Amino acid dipepetide frequency for Holdemania filiformis DSM 12042

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.581AlaAla: 8.581 ± 0.121	1.337AlaCys: 1.337 ± 0.033	4.526AlaAsp: 4.526 ± 0.073	5.945AlaGlu: 5.945 ± 0.084	3.161AlaPhe: 3.161 ± 0.053	6.197AlaGly: 6.197 ± 0.09	1.307AlaHis: 1.307 ± 0.034	5.077AlaIle: 5.077 ± 0.072	4.085AlaLys: 4.085 ± 0.068	9.016AlaLeu: 9.016 ± 0.123	2.835AlaMet: 2.835 ± 0.049	2.431AlaAsn: 2.431 ± 0.054	2.161AlaPro: 2.161 ± 0.038	3.696AlaGln: 3.696 ± 0.065	3.419AlaArg: 3.419 ± 0.057	4.299AlaSer: 4.299 ± 0.064	3.098AlaThr: 3.098 ± 0.062	6.301AlaVal: 6.301 ± 0.108	0.897AlaTrp: 0.897 ± 0.032	2.757AlaTyr: 2.757 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.291CysAla: 1.291 ± 0.031	0.282CysCys: 0.282 ± 0.017	0.844CysAsp: 0.844 ± 0.031	0.865CysGlu: 0.865 ± 0.028	0.805CysPhe: 0.805 ± 0.027	1.382CysGly: 1.382 ± 0.041	0.335CysHis: 0.335 ± 0.018	0.728CysIle: 0.728 ± 0.028	0.562CysLys: 0.562 ± 0.021	1.617CysLeu: 1.617 ± 0.042	0.383CysMet: 0.383 ± 0.016	0.436CysAsn: 0.436 ± 0.022	0.716CysPro: 0.716 ± 0.027	0.658CysGln: 0.658 ± 0.023	0.875CysArg: 0.875 ± 0.032	1.007CysSer: 1.007 ± 0.031	0.704CysThr: 0.704 ± 0.023	0.943CysVal: 0.943 ± 0.029	0.165CysTrp: 0.165 ± 0.011	0.534CysTyr: 0.534 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.904AspAla: 3.904 ± 0.067	0.895AspCys: 0.895 ± 0.03	2.646AspAsp: 2.646 ± 0.064	4.447AspGlu: 4.447 ± 0.076	2.705AspPhe: 2.705 ± 0.051	3.572AspGly: 3.572 ± 0.066	1.302AspHis: 1.302 ± 0.036	2.954AspIle: 2.954 ± 0.056	2.539AspLys: 2.539 ± 0.05	5.518AspLeu: 5.518 ± 0.072	1.234AspMet: 1.234 ± 0.035	1.751AspAsn: 1.751 ± 0.042	2.817AspPro: 2.817 ± 0.048	3.11AspGln: 3.11 ± 0.055	2.588AspArg: 2.588 ± 0.05	2.75AspSer: 2.75 ± 0.044	2.382AspThr: 2.382 ± 0.052	3.177AspVal: 3.177 ± 0.058	0.728AspTrp: 0.728 ± 0.026	2.529AspTyr: 2.529 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	6.089GluAla: 6.089 ± 0.083	0.803GluCys: 0.803 ± 0.029	3.628GluAsp: 3.628 ± 0.06	5.522GluGlu: 5.522 ± 0.086	2.436GluPhe: 2.436 ± 0.05	4.119GluGly: 4.119 ± 0.061	1.235GluHis: 1.235 ± 0.033	5.404GluIle: 5.404 ± 0.085	5.372GluLys: 5.372 ± 0.074	6.572GluLeu: 6.572 ± 0.086	2.364GluMet: 2.364 ± 0.052	3.682GluAsn: 3.682 ± 0.06	1.956GluPro: 1.956 ± 0.047	3.298GluGln: 3.298 ± 0.061	3.198GluArg: 3.198 ± 0.062	3.022GluSer: 3.022 ± 0.047	3.815GluThr: 3.815 ± 0.052	4.252GluVal: 4.252 ± 0.072	0.645GluTrp: 0.645 ± 0.021	2.167GluTyr: 2.167 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.174PheAla: 3.174 ± 0.057	0.79PheCys: 0.79 ± 0.027	2.684PheAsp: 2.684 ± 0.045	2.467PheGlu: 2.467 ± 0.05	2.159PhePhe: 2.159 ± 0.054	2.739PheGly: 2.739 ± 0.06	0.941PheHis: 0.941 ± 0.028	2.895PheIle: 2.895 ± 0.057	1.942PheLys: 1.942 ± 0.041	4.397PheLeu: 4.397 ± 0.078	1.163PheMet: 1.163 ± 0.037	1.807PheAsn: 1.807 ± 0.039	1.582PhePro: 1.582 ± 0.036	1.598PheGln: 1.598 ± 0.039	1.747PheArg: 1.747 ± 0.041	3.147PheSer: 3.147 ± 0.052	2.435PheThr: 2.435 ± 0.048	2.864PheVal: 2.864 ± 0.053	0.479PheTrp: 0.479 ± 0.023	1.839PheTyr: 1.839 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.662GlyAla: 4.662 ± 0.094	1.304GlyCys: 1.304 ± 0.034	2.889GlyAsp: 2.889 ± 0.053	3.985GlyGlu: 3.985 ± 0.063	3.107GlyPhe: 3.107 ± 0.057	4.405GlyGly: 4.405 ± 0.084	1.215GlyHis: 1.215 ± 0.038	5.048GlyIle: 5.048 ± 0.075	4.255GlyLys: 4.255 ± 0.069	6.864GlyLeu: 6.864 ± 0.091	2.291GlyMet: 2.291 ± 0.046	2.354GlyAsn: 2.354 ± 0.047	1.597GlyPro: 1.597 ± 0.054	2.706GlyGln: 2.706 ± 0.055	3.193GlyArg: 3.193 ± 0.057	3.85GlySer: 3.85 ± 0.054	3.595GlyThr: 3.595 ± 0.067	4.721GlyVal: 4.721 ± 0.067	0.95GlyTrp: 0.95 ± 0.031	2.972GlyTyr: 2.972 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.282HisAla: 1.282 ± 0.028	0.458HisCys: 0.458 ± 0.02	1.111HisAsp: 1.111 ± 0.03	1.162HisGlu: 1.162 ± 0.037	0.996HisPhe: 0.996 ± 0.029	1.42HisGly: 1.42 ± 0.04	0.598HisHis: 0.598 ± 0.031	1.107HisIle: 1.107 ± 0.029	0.693HisLys: 0.693 ± 0.026	1.848HisLeu: 1.848 ± 0.046	0.363HisMet: 0.363 ± 0.019	0.653HisAsn: 0.653 ± 0.022	1.192HisPro: 1.192 ± 0.035	0.977HisGln: 0.977 ± 0.033	1.075HisArg: 1.075 ± 0.032	1.147HisSer: 1.147 ± 0.034	0.921HisThr: 0.921 ± 0.029	1.143HisVal: 1.143 ± 0.031	0.268HisTrp: 0.268 ± 0.015	0.9HisTyr: 0.9 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.954IleAla: 5.954 ± 0.082	1.028IleCys: 1.028 ± 0.031	3.931IleAsp: 3.931 ± 0.065	4.841IleGlu: 4.841 ± 0.074	2.608IlePhe: 2.608 ± 0.054	4.535IleGly: 4.535 ± 0.073	1.502IleHis: 1.502 ± 0.039	3.953IleIle: 3.953 ± 0.069	3.141IleLys: 3.141 ± 0.062	7.527IleLeu: 7.527 ± 0.094	1.649IleMet: 1.649 ± 0.046	2.744IleAsn: 2.744 ± 0.06	3.077IlePro: 3.077 ± 0.055	3.113IleGln: 3.113 ± 0.047	3.749IleArg: 3.749 ± 0.059	4.249IleSer: 4.249 ± 0.065	3.825IleThr: 3.825 ± 0.061	4.793IleVal: 4.793 ± 0.071	0.545IleTrp: 0.545 ± 0.023	2.219IleTyr: 2.219 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.698LysAla: 4.698 ± 0.068	0.45LysCys: 0.45 ± 0.021	2.925LysAsp: 2.925 ± 0.061	4.753LysGlu: 4.753 ± 0.077	1.449LysPhe: 1.449 ± 0.033	3.236LysGly: 3.236 ± 0.063	0.932LysHis: 0.932 ± 0.03	4.013LysIle: 4.013 ± 0.079	4.513LysLys: 4.513 ± 0.078	5.113LysLeu: 5.113 ± 0.079	2.065LysMet: 2.065 ± 0.044	2.654LysAsn: 2.654 ± 0.056	2.226LysPro: 2.226 ± 0.047	2.817LysGln: 2.817 ± 0.051	2.966LysArg: 2.966 ± 0.059	2.713LysSer: 2.713 ± 0.052	3.768LysThr: 3.768 ± 0.053	3.244LysVal: 3.244 ± 0.062	0.51LysTrp: 0.51 ± 0.021	1.721LysTyr: 1.721 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	8.547LeuAla: 8.547 ± 0.113	1.811LeuCys: 1.811 ± 0.041	5.92LeuAsp: 5.92 ± 0.089	6.357LeuGlu: 6.357 ± 0.089	4.738LeuPhe: 4.738 ± 0.078	6.281LeuGly: 6.281 ± 0.099	1.901LeuHis: 1.901 ± 0.044	8.114LeuIle: 8.114 ± 0.099	6.458LeuLys: 6.458 ± 0.072	9.793LeuLeu: 9.793 ± 0.132	3.088LeuMet: 3.088 ± 0.051	4.554LeuAsn: 4.554 ± 0.065	4.254LeuPro: 4.254 ± 0.067	3.733LeuGln: 3.733 ± 0.071	5.066LeuArg: 5.066 ± 0.065	6.724LeuSer: 6.724 ± 0.086	6.139LeuThr: 6.139 ± 0.072	5.875LeuVal: 5.875 ± 0.083	1.003LeuTrp: 1.003 ± 0.029	3.085LeuTyr: 3.085 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.323MetAla: 2.323 ± 0.048	0.267MetCys: 0.267 ± 0.016	1.555MetAsp: 1.555 ± 0.04	2.115MetGlu: 2.115 ± 0.044	1.063MetPhe: 1.063 ± 0.035	1.739MetGly: 1.739 ± 0.043	0.384MetHis: 0.384 ± 0.017	2.61MetIle: 2.61 ± 0.056	2.644MetLys: 2.644 ± 0.046	2.855MetLeu: 2.855 ± 0.056	1.093MetMet: 1.093 ± 0.036	1.646MetAsn: 1.646 ± 0.042	1.155MetPro: 1.155 ± 0.032	1.128MetGln: 1.128 ± 0.032	1.375MetArg: 1.375 ± 0.036	1.639MetSer: 1.639 ± 0.036	1.901MetThr: 1.901 ± 0.047	1.544MetVal: 1.544 ± 0.035	0.183MetTrp: 0.183 ± 0.013	0.562MetTyr: 0.562 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.054AsnAla: 3.054 ± 0.052	0.53AsnCys: 0.53 ± 0.024	2.076AsnAsp: 2.076 ± 0.044	2.983AsnGlu: 2.983 ± 0.056	1.584AsnPhe: 1.584 ± 0.036	2.887AsnGly: 2.887 ± 0.053	0.834AsnHis: 0.834 ± 0.027	2.417AsnIle: 2.417 ± 0.043	2.03AsnLys: 2.03 ± 0.051	3.838AsnLeu: 3.838 ± 0.052	0.966AsnMet: 0.966 ± 0.031	1.458AsnAsn: 1.458 ± 0.042	2.147AsnPro: 2.147 ± 0.045	2.033AsnGln: 2.033 ± 0.042	2.061AsnArg: 2.061 ± 0.038	2.051AsnSer: 2.051 ± 0.048	2.037AsnThr: 2.037 ± 0.042	2.375AsnVal: 2.375 ± 0.048	0.458AsnTrp: 0.458 ± 0.023	1.581AsnTyr: 1.581 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.38ProAla: 3.38 ± 0.064	0.495ProCys: 0.495 ± 0.019	2.411ProAsp: 2.411 ± 0.047	3.483ProGlu: 3.483 ± 0.06	1.737ProPhe: 1.737 ± 0.038	2.322ProGly: 2.322 ± 0.059	0.741ProHis: 0.741 ± 0.025	2.313ProIle: 2.313 ± 0.049	1.784ProLys: 1.784 ± 0.04	3.887ProLeu: 3.887 ± 0.075	1.018ProMet: 1.018 ± 0.032	1.175ProAsn: 1.175 ± 0.033	0.845ProPro: 0.845 ± 0.03	2.147ProGln: 2.147 ± 0.049	1.391ProArg: 1.391 ± 0.033	2.033ProSer: 2.033 ± 0.041	1.737ProThr: 1.737 ± 0.047	3.236ProVal: 3.236 ± 0.054	0.384ProTrp: 0.384 ± 0.019	1.395ProTyr: 1.395 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.256GlnAla: 4.256 ± 0.075	0.539GlnCys: 0.539 ± 0.021	2.263GlnAsp: 2.263 ± 0.046	2.94GlnGlu: 2.94 ± 0.054	1.794GlnPhe: 1.794 ± 0.04	2.941GlnGly: 2.941 ± 0.053	0.658GlnHis: 0.658 ± 0.023	3.522GlnIle: 3.522 ± 0.057	2.7GlnLys: 2.7 ± 0.057	4.932GlnLeu: 4.932 ± 0.083	1.241GlnMet: 1.241 ± 0.033	1.73GlnAsn: 1.73 ± 0.043	1.801GlnPro: 1.801 ± 0.047	1.884GlnGln: 1.884 ± 0.053	2.699GlnArg: 2.699 ± 0.049	2.34GlnSer: 2.34 ± 0.045	2.444GlnThr: 2.444 ± 0.053	2.63GlnVal: 2.63 ± 0.044	0.543GlnTrp: 0.543 ± 0.024	1.346GlnTyr: 1.346 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.797ArgAla: 2.797 ± 0.053	0.879ArgCys: 0.879 ± 0.027	2.209ArgAsp: 2.209 ± 0.049	3.409ArgGlu: 3.409 ± 0.056	2.259ArgPhe: 2.259 ± 0.047	2.553ArgGly: 2.553 ± 0.046	1.029ArgHis: 1.029 ± 0.03	3.857ArgIle: 3.857 ± 0.062	3.345ArgLys: 3.345 ± 0.056	5.025ArgLeu: 5.025 ± 0.081	1.722ArgMet: 1.722 ± 0.04	1.988ArgAsn: 1.988 ± 0.046	1.622ArgPro: 1.622 ± 0.038	3.099ArgGln: 3.099 ± 0.057	3.24ArgArg: 3.24 ± 0.062	2.742ArgSer: 2.742 ± 0.051	2.446ArgThr: 2.446 ± 0.051	2.623ArgVal: 2.623 ± 0.048	0.727ArgTrp: 0.727 ± 0.029	2.164ArgTyr: 2.164 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.697SerAla: 4.697 ± 0.066	0.838SerCys: 0.838 ± 0.027	3.024SerAsp: 3.024 ± 0.058	3.897SerGlu: 3.897 ± 0.06	2.815SerPhe: 2.815 ± 0.052	4.506SerGly: 4.506 ± 0.065	1.08SerHis: 1.08 ± 0.028	3.413SerIle: 3.413 ± 0.057	2.509SerLys: 2.509 ± 0.057	6.356SerLeu: 6.356 ± 0.083	1.596SerMet: 1.596 ± 0.034	1.788SerAsn: 1.788 ± 0.043	2.011SerPro: 2.011 ± 0.043	2.43SerGln: 2.43 ± 0.047	2.906SerArg: 2.906 ± 0.053	3.364SerSer: 3.364 ± 0.066	2.757SerThr: 2.757 ± 0.052	3.994SerVal: 3.994 ± 0.062	0.693SerTrp: 0.693 ± 0.022	2.085SerTyr: 2.085 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	4.585ThrAla: 4.585 ± 0.074	0.633ThrCys: 0.633 ± 0.021	2.694ThrAsp: 2.694 ± 0.056	3.35ThrGlu: 3.35 ± 0.058	2.098ThrPhe: 2.098 ± 0.039	4.066ThrGly: 4.066 ± 0.081	1.016ThrHis: 1.016 ± 0.031	3.726ThrIle: 3.726 ± 0.057	2.238ThrLys: 2.238 ± 0.044	6.299ThrLeu: 6.299 ± 0.076	1.578ThrMet: 1.578 ± 0.039	1.652ThrAsn: 1.652 ± 0.043	2.597ThrPro: 2.597 ± 0.049	2.085ThrGln: 2.085 ± 0.045	2.365ThrArg: 2.365 ± 0.047	2.838ThrSer: 2.838 ± 0.049	2.633ThrThr: 2.633 ± 0.058	4.14ThrVal: 4.14 ± 0.068	0.513ThrTrp: 0.513 ± 0.024	1.764ThrTyr: 1.764 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	4.392ValAla: 4.392 ± 0.081	1.069ValCys: 1.069 ± 0.03	3.376ValAsp: 3.376 ± 0.065	4.216ValGlu: 4.216 ± 0.068	2.963ValPhe: 2.963 ± 0.051	3.838ValGly: 3.838 ± 0.064	1.218ValHis: 1.218 ± 0.032	4.822ValIle: 4.822 ± 0.065	3.682ValLys: 3.682 ± 0.063	7.091ValLeu: 7.091 ± 0.087	1.989ValMet: 1.989 ± 0.047	2.762ValAsn: 2.762 ± 0.054	2.233ValPro: 2.233 ± 0.039	2.451ValGln: 2.451 ± 0.048	3.337ValArg: 3.337 ± 0.066	4.264ValSer: 4.264 ± 0.059	3.677ValThr: 3.677 ± 0.069	4.379ValVal: 4.379 ± 0.076	0.665ValTrp: 0.665 ± 0.024	2.424ValTyr: 2.424 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.687TrpAla: 0.687 ± 0.03	0.124TrpCys: 0.124 ± 0.011	0.596TrpAsp: 0.596 ± 0.023	0.599TrpGlu: 0.599 ± 0.022	0.465TrpPhe: 0.465 ± 0.019	0.724TrpGly: 0.724 ± 0.026	0.237TrpHis: 0.237 ± 0.013	1.036TrpIle: 1.036 ± 0.032	0.697TrpLys: 0.697 ± 0.027	1.324TrpLeu: 1.324 ± 0.032	0.407TrpMet: 0.407 ± 0.019	0.542TrpAsn: 0.542 ± 0.027	0.273TrpPro: 0.273 ± 0.014	0.513TrpGln: 0.513 ± 0.024	0.448TrpArg: 0.448 ± 0.019	0.51TrpSer: 0.51 ± 0.022	0.621TrpThr: 0.621 ± 0.026	0.595TrpVal: 0.595 ± 0.022	0.092TrpTrp: 0.092 ± 0.009	0.332TrpTyr: 0.332 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.774TyrAla: 2.774 ± 0.047	0.604TyrCys: 0.604 ± 0.025	2.241TyrAsp: 2.241 ± 0.05	2.24TyrGlu: 2.24 ± 0.045	1.909TyrPhe: 1.909 ± 0.04	2.499TyrGly: 2.499 ± 0.049	0.851TyrHis: 0.851 ± 0.03	1.972TyrIle: 1.972 ± 0.047	1.576TyrLys: 1.576 ± 0.04	3.569TyrLeu: 3.569 ± 0.056	0.736TyrMet: 0.736 ± 0.023	1.593TyrAsn: 1.593 ± 0.037	1.651TyrPro: 1.651 ± 0.043	1.725TyrGln: 1.725 ± 0.041	2.036TyrArg: 2.036 ± 0.046	2.068TyrSer: 2.068 ± 0.045	1.935TyrThr: 1.935 ± 0.04	2.023TyrVal: 2.023 ± 0.047	0.372TyrTrp: 0.372 ± 0.019	1.588TyrTyr: 1.588 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4221 proteins (1145060 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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