Amino acid dipepetide frequency for Flavobacterium arcticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.885AlaAla: 4.885 ± 0.1	0.549AlaCys: 0.549 ± 0.026	3.746AlaAsp: 3.746 ± 0.081	4.272AlaGlu: 4.272 ± 0.072	3.367AlaPhe: 3.367 ± 0.067	4.5AlaGly: 4.5 ± 0.087	1.018AlaHis: 1.018 ± 0.037	5.677AlaIle: 5.677 ± 0.082	4.663AlaLys: 4.663 ± 0.09	6.353AlaLeu: 6.353 ± 0.109	1.723AlaMet: 1.723 ± 0.052	3.477AlaAsn: 3.477 ± 0.068	2.141AlaPro: 2.141 ± 0.062	2.632AlaGln: 2.632 ± 0.056	2.071AlaArg: 2.071 ± 0.049	4.001AlaSer: 4.001 ± 0.076	4.672AlaThr: 4.672 ± 0.12	4.518AlaVal: 4.518 ± 0.082	0.682AlaTrp: 0.682 ± 0.027	2.575AlaTyr: 2.575 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.457CysAla: 0.457 ± 0.024	0.103CysCys: 0.103 ± 0.013	0.505CysAsp: 0.505 ± 0.031	0.514CysGlu: 0.514 ± 0.026	0.408CysPhe: 0.408 ± 0.021	0.667CysGly: 0.667 ± 0.038	0.182CysHis: 0.182 ± 0.017	0.611CysIle: 0.611 ± 0.026	0.388CysLys: 0.388 ± 0.025	0.592CysLeu: 0.592 ± 0.027	0.153CysMet: 0.153 ± 0.014	0.465CysAsn: 0.465 ± 0.028	0.322CysPro: 0.322 ± 0.027	0.171CysGln: 0.171 ± 0.013	0.182CysArg: 0.182 ± 0.014	0.594CysSer: 0.594 ± 0.029	0.497CysThr: 0.497 ± 0.034	0.432CysVal: 0.432 ± 0.025	0.057CysTrp: 0.057 ± 0.007	0.317CysTyr: 0.317 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	4.039AspAla: 4.039 ± 0.082	0.455AspCys: 0.455 ± 0.025	3.295AspAsp: 3.295 ± 0.068	3.846AspGlu: 3.846 ± 0.073	3.498AspPhe: 3.498 ± 0.073	3.893AspGly: 3.893 ± 0.096	0.763AspHis: 0.763 ± 0.027	4.754AspIle: 4.754 ± 0.068	4.277AspLys: 4.277 ± 0.088	4.552AspLeu: 4.552 ± 0.072	1.298AspMet: 1.298 ± 0.041	3.747AspAsn: 3.747 ± 0.076	1.662AspPro: 1.662 ± 0.053	1.121AspGln: 1.121 ± 0.03	1.852AspArg: 1.852 ± 0.045	3.104AspSer: 3.104 ± 0.063	3.343AspThr: 3.343 ± 0.068	4.129AspVal: 4.129 ± 0.083	0.668AspTrp: 0.668 ± 0.029	3.086AspTyr: 3.086 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	4.724GluAla: 4.724 ± 0.088	0.359GluCys: 0.359 ± 0.02	3.633GluAsp: 3.633 ± 0.079	5.137GluGlu: 5.137 ± 0.102	2.823GluPhe: 2.823 ± 0.053	4.239GluGly: 4.239 ± 0.068	1.18GluHis: 1.18 ± 0.04	5.107GluIle: 5.107 ± 0.078	5.565GluLys: 5.565 ± 0.112	5.997GluLeu: 5.997 ± 0.093	1.72GluMet: 1.72 ± 0.041	4.532GluAsn: 4.532 ± 0.087	1.715GluPro: 1.715 ± 0.047	2.486GluGln: 2.486 ± 0.06	2.553GluArg: 2.553 ± 0.057	3.318GluSer: 3.318 ± 0.065	3.781GluThr: 3.781 ± 0.064	4.484GluVal: 4.484 ± 0.087	0.638GluTrp: 0.638 ± 0.029	2.807GluTyr: 2.807 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	3.011PheAla: 3.011 ± 0.065	0.454PheCys: 0.454 ± 0.024	3.192PheAsp: 3.192 ± 0.065	3.274PheGlu: 3.274 ± 0.062	2.567PhePhe: 2.567 ± 0.073	3.518PheGly: 3.518 ± 0.074	0.75PheHis: 0.75 ± 0.033	4.024PheIle: 4.024 ± 0.077	3.248PheLys: 3.248 ± 0.073	4.024PheLeu: 4.024 ± 0.075	1.203PheMet: 1.203 ± 0.044	3.169PheAsn: 3.169 ± 0.075	1.583PhePro: 1.583 ± 0.044	1.231PheGln: 1.231 ± 0.037	1.562PheArg: 1.562 ± 0.041	3.626PheSer: 3.626 ± 0.074	3.513PheThr: 3.513 ± 0.075	2.837PheVal: 2.837 ± 0.067	0.536PheTrp: 0.536 ± 0.026	2.146PheTyr: 2.146 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	4.224GlyAla: 4.224 ± 0.076	0.73GlyCys: 0.73 ± 0.044	3.561GlyAsp: 3.561 ± 0.095	3.801GlyGlu: 3.801 ± 0.068	3.386GlyPhe: 3.386 ± 0.064	4.547GlyGly: 4.547 ± 0.097	1.062GlyHis: 1.062 ± 0.032	5.394GlyIle: 5.394 ± 0.087	4.77GlyLys: 4.77 ± 0.088	5.43GlyLeu: 5.43 ± 0.093	1.661GlyMet: 1.661 ± 0.047	3.872GlyAsn: 3.872 ± 0.081	1.183GlyPro: 1.183 ± 0.045	1.868GlyGln: 1.868 ± 0.052	2.101GlyArg: 2.101 ± 0.053	4.093GlySer: 4.093 ± 0.08	4.523GlyThr: 4.523 ± 0.114	4.402GlyVal: 4.402 ± 0.066	0.761GlyTrp: 0.761 ± 0.033	3.069GlyTyr: 3.069 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	0.919HisAla: 0.919 ± 0.034	0.152HisCys: 0.152 ± 0.013	0.924HisAsp: 0.924 ± 0.03	1.055HisGlu: 1.055 ± 0.039	1.06HisPhe: 1.06 ± 0.037	0.941HisGly: 0.941 ± 0.034	0.432HisHis: 0.432 ± 0.026	1.323HisIle: 1.323 ± 0.04	1.138HisLys: 1.138 ± 0.036	1.563HisLeu: 1.563 ± 0.045	0.318HisMet: 0.318 ± 0.021	1.1HisAsn: 1.1 ± 0.037	0.79HisPro: 0.79 ± 0.03	0.628HisGln: 0.628 ± 0.026	0.606HisArg: 0.606 ± 0.026	0.928HisSer: 0.928 ± 0.037	0.972HisThr: 0.972 ± 0.035	0.851HisVal: 0.851 ± 0.036	0.189HisTrp: 0.189 ± 0.013	0.874HisTyr: 0.874 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.105IleAla: 6.105 ± 0.106	0.586IleCys: 0.586 ± 0.027	5.024IleAsp: 5.024 ± 0.077	5.417IleGlu: 5.417 ± 0.097	3.28IlePhe: 3.28 ± 0.072	4.804IleGly: 4.804 ± 0.082	1.265IleHis: 1.265 ± 0.038	6.241IleIle: 6.241 ± 0.123	5.626IleLys: 5.626 ± 0.1	6.353IleLeu: 6.353 ± 0.109	1.604IleMet: 1.604 ± 0.046	4.97IleAsn: 4.97 ± 0.088	3.194IlePro: 3.194 ± 0.067	2.465IleGln: 2.465 ± 0.06	2.402IleArg: 2.402 ± 0.055	5.067IleSer: 5.067 ± 0.079	5.73IleThr: 5.73 ± 0.098	4.99IleVal: 4.99 ± 0.076	0.625IleTrp: 0.625 ± 0.026	3.077IleTyr: 3.077 ± 0.067	0.0IleXaa: 0.0 ± 0.0
Lys	5.038LysAla: 5.038 ± 0.09	0.324LysCys: 0.324 ± 0.019	4.232LysAsp: 4.232 ± 0.081	5.955LysGlu: 5.955 ± 0.111	2.616LysPhe: 2.616 ± 0.061	4.235LysGly: 4.235 ± 0.077	1.283LysHis: 1.283 ± 0.038	5.695LysIle: 5.695 ± 0.099	6.601LysLys: 6.601 ± 0.132	6.11LysLeu: 6.11 ± 0.097	2.076LysMet: 2.076 ± 0.051	4.654LysAsn: 4.654 ± 0.084	2.369LysPro: 2.369 ± 0.056	2.683LysGln: 2.683 ± 0.065	2.689LysArg: 2.689 ± 0.055	3.955LysSer: 3.955 ± 0.08	4.203LysThr: 4.203 ± 0.074	4.477LysVal: 4.477 ± 0.084	0.679LysTrp: 0.679 ± 0.028	2.942LysTyr: 2.942 ± 0.074	0.0LysXaa: 0.0 ± 0.0
Leu	5.661LeuAla: 5.661 ± 0.097	0.662LeuCys: 0.662 ± 0.028	4.8LeuAsp: 4.8 ± 0.069	5.632LeuGlu: 5.632 ± 0.1	4.6LeuPhe: 4.6 ± 0.093	5.37LeuGly: 5.37 ± 0.085	1.55LeuHis: 1.55 ± 0.041	6.182LeuIle: 6.182 ± 0.103	6.628LeuLys: 6.628 ± 0.104	8.814LeuLeu: 8.814 ± 0.147	2.042LeuMet: 2.042 ± 0.053	5.184LeuAsn: 5.184 ± 0.084	3.549LeuPro: 3.549 ± 0.06	3.36LeuGln: 3.36 ± 0.081	2.908LeuArg: 2.908 ± 0.054	6.199LeuSer: 6.199 ± 0.089	5.259LeuThr: 5.259 ± 0.076	5.084LeuVal: 5.084 ± 0.073	0.767LeuTrp: 0.767 ± 0.035	3.57LeuTyr: 3.57 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.76MetAla: 1.76 ± 0.047	0.127MetCys: 0.127 ± 0.011	1.194MetAsp: 1.194 ± 0.04	1.521MetGlu: 1.521 ± 0.046	0.902MetPhe: 0.902 ± 0.042	1.58MetGly: 1.58 ± 0.047	0.44MetHis: 0.44 ± 0.024	1.571MetIle: 1.571 ± 0.045	2.229MetLys: 2.229 ± 0.051	2.091MetLeu: 2.091 ± 0.051	0.633MetMet: 0.633 ± 0.032	1.285MetAsn: 1.285 ± 0.033	0.977MetPro: 0.977 ± 0.036	0.99MetGln: 0.99 ± 0.037	0.952MetArg: 0.952 ± 0.041	1.483MetSer: 1.483 ± 0.044	1.206MetThr: 1.206 ± 0.035	1.411MetVal: 1.411 ± 0.042	0.191MetTrp: 0.191 ± 0.016	0.857MetTyr: 0.857 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.891AsnAla: 3.891 ± 0.073	0.472AsnCys: 0.472 ± 0.026	3.718AsnAsp: 3.718 ± 0.07	3.837AsnGlu: 3.837 ± 0.065	2.908AsnPhe: 2.908 ± 0.059	4.123AsnGly: 4.123 ± 0.084	1.008AsnHis: 1.008 ± 0.032	4.997AsnIle: 4.997 ± 0.085	4.242AsnLys: 4.242 ± 0.069	4.949AsnLeu: 4.949 ± 0.087	1.336AsnMet: 1.336 ± 0.046	4.349AsnAsn: 4.349 ± 0.095	2.876AsnPro: 2.876 ± 0.063	1.945AsnGln: 1.945 ± 0.054	2.142AsnArg: 2.142 ± 0.049	3.664AsnSer: 3.664 ± 0.079	4.085AsnThr: 4.085 ± 0.091	3.753AsnVal: 3.753 ± 0.081	0.758AsnTrp: 0.758 ± 0.029	2.946AsnTyr: 2.946 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	2.207ProAla: 2.207 ± 0.065	0.224ProCys: 0.224 ± 0.018	2.359ProAsp: 2.359 ± 0.063	3.042ProGlu: 3.042 ± 0.064	1.775ProPhe: 1.775 ± 0.048	1.857ProGly: 1.857 ± 0.056	0.601ProHis: 0.601 ± 0.028	2.672ProIle: 2.672 ± 0.055	2.234ProLys: 2.234 ± 0.059	2.96ProLeu: 2.96 ± 0.062	0.759ProMet: 0.759 ± 0.029	2.228ProAsn: 2.228 ± 0.054	0.867ProPro: 0.867 ± 0.033	1.216ProGln: 1.216 ± 0.036	0.898ProArg: 0.898 ± 0.034	2.069ProSer: 2.069 ± 0.049	2.101ProThr: 2.101 ± 0.067	2.699ProVal: 2.699 ± 0.059	0.288ProTrp: 0.288 ± 0.019	1.519ProTyr: 1.519 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.119GlnAla: 2.119 ± 0.054	0.194GlnCys: 0.194 ± 0.015	1.726GlnAsp: 1.726 ± 0.045	2.477GlnGlu: 2.477 ± 0.05	1.544GlnPhe: 1.544 ± 0.04	1.853GlnGly: 1.853 ± 0.044	0.61GlnHis: 0.61 ± 0.027	2.257GlnIle: 2.257 ± 0.053	2.644GlnLys: 2.644 ± 0.065	3.275GlnLeu: 3.275 ± 0.068	0.806GlnMet: 0.806 ± 0.03	1.986GlnAsn: 1.986 ± 0.052	1.207GlnPro: 1.207 ± 0.04	1.574GlnGln: 1.574 ± 0.047	1.207GlnArg: 1.207 ± 0.04	1.921GlnSer: 1.921 ± 0.049	1.852GlnThr: 1.852 ± 0.05	2.012GlnVal: 2.012 ± 0.047	0.384GlnTrp: 0.384 ± 0.023	1.542GlnTyr: 1.542 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	2.071ArgAla: 2.071 ± 0.055	0.186ArgCys: 0.186 ± 0.013	1.784ArgAsp: 1.784 ± 0.053	2.388ArgGlu: 2.388 ± 0.056	1.761ArgPhe: 1.761 ± 0.047	1.832ArgGly: 1.832 ± 0.045	0.597ArgHis: 0.597 ± 0.026	2.696ArgIle: 2.696 ± 0.054	2.776ArgLys: 2.776 ± 0.069	3.13ArgLeu: 3.13 ± 0.07	0.906ArgMet: 0.906 ± 0.034	1.977ArgAsn: 1.977 ± 0.05	1.047ArgPro: 1.047 ± 0.036	1.072ArgGln: 1.072 ± 0.041	1.262ArgArg: 1.262 ± 0.043	1.725ArgSer: 1.725 ± 0.048	1.795ArgThr: 1.795 ± 0.052	2.227ArgVal: 2.227 ± 0.047	0.37ArgTrp: 0.37 ± 0.02	1.571ArgTyr: 1.571 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	3.789SerAla: 3.789 ± 0.071	0.625SerCys: 0.625 ± 0.031	3.259SerAsp: 3.259 ± 0.06	3.66SerGlu: 3.66 ± 0.065	3.761SerPhe: 3.761 ± 0.069	4.715SerGly: 4.715 ± 0.089	1.04SerHis: 1.04 ± 0.035	4.967SerIle: 4.967 ± 0.081	3.875SerLys: 3.875 ± 0.082	5.658SerLeu: 5.658 ± 0.084	1.298SerMet: 1.298 ± 0.043	3.596SerAsn: 3.596 ± 0.076	2.09SerPro: 2.09 ± 0.051	2.005SerGln: 2.005 ± 0.045	1.984SerArg: 1.984 ± 0.052	4.077SerSer: 4.077 ± 0.086	3.707SerThr: 3.707 ± 0.081	4.012SerVal: 4.012 ± 0.073	0.674SerTrp: 0.674 ± 0.033	2.828SerTyr: 2.828 ± 0.065	0.0SerXaa: 0.0 ± 0.0
Thr	4.621ThrAla: 4.621 ± 0.104	0.403ThrCys: 0.403 ± 0.027	3.826ThrAsp: 3.826 ± 0.082	4.026ThrGlu: 4.026 ± 0.073	3.075ThrPhe: 3.075 ± 0.066	4.629ThrGly: 4.629 ± 0.117	0.96ThrHis: 0.96 ± 0.035	5.603ThrIle: 5.603 ± 0.11	3.69ThrLys: 3.69 ± 0.077	5.623ThrLeu: 5.623 ± 0.082	1.178ThrMet: 1.178 ± 0.041	3.542ThrAsn: 3.542 ± 0.081	2.786ThrPro: 2.786 ± 0.069	2.006ThrGln: 2.006 ± 0.047	1.698ThrArg: 1.698 ± 0.043	3.963ThrSer: 3.963 ± 0.092	4.589ThrThr: 4.589 ± 0.116	4.694ThrVal: 4.694 ± 0.124	0.584ThrTrp: 0.584 ± 0.028	2.689ThrTyr: 2.689 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	4.71ValAla: 4.71 ± 0.087	0.577ValCys: 0.577 ± 0.025	3.449ValAsp: 3.449 ± 0.068	3.717ValGlu: 3.717 ± 0.063	3.199ValPhe: 3.199 ± 0.063	3.797ValGly: 3.797 ± 0.076	1.002ValHis: 1.002 ± 0.035	5.092ValIle: 5.092 ± 0.082	4.493ValLys: 4.493 ± 0.083	5.765ValLeu: 5.765 ± 0.088	1.521ValMet: 1.521 ± 0.045	3.966ValAsn: 3.966 ± 0.086	2.413ValPro: 2.413 ± 0.056	1.914ValGln: 1.914 ± 0.048	2.093ValArg: 2.093 ± 0.055	4.28ValSer: 4.28 ± 0.073	4.809ValThr: 4.809 ± 0.128	4.51ValVal: 4.51 ± 0.093	0.58ValTrp: 0.58 ± 0.029	2.693ValTyr: 2.693 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.63TrpAla: 0.63 ± 0.028	0.09TrpCys: 0.09 ± 0.01	0.669TrpAsp: 0.669 ± 0.035	0.684TrpGlu: 0.684 ± 0.027	0.5TrpPhe: 0.5 ± 0.028	0.64TrpGly: 0.64 ± 0.026	0.222TrpHis: 0.222 ± 0.016	0.662TrpIle: 0.662 ± 0.028	0.677TrpLys: 0.677 ± 0.031	0.92TrpLeu: 0.92 ± 0.034	0.312TrpMet: 0.312 ± 0.018	0.658TrpAsn: 0.658 ± 0.024	0.18TrpPro: 0.18 ± 0.016	0.43TrpGln: 0.43 ± 0.024	0.377TrpArg: 0.377 ± 0.019	0.611TrpSer: 0.611 ± 0.025	0.534TrpThr: 0.534 ± 0.029	0.635TrpVal: 0.635 ± 0.029	0.116TrpTrp: 0.116 ± 0.013	0.472TrpTyr: 0.472 ± 0.03	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.658TyrAla: 2.658 ± 0.055	0.347TyrCys: 0.347 ± 0.019	2.487TyrAsp: 2.487 ± 0.055	2.546TyrGlu: 2.546 ± 0.053	2.438TyrPhe: 2.438 ± 0.056	2.698TyrGly: 2.698 ± 0.063	0.799TyrHis: 0.799 ± 0.033	3.299TyrIle: 3.299 ± 0.066	3.055TyrLys: 3.055 ± 0.074	3.659TyrLeu: 3.659 ± 0.061	0.851TyrMet: 0.851 ± 0.03	3.24TyrAsn: 3.24 ± 0.078	1.621TyrPro: 1.621 ± 0.048	1.396TyrGln: 1.396 ± 0.044	1.633TyrArg: 1.633 ± 0.053	2.941TyrSer: 2.941 ± 0.06	3.015TyrThr: 3.015 ± 0.073	2.421TyrVal: 2.421 ± 0.05	0.476TyrTrp: 0.476 ± 0.022	2.228TyrTyr: 2.228 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2621 proteins (896263 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---