Amino acid dipepetide frequency for Firmicutes bacterium CAG:308

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.052AlaAla: 4.052 ± 0.116
1.235AlaCys: 1.235 ± 0.058
3.075AlaAsp: 3.075 ± 0.073
2.619AlaGlu: 2.619 ± 0.092
2.767AlaPhe: 2.767 ± 0.085
4.002AlaGly: 4.002 ± 0.116
1.198AlaHis: 1.198 ± 0.059
5.547AlaIle: 5.547 ± 0.116
5.157AlaLys: 5.157 ± 0.111
6.788AlaLeu: 6.788 ± 0.133
2.074AlaMet: 2.074 ± 0.069
3.107AlaAsn: 3.107 ± 0.09
1.41AlaPro: 1.41 ± 0.055
2.343AlaGln: 2.343 ± 0.084
2.256AlaArg: 2.256 ± 0.062
3.92AlaSer: 3.92 ± 0.101
3.021AlaThr: 3.021 ± 0.074
3.606AlaVal: 3.606 ± 0.089
0.435AlaTrp: 0.435 ± 0.028
2.767AlaTyr: 2.767 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
1.033CysAla: 1.033 ± 0.044
0.212CysCys: 0.212 ± 0.02
0.944CysAsp: 0.944 ± 0.045
0.874CysGlu: 0.874 ± 0.042
0.779CysPhe: 0.779 ± 0.041
1.114CysGly: 1.114 ± 0.052
0.39CysHis: 0.39 ± 0.027
1.347CysIle: 1.347 ± 0.058
0.959CysLys: 0.959 ± 0.047
1.429CysLeu: 1.429 ± 0.061
0.454CysMet: 0.454 ± 0.033
0.614CysAsn: 0.614 ± 0.036
0.647CysPro: 0.647 ± 0.042
0.518CysGln: 0.518 ± 0.034
0.489CysArg: 0.489 ± 0.033
0.953CysSer: 0.953 ± 0.04
0.829CysThr: 0.829 ± 0.04
1.045CysVal: 1.045 ± 0.049
0.089CysTrp: 0.089 ± 0.014
0.466CysTyr: 0.466 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
3.732AspAla: 3.732 ± 0.08
0.854AspCys: 0.854 ± 0.045
3.361AspAsp: 3.361 ± 0.087
5.176AspGlu: 5.176 ± 0.123
3.046AspPhe: 3.046 ± 0.074
3.732AspGly: 3.732 ± 0.094
1.415AspHis: 1.415 ± 0.052
5.363AspIle: 5.363 ± 0.112
4.506AspLys: 4.506 ± 0.103
5.772AspLeu: 5.772 ± 0.097
1.821AspMet: 1.821 ± 0.064
2.388AspAsn: 2.388 ± 0.065
2.231AspPro: 2.231 ± 0.071
2.274AspGln: 2.274 ± 0.07
2.124AspArg: 2.124 ± 0.062
3.274AspSer: 3.274 ± 0.083
3.233AspThr: 3.233 ± 0.086
4.227AspVal: 4.227 ± 0.081
0.509AspTrp: 0.509 ± 0.032
2.841AspTyr: 2.841 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
4.322GluAla: 4.322 ± 0.108
0.901GluCys: 0.901 ± 0.044
4.724GluAsp: 4.724 ± 0.109
6.353GluGlu: 6.353 ± 0.145
2.703GluPhe: 2.703 ± 0.08
3.555GluGly: 3.555 ± 0.095
1.425GluHis: 1.425 ± 0.049
6.025GluIle: 6.025 ± 0.101
6.184GluLys: 6.184 ± 0.116
6.343GluLeu: 6.343 ± 0.122
2.386GluMet: 2.386 ± 0.069
4.728GluAsn: 4.728 ± 0.098
1.695GluPro: 1.695 ± 0.068
2.606GluGln: 2.606 ± 0.088
2.477GluArg: 2.477 ± 0.07
3.248GluSer: 3.248 ± 0.079
3.615GluThr: 3.615 ± 0.091
4.464GluVal: 4.464 ± 0.095
0.635GluTrp: 0.635 ± 0.038
3.089GluTyr: 3.089 ± 0.083
0.0GluXaa: 0.0 ± 0.0
Phe
2.483PheAla: 2.483 ± 0.077
0.687PheCys: 0.687 ± 0.038
3.285PheAsp: 3.285 ± 0.088
3.285PheGlu: 3.285 ± 0.077
2.046PhePhe: 2.046 ± 0.073
2.86PheGly: 2.86 ± 0.075
0.833PheHis: 0.833 ± 0.041
3.72PheIle: 3.72 ± 0.102
2.891PheLys: 2.891 ± 0.084
4.033PheLeu: 4.033 ± 0.108
1.272PheMet: 1.272 ± 0.045
2.114PheAsn: 2.114 ± 0.063
1.107PhePro: 1.107 ± 0.043
1.278PheGln: 1.278 ± 0.051
1.281PheArg: 1.281 ± 0.049
3.141PheSer: 3.141 ± 0.09
2.219PheThr: 2.219 ± 0.073
3.157PheVal: 3.157 ± 0.094
0.348PheTrp: 0.348 ± 0.027
1.839PheTyr: 1.839 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
3.806GlyAla: 3.806 ± 0.11
1.126GlyCys: 1.126 ± 0.05
2.806GlyAsp: 2.806 ± 0.083
2.864GlyGlu: 2.864 ± 0.074
3.112GlyPhe: 3.112 ± 0.082
3.708GlyGly: 3.708 ± 0.107
1.146GlyHis: 1.146 ± 0.045
5.759GlyIle: 5.759 ± 0.11
4.654GlyLys: 4.654 ± 0.107
5.576GlyLeu: 5.576 ± 0.116
2.105GlyMet: 2.105 ± 0.072
2.726GlyAsn: 2.726 ± 0.077
1.243GlyPro: 1.243 ± 0.054
1.909GlyGln: 1.909 ± 0.069
2.013GlyArg: 2.013 ± 0.066
3.615GlySer: 3.615 ± 0.091
3.442GlyThr: 3.442 ± 0.101
4.194GlyVal: 4.194 ± 0.111
0.608GlyTrp: 0.608 ± 0.042
3.194GlyTyr: 3.194 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
1.233HisAla: 1.233 ± 0.053
0.342HisCys: 0.342 ± 0.027
1.239HisAsp: 1.239 ± 0.062
1.425HisGlu: 1.425 ± 0.05
0.973HisPhe: 0.973 ± 0.048
1.303HisGly: 1.303 ± 0.052
0.515HisHis: 0.515 ± 0.033
1.615HisIle: 1.615 ± 0.064
1.278HisLys: 1.278 ± 0.055
1.806HisLeu: 1.806 ± 0.059
0.59HisMet: 0.59 ± 0.039
0.786HisAsn: 0.786 ± 0.039
0.903HisPro: 0.903 ± 0.05
0.734HisGln: 0.734 ± 0.035
0.748HisArg: 0.748 ± 0.036
1.08HisSer: 1.08 ± 0.053
1.052HisThr: 1.052 ± 0.04
1.398HisVal: 1.398 ± 0.06
0.173HisTrp: 0.173 ± 0.021
0.829HisTyr: 0.829 ± 0.042
0.0HisXaa: 0.0 ± 0.0
Ile
5.396IleAla: 5.396 ± 0.127
1.431IleCys: 1.431 ± 0.056
5.751IleAsp: 5.751 ± 0.129
6.609IleGlu: 6.609 ± 0.115
3.462IlePhe: 3.462 ± 0.103
5.062IleGly: 5.062 ± 0.123
1.845IleHis: 1.845 ± 0.06
6.351IleIle: 6.351 ± 0.13
5.805IleLys: 5.805 ± 0.117
8.292IleLeu: 8.292 ± 0.182
2.221IleMet: 2.221 ± 0.065
3.976IleAsn: 3.976 ± 0.092
3.019IlePro: 3.019 ± 0.09
3.609IleGln: 3.609 ± 0.095
3.093IleArg: 3.093 ± 0.087
5.396IleSer: 5.396 ± 0.12
4.085IleThr: 4.085 ± 0.103
5.963IleVal: 5.963 ± 0.118
0.59IleTrp: 0.59 ± 0.038
3.27IleTyr: 3.27 ± 0.085
0.0IleXaa: 0.0 ± 0.0
Lys
4.673LysAla: 4.673 ± 0.104
0.66LysCys: 0.66 ± 0.041
5.572LysAsp: 5.572 ± 0.114
8.487LysGlu: 8.487 ± 0.135
1.92LysPhe: 1.92 ± 0.065
4.155LysGly: 4.155 ± 0.088
1.497LysHis: 1.497 ± 0.055
5.914LysIle: 5.914 ± 0.11
7.394LysLys: 7.394 ± 0.168
5.71LysLeu: 5.71 ± 0.111
2.542LysMet: 2.542 ± 0.072
4.141LysAsn: 4.141 ± 0.098
2.295LysPro: 2.295 ± 0.063
3.06LysGln: 3.06 ± 0.081
3.116LysArg: 3.116 ± 0.089
3.642LysSer: 3.642 ± 0.086
4.176LysThr: 4.176 ± 0.111
4.57LysVal: 4.57 ± 0.107
0.52LysTrp: 0.52 ± 0.033
2.99LysTyr: 2.99 ± 0.081
0.002LysXaa: 0.002 ± 0.001
Leu
5.951LeuAla: 5.951 ± 0.111
1.557LeuCys: 1.557 ± 0.062
6.265LeuAsp: 6.265 ± 0.121
6.664LeuGlu: 6.664 ± 0.11
4.293LeuPhe: 4.293 ± 0.117
5.343LeuGly: 5.343 ± 0.12
1.722LeuHis: 1.722 ± 0.053
7.489LeuIle: 7.489 ± 0.155
7.448LeuLys: 7.448 ± 0.132
8.093LeuLeu: 8.093 ± 0.177
2.887LeuMet: 2.887 ± 0.067
4.889LeuAsn: 4.889 ± 0.099
3.041LeuPro: 3.041 ± 0.076
3.046LeuGln: 3.046 ± 0.087
3.227LeuArg: 3.227 ± 0.088
6.673LeuSer: 6.673 ± 0.124
4.404LeuThr: 4.404 ± 0.097
5.784LeuVal: 5.784 ± 0.095
0.689LeuTrp: 0.689 ± 0.035
3.569LeuTyr: 3.569 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
2.254MetAla: 2.254 ± 0.07
0.373MetCys: 0.373 ± 0.029
2.048MetAsp: 2.048 ± 0.058
2.161MetGlu: 2.161 ± 0.063
1.097MetPhe: 1.097 ± 0.051
1.563MetGly: 1.563 ± 0.056
0.542MetHis: 0.542 ± 0.034
2.815MetIle: 2.815 ± 0.085
2.778MetLys: 2.778 ± 0.079
2.575MetLeu: 2.575 ± 0.075
1.111MetMet: 1.111 ± 0.044
1.942MetAsn: 1.942 ± 0.05
1.122MetPro: 1.122 ± 0.045
1.107MetGln: 1.107 ± 0.045
0.946MetArg: 0.946 ± 0.04
1.846MetSer: 1.846 ± 0.062
1.505MetThr: 1.505 ± 0.054
1.916MetVal: 1.916 ± 0.067
0.146MetTrp: 0.146 ± 0.017
1.015MetTyr: 1.015 ± 0.042
0.0MetXaa: 0.0 ± 0.0
Asn
3.285AsnAla: 3.285 ± 0.083
0.748AsnCys: 0.748 ± 0.048
3.178AsnAsp: 3.178 ± 0.085
4.06AsnGlu: 4.06 ± 0.105
1.817AsnPhe: 1.817 ± 0.061
3.262AsnGly: 3.262 ± 0.098
1.045AsnHis: 1.045 ± 0.051
4.194AsnIle: 4.194 ± 0.095
3.681AsnLys: 3.681 ± 0.089
4.297AsnLeu: 4.297 ± 0.095
1.485AsnMet: 1.485 ± 0.053
2.351AsnAsn: 2.351 ± 0.069
1.848AsnPro: 1.848 ± 0.065
2.153AsnGln: 2.153 ± 0.077
1.765AsnArg: 1.765 ± 0.057
2.526AsnSer: 2.526 ± 0.07
2.745AsnThr: 2.745 ± 0.079
3.578AsnVal: 3.578 ± 0.08
0.377AsnTrp: 0.377 ± 0.03
2.0AsnTyr: 2.0 ± 0.074
0.0AsnXaa: 0.0 ± 0.0
Pro
1.631ProAla: 1.631 ± 0.073
0.495ProCys: 0.495 ± 0.033
1.868ProAsp: 1.868 ± 0.06
2.522ProGlu: 2.522 ± 0.086
1.627ProPhe: 1.627 ± 0.056
1.769ProGly: 1.769 ± 0.065
0.483ProHis: 0.483 ± 0.03
2.615ProIle: 2.615 ± 0.064
1.955ProLys: 1.955 ± 0.074
2.528ProLeu: 2.528 ± 0.08
0.891ProMet: 0.891 ± 0.047
1.577ProAsn: 1.577 ± 0.051
0.462ProPro: 0.462 ± 0.026
0.996ProGln: 0.996 ± 0.045
0.905ProArg: 0.905 ± 0.042
1.945ProSer: 1.945 ± 0.06
1.613ProThr: 1.613 ± 0.058
2.464ProVal: 2.464 ± 0.074
0.254ProTrp: 0.254 ± 0.021
1.472ProTyr: 1.472 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
2.534GlnAla: 2.534 ± 0.075
0.398GlnCys: 0.398 ± 0.03
2.38GlnAsp: 2.38 ± 0.079
2.71GlnGlu: 2.71 ± 0.071
1.415GlnPhe: 1.415 ± 0.056
1.998GlnGly: 1.998 ± 0.054
0.54GlnHis: 0.54 ± 0.034
3.254GlnIle: 3.254 ± 0.094
3.308GlnLys: 3.308 ± 0.084
3.145GlnLeu: 3.145 ± 0.094
1.159GlnMet: 1.159 ± 0.047
2.079GlnAsn: 2.079 ± 0.065
0.93GlnPro: 0.93 ± 0.045
1.188GlnGln: 1.188 ± 0.054
1.462GlnArg: 1.462 ± 0.054
2.037GlnSer: 2.037 ± 0.074
1.965GlnThr: 1.965 ± 0.058
2.142GlnVal: 2.142 ± 0.067
0.285GlnTrp: 0.285 ± 0.027
1.573GlnTyr: 1.573 ± 0.062
0.0GlnXaa: 0.0 ± 0.0
Arg
1.897ArgAla: 1.897 ± 0.059
0.476ArgCys: 0.476 ± 0.032
1.681ArgAsp: 1.681 ± 0.061
2.334ArgGlu: 2.334 ± 0.07
1.794ArgPhe: 1.794 ± 0.066
1.777ArgGly: 1.777 ± 0.056
0.697ArgHis: 0.697 ± 0.039
3.427ArgIle: 3.427 ± 0.077
3.072ArgLys: 3.072 ± 0.079
3.433ArgLeu: 3.433 ± 0.08
1.26ArgMet: 1.26 ± 0.054
1.928ArgAsn: 1.928 ± 0.066
1.039ArgPro: 1.039 ± 0.053
1.347ArgGln: 1.347 ± 0.057
1.423ArgArg: 1.423 ± 0.05
2.023ArgSer: 2.023 ± 0.07
1.703ArgThr: 1.703 ± 0.066
2.254ArgVal: 2.254 ± 0.063
0.289ArgTrp: 0.289 ± 0.025
1.734ArgTyr: 1.734 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
3.33SerAla: 3.33 ± 0.078
0.907SerCys: 0.907 ± 0.045
3.221SerAsp: 3.221 ± 0.085
3.165SerGlu: 3.165 ± 0.074
3.161SerPhe: 3.161 ± 0.077
3.912SerGly: 3.912 ± 0.096
1.266SerHis: 1.266 ± 0.051
5.343SerIle: 5.343 ± 0.112
4.621SerLys: 4.621 ± 0.105
6.341SerLeu: 6.341 ± 0.138
1.959SerMet: 1.959 ± 0.075
3.202SerAsn: 3.202 ± 0.09
1.384SerPro: 1.384 ± 0.055
2.198SerGln: 2.198 ± 0.073
2.2SerArg: 2.2 ± 0.063
3.893SerSer: 3.893 ± 0.109
3.077SerThr: 3.077 ± 0.092
3.825SerVal: 3.825 ± 0.099
0.544SerTrp: 0.544 ± 0.032
2.576SerTyr: 2.576 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
2.65ThrAla: 2.65 ± 0.069
0.781ThrCys: 0.781 ± 0.037
2.747ThrAsp: 2.747 ± 0.079
2.509ThrGlu: 2.509 ± 0.073
2.345ThrPhe: 2.345 ± 0.07
3.551ThrGly: 3.551 ± 0.097
0.98ThrHis: 0.98 ± 0.046
4.97ThrIle: 4.97 ± 0.088
3.817ThrLys: 3.817 ± 0.087
5.351ThrLeu: 5.351 ± 0.104
1.462ThrMet: 1.462 ± 0.054
2.565ThrAsn: 2.565 ± 0.071
1.914ThrPro: 1.914 ± 0.066
1.777ThrGln: 1.777 ± 0.069
1.821ThrArg: 1.821 ± 0.058
3.413ThrSer: 3.413 ± 0.077
2.767ThrThr: 2.767 ± 0.083
3.281ThrVal: 3.281 ± 0.097
0.425ThrTrp: 0.425 ± 0.032
2.357ThrTyr: 2.357 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
3.974ValAla: 3.974 ± 0.097
1.252ValCys: 1.252 ± 0.047
4.244ValAsp: 4.244 ± 0.091
4.332ValGlu: 4.332 ± 0.101
3.07ValPhe: 3.07 ± 0.082
3.864ValGly: 3.864 ± 0.097
1.311ValHis: 1.311 ± 0.048
5.438ValIle: 5.438 ± 0.104
4.314ValLys: 4.314 ± 0.099
6.772ValLeu: 6.772 ± 0.126
1.87ValMet: 1.87 ± 0.062
3.008ValAsn: 3.008 ± 0.076
1.922ValPro: 1.922 ± 0.058
2.149ValGln: 2.149 ± 0.068
2.34ValArg: 2.34 ± 0.067
4.619ValSer: 4.619 ± 0.103
3.219ValThr: 3.219 ± 0.108
4.448ValVal: 4.448 ± 0.108
0.468ValTrp: 0.468 ± 0.03
2.947ValTyr: 2.947 ± 0.079
0.0ValXaa: 0.0 ± 0.0
Trp
0.439TrpAla: 0.439 ± 0.025
0.122TrpCys: 0.122 ± 0.015
0.456TrpAsp: 0.456 ± 0.037
0.365TrpGlu: 0.365 ± 0.029
0.408TrpPhe: 0.408 ± 0.029
0.423TrpGly: 0.423 ± 0.031
0.171TrpHis: 0.171 ± 0.02
0.887TrpIle: 0.887 ± 0.048
0.561TrpLys: 0.561 ± 0.032
0.827TrpLeu: 0.827 ± 0.048
0.241TrpMet: 0.241 ± 0.02
0.476TrpAsn: 0.476 ± 0.033
0.183TrpPro: 0.183 ± 0.02
0.357TrpGln: 0.357 ± 0.024
0.237TrpArg: 0.237 ± 0.023
0.392TrpSer: 0.392 ± 0.027
0.412TrpThr: 0.412 ± 0.031
0.439TrpVal: 0.439 ± 0.03
0.091TrpTrp: 0.091 ± 0.014
0.336TrpTyr: 0.336 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.703TyrAla: 2.703 ± 0.071
0.629TyrCys: 0.629 ± 0.036
3.031TyrAsp: 3.031 ± 0.073
2.965TyrGlu: 2.965 ± 0.074
2.044TyrPhe: 2.044 ± 0.069
2.652TyrGly: 2.652 ± 0.069
1.0TyrHis: 1.0 ± 0.048
3.149TyrIle: 3.149 ± 0.089
2.654TyrLys: 2.654 ± 0.074
3.922TyrLeu: 3.922 ± 0.091
1.07TyrMet: 1.07 ± 0.05
1.802TyrAsn: 1.802 ± 0.067
1.679TyrPro: 1.679 ± 0.053
1.854TyrGln: 1.854 ± 0.065
1.664TyrArg: 1.664 ± 0.063
2.487TyrSer: 2.487 ± 0.072
2.402TyrThr: 2.402 ± 0.072
2.808TyrVal: 2.808 ± 0.075
0.348TyrTrp: 0.348 ± 0.028
1.998TyrTyr: 1.998 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.002XaaIle: 0.002 ± 0.001
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.003
Statistics based on 1735 proteins (515045 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski