Amino acid dipepetide frequency for Coprococcus eutactus CAG:665

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.605AlaAla: 6.605 ± 0.124	1.04AlaCys: 1.04 ± 0.037	5.505AlaAsp: 5.505 ± 0.091	5.181AlaGlu: 5.181 ± 0.091	2.822AlaPhe: 2.822 ± 0.071	5.86AlaGly: 5.86 ± 0.096	1.117AlaHis: 1.117 ± 0.045	5.108AlaIle: 5.108 ± 0.088	4.74AlaLys: 4.74 ± 0.108	5.822AlaLeu: 5.822 ± 0.097	2.29AlaMet: 2.29 ± 0.063	2.881AlaAsn: 2.881 ± 0.068	1.806AlaPro: 1.806 ± 0.052	1.943AlaGln: 1.943 ± 0.048	2.821AlaArg: 2.821 ± 0.065	4.055AlaSer: 4.055 ± 0.083	3.502AlaThr: 3.502 ± 0.082	6.177AlaVal: 6.177 ± 0.106	0.578AlaTrp: 0.578 ± 0.031	2.934AlaTyr: 2.934 ± 0.067	0.009AlaXaa: 0.009 ± 0.003
Cys	1.05CysAla: 1.05 ± 0.04	0.29CysCys: 0.29 ± 0.023	1.07CysAsp: 1.07 ± 0.036	0.858CysGlu: 0.858 ± 0.037	0.538CysPhe: 0.538 ± 0.028	1.524CysGly: 1.524 ± 0.052	0.309CysHis: 0.309 ± 0.022	1.222CysIle: 1.222 ± 0.038	0.847CysLys: 0.847 ± 0.036	1.01CysLeu: 1.01 ± 0.036	0.534CysMet: 0.534 ± 0.028	0.647CysAsn: 0.647 ± 0.03	0.528CysPro: 0.528 ± 0.029	0.378CysGln: 0.378 ± 0.021	0.636CysArg: 0.636 ± 0.034	0.973CysSer: 0.973 ± 0.034	0.786CysThr: 0.786 ± 0.039	1.16CysVal: 1.16 ± 0.043	0.11CysTrp: 0.11 ± 0.013	0.623CysTyr: 0.623 ± 0.031	0.0CysXaa: 0.0 ± 0.0
Asp	4.788AspAla: 4.788 ± 0.087	0.821AspCys: 0.821 ± 0.026	4.841AspAsp: 4.841 ± 0.106	5.621AspGlu: 5.621 ± 0.109	2.58AspPhe: 2.58 ± 0.061	5.394AspGly: 5.394 ± 0.114	0.951AspHis: 0.951 ± 0.041	6.029AspIle: 6.029 ± 0.104	4.766AspLys: 4.766 ± 0.086	4.523AspLeu: 4.523 ± 0.078	2.671AspMet: 2.671 ± 0.057	3.135AspAsn: 3.135 ± 0.067	1.805AspPro: 1.805 ± 0.05	1.352AspGln: 1.352 ± 0.043	3.025AspArg: 3.025 ± 0.07	4.322AspSer: 4.322 ± 0.084	3.702AspThr: 3.702 ± 0.075	5.058AspVal: 5.058 ± 0.088	0.564AspTrp: 0.564 ± 0.031	3.271AspTyr: 3.271 ± 0.082	0.005AspXaa: 0.005 ± 0.003
Glu	4.5GluAla: 4.5 ± 0.094	0.931GluCys: 0.931 ± 0.036	4.531GluAsp: 4.531 ± 0.085	5.157GluGlu: 5.157 ± 0.122	2.601GluPhe: 2.601 ± 0.058	3.732GluGly: 3.732 ± 0.076	1.23GluHis: 1.23 ± 0.042	5.176GluIle: 5.176 ± 0.081	5.814GluLys: 5.814 ± 0.104	6.253GluLeu: 6.253 ± 0.103	2.22GluMet: 2.22 ± 0.058	4.047GluAsn: 4.047 ± 0.077	1.609GluPro: 1.609 ± 0.053	2.259GluGln: 2.259 ± 0.051	2.932GluArg: 2.932 ± 0.082	3.701GluSer: 3.701 ± 0.086	3.384GluThr: 3.384 ± 0.074	4.046GluVal: 4.046 ± 0.078	0.552GluTrp: 0.552 ± 0.027	3.42GluTyr: 3.42 ± 0.069	0.001GluXaa: 0.001 ± 0.001
Phe	2.95PheAla: 2.95 ± 0.062	0.691PheCys: 0.691 ± 0.034	2.994PheAsp: 2.994 ± 0.06	2.338PheGlu: 2.338 ± 0.059	1.516PhePhe: 1.516 ± 0.053	2.863PheGly: 2.863 ± 0.059	0.628PheHis: 0.628 ± 0.028	2.932PheIle: 2.932 ± 0.07	2.146PheLys: 2.146 ± 0.054	2.951PheLeu: 2.951 ± 0.068	1.199PheMet: 1.199 ± 0.047	1.648PheAsn: 1.648 ± 0.045	1.131PhePro: 1.131 ± 0.039	0.936PheGln: 0.936 ± 0.033	1.629PheArg: 1.629 ± 0.045	2.55PheSer: 2.55 ± 0.06	2.249PheThr: 2.249 ± 0.051	3.144PheVal: 3.144 ± 0.073	0.357PheTrp: 0.357 ± 0.022	1.575PheTyr: 1.575 ± 0.052	0.001PheXaa: 0.001 ± 0.001
Gly	4.926GlyAla: 4.926 ± 0.09	1.207GlyCys: 1.207 ± 0.046	4.592GlyAsp: 4.592 ± 0.086	4.23GlyGlu: 4.23 ± 0.069	2.818GlyPhe: 2.818 ± 0.065	4.94GlyGly: 4.94 ± 0.098	1.218GlyHis: 1.218 ± 0.04	6.053GlyIle: 6.053 ± 0.112	5.325GlyLys: 5.325 ± 0.086	5.316GlyLeu: 5.316 ± 0.101	2.357GlyMet: 2.357 ± 0.058	3.143GlyAsn: 3.143 ± 0.069	1.148GlyPro: 1.148 ± 0.039	2.072GlyGln: 2.072 ± 0.056	3.309GlyArg: 3.309 ± 0.078	4.538GlySer: 4.538 ± 0.085	4.199GlyThr: 4.199 ± 0.102	5.276GlyVal: 5.276 ± 0.092	0.69GlyTrp: 0.69 ± 0.039	3.672GlyTyr: 3.672 ± 0.078	0.001GlyXaa: 0.001 ± 0.001
His	0.903HisAla: 0.903 ± 0.03	0.235HisCys: 0.235 ± 0.017	1.032HisAsp: 1.032 ± 0.04	1.005HisGlu: 1.005 ± 0.04	0.635HisPhe: 0.635 ± 0.029	1.303HisGly: 1.303 ± 0.045	0.319HisHis: 0.319 ± 0.026	1.397HisIle: 1.397 ± 0.046	0.89HisLys: 0.89 ± 0.035	1.101HisLeu: 1.101 ± 0.042	0.572HisMet: 0.572 ± 0.027	0.78HisAsn: 0.78 ± 0.031	0.671HisPro: 0.671 ± 0.031	0.418HisGln: 0.418 ± 0.024	0.78HisArg: 0.78 ± 0.031	0.948HisSer: 0.948 ± 0.037	0.909HisThr: 0.909 ± 0.032	1.114HisVal: 1.114 ± 0.039	0.143HisTrp: 0.143 ± 0.015	0.641HisTyr: 0.641 ± 0.028	0.001HisXaa: 0.001 ± 0.001
Ile	5.681IleAla: 5.681 ± 0.081	1.372IleCys: 1.372 ± 0.048	5.335IleAsp: 5.335 ± 0.086	4.945IleGlu: 4.945 ± 0.092	2.832IlePhe: 2.832 ± 0.072	5.087IleGly: 5.087 ± 0.083	1.18IleHis: 1.18 ± 0.046	5.566IleIle: 5.566 ± 0.107	5.107IleLys: 5.107 ± 0.094	6.152IleLeu: 6.152 ± 0.116	2.165IleMet: 2.165 ± 0.053	3.413IleAsn: 3.413 ± 0.079	2.862IlePro: 2.862 ± 0.065	1.929IleGln: 1.929 ± 0.054	3.197IleArg: 3.197 ± 0.067	5.294IleSer: 5.294 ± 0.092	4.516IleThr: 4.516 ± 0.12	5.847IleVal: 5.847 ± 0.095	0.577IleTrp: 0.577 ± 0.03	3.122IleTyr: 3.122 ± 0.062	0.006IleXaa: 0.006 ± 0.003
Lys	5.152LysAla: 5.152 ± 0.105	0.883LysCys: 0.883 ± 0.041	4.432LysAsp: 4.432 ± 0.082	5.046LysGlu: 5.046 ± 0.089	2.11LysPhe: 2.11 ± 0.055	4.166LysGly: 4.166 ± 0.068	0.99LysHis: 0.99 ± 0.038	4.896LysIle: 4.896 ± 0.084	6.144LysLys: 6.144 ± 0.124	5.832LysLeu: 5.832 ± 0.089	2.298LysMet: 2.298 ± 0.05	4.036LysAsn: 4.036 ± 0.079	1.96LysPro: 1.96 ± 0.051	2.031LysGln: 2.031 ± 0.057	2.956LysArg: 2.956 ± 0.064	3.936LysSer: 3.936 ± 0.088	3.958LysThr: 3.958 ± 0.088	4.889LysVal: 4.889 ± 0.084	0.626LysTrp: 0.626 ± 0.032	3.416LysTyr: 3.416 ± 0.066	0.001LysXaa: 0.001 ± 0.001
Leu	6.224LeuAla: 6.224 ± 0.105	1.376LeuCys: 1.376 ± 0.043	5.291LeuAsp: 5.291 ± 0.095	4.989LeuGlu: 4.989 ± 0.095	3.093LeuPhe: 3.093 ± 0.077	5.567LeuGly: 5.567 ± 0.094	1.195LeuHis: 1.195 ± 0.041	5.542LeuIle: 5.542 ± 0.096	5.451LeuLys: 5.451 ± 0.077	6.63LeuLeu: 6.63 ± 0.112	2.581LeuMet: 2.581 ± 0.068	3.43LeuAsn: 3.43 ± 0.07	2.784LeuPro: 2.784 ± 0.061	2.108LeuGln: 2.108 ± 0.052	3.41LeuArg: 3.41 ± 0.066	5.62LeuSer: 5.62 ± 0.099	4.575LeuThr: 4.575 ± 0.083	5.522LeuVal: 5.522 ± 0.094	0.601LeuTrp: 0.601 ± 0.029	3.23LeuTyr: 3.23 ± 0.069	0.004LeuXaa: 0.004 ± 0.002
Met	2.63MetAla: 2.63 ± 0.059	0.499MetCys: 0.499 ± 0.024	2.22MetAsp: 2.22 ± 0.05	2.105MetGlu: 2.105 ± 0.053	1.153MetPhe: 1.153 ± 0.042	2.108MetGly: 2.108 ± 0.055	0.45MetHis: 0.45 ± 0.023	2.263MetIle: 2.263 ± 0.052	2.516MetLys: 2.516 ± 0.055	2.718MetLeu: 2.718 ± 0.068	1.017MetMet: 1.017 ± 0.035	1.753MetAsn: 1.753 ± 0.04	1.102MetPro: 1.102 ± 0.038	0.85MetGln: 0.85 ± 0.032	1.253MetArg: 1.253 ± 0.039	2.102MetSer: 2.102 ± 0.055	1.775MetThr: 1.775 ± 0.047	2.082MetVal: 2.082 ± 0.052	0.238MetTrp: 0.238 ± 0.018	1.279MetTyr: 1.279 ± 0.044	0.003MetXaa: 0.003 ± 0.002
Asn	3.263AsnAla: 3.263 ± 0.072	0.682AsnCys: 0.682 ± 0.031	2.91AsnAsp: 2.91 ± 0.061	2.88AsnGlu: 2.88 ± 0.065	1.559AsnPhe: 1.559 ± 0.051	3.768AsnGly: 3.768 ± 0.087	0.709AsnHis: 0.709 ± 0.034	4.204AsnIle: 4.204 ± 0.076	3.209AsnLys: 3.209 ± 0.071	3.372AsnLeu: 3.372 ± 0.073	1.612AsnMet: 1.612 ± 0.044	2.353AsnAsn: 2.353 ± 0.062	1.756AsnPro: 1.756 ± 0.056	1.218AsnGln: 1.218 ± 0.046	2.151AsnArg: 2.151 ± 0.056	2.922AsnSer: 2.922 ± 0.072	2.609AsnThr: 2.609 ± 0.065	3.539AsnVal: 3.539 ± 0.069	0.416AsnTrp: 0.416 ± 0.022	2.112AsnTyr: 2.112 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.044ProAla: 2.044 ± 0.053	0.41ProCys: 0.41 ± 0.022	2.498ProAsp: 2.498 ± 0.06	2.834ProGlu: 2.834 ± 0.07	1.306ProPhe: 1.306 ± 0.038	2.25ProGly: 2.25 ± 0.067	0.514ProHis: 0.514 ± 0.028	1.87ProIle: 1.87 ± 0.05	1.693ProLys: 1.693 ± 0.046	2.186ProLeu: 2.186 ± 0.059	0.79ProMet: 0.79 ± 0.038	1.13ProAsn: 1.13 ± 0.044	0.557ProPro: 0.557 ± 0.027	0.827ProGln: 0.827 ± 0.034	0.893ProArg: 0.893 ± 0.036	1.599ProSer: 1.599 ± 0.041	1.408ProThr: 1.408 ± 0.051	2.712ProVal: 2.712 ± 0.062	0.243ProTrp: 0.243 ± 0.02	1.323ProTyr: 1.323 ± 0.045	0.003ProXaa: 0.003 ± 0.002
Gln	1.987GlnAla: 1.987 ± 0.059	0.292GlnCys: 0.292 ± 0.019	1.533GlnAsp: 1.533 ± 0.045	1.819GlnGlu: 1.819 ± 0.047	1.012GlnPhe: 1.012 ± 0.032	1.54GlnGly: 1.54 ± 0.039	0.385GlnHis: 0.385 ± 0.022	2.194GlnIle: 2.194 ± 0.051	2.127GlnLys: 2.127 ± 0.045	2.417GlnLeu: 2.417 ± 0.058	1.071GlnMet: 1.071 ± 0.039	1.563GlnAsn: 1.563 ± 0.057	0.78GlnPro: 0.78 ± 0.033	0.939GlnGln: 0.939 ± 0.053	1.18GlnArg: 1.18 ± 0.034	1.544GlnSer: 1.544 ± 0.05	1.569GlnThr: 1.569 ± 0.049	1.785GlnVal: 1.785 ± 0.05	0.212GlnTrp: 0.212 ± 0.018	1.225GlnTyr: 1.225 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.59ArgAla: 2.59 ± 0.063	0.623ArgCys: 0.623 ± 0.035	2.619ArgAsp: 2.619 ± 0.064	3.212ArgGlu: 3.212 ± 0.072	1.762ArgPhe: 1.762 ± 0.049	2.433ArgGly: 2.433 ± 0.069	0.788ArgHis: 0.788 ± 0.034	3.292ArgIle: 3.292 ± 0.07	3.449ArgLys: 3.449 ± 0.064	3.666ArgLeu: 3.666 ± 0.082	1.464ArgMet: 1.464 ± 0.045	2.146ArgAsn: 2.146 ± 0.06	1.181ArgPro: 1.181 ± 0.047	1.529ArgGln: 1.529 ± 0.045	2.299ArgArg: 2.299 ± 0.066	2.303ArgSer: 2.303 ± 0.06	2.184ArgThr: 2.184 ± 0.056	2.69ArgVal: 2.69 ± 0.059	0.331ArgTrp: 0.331 ± 0.021	2.242ArgTyr: 2.242 ± 0.056	0.004ArgXaa: 0.004 ± 0.002
Ser	4.533SerAla: 4.533 ± 0.094	0.857SerCys: 0.857 ± 0.036	4.658SerAsp: 4.658 ± 0.094	4.195SerGlu: 4.195 ± 0.086	2.659SerPhe: 2.659 ± 0.066	5.387SerGly: 5.387 ± 0.105	0.986SerHis: 0.986 ± 0.038	4.361SerIle: 4.361 ± 0.083	3.86SerLys: 3.86 ± 0.075	4.707SerLeu: 4.707 ± 0.093	1.896SerMet: 1.896 ± 0.056	2.571SerAsn: 2.571 ± 0.066	1.627SerPro: 1.627 ± 0.049	1.761SerGln: 1.761 ± 0.043	2.753SerArg: 2.753 ± 0.056	4.114SerSer: 4.114 ± 0.102	3.207SerThr: 3.207 ± 0.073	4.879SerVal: 4.879 ± 0.094	0.547SerTrp: 0.547 ± 0.03	2.877SerTyr: 2.877 ± 0.066	0.001SerXaa: 0.001 ± 0.001
Thr	4.253ThrAla: 4.253 ± 0.092	0.759ThrCys: 0.759 ± 0.036	4.12ThrAsp: 4.12 ± 0.09	3.898ThrGlu: 3.898 ± 0.098	2.199ThrPhe: 2.199 ± 0.058	4.852ThrGly: 4.852 ± 0.107	0.839ThrHis: 0.839 ± 0.041	3.957ThrIle: 3.957 ± 0.081	3.132ThrLys: 3.132 ± 0.078	4.44ThrLeu: 4.44 ± 0.086	1.402ThrMet: 1.402 ± 0.04	2.199ThrAsn: 2.199 ± 0.064	1.96ThrPro: 1.96 ± 0.051	1.329ThrGln: 1.329 ± 0.042	1.919ThrArg: 1.919 ± 0.049	3.29ThrSer: 3.29 ± 0.073	3.129ThrThr: 3.129 ± 0.11	4.708ThrVal: 4.708 ± 0.132	0.505ThrTrp: 0.505 ± 0.031	2.527ThrTyr: 2.527 ± 0.071	0.003ThrXaa: 0.003 ± 0.002
Val	5.294ValAla: 5.294 ± 0.102	1.334ValCys: 1.334 ± 0.05	5.118ValAsp: 5.118 ± 0.091	4.388ValGlu: 4.388 ± 0.08	2.989ValPhe: 2.989 ± 0.067	4.477ValGly: 4.477 ± 0.076	1.079ValHis: 1.079 ± 0.042	5.961ValIle: 5.961 ± 0.085	5.071ValLys: 5.071 ± 0.098	6.125ValLeu: 6.125 ± 0.104	2.324ValMet: 2.324 ± 0.055	3.41ValAsn: 3.41 ± 0.064	2.414ValPro: 2.414 ± 0.059	1.829ValGln: 1.829 ± 0.046	3.132ValArg: 3.132 ± 0.065	5.094ValSer: 5.094 ± 0.091	4.555ValThr: 4.555 ± 0.121	5.586ValVal: 5.586 ± 0.103	0.623ValTrp: 0.623 ± 0.03	3.346ValTyr: 3.346 ± 0.076	0.006ValXaa: 0.006 ± 0.003
Trp	0.498TrpAla: 0.498 ± 0.028	0.142TrpCys: 0.142 ± 0.012	0.52TrpAsp: 0.52 ± 0.028	0.503TrpGlu: 0.503 ± 0.028	0.426TrpPhe: 0.426 ± 0.023	0.589TrpGly: 0.589 ± 0.032	0.176TrpHis: 0.176 ± 0.014	0.613TrpIle: 0.613 ± 0.029	0.562TrpLys: 0.562 ± 0.028	0.741TrpLeu: 0.741 ± 0.031	0.268TrpMet: 0.268 ± 0.02	0.534TrpAsn: 0.534 ± 0.028	0.173TrpPro: 0.173 ± 0.016	0.329TrpGln: 0.329 ± 0.02	0.349TrpArg: 0.349 ± 0.021	0.512TrpSer: 0.512 ± 0.028	0.453TrpThr: 0.453 ± 0.026	0.505TrpVal: 0.505 ± 0.026	0.102TrpTrp: 0.102 ± 0.012	0.393TrpTyr: 0.393 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.916TyrAla: 2.916 ± 0.057	0.646TyrCys: 0.646 ± 0.028	3.403TyrAsp: 3.403 ± 0.079	2.895TyrGlu: 2.895 ± 0.069	1.82TyrPhe: 1.82 ± 0.054	3.182TyrGly: 3.182 ± 0.069	0.735TyrHis: 0.735 ± 0.033	3.549TyrIle: 3.549 ± 0.084	2.907TyrLys: 2.907 ± 0.064	3.257TyrLeu: 3.257 ± 0.066	1.381TyrMet: 1.381 ± 0.038	2.424TyrAsn: 2.424 ± 0.066	1.234TyrPro: 1.234 ± 0.042	1.138TyrGln: 1.138 ± 0.039	2.177TyrArg: 2.177 ± 0.061	3.014TyrSer: 3.014 ± 0.066	2.745TyrThr: 2.745 ± 0.087	3.436TyrVal: 3.436 ± 0.08	0.371TyrTrp: 0.371 ± 0.022	2.202TyrTyr: 2.202 ± 0.072	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.005XaaAla: 0.005 ± 0.002	0.003XaaCys: 0.003 ± 0.002	0.004XaaAsp: 0.004 ± 0.002	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.005XaaGly: 0.005 ± 0.003	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.003XaaLys: 0.003 ± 0.002	0.005XaaLeu: 0.005 ± 0.002	0.003XaaMet: 0.003 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.006XaaArg: 0.006 ± 0.003	0.005XaaSer: 0.005 ± 0.003	0.005XaaThr: 0.005 ± 0.003	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.003XaaTyr: 0.003 ± 0.002	0.059XaaXaa: 0.059 ± 0.013

Statistics based on 2415 proteins (797336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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