Amino acid dipepetide frequency for Rhizobium phage V1VFA-S

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.062AlaAla: 16.062 ± 1.242
0.734AlaCys: 0.734 ± 0.157
7.114AlaAsp: 7.114 ± 0.429
7.085AlaGlu: 7.085 ± 0.515
3.783AlaPhe: 3.783 ± 0.257
8.299AlaGly: 8.299 ± 0.444
1.496AlaHis: 1.496 ± 0.213
5.646AlaIle: 5.646 ± 0.38
6.436AlaLys: 6.436 ± 0.437
9.203AlaLeu: 9.203 ± 0.552
3.67AlaMet: 3.67 ± 0.294
3.924AlaAsn: 3.924 ± 0.372
3.754AlaPro: 3.754 ± 0.373
3.98AlaGln: 3.98 ± 0.399
5.138AlaArg: 5.138 ± 0.378
5.194AlaSer: 5.194 ± 0.36
6.069AlaThr: 6.069 ± 0.522
6.267AlaVal: 6.267 ± 0.387
1.073AlaTrp: 1.073 ± 0.164
3.303AlaTyr: 3.303 ± 0.286
0.0AlaXaa: 0.0 ± 0.0
Cys
0.649CysAla: 0.649 ± 0.137
0.169CysCys: 0.169 ± 0.068
0.621CysAsp: 0.621 ± 0.129
0.649CysGlu: 0.649 ± 0.152
0.311CysPhe: 0.311 ± 0.091
0.565CysGly: 0.565 ± 0.135
0.141CysHis: 0.141 ± 0.068
0.311CysIle: 0.311 ± 0.092
0.452CysLys: 0.452 ± 0.114
0.452CysLeu: 0.452 ± 0.127
0.169CysMet: 0.169 ± 0.084
0.311CysAsn: 0.311 ± 0.096
0.48CysPro: 0.48 ± 0.132
0.423CysGln: 0.423 ± 0.104
0.536CysArg: 0.536 ± 0.127
0.282CysSer: 0.282 ± 0.103
0.452CysThr: 0.452 ± 0.099
0.565CysVal: 0.565 ± 0.14
0.113CysTrp: 0.113 ± 0.047
0.282CysTyr: 0.282 ± 0.081
0.0CysXaa: 0.0 ± 0.0
Asp
6.747AspAla: 6.747 ± 0.431
0.593AspCys: 0.593 ± 0.149
4.488AspAsp: 4.488 ± 0.547
4.968AspGlu: 4.968 ± 0.515
2.795AspPhe: 2.795 ± 0.259
5.307AspGly: 5.307 ± 0.43
1.44AspHis: 1.44 ± 0.186
3.444AspIle: 3.444 ± 0.294
3.246AspLys: 3.246 ± 0.317
5.9AspLeu: 5.9 ± 0.395
1.581AspMet: 1.581 ± 0.193
2.484AspAsn: 2.484 ± 0.253
3.557AspPro: 3.557 ± 0.407
1.807AspGln: 1.807 ± 0.218
3.783AspArg: 3.783 ± 0.319
2.908AspSer: 2.908 ± 0.247
3.359AspThr: 3.359 ± 0.351
3.02AspVal: 3.02 ± 0.234
1.101AspTrp: 1.101 ± 0.165
1.976AspTyr: 1.976 ± 0.29
0.0AspXaa: 0.0 ± 0.0
Glu
7.819GluAla: 7.819 ± 0.501
0.536GluCys: 0.536 ± 0.128
3.783GluAsp: 3.783 ± 0.51
5.589GluGlu: 5.589 ± 0.518
2.682GluPhe: 2.682 ± 0.303
3.924GluGly: 3.924 ± 0.316
1.383GluHis: 1.383 ± 0.219
4.347GluIle: 4.347 ± 0.381
4.94GluLys: 4.94 ± 0.443
6.86GluLeu: 6.86 ± 0.452
2.089GluMet: 2.089 ± 0.277
2.287GluAsn: 2.287 ± 0.283
2.117GluPro: 2.117 ± 0.275
2.399GluGln: 2.399 ± 0.29
4.771GluArg: 4.771 ± 0.499
2.399GluSer: 2.399 ± 0.313
4.178GluThr: 4.178 ± 0.403
4.601GluVal: 4.601 ± 0.379
1.073GluTrp: 1.073 ± 0.175
1.863GluTyr: 1.863 ± 0.237
0.0GluXaa: 0.0 ± 0.0
Phe
3.444PheAla: 3.444 ± 0.299
0.367PheCys: 0.367 ± 0.096
2.71PheAsp: 2.71 ± 0.296
2.964PheGlu: 2.964 ± 0.299
1.129PhePhe: 1.129 ± 0.166
3.387PheGly: 3.387 ± 0.367
0.932PheHis: 0.932 ± 0.172
1.609PheIle: 1.609 ± 0.217
2.512PheLys: 2.512 ± 0.233
2.851PheLeu: 2.851 ± 0.311
1.27PheMet: 1.27 ± 0.205
1.948PheAsn: 1.948 ± 0.279
1.214PhePro: 1.214 ± 0.153
1.186PheGln: 1.186 ± 0.188
2.202PheArg: 2.202 ± 0.267
2.315PheSer: 2.315 ± 0.236
2.117PheThr: 2.117 ± 0.247
2.484PheVal: 2.484 ± 0.228
0.452PheTrp: 0.452 ± 0.114
1.44PheTyr: 1.44 ± 0.212
0.0PheXaa: 0.0 ± 0.0
Gly
6.888GlyAla: 6.888 ± 0.461
0.875GlyCys: 0.875 ± 0.147
4.714GlyAsp: 4.714 ± 0.409
5.251GlyGlu: 5.251 ± 0.375
3.02GlyPhe: 3.02 ± 0.3
5.307GlyGly: 5.307 ± 0.62
1.553GlyHis: 1.553 ± 0.207
3.839GlyIle: 3.839 ± 0.349
4.912GlyLys: 4.912 ± 0.385
5.759GlyLeu: 5.759 ± 0.434
1.835GlyMet: 1.835 ± 0.29
3.162GlyAsn: 3.162 ± 0.327
2.371GlyPro: 2.371 ± 0.265
3.02GlyGln: 3.02 ± 0.305
3.557GlyArg: 3.557 ± 0.321
4.686GlySer: 4.686 ± 0.476
4.375GlyThr: 4.375 ± 0.443
5.053GlyVal: 5.053 ± 0.405
1.27GlyTrp: 1.27 ± 0.161
2.512GlyTyr: 2.512 ± 0.273
0.0GlyXaa: 0.0 ± 0.0
His
1.694HisAla: 1.694 ± 0.222
0.085HisCys: 0.085 ± 0.047
1.186HisAsp: 1.186 ± 0.176
1.157HisGlu: 1.157 ± 0.175
0.932HisPhe: 0.932 ± 0.209
1.665HisGly: 1.665 ± 0.221
0.508HisHis: 0.508 ± 0.137
0.932HisIle: 0.932 ± 0.185
1.016HisLys: 1.016 ± 0.138
1.75HisLeu: 1.75 ± 0.224
0.565HisMet: 0.565 ± 0.132
0.734HisAsn: 0.734 ± 0.16
1.073HisPro: 1.073 ± 0.195
0.621HisGln: 0.621 ± 0.113
1.299HisArg: 1.299 ± 0.226
0.988HisSer: 0.988 ± 0.137
0.96HisThr: 0.96 ± 0.138
1.186HisVal: 1.186 ± 0.166
0.339HisTrp: 0.339 ± 0.098
0.508HisTyr: 0.508 ± 0.1
0.0HisXaa: 0.0 ± 0.0
Ile
6.718IleAla: 6.718 ± 0.346
0.423IleCys: 0.423 ± 0.119
4.037IleAsp: 4.037 ± 0.307
4.601IleGlu: 4.601 ± 0.375
1.553IlePhe: 1.553 ± 0.224
3.754IleGly: 3.754 ± 0.322
0.875IleHis: 0.875 ± 0.174
3.246IleIle: 3.246 ± 0.269
2.992IleLys: 2.992 ± 0.264
4.234IleLeu: 4.234 ± 0.302
1.355IleMet: 1.355 ± 0.201
2.456IleAsn: 2.456 ± 0.233
2.343IlePro: 2.343 ± 0.261
1.75IleGln: 1.75 ± 0.254
3.303IleArg: 3.303 ± 0.264
3.303IleSer: 3.303 ± 0.243
3.896IleThr: 3.896 ± 0.42
3.839IleVal: 3.839 ± 0.352
0.677IleTrp: 0.677 ± 0.132
1.637IleTyr: 1.637 ± 0.237
0.0IleXaa: 0.0 ± 0.0
Lys
6.944LysAla: 6.944 ± 0.54
0.282LysCys: 0.282 ± 0.088
4.15LysAsp: 4.15 ± 0.431
4.432LysGlu: 4.432 ± 0.353
2.117LysPhe: 2.117 ± 0.287
4.008LysGly: 4.008 ± 0.377
1.468LysHis: 1.468 ± 0.235
3.585LysIle: 3.585 ± 0.268
4.488LysLys: 4.488 ± 0.438
4.968LysLeu: 4.968 ± 0.485
1.665LysMet: 1.665 ± 0.245
1.948LysAsn: 1.948 ± 0.199
2.682LysPro: 2.682 ± 0.369
1.948LysGln: 1.948 ± 0.215
3.754LysArg: 3.754 ± 0.445
2.512LysSer: 2.512 ± 0.262
3.641LysThr: 3.641 ± 0.279
3.924LysVal: 3.924 ± 0.312
0.734LysTrp: 0.734 ± 0.149
1.27LysTyr: 1.27 ± 0.188
0.0LysXaa: 0.0 ± 0.0
Leu
8.948LeuAla: 8.948 ± 0.483
0.452LeuCys: 0.452 ± 0.1
5.194LeuAsp: 5.194 ± 0.378
5.42LeuGlu: 5.42 ± 0.398
2.512LeuPhe: 2.512 ± 0.309
5.307LeuGly: 5.307 ± 0.358
1.835LeuHis: 1.835 ± 0.239
4.432LeuIle: 4.432 ± 0.358
5.081LeuLys: 5.081 ± 0.402
5.081LeuLeu: 5.081 ± 0.313
1.948LeuMet: 1.948 ± 0.24
3.162LeuAsn: 3.162 ± 0.312
4.375LeuPro: 4.375 ± 0.326
2.851LeuGln: 2.851 ± 0.42
4.714LeuArg: 4.714 ± 0.41
4.037LeuSer: 4.037 ± 0.392
5.815LeuThr: 5.815 ± 0.527
5.589LeuVal: 5.589 ± 0.423
0.847LeuTrp: 0.847 ± 0.152
1.976LeuTyr: 1.976 ± 0.224
0.0LeuXaa: 0.0 ± 0.0
Met
2.936MetAla: 2.936 ± 0.347
0.169MetCys: 0.169 ± 0.064
1.242MetAsp: 1.242 ± 0.179
1.411MetGlu: 1.411 ± 0.229
0.988MetPhe: 0.988 ± 0.158
1.92MetGly: 1.92 ± 0.217
0.48MetHis: 0.48 ± 0.117
1.383MetIle: 1.383 ± 0.195
2.399MetLys: 2.399 ± 0.275
1.524MetLeu: 1.524 ± 0.228
0.706MetMet: 0.706 ± 0.186
1.186MetAsn: 1.186 ± 0.184
1.44MetPro: 1.44 ± 0.199
0.903MetGln: 0.903 ± 0.153
2.089MetArg: 2.089 ± 0.247
2.371MetSer: 2.371 ± 0.261
2.004MetThr: 2.004 ± 0.281
1.411MetVal: 1.411 ± 0.19
0.226MetTrp: 0.226 ± 0.079
0.367MetTyr: 0.367 ± 0.091
0.0MetXaa: 0.0 ± 0.0
Asn
4.037AsnAla: 4.037 ± 0.317
0.423AsnCys: 0.423 ± 0.12
2.625AsnAsp: 2.625 ± 0.244
2.541AsnGlu: 2.541 ± 0.275
1.778AsnPhe: 1.778 ± 0.216
3.557AsnGly: 3.557 ± 0.486
0.734AsnHis: 0.734 ± 0.158
2.456AsnIle: 2.456 ± 0.252
1.694AsnLys: 1.694 ± 0.213
2.682AsnLeu: 2.682 ± 0.276
0.988AsnMet: 0.988 ± 0.201
1.665AsnAsn: 1.665 ± 0.257
1.92AsnPro: 1.92 ± 0.205
1.242AsnGln: 1.242 ± 0.255
2.117AsnArg: 2.117 ± 0.241
1.722AsnSer: 1.722 ± 0.236
2.428AsnThr: 2.428 ± 0.36
2.653AsnVal: 2.653 ± 0.293
0.593AsnTrp: 0.593 ± 0.129
1.214AsnTyr: 1.214 ± 0.149
0.0AsnXaa: 0.0 ± 0.0
Pro
4.771ProAla: 4.771 ± 0.451
0.169ProCys: 0.169 ± 0.075
3.387ProAsp: 3.387 ± 0.261
3.275ProGlu: 3.275 ± 0.36
1.807ProPhe: 1.807 ± 0.263
3.049ProGly: 3.049 ± 0.317
0.677ProHis: 0.677 ± 0.129
2.795ProIle: 2.795 ± 0.266
2.004ProLys: 2.004 ± 0.246
2.936ProLeu: 2.936 ± 0.3
1.101ProMet: 1.101 ± 0.186
1.609ProAsn: 1.609 ± 0.245
1.101ProPro: 1.101 ± 0.236
1.355ProGln: 1.355 ± 0.194
1.863ProArg: 1.863 ± 0.256
2.428ProSer: 2.428 ± 0.258
2.456ProThr: 2.456 ± 0.298
3.049ProVal: 3.049 ± 0.366
0.508ProTrp: 0.508 ± 0.12
1.044ProTyr: 1.044 ± 0.14
0.0ProXaa: 0.0 ± 0.0
Gln
4.319GlnAla: 4.319 ± 0.434
0.085GlnCys: 0.085 ± 0.047
1.581GlnAsp: 1.581 ± 0.166
2.569GlnGlu: 2.569 ± 0.278
1.553GlnPhe: 1.553 ± 0.175
2.258GlnGly: 2.258 ± 0.318
0.423GlnHis: 0.423 ± 0.105
2.569GlnIle: 2.569 ± 0.249
2.287GlnLys: 2.287 ± 0.269
3.246GlnLeu: 3.246 ± 0.321
0.988GlnMet: 0.988 ± 0.184
1.327GlnAsn: 1.327 ± 0.221
1.75GlnPro: 1.75 ± 0.219
1.327GlnGln: 1.327 ± 0.282
1.92GlnArg: 1.92 ± 0.241
1.665GlnSer: 1.665 ± 0.208
1.92GlnThr: 1.92 ± 0.295
2.682GlnVal: 2.682 ± 0.247
0.423GlnTrp: 0.423 ± 0.143
0.677GlnTyr: 0.677 ± 0.132
0.0GlnXaa: 0.0 ± 0.0
Arg
5.392ArgAla: 5.392 ± 0.389
0.48ArgCys: 0.48 ± 0.126
3.585ArgAsp: 3.585 ± 0.386
3.641ArgGlu: 3.641 ± 0.375
2.682ArgPhe: 2.682 ± 0.292
4.234ArgGly: 4.234 ± 0.329
1.214ArgHis: 1.214 ± 0.171
3.557ArgIle: 3.557 ± 0.326
3.529ArgLys: 3.529 ± 0.33
4.968ArgLeu: 4.968 ± 0.345
1.355ArgMet: 1.355 ± 0.212
2.23ArgAsn: 2.23 ± 0.23
1.863ArgPro: 1.863 ± 0.222
2.399ArgGln: 2.399 ± 0.265
3.5ArgArg: 3.5 ± 0.389
2.597ArgSer: 2.597 ± 0.31
3.359ArgThr: 3.359 ± 0.301
4.319ArgVal: 4.319 ± 0.338
0.932ArgTrp: 0.932 ± 0.193
1.75ArgTyr: 1.75 ± 0.221
0.0ArgXaa: 0.0 ± 0.0
Ser
4.714SerAla: 4.714 ± 0.464
0.536SerCys: 0.536 ± 0.132
2.992SerAsp: 2.992 ± 0.284
3.162SerGlu: 3.162 ± 0.307
2.117SerPhe: 2.117 ± 0.242
4.968SerGly: 4.968 ± 0.544
0.932SerHis: 0.932 ± 0.151
3.049SerIle: 3.049 ± 0.278
3.02SerLys: 3.02 ± 0.281
4.065SerLeu: 4.065 ± 0.31
1.496SerMet: 1.496 ± 0.238
2.202SerAsn: 2.202 ± 0.394
2.145SerPro: 2.145 ± 0.23
2.23SerGln: 2.23 ± 0.242
2.484SerArg: 2.484 ± 0.283
3.077SerSer: 3.077 ± 0.31
2.71SerThr: 2.71 ± 0.342
3.557SerVal: 3.557 ± 0.27
0.649SerTrp: 0.649 ± 0.123
1.863SerTyr: 1.863 ± 0.257
0.0SerXaa: 0.0 ± 0.0
Thr
6.013ThrAla: 6.013 ± 0.67
0.48ThrCys: 0.48 ± 0.125
3.02ThrAsp: 3.02 ± 0.285
3.839ThrGlu: 3.839 ± 0.401
2.145ThrPhe: 2.145 ± 0.207
5.392ThrGly: 5.392 ± 0.565
0.79ThrHis: 0.79 ± 0.118
3.896ThrIle: 3.896 ± 0.463
3.387ThrLys: 3.387 ± 0.271
5.053ThrLeu: 5.053 ± 0.412
1.242ThrMet: 1.242 ± 0.24
2.597ThrAsn: 2.597 ± 0.331
2.992ThrPro: 2.992 ± 0.282
1.891ThrGln: 1.891 ± 0.233
3.387ThrArg: 3.387 ± 0.288
3.162ThrSer: 3.162 ± 0.533
4.206ThrThr: 4.206 ± 0.456
4.263ThrVal: 4.263 ± 0.475
0.875ThrTrp: 0.875 ± 0.157
1.637ThrTyr: 1.637 ± 0.297
0.0ThrXaa: 0.0 ± 0.0
Val
6.662ValAla: 6.662 ± 0.402
0.508ValCys: 0.508 ± 0.125
4.488ValAsp: 4.488 ± 0.419
4.573ValGlu: 4.573 ± 0.379
2.569ValPhe: 2.569 ± 0.227
4.263ValGly: 4.263 ± 0.328
1.129ValHis: 1.129 ± 0.203
3.811ValIle: 3.811 ± 0.348
3.98ValLys: 3.98 ± 0.34
4.714ValLeu: 4.714 ± 0.412
2.089ValMet: 2.089 ± 0.239
2.343ValAsn: 2.343 ± 0.29
2.851ValPro: 2.851 ± 0.3
2.512ValGln: 2.512 ± 0.311
4.15ValArg: 4.15 ± 0.359
4.121ValSer: 4.121 ± 0.345
3.867ValThr: 3.867 ± 0.377
4.996ValVal: 4.996 ± 0.41
0.677ValTrp: 0.677 ± 0.152
2.004ValTyr: 2.004 ± 0.232
0.0ValXaa: 0.0 ± 0.0
Trp
0.847TrpAla: 0.847 ± 0.141
0.198TrpCys: 0.198 ± 0.075
1.044TrpAsp: 1.044 ± 0.167
0.847TrpGlu: 0.847 ± 0.176
0.593TrpPhe: 0.593 ± 0.122
0.706TrpGly: 0.706 ± 0.149
0.48TrpHis: 0.48 ± 0.116
0.819TrpIle: 0.819 ± 0.159
0.932TrpLys: 0.932 ± 0.163
0.932TrpLeu: 0.932 ± 0.181
0.339TrpMet: 0.339 ± 0.116
0.508TrpAsn: 0.508 ± 0.118
0.282TrpPro: 0.282 ± 0.103
0.423TrpGln: 0.423 ± 0.116
0.96TrpArg: 0.96 ± 0.163
0.734TrpSer: 0.734 ± 0.147
0.932TrpThr: 0.932 ± 0.201
0.96TrpVal: 0.96 ± 0.155
0.169TrpTrp: 0.169 ± 0.081
0.423TrpTyr: 0.423 ± 0.116
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.625TyrAla: 2.625 ± 0.291
0.367TyrCys: 0.367 ± 0.108
2.541TyrAsp: 2.541 ± 0.3
1.665TyrGlu: 1.665 ± 0.239
1.468TyrPhe: 1.468 ± 0.241
2.089TyrGly: 2.089 ± 0.233
0.706TyrHis: 0.706 ± 0.156
1.27TyrIle: 1.27 ± 0.214
1.242TyrLys: 1.242 ± 0.184
2.399TyrLeu: 2.399 ± 0.258
0.677TyrMet: 0.677 ± 0.156
0.988TyrAsn: 0.988 ± 0.184
1.073TyrPro: 1.073 ± 0.205
1.299TyrGln: 1.299 ± 0.183
2.061TyrArg: 2.061 ± 0.296
1.468TyrSer: 1.468 ± 0.186
1.524TyrThr: 1.524 ± 0.331
1.891TyrVal: 1.891 ± 0.27
0.395TyrTrp: 0.395 ± 0.11
0.734TyrTyr: 0.734 ± 0.14
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 157 proteins (35426 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski