Amino acid dipepetide frequency for Basilea psittacipulmonis DSM 24701

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.221AlaAla: 6.221 ± 0.172
1.128AlaCys: 1.128 ± 0.05
4.435AlaAsp: 4.435 ± 0.151
4.305AlaGlu: 4.305 ± 0.106
3.369AlaPhe: 3.369 ± 0.095
5.987AlaGly: 5.987 ± 0.205
1.677AlaHis: 1.677 ± 0.065
6.068AlaIle: 6.068 ± 0.128
5.404AlaLys: 5.404 ± 0.144
9.128AlaLeu: 9.128 ± 0.152
2.366AlaMet: 2.366 ± 0.082
3.5AlaAsn: 3.5 ± 0.152
2.553AlaPro: 2.553 ± 0.075
4.045AlaGln: 4.045 ± 0.104
3.666AlaArg: 3.666 ± 0.099
5.412AlaSer: 5.412 ± 0.137
4.772AlaThr: 4.772 ± 0.207
5.9AlaVal: 5.9 ± 0.156
1.062AlaTrp: 1.062 ± 0.045
2.719AlaTyr: 2.719 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.731CysAla: 0.731 ± 0.04
0.121CysCys: 0.121 ± 0.014
0.511CysAsp: 0.511 ± 0.031
0.551CysGlu: 0.551 ± 0.034
0.513CysPhe: 0.513 ± 0.037
0.842CysGly: 0.842 ± 0.045
0.373CysHis: 0.373 ± 0.026
0.612CysIle: 0.612 ± 0.035
0.363CysLys: 0.363 ± 0.028
1.231CysLeu: 1.231 ± 0.057
0.238CysMet: 0.238 ± 0.02
0.301CysAsn: 0.301 ± 0.026
0.519CysPro: 0.519 ± 0.036
0.519CysGln: 0.519 ± 0.031
0.4CysArg: 0.4 ± 0.03
0.644CysSer: 0.644 ± 0.038
0.488CysThr: 0.488 ± 0.032
0.791CysVal: 0.791 ± 0.044
0.113CysTrp: 0.113 ± 0.015
0.337CysTyr: 0.337 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
4.307AspAla: 4.307 ± 0.136
0.474AspCys: 0.474 ± 0.029
2.858AspAsp: 2.858 ± 0.091
3.825AspGlu: 3.825 ± 0.098
2.35AspPhe: 2.35 ± 0.072
3.623AspGly: 3.623 ± 0.233
1.144AspHis: 1.144 ± 0.048
4.029AspIle: 4.029 ± 0.096
3.381AspLys: 3.381 ± 0.083
5.363AspLeu: 5.363 ± 0.117
1.336AspMet: 1.336 ± 0.058
2.089AspAsn: 2.089 ± 0.1
2.271AspPro: 2.271 ± 0.069
1.962AspGln: 1.962 ± 0.068
2.358AspArg: 2.358 ± 0.077
2.987AspSer: 2.987 ± 0.102
2.834AspThr: 2.834 ± 0.108
3.92AspVal: 3.92 ± 0.098
0.785AspTrp: 0.785 ± 0.039
2.031AspTyr: 2.031 ± 0.069
0.0AspXaa: 0.0 ± 0.0
Glu
4.98GluAla: 4.98 ± 0.119
0.488GluCys: 0.488 ± 0.031
2.65GluAsp: 2.65 ± 0.071
3.472GluGlu: 3.472 ± 0.115
2.069GluPhe: 2.069 ± 0.076
3.391GluGly: 3.391 ± 0.092
1.817GluHis: 1.817 ± 0.069
4.116GluIle: 4.116 ± 0.11
4.531GluLys: 4.531 ± 0.119
5.599GluLeu: 5.599 ± 0.139
1.685GluMet: 1.685 ± 0.067
2.798GluAsn: 2.798 ± 0.09
1.912GluPro: 1.912 ± 0.079
3.211GluGln: 3.211 ± 0.104
3.222GluArg: 3.222 ± 0.103
3.276GluSer: 3.276 ± 0.085
3.331GluThr: 3.331 ± 0.106
4.094GluVal: 4.094 ± 0.118
0.672GluTrp: 0.672 ± 0.032
1.809GluTyr: 1.809 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.125PheAla: 3.125 ± 0.074
0.563PheCys: 0.563 ± 0.033
2.507PheAsp: 2.507 ± 0.091
2.317PheGlu: 2.317 ± 0.071
1.928PhePhe: 1.928 ± 0.086
2.955PheGly: 2.955 ± 0.107
0.888PheHis: 0.888 ± 0.042
2.836PheIle: 2.836 ± 0.107
2.283PheLys: 2.283 ± 0.065
3.936PheLeu: 3.936 ± 0.13
1.035PheMet: 1.035 ± 0.048
1.867PheAsn: 1.867 ± 0.065
1.534PhePro: 1.534 ± 0.065
1.326PheGln: 1.326 ± 0.051
1.433PheArg: 1.433 ± 0.058
3.07PheSer: 3.07 ± 0.091
1.97PheThr: 1.97 ± 0.055
2.862PheVal: 2.862 ± 0.086
0.537PheTrp: 0.537 ± 0.043
1.455PheTyr: 1.455 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
5.288GlyAla: 5.288 ± 0.154
0.704GlyCys: 0.704 ± 0.045
3.577GlyAsp: 3.577 ± 0.172
3.617GlyGlu: 3.617 ± 0.133
3.022GlyPhe: 3.022 ± 0.099
4.544GlyGly: 4.544 ± 0.145
1.572GlyHis: 1.572 ± 0.06
4.992GlyIle: 4.992 ± 0.109
4.584GlyLys: 4.584 ± 0.133
7.147GlyLeu: 7.147 ± 0.164
1.972GlyMet: 1.972 ± 0.068
2.731GlyAsn: 2.731 ± 0.154
1.776GlyPro: 1.776 ± 0.072
3.012GlyGln: 3.012 ± 0.088
3.056GlyArg: 3.056 ± 0.092
4.348GlySer: 4.348 ± 0.154
4.114GlyThr: 4.114 ± 0.24
5.214GlyVal: 5.214 ± 0.107
0.906GlyTrp: 0.906 ± 0.045
2.293GlyTyr: 2.293 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.881HisAla: 1.881 ± 0.072
0.287HisCys: 0.287 ± 0.025
1.233HisAsp: 1.233 ± 0.052
1.415HisGlu: 1.415 ± 0.06
1.074HisPhe: 1.074 ± 0.048
1.465HisGly: 1.465 ± 0.069
0.995HisHis: 0.995 ± 0.052
1.841HisIle: 1.841 ± 0.077
0.916HisLys: 0.916 ± 0.045
2.418HisLeu: 2.418 ± 0.077
0.499HisMet: 0.499 ± 0.031
0.723HisAsn: 0.723 ± 0.04
1.524HisPro: 1.524 ± 0.06
1.312HisGln: 1.312 ± 0.056
1.094HisArg: 1.094 ± 0.056
1.169HisSer: 1.169 ± 0.052
1.358HisThr: 1.358 ± 0.048
1.306HisVal: 1.306 ± 0.055
0.252HisTrp: 0.252 ± 0.022
1.048HisTyr: 1.048 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.564IleAla: 6.564 ± 0.135
0.723IleCys: 0.723 ± 0.042
4.364IleAsp: 4.364 ± 0.1
4.598IleGlu: 4.598 ± 0.103
2.634IlePhe: 2.634 ± 0.101
4.838IleGly: 4.838 ± 0.125
1.768IleHis: 1.768 ± 0.073
4.336IleIle: 4.336 ± 0.131
4.013IleLys: 4.013 ± 0.102
6.391IleLeu: 6.391 ± 0.169
1.461IleMet: 1.461 ± 0.062
2.88IleAsn: 2.88 ± 0.095
2.979IlePro: 2.979 ± 0.098
2.951IleGln: 2.951 ± 0.087
3.201IleArg: 3.201 ± 0.096
4.515IleSer: 4.515 ± 0.114
3.95IleThr: 3.95 ± 0.144
4.342IleVal: 4.342 ± 0.104
0.684IleTrp: 0.684 ± 0.04
2.105IleTyr: 2.105 ± 0.082
0.0IleXaa: 0.0 ± 0.0
Lys
5.305LysAla: 5.305 ± 0.178
0.363LysCys: 0.363 ± 0.026
3.53LysAsp: 3.53 ± 0.109
4.386LysGlu: 4.386 ± 0.127
1.675LysPhe: 1.675 ± 0.067
4.132LysGly: 4.132 ± 0.132
1.29LysHis: 1.29 ± 0.054
3.888LysIle: 3.888 ± 0.078
3.982LysLys: 3.982 ± 0.099
5.299LysLeu: 5.299 ± 0.117
1.467LysMet: 1.467 ± 0.059
2.999LysAsn: 2.999 ± 0.094
2.196LysPro: 2.196 ± 0.064
2.695LysGln: 2.695 ± 0.071
3.08LysArg: 3.08 ± 0.092
3.05LysSer: 3.05 ± 0.082
3.69LysThr: 3.69 ± 0.102
4.007LysVal: 4.007 ± 0.127
0.698LysTrp: 0.698 ± 0.04
1.714LysTyr: 1.714 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
8.613LeuAla: 8.613 ± 0.142
1.251LeuCys: 1.251 ± 0.06
5.347LeuAsp: 5.347 ± 0.105
5.747LeuGlu: 5.747 ± 0.143
3.958LeuPhe: 3.958 ± 0.138
7.204LeuGly: 7.204 ± 0.153
2.099LeuHis: 2.099 ± 0.075
6.57LeuIle: 6.57 ± 0.173
6.5LeuLys: 6.5 ± 0.129
9.747LeuLeu: 9.747 ± 0.235
2.578LeuMet: 2.578 ± 0.08
5.177LeuAsn: 5.177 ± 0.13
4.622LeuPro: 4.622 ± 0.103
3.565LeuGln: 3.565 ± 0.092
4.487LeuArg: 4.487 ± 0.125
8.233LeuSer: 8.233 ± 0.153
5.874LeuThr: 5.874 ± 0.138
6.241LeuVal: 6.241 ± 0.135
0.997LeuTrp: 0.997 ± 0.05
2.747LeuTyr: 2.747 ± 0.099
0.0LeuXaa: 0.0 ± 0.0
Met
2.319MetAla: 2.319 ± 0.073
0.194MetCys: 0.194 ± 0.019
1.132MetAsp: 1.132 ± 0.048
1.064MetGlu: 1.064 ± 0.053
0.807MetPhe: 0.807 ± 0.037
1.851MetGly: 1.851 ± 0.07
0.42MetHis: 0.42 ± 0.033
1.772MetIle: 1.772 ± 0.058
1.675MetLys: 1.675 ± 0.058
2.454MetLeu: 2.454 ± 0.084
0.884MetMet: 0.884 ± 0.045
1.336MetAsn: 1.336 ± 0.05
1.155MetPro: 1.155 ± 0.048
1.033MetGln: 1.033 ± 0.053
1.197MetArg: 1.197 ± 0.046
1.952MetSer: 1.952 ± 0.062
1.401MetThr: 1.401 ± 0.046
1.728MetVal: 1.728 ± 0.068
0.174MetTrp: 0.174 ± 0.02
0.587MetTyr: 0.587 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.904AsnAla: 3.904 ± 0.15
0.369AsnCys: 0.369 ± 0.033
2.109AsnAsp: 2.109 ± 0.069
2.491AsnGlu: 2.491 ± 0.081
1.595AsnPhe: 1.595 ± 0.07
3.018AsnGly: 3.018 ± 0.178
1.048AsnHis: 1.048 ± 0.049
3.431AsnIle: 3.431 ± 0.106
2.384AsnLys: 2.384 ± 0.095
4.219AsnLeu: 4.219 ± 0.107
0.971AsnMet: 0.971 ± 0.04
1.845AsnAsn: 1.845 ± 0.105
2.134AsnPro: 2.134 ± 0.076
1.784AsnGln: 1.784 ± 0.077
1.96AsnArg: 1.96 ± 0.065
2.313AsnSer: 2.313 ± 0.104
2.574AsnThr: 2.574 ± 0.119
2.878AsnVal: 2.878 ± 0.114
0.583AsnTrp: 0.583 ± 0.036
1.397AsnTyr: 1.397 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
2.818ProAla: 2.818 ± 0.083
0.381ProCys: 0.381 ± 0.028
2.467ProAsp: 2.467 ± 0.078
3.088ProGlu: 3.088 ± 0.085
1.758ProPhe: 1.758 ± 0.063
2.101ProGly: 2.101 ± 0.072
0.975ProHis: 0.975 ± 0.049
2.737ProIle: 2.737 ± 0.093
2.305ProLys: 2.305 ± 0.066
3.756ProLeu: 3.756 ± 0.105
0.846ProMet: 0.846 ± 0.045
1.952ProAsn: 1.952 ± 0.07
1.11ProPro: 1.11 ± 0.055
1.619ProGln: 1.619 ± 0.061
1.407ProArg: 1.407 ± 0.065
2.582ProSer: 2.582 ± 0.086
2.065ProThr: 2.065 ± 0.065
3.074ProVal: 3.074 ± 0.089
0.464ProTrp: 0.464 ± 0.031
1.397ProTyr: 1.397 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
4.822GlnAla: 4.822 ± 0.114
0.299GlnCys: 0.299 ± 0.026
2.315GlnAsp: 2.315 ± 0.076
2.921GlnGlu: 2.921 ± 0.092
1.469GlnPhe: 1.469 ± 0.056
2.745GlnGly: 2.745 ± 0.091
1.094GlnHis: 1.094 ± 0.049
2.786GlnIle: 2.786 ± 0.077
2.82GlnLys: 2.82 ± 0.092
4.277GlnLeu: 4.277 ± 0.107
1.029GlnMet: 1.029 ± 0.051
1.76GlnAsn: 1.76 ± 0.058
1.29GlnPro: 1.29 ± 0.047
1.934GlnGln: 1.934 ± 0.078
1.98GlnArg: 1.98 ± 0.083
2.662GlnSer: 2.662 ± 0.086
2.572GlnThr: 2.572 ± 0.078
3.034GlnVal: 3.034 ± 0.092
0.614GlnTrp: 0.614 ± 0.041
1.492GlnTyr: 1.492 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
3.262ArgAla: 3.262 ± 0.087
0.396ArgCys: 0.396 ± 0.028
2.341ArgAsp: 2.341 ± 0.076
2.85ArgGlu: 2.85 ± 0.092
2.125ArgPhe: 2.125 ± 0.074
2.576ArgGly: 2.576 ± 0.081
1.122ArgHis: 1.122 ± 0.046
3.387ArgIle: 3.387 ± 0.093
2.368ArgLys: 2.368 ± 0.073
5.145ArgLeu: 5.145 ± 0.136
1.336ArgMet: 1.336 ± 0.055
1.647ArgAsn: 1.647 ± 0.064
1.681ArgPro: 1.681 ± 0.064
2.218ArgGln: 2.218 ± 0.07
2.166ArgArg: 2.166 ± 0.082
2.743ArgSer: 2.743 ± 0.081
2.182ArgThr: 2.182 ± 0.066
2.935ArgVal: 2.935 ± 0.095
0.519ArgTrp: 0.519 ± 0.032
1.942ArgTyr: 1.942 ± 0.077
0.0ArgXaa: 0.0 ± 0.0
Ser
4.747SerAla: 4.747 ± 0.124
0.656SerCys: 0.656 ± 0.04
3.595SerAsp: 3.595 ± 0.122
3.494SerGlu: 3.494 ± 0.099
2.911SerPhe: 2.911 ± 0.096
4.996SerGly: 4.996 ± 0.131
1.461SerHis: 1.461 ± 0.054
4.378SerIle: 4.378 ± 0.113
3.585SerLys: 3.585 ± 0.081
7.073SerLeu: 7.073 ± 0.127
1.583SerMet: 1.583 ± 0.063
2.473SerAsn: 2.473 ± 0.091
2.307SerPro: 2.307 ± 0.085
3.022SerGln: 3.022 ± 0.086
2.765SerArg: 2.765 ± 0.095
4.36SerSer: 4.36 ± 0.131
3.417SerThr: 3.417 ± 0.13
4.437SerVal: 4.437 ± 0.135
0.793SerTrp: 0.793 ± 0.042
2.196SerTyr: 2.196 ± 0.078
0.0SerXaa: 0.0 ± 0.0
Thr
4.735ThrAla: 4.735 ± 0.185
0.48ThrCys: 0.48 ± 0.032
2.925ThrAsp: 2.925 ± 0.132
2.783ThrGlu: 2.783 ± 0.075
2.158ThrPhe: 2.158 ± 0.077
4.523ThrGly: 4.523 ± 0.226
1.471ThrHis: 1.471 ± 0.059
3.924ThrIle: 3.924 ± 0.137
2.602ThrLys: 2.602 ± 0.087
6.378ThrLeu: 6.378 ± 0.14
1.078ThrMet: 1.078 ± 0.05
2.232ThrAsn: 2.232 ± 0.15
2.757ThrPro: 2.757 ± 0.079
2.62ThrGln: 2.62 ± 0.094
2.212ThrArg: 2.212 ± 0.066
3.53ThrSer: 3.53 ± 0.122
3.147ThrThr: 3.147 ± 0.183
4.267ThrVal: 4.267 ± 0.203
0.666ThrTrp: 0.666 ± 0.04
1.641ThrTyr: 1.641 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
6.378ValAla: 6.378 ± 0.153
0.795ValCys: 0.795 ± 0.041
3.641ValAsp: 3.641 ± 0.082
3.692ValGlu: 3.692 ± 0.09
2.892ValPhe: 2.892 ± 0.097
4.616ValGly: 4.616 ± 0.115
1.356ValHis: 1.356 ± 0.05
4.796ValIle: 4.796 ± 0.109
3.849ValLys: 3.849 ± 0.13
7.055ValLeu: 7.055 ± 0.146
1.853ValMet: 1.853 ± 0.061
3.143ValAsn: 3.143 ± 0.105
2.781ValPro: 2.781 ± 0.098
2.495ValGln: 2.495 ± 0.07
2.828ValArg: 2.828 ± 0.085
4.846ValSer: 4.846 ± 0.113
3.999ValThr: 3.999 ± 0.188
5.226ValVal: 5.226 ± 0.122
0.811ValTrp: 0.811 ± 0.046
2.136ValTyr: 2.136 ± 0.06
0.0ValXaa: 0.0 ± 0.0
Trp
0.819TrpAla: 0.819 ± 0.044
0.153TrpCys: 0.153 ± 0.016
0.531TrpAsp: 0.531 ± 0.037
0.612TrpGlu: 0.612 ± 0.038
0.537TrpPhe: 0.537 ± 0.037
0.787TrpGly: 0.787 ± 0.044
0.377TrpHis: 0.377 ± 0.029
0.819TrpIle: 0.819 ± 0.043
0.624TrpLys: 0.624 ± 0.038
1.474TrpLeu: 1.474 ± 0.066
0.301TrpMet: 0.301 ± 0.023
0.503TrpAsn: 0.503 ± 0.033
0.359TrpPro: 0.359 ± 0.027
0.682TrpGln: 0.682 ± 0.035
0.66TrpArg: 0.66 ± 0.043
0.698TrpSer: 0.698 ± 0.036
0.543TrpThr: 0.543 ± 0.032
0.924TrpVal: 0.924 ± 0.036
0.141TrpTrp: 0.141 ± 0.018
0.373TrpTyr: 0.373 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.901TyrAla: 2.901 ± 0.084
0.377TyrCys: 0.377 ± 0.031
1.861TyrAsp: 1.861 ± 0.062
1.897TyrGlu: 1.897 ± 0.072
1.582TyrPhe: 1.582 ± 0.067
2.275TyrGly: 2.275 ± 0.076
0.866TyrHis: 0.866 ± 0.041
1.976TyrIle: 1.976 ± 0.078
1.276TyrLys: 1.276 ± 0.049
3.466TyrLeu: 3.466 ± 0.105
0.614TyrMet: 0.614 ± 0.033
1.052TyrAsn: 1.052 ± 0.047
1.443TyrPro: 1.443 ± 0.067
1.91TyrGln: 1.91 ± 0.061
1.768TyrArg: 1.768 ± 0.058
1.861TyrSer: 1.861 ± 0.059
1.843TyrThr: 1.843 ± 0.068
2.006TyrVal: 2.006 ± 0.063
0.446TyrTrp: 0.446 ± 0.029
1.235TyrTyr: 1.235 ± 0.056
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1452 proteins (504581 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski