn: 2.306 ± 0.048
1.83ThrPro: 1.83 ± 0.046
1.334ThrGln: 1.334 ± 0.035
1.764ThrArg: 1.764 ± 0.039
3.205ThrSer: 3.205 ± 0.065
2.944ThrThr: 2.944 ± 0.076
4.132ThrVal: 4.132 ± 0.067
0.494ThrTrp: 0.494 ± 0.022
2.209ThrTyr: 2.209 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
4.6ValAla: 4.6 ± 0.068
1.115ValCys: 1.115 ± 0.031
4.17ValAsp: 4.17 ± 0.049
4.268ValGlu: 4.268 ± 0.066
3.14ValPhe: 3.14 ± 0.049
4.082ValGly: 4.082 ± 0.064
0.967ValHis: 0.967 ± 0.027
5.562ValIle: 5.562 ± 0.074
4.69ValLys: 4.69 ± 0.06
6.2ValLeu: 6.2 ± 0.08
1.991ValMet: 1.991 ± 0.033
3.189ValAsn: 3.189 ± 0.062
2.277ValPro: 2.277 ± 0.044
1.569ValGln: 1.569 ± 0.036
2.601ValArg: 2.601 ± 0.047
4.852ValSer: 4.852 ± 0.074
3.849ValThr: 3.849 ± 0.083
4.793ValVal: 4.793 ± 0.07
0.603ValTrp: 0.603 ± 0.021
2.82ValTyr: 2.82 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
0.521TrpAla: 0.521 ± 0.018
0.147TrpCys: 0.147 ± 0.011
0.638TrpAsp: 0.638 ± 0.023
0.63TrpGlu: 0.63 ± 0.023
0.426TrpPhe: 0.426 ± 0.018
0.704TrpGly: 0.704 ± 0.026
0.215TrpHis: 0.215 ± 0.014
0.694TrpIle: 0.694 ± 0.026
0.643TrpLys: 0.643 ± 0.023
0.819TrpLeu: 0.819 ± 0.027
0.307TrpMet: 0.307 ± 0.016
0.651TrpAsn: 0.651 ± 0.022
0.202TrpPro: 0.202 ± 0.013
0.343TrpGln: 0.343 ± 0.017
0.342TrpArg: 0.342 ± 0.015
0.492TrpSer: 0.492 ± 0.021
0.439TrpThr: 0.439 ± 0.018
0.5TrpVal: 0.5 ± 0.022
0.14TrpTrp: 0.14 ± 0.013
0.478TrpTyr: 0.478 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.75TyrAla: 2.75 ± 0.048
0.658TyrCys: 0.658 ± 0.022
3.162TyrAsp: 3.162 ± 0.057
3.27TyrGlu: 3.27 ± 0.05
2.091TyrPhe: 2.091 ± 0.045
3.085TyrGly: 3.085 ± 0.051
0.811TyrHis: 0.811 ± 0.024
3.217TyrIle: 3.217 ± 0.051
2.877TyrLys: 2.877 ± 0.047
3.883TyrLeu: 3.883 ± 0.066
1.181TyrMet: 1.181 ± 0.029
2.258TyrAsn: 2.258 ± 0.042
1.426TyrPro: 1.426 ± 0.035
1.25TyrGln: 1.25 ± 0.037
1.878TyrArg: 1.878 ± 0.044
3.099TyrSer: 3.099 ± 0.054
2.256TyrThr: 2.256 ± 0.043
2.901TyrVal: 2.901 ± 0.049
0.421TyrTrp: 0.421 ± 0.02
2.291TyrTyr: 2.291 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.001XaaGln: 0.001 ± 0.001
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.01XaaXaa: 0.01 ± 0.01
Statistics based on 4055 proteins (1348307 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski