Amino acid dipepetide frequency for Collinsella sp. CAG:289

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.713AlaAla: 13.713 ± 0.255
2.204AlaCys: 2.204 ± 0.074
6.721AlaAsp: 6.721 ± 0.148
6.747AlaGlu: 6.747 ± 0.137
3.858AlaPhe: 3.858 ± 0.097
8.825AlaGly: 8.825 ± 0.153
2.511AlaHis: 2.511 ± 0.076
5.983AlaIle: 5.983 ± 0.104
4.536AlaLys: 4.536 ± 0.108
10.772AlaLeu: 10.772 ± 0.191
2.939AlaMet: 2.939 ± 0.087
3.23AlaAsn: 3.23 ± 0.078
4.125AlaPro: 4.125 ± 0.102
4.242AlaGln: 4.242 ± 0.116
6.816AlaArg: 6.816 ± 0.13
6.738AlaSer: 6.738 ± 0.143
5.319AlaThr: 5.319 ± 0.113
7.962AlaVal: 7.962 ± 0.124
0.993AlaTrp: 0.993 ± 0.046
2.732AlaTyr: 2.732 ± 0.076
0.002AlaXaa: 0.002 ± 0.002
Cys
1.932CysAla: 1.932 ± 0.06
0.324CysCys: 0.324 ± 0.025
1.186CysAsp: 1.186 ± 0.046
1.175CysGlu: 1.175 ± 0.047
0.522CysPhe: 0.522 ± 0.03
1.972CysGly: 1.972 ± 0.076
0.354CysHis: 0.354 ± 0.031
0.84CysIle: 0.84 ± 0.045
0.564CysLys: 0.564 ± 0.033
1.247CysLeu: 1.247 ± 0.055
0.401CysMet: 0.401 ± 0.028
0.439CysAsn: 0.439 ± 0.029
0.834CysPro: 0.834 ± 0.046
0.437CysGln: 0.437 ± 0.029
0.935CysArg: 0.935 ± 0.048
1.007CysSer: 1.007 ± 0.045
0.925CysThr: 0.925 ± 0.044
1.357CysVal: 1.357 ± 0.057
0.157CysTrp: 0.157 ± 0.017
0.39CysTyr: 0.39 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
8.057AspAla: 8.057 ± 0.143
0.861AspCys: 0.861 ± 0.047
3.905AspAsp: 3.905 ± 0.101
5.323AspGlu: 5.323 ± 0.108
2.348AspPhe: 2.348 ± 0.059
5.313AspGly: 5.313 ± 0.126
1.177AspHis: 1.177 ± 0.047
3.758AspIle: 3.758 ± 0.093
2.271AspLys: 2.271 ± 0.072
5.631AspLeu: 5.631 ± 0.111
1.686AspMet: 1.686 ± 0.058
1.756AspAsn: 1.756 ± 0.067
2.914AspPro: 2.914 ± 0.077
1.412AspGln: 1.412 ± 0.052
3.2AspArg: 3.2 ± 0.08
3.285AspSer: 3.285 ± 0.089
3.328AspThr: 3.328 ± 0.096
4.957AspVal: 4.957 ± 0.104
0.605AspTrp: 0.605 ± 0.038
1.856AspTyr: 1.856 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
7.001GluAla: 7.001 ± 0.131
0.878GluCys: 0.878 ± 0.048
3.989GluAsp: 3.989 ± 0.095
4.422GluGlu: 4.422 ± 0.11
2.112GluPhe: 2.112 ± 0.064
4.814GluGly: 4.814 ± 0.092
1.943GluHis: 1.943 ± 0.066
3.232GluIle: 3.232 ± 0.092
2.772GluLys: 2.772 ± 0.086
6.789GluLeu: 6.789 ± 0.114
1.945GluMet: 1.945 ± 0.059
2.286GluAsn: 2.286 ± 0.073
2.435GluPro: 2.435 ± 0.073
2.761GluGln: 2.761 ± 0.08
4.848GluArg: 4.848 ± 0.145
3.128GluSer: 3.128 ± 0.075
2.963GluThr: 2.963 ± 0.072
4.626GluVal: 4.626 ± 0.101
0.547GluTrp: 0.547 ± 0.034
1.775GluTyr: 1.775 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
3.809PheAla: 3.809 ± 0.094
0.747PheCys: 0.747 ± 0.037
3.062PheAsp: 3.062 ± 0.085
2.484PheGlu: 2.484 ± 0.079
1.466PhePhe: 1.466 ± 0.074
3.247PheGly: 3.247 ± 0.091
0.696PheHis: 0.696 ± 0.031
1.975PheIle: 1.975 ± 0.052
1.304PheLys: 1.304 ± 0.049
2.887PheLeu: 2.887 ± 0.078
1.05PheMet: 1.05 ± 0.05
1.173PheAsn: 1.173 ± 0.046
1.349PhePro: 1.349 ± 0.048
0.817PheGln: 0.817 ± 0.037
1.514PheArg: 1.514 ± 0.054
2.437PheSer: 2.437 ± 0.077
2.112PheThr: 2.112 ± 0.067
2.816PheVal: 2.816 ± 0.077
0.38PheTrp: 0.38 ± 0.03
1.009PheTyr: 1.009 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
7.994GlyAla: 7.994 ± 0.145
1.608GlyCys: 1.608 ± 0.059
4.547GlyAsp: 4.547 ± 0.11
4.874GlyGlu: 4.874 ± 0.096
3.251GlyPhe: 3.251 ± 0.074
6.157GlyGly: 6.157 ± 0.155
1.693GlyHis: 1.693 ± 0.065
5.164GlyIle: 5.164 ± 0.132
3.97GlyLys: 3.97 ± 0.096
6.806GlyLeu: 6.806 ± 0.119
2.422GlyMet: 2.422 ± 0.067
2.702GlyAsn: 2.702 ± 0.083
2.142GlyPro: 2.142 ± 0.062
2.157GlyGln: 2.157 ± 0.067
4.246GlyArg: 4.246 ± 0.097
5.065GlySer: 5.065 ± 0.126
4.702GlyThr: 4.702 ± 0.109
6.416GlyVal: 6.416 ± 0.117
0.81GlyTrp: 0.81 ± 0.042
2.549GlyTyr: 2.549 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
2.503HisAla: 2.503 ± 0.081
0.327HisCys: 0.327 ± 0.03
1.47HisAsp: 1.47 ± 0.056
1.535HisGlu: 1.535 ± 0.057
0.751HisPhe: 0.751 ± 0.043
1.93HisGly: 1.93 ± 0.076
0.554HisHis: 0.554 ± 0.043
1.103HisIle: 1.103 ± 0.048
0.685HisLys: 0.685 ± 0.038
1.845HisLeu: 1.845 ± 0.057
0.602HisMet: 0.602 ± 0.032
0.626HisAsn: 0.626 ± 0.039
1.114HisPro: 1.114 ± 0.056
0.53HisGln: 0.53 ± 0.038
1.228HisArg: 1.228 ± 0.054
0.925HisSer: 0.925 ± 0.043
1.063HisThr: 1.063 ± 0.048
1.994HisVal: 1.994 ± 0.066
0.168HisTrp: 0.168 ± 0.017
0.587HisTyr: 0.587 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.759IleAla: 6.759 ± 0.113
1.175IleCys: 1.175 ± 0.048
4.462IleAsp: 4.462 ± 0.097
4.151IleGlu: 4.151 ± 0.091
1.676IlePhe: 1.676 ± 0.063
4.115IleGly: 4.115 ± 0.087
1.111IleHis: 1.111 ± 0.047
2.946IleIle: 2.946 ± 0.091
2.193IleLys: 2.193 ± 0.073
4.238IleLeu: 4.238 ± 0.094
1.376IleMet: 1.376 ± 0.058
1.701IleAsn: 1.701 ± 0.06
2.517IlePro: 2.517 ± 0.074
1.36IleGln: 1.36 ± 0.056
2.799IleArg: 2.799 ± 0.082
3.372IleSer: 3.372 ± 0.074
3.007IleThr: 3.007 ± 0.081
4.882IleVal: 4.882 ± 0.102
0.45IleTrp: 0.45 ± 0.033
1.342IleTyr: 1.342 ± 0.047
0.0IleXaa: 0.0 ± 0.0
Lys
3.888LysAla: 3.888 ± 0.112
0.439LysCys: 0.439 ± 0.03
2.238LysAsp: 2.238 ± 0.072
2.237LysGlu: 2.237 ± 0.083
1.126LysPhe: 1.126 ± 0.053
2.821LysGly: 2.821 ± 0.074
0.897LysHis: 0.897 ± 0.046
2.295LysIle: 2.295 ± 0.057
2.594LysLys: 2.594 ± 0.086
3.86LysLeu: 3.86 ± 0.097
1.219LysMet: 1.219 ± 0.049
1.567LysAsn: 1.567 ± 0.061
1.96LysPro: 1.96 ± 0.069
1.434LysGln: 1.434 ± 0.058
2.927LysArg: 2.927 ± 0.086
2.39LysSer: 2.39 ± 0.069
2.746LysThr: 2.746 ± 0.073
2.863LysVal: 2.863 ± 0.088
0.32LysTrp: 0.32 ± 0.025
1.05LysTyr: 1.05 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
10.657LeuAla: 10.657 ± 0.168
1.459LeuCys: 1.459 ± 0.056
6.316LeuAsp: 6.316 ± 0.138
5.951LeuGlu: 5.951 ± 0.121
3.436LeuPhe: 3.436 ± 0.099
7.474LeuGly: 7.474 ± 0.148
1.758LeuHis: 1.758 ± 0.057
4.607LeuIle: 4.607 ± 0.098
3.44LeuLys: 3.44 ± 0.087
8.07LeuLeu: 8.07 ± 0.167
2.537LeuMet: 2.537 ± 0.076
2.736LeuAsn: 2.736 ± 0.072
4.044LeuPro: 4.044 ± 0.089
2.274LeuGln: 2.274 ± 0.072
5.099LeuArg: 5.099 ± 0.11
6.274LeuSer: 6.274 ± 0.124
5.075LeuThr: 5.075 ± 0.103
6.897LeuVal: 6.897 ± 0.14
0.744LeuTrp: 0.744 ± 0.037
2.163LeuTyr: 2.163 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
3.09MetAla: 3.09 ± 0.085
0.382MetCys: 0.382 ± 0.028
1.65MetAsp: 1.65 ± 0.053
1.396MetGlu: 1.396 ± 0.052
0.901MetPhe: 0.901 ± 0.041
2.377MetGly: 2.377 ± 0.07
0.594MetHis: 0.594 ± 0.037
1.372MetIle: 1.372 ± 0.055
1.202MetLys: 1.202 ± 0.051
2.551MetLeu: 2.551 ± 0.068
0.71MetMet: 0.71 ± 0.036
1.026MetAsn: 1.026 ± 0.047
1.482MetPro: 1.482 ± 0.052
0.946MetGln: 0.946 ± 0.043
1.813MetArg: 1.813 ± 0.064
1.813MetSer: 1.813 ± 0.06
1.529MetThr: 1.529 ± 0.045
1.824MetVal: 1.824 ± 0.068
0.223MetTrp: 0.223 ± 0.02
0.594MetTyr: 0.594 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
3.351AsnAla: 3.351 ± 0.096
0.443AsnCys: 0.443 ± 0.031
1.966AsnAsp: 1.966 ± 0.063
2.004AsnGlu: 2.004 ± 0.061
0.935AsnPhe: 0.935 ± 0.047
2.571AsnGly: 2.571 ± 0.092
0.657AsnHis: 0.657 ± 0.036
1.864AsnIle: 1.864 ± 0.06
1.347AsnLys: 1.347 ± 0.059
3.018AsnLeu: 3.018 ± 0.089
0.895AsnMet: 0.895 ± 0.044
1.02AsnAsn: 1.02 ± 0.052
1.82AsnPro: 1.82 ± 0.071
0.895AsnGln: 0.895 ± 0.043
1.737AsnArg: 1.737 ± 0.063
1.62AsnSer: 1.62 ± 0.072
1.625AsnThr: 1.625 ± 0.051
2.573AsnVal: 2.573 ± 0.067
0.32AsnTrp: 0.32 ± 0.022
0.831AsnTyr: 0.831 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
4.846ProAla: 4.846 ± 0.131
0.623ProCys: 0.623 ± 0.04
2.636ProAsp: 2.636 ± 0.066
3.323ProGlu: 3.323 ± 0.081
1.627ProPhe: 1.627 ± 0.059
3.154ProGly: 3.154 ± 0.081
0.855ProHis: 0.855 ± 0.044
2.089ProIle: 2.089 ± 0.063
1.576ProLys: 1.576 ± 0.063
3.525ProLeu: 3.525 ± 0.089
0.988ProMet: 0.988 ± 0.041
1.307ProAsn: 1.307 ± 0.046
0.973ProPro: 0.973 ± 0.054
1.525ProGln: 1.525 ± 0.056
2.172ProArg: 2.172 ± 0.07
2.556ProSer: 2.556 ± 0.074
2.248ProThr: 2.248 ± 0.07
3.588ProVal: 3.588 ± 0.07
0.462ProTrp: 0.462 ± 0.027
1.237ProTyr: 1.237 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
3.531GlnAla: 3.531 ± 0.103
0.293GlnCys: 0.293 ± 0.023
1.516GlnAsp: 1.516 ± 0.058
1.705GlnGlu: 1.705 ± 0.065
1.016GlnPhe: 1.016 ± 0.043
2.212GlnGly: 2.212 ± 0.07
0.634GlnHis: 0.634 ± 0.033
1.9GlnIle: 1.9 ± 0.065
1.395GlnLys: 1.395 ± 0.057
3.056GlnLeu: 3.056 ± 0.076
0.982GlnMet: 0.982 ± 0.05
1.06GlnAsn: 1.06 ± 0.043
1.177GlnPro: 1.177 ± 0.05
1.376GlnGln: 1.376 ± 0.068
1.974GlnArg: 1.974 ± 0.079
1.542GlnSer: 1.542 ± 0.066
1.811GlnThr: 1.811 ± 0.067
2.35GlnVal: 2.35 ± 0.07
0.263GlnTrp: 0.263 ± 0.023
0.761GlnTyr: 0.761 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
6.484ArgAla: 6.484 ± 0.151
0.956ArgCys: 0.956 ± 0.045
3.474ArgAsp: 3.474 ± 0.083
4.414ArgGlu: 4.414 ± 0.108
2.1ArgPhe: 2.1 ± 0.068
4.131ArgGly: 4.131 ± 0.096
1.315ArgHis: 1.315 ± 0.065
3.485ArgIle: 3.485 ± 0.092
2.254ArgLys: 2.254 ± 0.064
5.268ArgLeu: 5.268 ± 0.126
1.809ArgMet: 1.809 ± 0.063
1.623ArgAsn: 1.623 ± 0.052
2.195ArgPro: 2.195 ± 0.077
1.799ArgGln: 1.799 ± 0.063
4.407ArgArg: 4.407 ± 0.117
3.319ArgSer: 3.319 ± 0.096
2.829ArgThr: 2.829 ± 0.068
4.592ArgVal: 4.592 ± 0.102
0.539ArgTrp: 0.539 ± 0.035
1.799ArgTyr: 1.799 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
6.187SerAla: 6.187 ± 0.137
1.065SerCys: 1.065 ± 0.045
3.548SerAsp: 3.548 ± 0.098
3.238SerGlu: 3.238 ± 0.081
2.56SerPhe: 2.56 ± 0.071
4.997SerGly: 4.997 ± 0.112
1.296SerHis: 1.296 ± 0.055
3.51SerIle: 3.51 ± 0.083
2.411SerLys: 2.411 ± 0.072
5.593SerLeu: 5.593 ± 0.122
1.616SerMet: 1.616 ± 0.052
1.913SerAsn: 1.913 ± 0.068
2.254SerPro: 2.254 ± 0.066
1.811SerGln: 1.811 ± 0.058
3.368SerArg: 3.368 ± 0.083
4.231SerSer: 4.231 ± 0.149
3.306SerThr: 3.306 ± 0.091
4.515SerVal: 4.515 ± 0.091
0.638SerTrp: 0.638 ± 0.036
2.059SerTyr: 2.059 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
5.177ThrAla: 5.177 ± 0.111
0.978ThrCys: 0.978 ± 0.042
3.152ThrAsp: 3.152 ± 0.087
2.869ThrGlu: 2.869 ± 0.08
2.221ThrPhe: 2.221 ± 0.076
4.611ThrGly: 4.611 ± 0.103
1.215ThrHis: 1.215 ± 0.046
3.226ThrIle: 3.226 ± 0.081
2.036ThrLys: 2.036 ± 0.068
5.039ThrLeu: 5.039 ± 0.099
1.366ThrMet: 1.366 ± 0.047
1.548ThrAsn: 1.548 ± 0.051
2.933ThrPro: 2.933 ± 0.084
1.661ThrGln: 1.661 ± 0.059
2.863ThrArg: 2.863 ± 0.083
3.315ThrSer: 3.315 ± 0.091
2.982ThrThr: 2.982 ± 0.084
4.71ThrVal: 4.71 ± 0.111
0.52ThrTrp: 0.52 ± 0.034
1.684ThrTyr: 1.684 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
8.31ValAla: 8.31 ± 0.136
1.58ValCys: 1.58 ± 0.054
5.343ValAsp: 5.343 ± 0.107
5.096ValGlu: 5.096 ± 0.096
3.014ValPhe: 3.014 ± 0.084
5.476ValGly: 5.476 ± 0.106
1.434ValHis: 1.434 ± 0.056
4.439ValIle: 4.439 ± 0.099
3.031ValLys: 3.031 ± 0.084
7.325ValLeu: 7.325 ± 0.138
2.051ValMet: 2.051 ± 0.067
2.471ValAsn: 2.471 ± 0.077
3.518ValPro: 3.518 ± 0.082
1.885ValGln: 1.885 ± 0.066
4.498ValArg: 4.498 ± 0.099
5.075ValSer: 5.075 ± 0.103
4.422ValThr: 4.422 ± 0.111
6.46ValVal: 6.46 ± 0.132
0.677ValTrp: 0.677 ± 0.039
1.852ValTyr: 1.852 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.819TrpAla: 0.819 ± 0.047
0.21TrpCys: 0.21 ± 0.02
0.579TrpAsp: 0.579 ± 0.037
0.515TrpGlu: 0.515 ± 0.033
0.369TrpPhe: 0.369 ± 0.026
0.795TrpGly: 0.795 ± 0.039
0.221TrpHis: 0.221 ± 0.017
0.517TrpIle: 0.517 ± 0.033
0.367TrpLys: 0.367 ± 0.03
0.863TrpLeu: 0.863 ± 0.04
0.301TrpMet: 0.301 ± 0.027
0.397TrpAsn: 0.397 ± 0.027
0.348TrpPro: 0.348 ± 0.029
0.297TrpGln: 0.297 ± 0.025
0.588TrpArg: 0.588 ± 0.041
0.588TrpSer: 0.588 ± 0.037
0.484TrpThr: 0.484 ± 0.029
0.566TrpVal: 0.566 ± 0.035
0.129TrpTrp: 0.129 ± 0.016
0.269TrpTyr: 0.269 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.859TyrAla: 2.859 ± 0.08
0.445TyrCys: 0.445 ± 0.026
1.883TyrAsp: 1.883 ± 0.064
1.805TyrGlu: 1.805 ± 0.061
1.044TyrPhe: 1.044 ± 0.048
2.284TyrGly: 2.284 ± 0.069
0.626TyrHis: 0.626 ± 0.03
1.326TyrIle: 1.326 ± 0.045
0.925TyrLys: 0.925 ± 0.045
2.628TyrLeu: 2.628 ± 0.07
0.577TyrMet: 0.577 ± 0.039
0.91TyrAsn: 0.91 ± 0.048
1.177TyrPro: 1.177 ± 0.054
0.931TyrGln: 0.931 ± 0.051
1.765TyrArg: 1.765 ± 0.07
1.434TyrSer: 1.434 ± 0.051
1.631TyrThr: 1.631 ± 0.065
2.009TyrVal: 2.009 ± 0.061
0.276TyrTrp: 0.276 ± 0.026
0.895TyrTyr: 0.895 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.002XaaGlu: 0.002 ± 0.002
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.004XaaXaa: 0.004 ± 0.004
Statistics based on 1652 proteins (528494 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski