Amino acid dipepetide frequency for Clostridium sp. CAG:451

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.899AlaAla: 1.899 ± 0.075
0.532AlaCys: 0.532 ± 0.046
2.17AlaAsp: 2.17 ± 0.08
2.069AlaGlu: 2.069 ± 0.083
2.087AlaPhe: 2.087 ± 0.08
2.508AlaGly: 2.508 ± 0.089
0.687AlaHis: 0.687 ± 0.052
4.409AlaIle: 4.409 ± 0.111
4.735AlaLys: 4.735 ± 0.131
4.588AlaLeu: 4.588 ± 0.128
1.119AlaMet: 1.119 ± 0.058
2.717AlaAsn: 2.717 ± 0.085
1.046AlaPro: 1.046 ± 0.056
0.708AlaGln: 0.708 ± 0.05
1.847AlaArg: 1.847 ± 0.073
3.567AlaSer: 3.567 ± 0.093
3.035AlaThr: 3.035 ± 0.093
2.516AlaVal: 2.516 ± 0.087
0.222AlaTrp: 0.222 ± 0.026
2.167AlaTyr: 2.167 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.413CysAla: 0.413 ± 0.032
0.155CysCys: 0.155 ± 0.02
0.656CysAsp: 0.656 ± 0.038
0.576CysGlu: 0.576 ± 0.05
0.522CysPhe: 0.522 ± 0.04
0.749CysGly: 0.749 ± 0.048
0.232CysHis: 0.232 ± 0.024
0.824CysIle: 0.824 ± 0.047
0.752CysLys: 0.752 ± 0.052
1.046CysLeu: 1.046 ± 0.059
0.181CysMet: 0.181 ± 0.023
0.677CysAsn: 0.677 ± 0.043
0.39CysPro: 0.39 ± 0.04
0.271CysGln: 0.271 ± 0.027
0.269CysArg: 0.269 ± 0.028
0.858CysSer: 0.858 ± 0.061
0.46CysThr: 0.46 ± 0.039
0.527CysVal: 0.527 ± 0.043
0.049CysTrp: 0.049 ± 0.012
0.599CysTyr: 0.599 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
2.568AspAla: 2.568 ± 0.073
0.628AspCys: 0.628 ± 0.043
3.963AspAsp: 3.963 ± 0.126
4.825AspGlu: 4.825 ± 0.11
2.795AspPhe: 2.795 ± 0.095
3.221AspGly: 3.221 ± 0.103
0.592AspHis: 0.592 ± 0.038
5.99AspIle: 5.99 ± 0.129
6.876AspLys: 6.876 ± 0.135
5.577AspLeu: 5.577 ± 0.138
1.614AspMet: 1.614 ± 0.067
4.655AspAsn: 4.655 ± 0.121
1.111AspPro: 1.111 ± 0.053
1.018AspGln: 1.018 ± 0.054
1.816AspArg: 1.816 ± 0.075
4.048AspSer: 4.048 ± 0.112
3.557AspThr: 3.557 ± 0.123
3.505AspVal: 3.505 ± 0.103
0.338AspTrp: 0.338 ± 0.031
3.841AspTyr: 3.841 ± 0.102
0.0AspXaa: 0.0 ± 0.0
Glu
3.402GluAla: 3.402 ± 0.088
0.563GluCys: 0.563 ± 0.041
4.211GluAsp: 4.211 ± 0.106
7.543GluGlu: 7.543 ± 0.176
2.883GluPhe: 2.883 ± 0.098
3.02GluGly: 3.02 ± 0.098
0.912GluHis: 0.912 ± 0.049
6.67GluIle: 6.67 ± 0.124
8.295GluLys: 8.295 ± 0.185
6.902GluLeu: 6.902 ± 0.147
2.002GluMet: 2.002 ± 0.077
4.792GluAsn: 4.792 ± 0.116
1.175GluPro: 1.175 ± 0.069
1.937GluGln: 1.937 ± 0.079
2.508GluArg: 2.508 ± 0.082
3.387GluSer: 3.387 ± 0.109
3.498GluThr: 3.498 ± 0.093
4.903GluVal: 4.903 ± 0.128
0.349GluTrp: 0.349 ± 0.028
3.118GluTyr: 3.118 ± 0.088
0.0GluXaa: 0.0 ± 0.0
Phe
2.036PheAla: 2.036 ± 0.077
0.493PheCys: 0.493 ± 0.038
2.999PheAsp: 2.999 ± 0.115
2.493PheGlu: 2.493 ± 0.08
2.092PhePhe: 2.092 ± 0.103
2.258PheGly: 2.258 ± 0.093
0.643PheHis: 0.643 ± 0.041
4.136PheIle: 4.136 ± 0.144
3.549PheLys: 3.549 ± 0.109
4.714PheLeu: 4.714 ± 0.161
0.909PheMet: 0.909 ± 0.053
2.643PheAsn: 2.643 ± 0.094
1.085PhePro: 1.085 ± 0.057
0.912PheGln: 0.912 ± 0.047
1.273PheArg: 1.273 ± 0.051
3.281PheSer: 3.281 ± 0.108
2.705PheThr: 2.705 ± 0.092
2.408PheVal: 2.408 ± 0.074
0.194PheTrp: 0.194 ± 0.021
2.26PheTyr: 2.26 ± 0.077
0.0PheXaa: 0.0 ± 0.0
Gly
2.48GlyAla: 2.48 ± 0.106
0.685GlyCys: 0.685 ± 0.047
2.767GlyAsp: 2.767 ± 0.097
3.177GlyGlu: 3.177 ± 0.108
2.389GlyPhe: 2.389 ± 0.074
3.234GlyGly: 3.234 ± 0.167
0.855GlyHis: 0.855 ± 0.054
4.849GlyIle: 4.849 ± 0.114
5.133GlyLys: 5.133 ± 0.126
4.474GlyLeu: 4.474 ± 0.114
1.374GlyMet: 1.374 ± 0.068
3.151GlyAsn: 3.151 ± 0.124
0.855GlyPro: 0.855 ± 0.053
1.051GlyGln: 1.051 ± 0.056
1.839GlyArg: 1.839 ± 0.079
3.557GlySer: 3.557 ± 0.115
3.301GlyThr: 3.301 ± 0.127
3.5GlyVal: 3.5 ± 0.109
0.276GlyTrp: 0.276 ± 0.031
3.229GlyTyr: 3.229 ± 0.097
0.0GlyXaa: 0.0 ± 0.0
His
0.607HisAla: 0.607 ± 0.046
0.147HisCys: 0.147 ± 0.02
0.803HisAsp: 0.803 ± 0.054
0.909HisGlu: 0.909 ± 0.045
0.679HisPhe: 0.679 ± 0.047
0.752HisGly: 0.752 ± 0.045
0.3HisHis: 0.3 ± 0.026
1.144HisIle: 1.144 ± 0.055
1.002HisLys: 1.002 ± 0.05
1.299HisLeu: 1.299 ± 0.06
0.282HisMet: 0.282 ± 0.029
0.917HisAsn: 0.917 ± 0.05
0.635HisPro: 0.635 ± 0.041
0.411HisGln: 0.411 ± 0.034
0.506HisArg: 0.506 ± 0.031
0.713HisSer: 0.713 ± 0.043
0.728HisThr: 0.728 ± 0.045
0.687HisVal: 0.687 ± 0.048
0.072HisTrp: 0.072 ± 0.014
0.754HisTyr: 0.754 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
4.497IleAla: 4.497 ± 0.128
0.902IleCys: 0.902 ± 0.06
6.228IleAsp: 6.228 ± 0.142
6.29IleGlu: 6.29 ± 0.131
3.609IlePhe: 3.609 ± 0.116
4.681IleGly: 4.681 ± 0.132
1.196IleHis: 1.196 ± 0.049
8.842IleIle: 8.842 ± 0.212
8.705IleLys: 8.705 ± 0.154
8.966IleLeu: 8.966 ± 0.186
1.819IleMet: 1.819 ± 0.071
6.181IleAsn: 6.181 ± 0.168
2.86IlePro: 2.86 ± 0.088
1.33IleGln: 1.33 ± 0.055
2.813IleArg: 2.813 ± 0.087
6.342IleSer: 6.342 ± 0.137
5.621IleThr: 5.621 ± 0.149
5.853IleVal: 5.853 ± 0.153
0.4IleTrp: 0.4 ± 0.03
4.174IleTyr: 4.174 ± 0.106
0.0IleXaa: 0.0 ± 0.0
Lys
3.908LysAla: 3.908 ± 0.103
0.84LysCys: 0.84 ± 0.049
7.251LysAsp: 7.251 ± 0.16
11.136LysGlu: 11.136 ± 0.193
2.81LysPhe: 2.81 ± 0.095
4.58LysGly: 4.58 ± 0.125
1.013LysHis: 1.013 ± 0.05
8.553LysIle: 8.553 ± 0.154
11.108LysLys: 11.108 ± 0.207
8.08LysLeu: 8.08 ± 0.13
2.779LysMet: 2.779 ± 0.09
7.024LysAsn: 7.024 ± 0.149
1.795LysPro: 1.795 ± 0.072
2.511LysGln: 2.511 ± 0.091
3.446LysArg: 3.446 ± 0.105
5.066LysSer: 5.066 ± 0.103
5.36LysThr: 5.36 ± 0.114
6.649LysVal: 6.649 ± 0.141
0.47LysTrp: 0.47 ± 0.035
5.231LysTyr: 5.231 ± 0.122
0.0LysXaa: 0.0 ± 0.0
Leu
5.246LeuAla: 5.246 ± 0.123
0.886LeuCys: 0.886 ± 0.051
6.543LeuAsp: 6.543 ± 0.15
7.119LeuGlu: 7.119 ± 0.154
4.371LeuPhe: 4.371 ± 0.156
4.973LeuGly: 4.973 ± 0.118
1.139LeuHis: 1.139 ± 0.074
8.152LeuIle: 8.152 ± 0.182
9.266LeuLys: 9.266 ± 0.181
9.834LeuLeu: 9.834 ± 0.223
2.072LeuMet: 2.072 ± 0.071
5.789LeuAsn: 5.789 ± 0.127
2.754LeuPro: 2.754 ± 0.098
1.896LeuGln: 1.896 ± 0.086
3.033LeuArg: 3.033 ± 0.095
6.822LeuSer: 6.822 ± 0.115
6.101LeuThr: 6.101 ± 0.128
5.892LeuVal: 5.892 ± 0.123
0.561LeuTrp: 0.561 ± 0.037
4.146LeuTyr: 4.146 ± 0.105
0.0LeuXaa: 0.0 ± 0.0
Met
1.248MetAla: 1.248 ± 0.055
0.168MetCys: 0.168 ± 0.019
1.343MetAsp: 1.343 ± 0.052
1.746MetGlu: 1.746 ± 0.068
1.261MetPhe: 1.261 ± 0.085
1.286MetGly: 1.286 ± 0.064
0.307MetHis: 0.307 ± 0.032
2.281MetIle: 2.281 ± 0.079
2.521MetLys: 2.521 ± 0.088
2.253MetLeu: 2.253 ± 0.075
0.679MetMet: 0.679 ± 0.046
1.648MetAsn: 1.648 ± 0.06
0.669MetPro: 0.669 ± 0.041
0.654MetGln: 0.654 ± 0.041
0.767MetArg: 0.767 ± 0.048
1.511MetSer: 1.511 ± 0.067
1.361MetThr: 1.361 ± 0.061
1.31MetVal: 1.31 ± 0.064
0.145MetTrp: 0.145 ± 0.019
0.969MetTyr: 0.969 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
2.462AsnAla: 2.462 ± 0.078
0.757AsnCys: 0.757 ± 0.049
4.27AsnAsp: 4.27 ± 0.11
4.242AsnGlu: 4.242 ± 0.11
2.767AsnPhe: 2.767 ± 0.096
3.49AsnGly: 3.49 ± 0.106
0.976AsnHis: 0.976 ± 0.049
6.525AsnIle: 6.525 ± 0.137
6.98AsnLys: 6.98 ± 0.162
6.109AsnLeu: 6.109 ± 0.131
1.813AsnMet: 1.813 ± 0.084
6.042AsnAsn: 6.042 ± 0.166
1.829AsnPro: 1.829 ± 0.054
1.917AsnGln: 1.917 ± 0.073
2.196AsnArg: 2.196 ± 0.077
4.293AsnSer: 4.293 ± 0.125
3.771AsnThr: 3.771 ± 0.11
3.379AsnVal: 3.379 ± 0.094
0.411AsnTrp: 0.411 ± 0.036
4.151AsnTyr: 4.151 ± 0.122
0.0AsnXaa: 0.0 ± 0.0
Pro
0.992ProAla: 0.992 ± 0.056
0.23ProCys: 0.23 ± 0.024
1.212ProAsp: 1.212 ± 0.058
1.372ProGlu: 1.372 ± 0.066
1.421ProPhe: 1.421 ± 0.063
1.067ProGly: 1.067 ± 0.066
0.413ProHis: 0.413 ± 0.035
2.296ProIle: 2.296 ± 0.095
2.172ProLys: 2.172 ± 0.066
2.506ProLeu: 2.506 ± 0.076
0.509ProMet: 0.509 ± 0.042
1.751ProAsn: 1.751 ± 0.061
0.457ProPro: 0.457 ± 0.04
0.568ProGln: 0.568 ± 0.039
0.778ProArg: 0.778 ± 0.04
1.759ProSer: 1.759 ± 0.073
1.545ProThr: 1.545 ± 0.077
1.834ProVal: 1.834 ± 0.098
0.168ProTrp: 0.168 ± 0.023
1.441ProTyr: 1.441 ± 0.064
0.0ProXaa: 0.0 ± 0.0
Gln
1.23GlnAla: 1.23 ± 0.063
0.142GlnCys: 0.142 ± 0.023
1.49GlnAsp: 1.49 ± 0.061
1.917GlnGlu: 1.917 ± 0.066
0.834GlnPhe: 0.834 ± 0.044
1.181GlnGly: 1.181 ± 0.054
0.214GlnHis: 0.214 ± 0.022
1.937GlnIle: 1.937 ± 0.087
2.214GlnLys: 2.214 ± 0.08
2.103GlnLeu: 2.103 ± 0.08
0.61GlnMet: 0.61 ± 0.042
1.405GlnAsn: 1.405 ± 0.066
0.511GlnPro: 0.511 ± 0.045
0.638GlnGln: 0.638 ± 0.051
0.7GlnArg: 0.7 ± 0.042
1.188GlnSer: 1.188 ± 0.055
1.263GlnThr: 1.263 ± 0.061
1.596GlnVal: 1.596 ± 0.071
0.152GlnTrp: 0.152 ± 0.025
0.811GlnTyr: 0.811 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
1.333ArgAla: 1.333 ± 0.052
0.416ArgCys: 0.416 ± 0.031
1.767ArgAsp: 1.767 ± 0.074
2.891ArgGlu: 2.891 ± 0.096
1.286ArgPhe: 1.286 ± 0.058
1.684ArgGly: 1.684 ± 0.08
0.447ArgHis: 0.447 ± 0.031
2.922ArgIle: 2.922 ± 0.096
3.402ArgLys: 3.402 ± 0.106
3.294ArgLeu: 3.294 ± 0.108
0.907ArgMet: 0.907 ± 0.045
2.222ArgAsn: 2.222 ± 0.07
0.757ArgPro: 0.757 ± 0.045
0.855ArgGln: 0.855 ± 0.045
1.465ArgArg: 1.465 ± 0.062
1.713ArgSer: 1.713 ± 0.071
1.527ArgThr: 1.527 ± 0.063
2.131ArgVal: 2.131 ± 0.07
0.183ArgTrp: 0.183 ± 0.023
1.7ArgTyr: 1.7 ± 0.071
0.0ArgXaa: 0.0 ± 0.0
Ser
2.397SerAla: 2.397 ± 0.097
0.803SerCys: 0.803 ± 0.054
3.841SerAsp: 3.841 ± 0.113
3.73SerGlu: 3.73 ± 0.103
3.438SerPhe: 3.438 ± 0.091
3.495SerGly: 3.495 ± 0.121
0.837SerHis: 0.837 ± 0.052
6.019SerIle: 6.019 ± 0.128
6.794SerLys: 6.794 ± 0.145
7.439SerLeu: 7.439 ± 0.168
1.651SerMet: 1.651 ± 0.064
4.652SerAsn: 4.652 ± 0.135
1.449SerPro: 1.449 ± 0.071
1.351SerGln: 1.351 ± 0.062
1.906SerArg: 1.906 ± 0.079
5.414SerSer: 5.414 ± 0.163
3.441SerThr: 3.441 ± 0.117
3.387SerVal: 3.387 ± 0.097
0.359SerTrp: 0.359 ± 0.028
3.867SerTyr: 3.867 ± 0.105
0.0SerXaa: 0.0 ± 0.0
Thr
2.495ThrAla: 2.495 ± 0.082
0.581ThrCys: 0.581 ± 0.046
3.658ThrAsp: 3.658 ± 0.114
2.787ThrGlu: 2.787 ± 0.103
2.568ThrPhe: 2.568 ± 0.088
3.748ThrGly: 3.748 ± 0.11
0.734ThrHis: 0.734 ± 0.051
5.717ThrIle: 5.717 ± 0.138
5.306ThrLys: 5.306 ± 0.116
5.262ThrLeu: 5.262 ± 0.109
1.144ThrMet: 1.144 ± 0.055
4.058ThrAsn: 4.058 ± 0.144
1.844ThrPro: 1.844 ± 0.082
0.907ThrGln: 0.907 ± 0.043
1.754ThrArg: 1.754 ± 0.063
4.694ThrSer: 4.694 ± 0.183
4.136ThrThr: 4.136 ± 0.147
3.65ThrVal: 3.65 ± 0.111
0.294ThrTrp: 0.294 ± 0.03
3.025ThrTyr: 3.025 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
3.1ValAla: 3.1 ± 0.107
0.604ValCys: 0.604 ± 0.042
3.882ValAsp: 3.882 ± 0.1
3.942ValGlu: 3.942 ± 0.099
2.544ValPhe: 2.544 ± 0.082
3.281ValGly: 3.281 ± 0.109
0.734ValHis: 0.734 ± 0.041
5.727ValIle: 5.727 ± 0.15
5.536ValLys: 5.536 ± 0.125
5.779ValLeu: 5.779 ± 0.143
1.47ValMet: 1.47 ± 0.062
3.849ValAsn: 3.849 ± 0.111
1.754ValPro: 1.754 ± 0.072
0.904ValGln: 0.904 ± 0.053
1.966ValArg: 1.966 ± 0.072
4.464ValSer: 4.464 ± 0.118
4.156ValThr: 4.156 ± 0.134
4.285ValVal: 4.285 ± 0.127
0.333ValTrp: 0.333 ± 0.028
2.614ValTyr: 2.614 ± 0.091
0.0ValXaa: 0.0 ± 0.0
Trp
0.238TrpAla: 0.238 ± 0.026
0.088TrpCys: 0.088 ± 0.015
0.32TrpAsp: 0.32 ± 0.029
0.292TrpGlu: 0.292 ± 0.027
0.328TrpPhe: 0.328 ± 0.03
0.222TrpGly: 0.222 ± 0.026
0.103TrpHis: 0.103 ± 0.016
0.387TrpIle: 0.387 ± 0.033
0.395TrpLys: 0.395 ± 0.03
0.537TrpLeu: 0.537 ± 0.038
0.137TrpMet: 0.137 ± 0.021
0.421TrpAsn: 0.421 ± 0.033
0.111TrpPro: 0.111 ± 0.017
0.16TrpGln: 0.16 ± 0.019
0.176TrpArg: 0.176 ± 0.021
0.261TrpSer: 0.261 ± 0.025
0.279TrpThr: 0.279 ± 0.032
0.287TrpVal: 0.287 ± 0.032
0.077TrpTrp: 0.077 ± 0.013
0.46TrpTyr: 0.46 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.079TyrAla: 2.079 ± 0.067
0.586TyrCys: 0.586 ± 0.041
3.164TyrAsp: 3.164 ± 0.096
3.015TyrGlu: 3.015 ± 0.092
2.397TyrPhe: 2.397 ± 0.086
2.748TyrGly: 2.748 ± 0.112
1.015TyrHis: 1.015 ± 0.053
3.929TyrIle: 3.929 ± 0.095
4.869TyrLys: 4.869 ± 0.126
5.833TyrLeu: 5.833 ± 0.161
1.054TyrMet: 1.054 ± 0.062
3.784TyrAsn: 3.784 ± 0.11
1.403TyrPro: 1.403 ± 0.064
2.139TyrGln: 2.139 ± 0.069
1.842TyrArg: 1.842 ± 0.063
3.335TyrSer: 3.335 ± 0.088
2.516TyrThr: 2.516 ± 0.085
2.624TyrVal: 2.624 ± 0.089
0.225TyrTrp: 0.225 ± 0.025
3.009TyrTyr: 3.009 ± 0.114
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1322 proteins (387124 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski