Amino acid dipepetide frequency for Clostridium sp. CAG:356

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.649AlaAla: 2.649 ± 0.085
0.548AlaCys: 0.548 ± 0.04
2.74AlaAsp: 2.74 ± 0.089
4.188AlaGlu: 4.188 ± 0.11
1.912AlaPhe: 1.912 ± 0.081
3.383AlaGly: 3.383 ± 0.1
0.701AlaHis: 0.701 ± 0.042
5.628AlaIle: 5.628 ± 0.12
5.519AlaLys: 5.519 ± 0.131
4.153AlaLeu: 4.153 ± 0.109
1.431AlaMet: 1.431 ± 0.065
3.17AlaAsn: 3.17 ± 0.089
1.171AlaPro: 1.171 ± 0.055
1.699AlaGln: 1.699 ± 0.063
2.008AlaArg: 2.008 ± 0.068
2.813AlaSer: 2.813 ± 0.096
3.084AlaThr: 3.084 ± 0.105
3.543AlaVal: 3.543 ± 0.104
0.348AlaTrp: 0.348 ± 0.03
2.072AlaTyr: 2.072 ± 0.07
0.0AlaXaa: 0.0 ± 0.0
Cys
0.586CysAla: 0.586 ± 0.032
0.164CysCys: 0.164 ± 0.021
0.581CysAsp: 0.581 ± 0.035
0.779CysGlu: 0.779 ± 0.044
0.464CysPhe: 0.464 ± 0.035
0.881CysGly: 0.881 ± 0.054
0.18CysHis: 0.18 ± 0.019
1.003CysIle: 1.003 ± 0.051
1.058CysLys: 1.058 ± 0.053
0.87CysLeu: 0.87 ± 0.044
0.284CysMet: 0.284 ± 0.022
0.739CysAsn: 0.739 ± 0.047
0.393CysPro: 0.393 ± 0.03
0.257CysGln: 0.257 ± 0.026
0.337CysArg: 0.337 ± 0.031
0.652CysSer: 0.652 ± 0.039
0.575CysThr: 0.575 ± 0.04
0.557CysVal: 0.557 ± 0.035
0.06CysTrp: 0.06 ± 0.011
0.457CysTyr: 0.457 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
2.591AspAla: 2.591 ± 0.088
0.599AspCys: 0.599 ± 0.036
2.917AspAsp: 2.917 ± 0.101
5.355AspGlu: 5.355 ± 0.117
2.5AspPhe: 2.5 ± 0.085
3.627AspGly: 3.627 ± 0.114
0.475AspHis: 0.475 ± 0.032
5.863AspIle: 5.863 ± 0.123
5.541AspLys: 5.541 ± 0.133
4.415AspLeu: 4.415 ± 0.112
1.564AspMet: 1.564 ± 0.059
3.578AspAsn: 3.578 ± 0.102
1.025AspPro: 1.025 ± 0.057
0.927AspGln: 0.927 ± 0.037
1.677AspArg: 1.677 ± 0.066
3.066AspSer: 3.066 ± 0.091
3.028AspThr: 3.028 ± 0.095
3.518AspVal: 3.518 ± 0.087
0.397AspTrp: 0.397 ± 0.032
2.722AspTyr: 2.722 ± 0.085
0.0AspXaa: 0.0 ± 0.0
Glu
3.986GluAla: 3.986 ± 0.104
0.772GluCys: 0.772 ± 0.042
4.392GluAsp: 4.392 ± 0.118
8.445GluGlu: 8.445 ± 0.191
3.128GluPhe: 3.128 ± 0.086
3.325GluGly: 3.325 ± 0.104
0.992GluHis: 0.992 ± 0.048
8.607GluIle: 8.607 ± 0.148
10.562GluLys: 10.562 ± 0.212
7.294GluLeu: 7.294 ± 0.147
2.278GluMet: 2.278 ± 0.071
7.23GluAsn: 7.23 ± 0.143
1.633GluPro: 1.633 ± 0.069
3.037GluGln: 3.037 ± 0.094
2.882GluArg: 2.882 ± 0.092
3.365GluSer: 3.365 ± 0.078
4.057GluThr: 4.057 ± 0.101
4.769GluVal: 4.769 ± 0.103
0.528GluTrp: 0.528 ± 0.04
4.082GluTyr: 4.082 ± 0.106
0.0GluXaa: 0.0 ± 0.0
Phe
2.241PheAla: 2.241 ± 0.073
0.51PheCys: 0.51 ± 0.039
2.547PheAsp: 2.547 ± 0.091
3.248PheGlu: 3.248 ± 0.087
1.517PhePhe: 1.517 ± 0.061
2.243PheGly: 2.243 ± 0.081
0.426PheHis: 0.426 ± 0.031
3.618PheIle: 3.618 ± 0.132
3.541PheLys: 3.541 ± 0.101
3.274PheLeu: 3.274 ± 0.099
0.929PheMet: 0.929 ± 0.048
2.418PheAsn: 2.418 ± 0.083
0.905PhePro: 0.905 ± 0.046
0.832PheGln: 0.832 ± 0.048
1.236PheArg: 1.236 ± 0.06
2.502PheSer: 2.502 ± 0.085
2.107PheThr: 2.107 ± 0.071
2.314PheVal: 2.314 ± 0.083
0.342PheTrp: 0.342 ± 0.027
1.606PheTyr: 1.606 ± 0.069
0.0PheXaa: 0.0 ± 0.0
Gly
3.155GlyAla: 3.155 ± 0.122
0.614GlyCys: 0.614 ± 0.042
2.633GlyAsp: 2.633 ± 0.085
4.182GlyGlu: 4.182 ± 0.105
2.396GlyPhe: 2.396 ± 0.079
3.257GlyGly: 3.257 ± 0.112
0.865GlyHis: 0.865 ± 0.048
6.183GlyIle: 6.183 ± 0.137
6.147GlyLys: 6.147 ± 0.106
4.395GlyLeu: 4.395 ± 0.106
1.524GlyMet: 1.524 ± 0.061
3.274GlyAsn: 3.274 ± 0.098
0.918GlyPro: 0.918 ± 0.048
1.533GlyGln: 1.533 ± 0.063
1.866GlyArg: 1.866 ± 0.074
2.8GlySer: 2.8 ± 0.08
3.682GlyThr: 3.682 ± 0.098
3.674GlyVal: 3.674 ± 0.095
0.43GlyTrp: 0.43 ± 0.037
2.771GlyTyr: 2.771 ± 0.101
0.0GlyXaa: 0.0 ± 0.0
His
0.599HisAla: 0.599 ± 0.036
0.182HisCys: 0.182 ± 0.02
0.588HisAsp: 0.588 ± 0.041
0.801HisGlu: 0.801 ± 0.038
0.568HisPhe: 0.568 ± 0.037
0.79HisGly: 0.79 ± 0.046
0.264HisHis: 0.264 ± 0.025
1.229HisIle: 1.229 ± 0.05
0.934HisLys: 0.934 ± 0.044
1.009HisLeu: 1.009 ± 0.05
0.297HisMet: 0.297 ± 0.023
0.741HisAsn: 0.741 ± 0.041
0.53HisPro: 0.53 ± 0.039
0.339HisGln: 0.339 ± 0.027
0.459HisArg: 0.459 ± 0.03
0.725HisSer: 0.725 ± 0.04
0.69HisThr: 0.69 ± 0.044
0.626HisVal: 0.626 ± 0.043
0.104HisTrp: 0.104 ± 0.015
0.497HisTyr: 0.497 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.945IleAla: 5.945 ± 0.152
1.28IleCys: 1.28 ± 0.066
5.978IleAsp: 5.978 ± 0.129
8.17IleGlu: 8.17 ± 0.148
3.827IlePhe: 3.827 ± 0.131
5.384IleGly: 5.384 ± 0.125
1.029IleHis: 1.029 ± 0.049
9.912IleIle: 9.912 ± 0.234
9.628IleLys: 9.628 ± 0.159
9.018IleLeu: 9.018 ± 0.193
2.265IleMet: 2.265 ± 0.08
6.149IleAsn: 6.149 ± 0.139
2.964IlePro: 2.964 ± 0.092
2.837IleGln: 2.837 ± 0.081
2.966IleArg: 2.966 ± 0.09
6.611IleSer: 6.611 ± 0.127
5.639IleThr: 5.639 ± 0.144
6.313IleVal: 6.313 ± 0.142
0.557IleTrp: 0.557 ± 0.034
4.082IleTyr: 4.082 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
4.843LysAla: 4.843 ± 0.123
0.976LysCys: 0.976 ± 0.059
5.814LysAsp: 5.814 ± 0.135
10.253LysGlu: 10.253 ± 0.192
3.392LysPhe: 3.392 ± 0.085
4.35LysGly: 4.35 ± 0.117
1.067LysHis: 1.067 ± 0.058
10.706LysIle: 10.706 ± 0.174
10.018LysLys: 10.018 ± 0.182
7.917LysLeu: 7.917 ± 0.14
2.984LysMet: 2.984 ± 0.087
7.403LysAsn: 7.403 ± 0.155
2.054LysPro: 2.054 ± 0.073
3.412LysGln: 3.412 ± 0.098
3.452LysArg: 3.452 ± 0.097
4.907LysSer: 4.907 ± 0.112
5.522LysThr: 5.522 ± 0.123
6.087LysVal: 6.087 ± 0.137
0.621LysTrp: 0.621 ± 0.039
5.291LysTyr: 5.291 ± 0.118
0.0LysXaa: 0.0 ± 0.0
Leu
4.845LeuAla: 4.845 ± 0.111
0.832LeuCys: 0.832 ± 0.047
4.676LeuAsp: 4.676 ± 0.115
7.003LeuGlu: 7.003 ± 0.136
3.033LeuPhe: 3.033 ± 0.1
4.931LeuGly: 4.931 ± 0.135
1.047LeuHis: 1.047 ± 0.054
7.261LeuIle: 7.261 ± 0.16
8.523LeuLys: 8.523 ± 0.156
6.42LeuLeu: 6.42 ± 0.154
1.786LeuMet: 1.786 ± 0.059
5.446LeuAsn: 5.446 ± 0.138
2.476LeuPro: 2.476 ± 0.079
2.505LeuGln: 2.505 ± 0.075
2.653LeuArg: 2.653 ± 0.083
5.033LeuSer: 5.033 ± 0.125
4.512LeuThr: 4.512 ± 0.117
4.847LeuVal: 4.847 ± 0.112
0.515LeuTrp: 0.515 ± 0.038
3.23LeuTyr: 3.23 ± 0.098
0.0LeuXaa: 0.0 ± 0.0
Met
1.486MetAla: 1.486 ± 0.074
0.317MetCys: 0.317 ± 0.026
1.245MetAsp: 1.245 ± 0.055
1.988MetGlu: 1.988 ± 0.067
1.156MetPhe: 1.156 ± 0.08
1.247MetGly: 1.247 ± 0.061
0.299MetHis: 0.299 ± 0.023
2.112MetIle: 2.112 ± 0.073
2.68MetLys: 2.68 ± 0.077
2.298MetLeu: 2.298 ± 0.08
0.606MetMet: 0.606 ± 0.039
1.706MetAsn: 1.706 ± 0.063
1.014MetPro: 1.014 ± 0.046
1.007MetGln: 1.007 ± 0.049
0.783MetArg: 0.783 ± 0.049
1.466MetSer: 1.466 ± 0.057
1.307MetThr: 1.307 ± 0.063
1.358MetVal: 1.358 ± 0.062
0.169MetTrp: 0.169 ± 0.019
0.985MetTyr: 0.985 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
3.119AsnAla: 3.119 ± 0.087
0.756AsnCys: 0.756 ± 0.051
3.21AsnAsp: 3.21 ± 0.103
5.224AsnGlu: 5.224 ± 0.114
2.44AsnPhe: 2.44 ± 0.084
4.197AsnGly: 4.197 ± 0.119
0.639AsnHis: 0.639 ± 0.04
7.278AsnIle: 7.278 ± 0.167
6.85AsnLys: 6.85 ± 0.143
5.539AsnLeu: 5.539 ± 0.139
1.724AsnMet: 1.724 ± 0.068
4.949AsnAsn: 4.949 ± 0.159
2.048AsnPro: 2.048 ± 0.08
2.039AsnGln: 2.039 ± 0.083
2.099AsnArg: 2.099 ± 0.078
4.219AsnSer: 4.219 ± 0.127
3.913AsnThr: 3.913 ± 0.116
3.973AsnVal: 3.973 ± 0.104
0.532AsnTrp: 0.532 ± 0.042
3.048AsnTyr: 3.048 ± 0.103
0.0AsnXaa: 0.0 ± 0.0
Pro
1.258ProAla: 1.258 ± 0.056
0.311ProCys: 0.311 ± 0.026
1.548ProAsp: 1.548 ± 0.065
2.611ProGlu: 2.611 ± 0.083
1.032ProPhe: 1.032 ± 0.053
1.437ProGly: 1.437 ± 0.068
0.388ProHis: 0.388 ± 0.026
2.422ProIle: 2.422 ± 0.084
2.145ProLys: 2.145 ± 0.068
1.795ProLeu: 1.795 ± 0.071
0.63ProMet: 0.63 ± 0.038
1.548ProAsn: 1.548 ± 0.059
0.457ProPro: 0.457 ± 0.04
0.825ProGln: 0.825 ± 0.048
0.77ProArg: 0.77 ± 0.049
1.411ProSer: 1.411 ± 0.07
1.493ProThr: 1.493 ± 0.07
1.67ProVal: 1.67 ± 0.078
0.193ProTrp: 0.193 ± 0.02
1.089ProTyr: 1.089 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
1.624GlnAla: 1.624 ± 0.063
0.224GlnCys: 0.224 ± 0.021
1.682GlnAsp: 1.682 ± 0.063
2.902GlnGlu: 2.902 ± 0.079
0.961GlnPhe: 0.961 ± 0.045
1.548GlnGly: 1.548 ± 0.059
0.297GlnHis: 0.297 ± 0.026
3.192GlnIle: 3.192 ± 0.1
3.137GlnLys: 3.137 ± 0.079
2.383GlnLeu: 2.383 ± 0.08
0.816GlnMet: 0.816 ± 0.044
2.343GlnAsn: 2.343 ± 0.081
0.572GlnPro: 0.572 ± 0.038
0.827GlnGln: 0.827 ± 0.045
1.025GlnArg: 1.025 ± 0.048
1.369GlnSer: 1.369 ± 0.06
1.704GlnThr: 1.704 ± 0.072
1.801GlnVal: 1.801 ± 0.06
0.149GlnTrp: 0.149 ± 0.018
1.395GlnTyr: 1.395 ± 0.055
0.0GlnXaa: 0.0 ± 0.0
Arg
1.721ArgAla: 1.721 ± 0.07
0.379ArgCys: 0.379 ± 0.031
1.77ArgAsp: 1.77 ± 0.062
2.658ArgGlu: 2.658 ± 0.088
1.344ArgPhe: 1.344 ± 0.059
1.655ArgGly: 1.655 ± 0.069
0.464ArgHis: 0.464 ± 0.035
3.163ArgIle: 3.163 ± 0.083
3.687ArgLys: 3.687 ± 0.099
2.582ArgLeu: 2.582 ± 0.079
0.929ArgMet: 0.929 ± 0.047
2.298ArgAsn: 2.298 ± 0.08
0.892ArgPro: 0.892 ± 0.058
1.0ArgGln: 1.0 ± 0.045
1.451ArgArg: 1.451 ± 0.069
1.284ArgSer: 1.284 ± 0.055
1.85ArgThr: 1.85 ± 0.07
1.954ArgVal: 1.954 ± 0.065
0.242ArgTrp: 0.242 ± 0.023
1.584ArgTyr: 1.584 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
2.84SerAla: 2.84 ± 0.096
0.528SerCys: 0.528 ± 0.033
3.059SerAsp: 3.059 ± 0.103
4.257SerGlu: 4.257 ± 0.115
2.207SerPhe: 2.207 ± 0.068
3.685SerGly: 3.685 ± 0.096
0.728SerHis: 0.728 ± 0.043
5.803SerIle: 5.803 ± 0.125
5.63SerLys: 5.63 ± 0.123
4.293SerLeu: 4.293 ± 0.114
1.335SerMet: 1.335 ± 0.063
3.935SerAsn: 3.935 ± 0.124
1.187SerPro: 1.187 ± 0.058
1.81SerGln: 1.81 ± 0.063
1.875SerArg: 1.875 ± 0.071
3.638SerSer: 3.638 ± 0.123
3.217SerThr: 3.217 ± 0.098
3.268SerVal: 3.268 ± 0.088
0.368SerTrp: 0.368 ± 0.03
2.36SerTyr: 2.36 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
3.15ThrAla: 3.15 ± 0.097
0.535ThrCys: 0.535 ± 0.041
3.348ThrAsp: 3.348 ± 0.099
4.319ThrGlu: 4.319 ± 0.1
2.17ThrPhe: 2.17 ± 0.072
3.773ThrGly: 3.773 ± 0.102
0.741ThrHis: 0.741 ± 0.041
5.663ThrIle: 5.663 ± 0.142
4.858ThrLys: 4.858 ± 0.114
4.477ThrLeu: 4.477 ± 0.113
1.1ThrMet: 1.1 ± 0.052
3.785ThrAsn: 3.785 ± 0.147
1.755ThrPro: 1.755 ± 0.068
1.726ThrGln: 1.726 ± 0.072
1.748ThrArg: 1.748 ± 0.067
3.465ThrSer: 3.465 ± 0.113
3.569ThrThr: 3.569 ± 0.142
3.56ThrVal: 3.56 ± 0.13
0.408ThrTrp: 0.408 ± 0.028
2.465ThrTyr: 2.465 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
3.647ValAla: 3.647 ± 0.099
0.723ValCys: 0.723 ± 0.044
3.494ValAsp: 3.494 ± 0.097
5.198ValGlu: 5.198 ± 0.112
2.194ValPhe: 2.194 ± 0.066
3.518ValGly: 3.518 ± 0.109
0.714ValHis: 0.714 ± 0.048
5.892ValIle: 5.892 ± 0.127
5.679ValLys: 5.679 ± 0.124
5.147ValLeu: 5.147 ± 0.125
1.424ValMet: 1.424 ± 0.063
3.348ValAsn: 3.348 ± 0.096
1.781ValPro: 1.781 ± 0.066
1.737ValGln: 1.737 ± 0.068
1.965ValArg: 1.965 ± 0.07
3.707ValSer: 3.707 ± 0.095
3.691ValThr: 3.691 ± 0.117
4.139ValVal: 4.139 ± 0.104
0.368ValTrp: 0.368 ± 0.032
2.42ValTyr: 2.42 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
0.315TrpAla: 0.315 ± 0.027
0.091TrpCys: 0.091 ± 0.014
0.364TrpAsp: 0.364 ± 0.028
0.468TrpGlu: 0.468 ± 0.04
0.273TrpPhe: 0.273 ± 0.027
0.439TrpGly: 0.439 ± 0.03
0.115TrpHis: 0.115 ± 0.016
0.697TrpIle: 0.697 ± 0.039
0.657TrpLys: 0.657 ± 0.043
0.548TrpLeu: 0.548 ± 0.041
0.173TrpMet: 0.173 ± 0.02
0.572TrpAsn: 0.572 ± 0.049
0.133TrpPro: 0.133 ± 0.02
0.264TrpGln: 0.264 ± 0.027
0.224TrpArg: 0.224 ± 0.026
0.337TrpSer: 0.337 ± 0.028
0.359TrpThr: 0.359 ± 0.031
0.315TrpVal: 0.315 ± 0.025
0.095TrpTrp: 0.095 ± 0.016
0.317TrpTyr: 0.317 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.161TyrAla: 2.161 ± 0.069
0.532TyrCys: 0.532 ± 0.036
2.802TyrAsp: 2.802 ± 0.087
3.316TyrGlu: 3.316 ± 0.104
1.843TyrPhe: 1.843 ± 0.07
2.627TyrGly: 2.627 ± 0.084
0.541TyrHis: 0.541 ± 0.034
4.321TyrIle: 4.321 ± 0.108
4.275TyrLys: 4.275 ± 0.116
3.749TyrLeu: 3.749 ± 0.103
1.145TyrMet: 1.145 ± 0.052
3.166TyrAsn: 3.166 ± 0.097
1.127TyrPro: 1.127 ± 0.051
1.335TyrGln: 1.335 ± 0.048
1.435TyrArg: 1.435 ± 0.047
2.651TyrSer: 2.651 ± 0.076
2.615TyrThr: 2.615 ± 0.103
2.5TyrVal: 2.5 ± 0.066
0.331TyrTrp: 0.331 ± 0.03
2.221TyrTyr: 2.221 ± 0.091
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1500 proteins (450784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski