Amino acid dipepetide frequency for Hathewaya proteolytica DSM 3090

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.582AlaAla: 3.582 ± 0.085	0.801AlaCys: 0.801 ± 0.033	2.786AlaAsp: 2.786 ± 0.053	3.819AlaGlu: 3.819 ± 0.068	2.464AlaPhe: 2.464 ± 0.068	3.544AlaGly: 3.544 ± 0.08	0.779AlaHis: 0.779 ± 0.031	5.463AlaIle: 5.463 ± 0.088	4.593AlaLys: 4.593 ± 0.087	5.518AlaLeu: 5.518 ± 0.084	2.002AlaMet: 2.002 ± 0.051	2.367AlaAsn: 2.367 ± 0.049	1.351AlaPro: 1.351 ± 0.04	1.503AlaGln: 1.503 ± 0.045	1.985AlaArg: 1.985 ± 0.05	3.364AlaSer: 3.364 ± 0.067	2.798AlaThr: 2.798 ± 0.066	4.285AlaVal: 4.285 ± 0.086	0.383AlaTrp: 0.383 ± 0.023	2.294AlaTyr: 2.294 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.792CysAla: 0.792 ± 0.033	0.323CysCys: 0.323 ± 0.031	0.868CysAsp: 0.868 ± 0.035	1.055CysGlu: 1.055 ± 0.033	0.69CysPhe: 0.69 ± 0.029	1.357CysGly: 1.357 ± 0.043	0.34CysHis: 0.34 ± 0.022	1.412CysIle: 1.412 ± 0.045	1.26CysLys: 1.26 ± 0.044	1.003CysLeu: 1.003 ± 0.032	0.406CysMet: 0.406 ± 0.022	0.92CysAsn: 0.92 ± 0.037	0.549CysPro: 0.549 ± 0.028	0.365CysGln: 0.365 ± 0.02	0.521CysArg: 0.521 ± 0.025	1.088CysSer: 1.088 ± 0.037	0.765CysThr: 0.765 ± 0.033	0.97CysVal: 0.97 ± 0.033	0.091CysTrp: 0.091 ± 0.011	0.567CysTyr: 0.567 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	2.754AspAla: 2.754 ± 0.06	0.704AspCys: 0.704 ± 0.027	2.867AspAsp: 2.867 ± 0.065	4.869AspGlu: 4.869 ± 0.084	2.865AspPhe: 2.865 ± 0.064	3.268AspGly: 3.268 ± 0.078	0.66AspHis: 0.66 ± 0.024	5.805AspIle: 5.805 ± 0.082	5.481AspLys: 5.481 ± 0.091	4.638AspLeu: 4.638 ± 0.074	1.823AspMet: 1.823 ± 0.046	3.364AspAsn: 3.364 ± 0.064	1.225AspPro: 1.225 ± 0.041	0.797AspGln: 0.797 ± 0.031	1.838AspArg: 1.838 ± 0.052	3.225AspSer: 3.225 ± 0.059	2.655AspThr: 2.655 ± 0.065	3.923AspVal: 3.923 ± 0.075	0.339AspTrp: 0.339 ± 0.024	2.613AspTyr: 2.613 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.175GluAla: 4.175 ± 0.084	0.82GluCys: 0.82 ± 0.032	4.458GluAsp: 4.458 ± 0.075	7.139GluGlu: 7.139 ± 0.135	3.161GluPhe: 3.161 ± 0.066	3.957GluGly: 3.957 ± 0.074	1.091GluHis: 1.091 ± 0.036	6.649GluIle: 6.649 ± 0.107	8.023GluLys: 8.023 ± 0.12	6.951GluLeu: 6.951 ± 0.11	2.18GluMet: 2.18 ± 0.056	5.54GluAsn: 5.54 ± 0.083	1.576GluPro: 1.576 ± 0.047	2.35GluGln: 2.35 ± 0.053	2.647GluArg: 2.647 ± 0.06	3.767GluSer: 3.767 ± 0.078	2.981GluThr: 2.981 ± 0.051	4.597GluVal: 4.597 ± 0.082	0.423GluTrp: 0.423 ± 0.026	3.227GluTyr: 3.227 ± 0.072	0.0GluXaa: 0.0 ± 0.0
Phe	2.383PheAla: 2.383 ± 0.055	0.652PheCys: 0.652 ± 0.027	2.234PheAsp: 2.234 ± 0.054	2.526PheGlu: 2.526 ± 0.057	1.933PhePhe: 1.933 ± 0.059	2.715PheGly: 2.715 ± 0.073	0.681PheHis: 0.681 ± 0.028	4.146PheIle: 4.146 ± 0.077	3.744PheLys: 3.744 ± 0.068	3.757PheLeu: 3.757 ± 0.077	1.323PheMet: 1.323 ± 0.044	2.664PheAsn: 2.664 ± 0.068	1.173PhePro: 1.173 ± 0.039	1.305PheGln: 1.305 ± 0.041	1.408PheArg: 1.408 ± 0.043	3.145PheSer: 3.145 ± 0.067	2.375PheThr: 2.375 ± 0.058	2.79PheVal: 2.79 ± 0.065	0.291PheTrp: 0.291 ± 0.019	1.715PheTyr: 1.715 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.039GlyAla: 4.039 ± 0.074	1.057GlyCys: 1.057 ± 0.04	3.34GlyAsp: 3.34 ± 0.071	4.384GlyGlu: 4.384 ± 0.069	2.931GlyPhe: 2.931 ± 0.065	4.05GlyGly: 4.05 ± 0.093	1.052GlyHis: 1.052 ± 0.038	6.344GlyIle: 6.344 ± 0.102	5.77GlyLys: 5.77 ± 0.098	4.904GlyLeu: 4.904 ± 0.082	1.896GlyMet: 1.896 ± 0.055	3.421GlyAsn: 3.421 ± 0.085	1.087GlyPro: 1.087 ± 0.037	1.603GlyGln: 1.603 ± 0.044	2.429GlyArg: 2.429 ± 0.059	3.495GlySer: 3.495 ± 0.07	3.454GlyThr: 3.454 ± 0.069	4.636GlyVal: 4.636 ± 0.078	0.408GlyTrp: 0.408 ± 0.022	2.776GlyTyr: 2.776 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	0.653HisAla: 0.653 ± 0.026	0.324HisCys: 0.324 ± 0.023	0.778HisAsp: 0.778 ± 0.031	1.059HisGlu: 1.059 ± 0.036	0.63HisPhe: 0.63 ± 0.029	1.121HisGly: 1.121 ± 0.041	0.354HisHis: 0.354 ± 0.023	1.502HisIle: 1.502 ± 0.043	1.204HisLys: 1.204 ± 0.037	1.141HisLeu: 1.141 ± 0.036	0.431HisMet: 0.431 ± 0.022	0.895HisAsn: 0.895 ± 0.035	0.552HisPro: 0.552 ± 0.034	0.323HisGln: 0.323 ± 0.021	0.646HisArg: 0.646 ± 0.029	0.901HisSer: 0.901 ± 0.033	0.725HisThr: 0.725 ± 0.028	0.931HisVal: 0.931 ± 0.033	0.102HisTrp: 0.102 ± 0.011	0.556HisTyr: 0.556 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.393IleAla: 5.393 ± 0.081	1.679IleCys: 1.679 ± 0.045	5.303IleAsp: 5.303 ± 0.088	6.461IleGlu: 6.461 ± 0.107	3.775IlePhe: 3.775 ± 0.073	5.534IleGly: 5.534 ± 0.099	1.321IleHis: 1.321 ± 0.04	8.34IleIle: 8.34 ± 0.124	8.005IleLys: 8.005 ± 0.091	8.136IleLeu: 8.136 ± 0.098	2.685IleMet: 2.685 ± 0.057	5.509IleAsn: 5.509 ± 0.086	3.091IlePro: 3.091 ± 0.07	2.267IleGln: 2.267 ± 0.057	3.195IleArg: 3.195 ± 0.068	6.682IleSer: 6.682 ± 0.109	4.521IleThr: 4.521 ± 0.075	6.039IleVal: 6.039 ± 0.089	0.527IleTrp: 0.527 ± 0.027	3.316IleTyr: 3.316 ± 0.074	0.0IleXaa: 0.0 ± 0.0
Lys	4.901LysAla: 4.901 ± 0.088	1.108LysCys: 1.108 ± 0.039	5.725LysAsp: 5.725 ± 0.086	8.067LysGlu: 8.067 ± 0.11	3.097LysPhe: 3.097 ± 0.068	5.049LysGly: 5.049 ± 0.085	1.186LysHis: 1.186 ± 0.034	7.534LysIle: 7.534 ± 0.112	8.089LysLys: 8.089 ± 0.116	7.521LysLeu: 7.521 ± 0.096	2.628LysMet: 2.628 ± 0.059	6.229LysAsn: 6.229 ± 0.073	2.125LysPro: 2.125 ± 0.056	2.542LysGln: 2.542 ± 0.057	3.112LysArg: 3.112 ± 0.053	5.254LysSer: 5.254 ± 0.083	4.217LysThr: 4.217 ± 0.068	5.694LysVal: 5.694 ± 0.104	0.657LysTrp: 0.657 ± 0.031	4.14LysTyr: 4.14 ± 0.08	0.0LysXaa: 0.0 ± 0.0
Leu	4.678LeuAla: 4.678 ± 0.081	1.597LeuCys: 1.597 ± 0.047	4.764LeuAsp: 4.764 ± 0.076	5.978LeuGlu: 5.978 ± 0.105	3.482LeuPhe: 3.482 ± 0.075	5.664LeuGly: 5.664 ± 0.089	1.286LeuHis: 1.286 ± 0.049	7.066LeuIle: 7.066 ± 0.106	8.366LeuLys: 8.366 ± 0.106	7.538LeuLeu: 7.538 ± 0.126	2.641LeuMet: 2.641 ± 0.062	5.357LeuAsn: 5.357 ± 0.083	2.798LeuPro: 2.798 ± 0.061	2.651LeuGln: 2.651 ± 0.056	3.286LeuArg: 3.286 ± 0.068	6.685LeuSer: 6.685 ± 0.1	4.231LeuThr: 4.231 ± 0.069	5.336LeuVal: 5.336 ± 0.079	0.581LeuTrp: 0.581 ± 0.026	3.259LeuTyr: 3.259 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	2.017MetAla: 2.017 ± 0.056	0.444MetCys: 0.444 ± 0.024	2.135MetAsp: 2.135 ± 0.049	2.691MetGlu: 2.691 ± 0.064	1.067MetPhe: 1.067 ± 0.036	2.2MetGly: 2.2 ± 0.058	0.391MetHis: 0.391 ± 0.021	2.282MetIle: 2.282 ± 0.055	2.848MetLys: 2.848 ± 0.065	2.43MetLeu: 2.43 ± 0.057	0.852MetMet: 0.852 ± 0.036	1.781MetAsn: 1.781 ± 0.054	0.968MetPro: 0.968 ± 0.036	0.743MetGln: 0.743 ± 0.03	1.087MetArg: 1.087 ± 0.038	1.928MetSer: 1.928 ± 0.049	1.306MetThr: 1.306 ± 0.043	2.143MetVal: 2.143 ± 0.061	0.204MetTrp: 0.204 ± 0.016	1.085MetTyr: 1.085 ± 0.041	0.0MetXaa: 0.0 ± 0.0
Asn	2.888AsnAla: 2.888 ± 0.058	0.939AsnCys: 0.939 ± 0.032	2.831AsnAsp: 2.831 ± 0.069	4.129AsnGlu: 4.129 ± 0.071	2.377AsnPhe: 2.377 ± 0.051	3.699AsnGly: 3.699 ± 0.08	0.862AsnHis: 0.862 ± 0.033	6.52AsnIle: 6.52 ± 0.092	5.343AsnLys: 5.343 ± 0.091	5.231AsnLeu: 5.231 ± 0.085	2.06AsnMet: 2.06 ± 0.061	4.087AsnAsn: 4.087 ± 0.093	1.998AsnPro: 1.998 ± 0.054	1.434AsnGln: 1.434 ± 0.045	2.132AsnArg: 2.132 ± 0.049	3.839AsnSer: 3.839 ± 0.078	2.894AsnThr: 2.894 ± 0.061	3.876AsnVal: 3.876 ± 0.075	0.379AsnTrp: 0.379 ± 0.024	2.575AsnTyr: 2.575 ± 0.06	0.0AsnXaa: 0.0 ± 0.0
Pro	1.339ProAla: 1.339 ± 0.044	0.478ProCys: 0.478 ± 0.026	1.447ProAsp: 1.447 ± 0.046	2.262ProGlu: 2.262 ± 0.055	1.33ProPhe: 1.33 ± 0.036	1.639ProGly: 1.639 ± 0.045	0.481ProHis: 0.481 ± 0.025	2.31ProIle: 2.31 ± 0.06	2.125ProLys: 2.125 ± 0.049	2.406ProLeu: 2.406 ± 0.055	0.869ProMet: 0.869 ± 0.035	1.315ProAsn: 1.315 ± 0.039	0.611ProPro: 0.611 ± 0.026	0.893ProGln: 0.893 ± 0.034	0.876ProArg: 0.876 ± 0.032	1.769ProSer: 1.769 ± 0.045	1.488ProThr: 1.488 ± 0.044	2.194ProVal: 2.194 ± 0.056	0.235ProTrp: 0.235 ± 0.018	1.303ProTyr: 1.303 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.509GlnAla: 1.509 ± 0.042	0.608GlnCys: 0.608 ± 0.027	1.39GlnAsp: 1.39 ± 0.037	1.998GlnGlu: 1.998 ± 0.054	1.013GlnPhe: 1.013 ± 0.036	1.945GlnGly: 1.945 ± 0.053	0.42GlnHis: 0.42 ± 0.02	2.191GlnIle: 2.191 ± 0.053	2.104GlnLys: 2.104 ± 0.053	2.524GlnLeu: 2.524 ± 0.063	0.725GlnMet: 0.725 ± 0.032	1.592GlnAsn: 1.592 ± 0.043	0.635GlnPro: 0.635 ± 0.03	0.959GlnGln: 0.959 ± 0.039	1.166GlnArg: 1.166 ± 0.041	1.574GlnSer: 1.574 ± 0.049	0.949GlnThr: 0.949 ± 0.037	1.676GlnVal: 1.676 ± 0.042	0.287GlnTrp: 0.287 ± 0.018	1.358GlnTyr: 1.358 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	1.969ArgAla: 1.969 ± 0.05	0.503ArgCys: 0.503 ± 0.026	2.071ArgAsp: 2.071 ± 0.053	3.302ArgGlu: 3.302 ± 0.068	1.514ArgPhe: 1.514 ± 0.043	2.172ArgGly: 2.172 ± 0.055	0.481ArgHis: 0.481 ± 0.025	3.317ArgIle: 3.317 ± 0.064	3.259ArgLys: 3.259 ± 0.067	2.945ArgLeu: 2.945 ± 0.068	1.085ArgMet: 1.085 ± 0.036	2.168ArgAsn: 2.168 ± 0.049	0.869ArgPro: 0.869 ± 0.032	1.123ArgGln: 1.123 ± 0.036	1.674ArgArg: 1.674 ± 0.05	1.689ArgSer: 1.689 ± 0.048	1.567ArgThr: 1.567 ± 0.043	2.399ArgVal: 2.399 ± 0.054	0.258ArgTrp: 0.258 ± 0.016	1.545ArgTyr: 1.545 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.229SerAla: 3.229 ± 0.061	0.862SerCys: 0.862 ± 0.033	3.089SerAsp: 3.089 ± 0.065	4.282SerGlu: 4.282 ± 0.073	2.906SerPhe: 2.906 ± 0.066	4.238SerGly: 4.238 ± 0.073	1.024SerHis: 1.024 ± 0.04	6.153SerIle: 6.153 ± 0.104	5.378SerLys: 5.378 ± 0.091	5.728SerLeu: 5.728 ± 0.097	2.138SerMet: 2.138 ± 0.049	3.582SerAsn: 3.582 ± 0.074	1.677SerPro: 1.677 ± 0.049	1.904SerGln: 1.904 ± 0.044	2.201SerArg: 2.201 ± 0.053	4.346SerSer: 4.346 ± 0.079	3.205SerThr: 3.205 ± 0.068	4.241SerVal: 4.241 ± 0.07	0.433SerTrp: 0.433 ± 0.026	2.694SerTyr: 2.694 ± 0.07	0.0SerXaa: 0.0 ± 0.0
Thr	2.95ThrAla: 2.95 ± 0.074	0.629ThrCys: 0.629 ± 0.029	2.448ThrAsp: 2.448 ± 0.059	3.335ThrGlu: 3.335 ± 0.063	2.254ThrPhe: 2.254 ± 0.06	3.594ThrGly: 3.594 ± 0.07	0.734ThrHis: 0.734 ± 0.03	4.388ThrIle: 4.388 ± 0.076	3.487ThrLys: 3.487 ± 0.068	4.727ThrLeu: 4.727 ± 0.086	1.388ThrMet: 1.388 ± 0.036	2.387ThrAsn: 2.387 ± 0.053	1.731ThrPro: 1.731 ± 0.048	1.129ThrGln: 1.129 ± 0.039	1.581ThrArg: 1.581 ± 0.044	3.11ThrSer: 3.11 ± 0.073	2.736ThrThr: 2.736 ± 0.065	3.81ThrVal: 3.81 ± 0.074	0.349ThrTrp: 0.349 ± 0.023	2.056ThrTyr: 2.056 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	3.986ValAla: 3.986 ± 0.085	1.042ValCys: 1.042 ± 0.04	4.123ValAsp: 4.123 ± 0.075	4.954ValGlu: 4.954 ± 0.085	3.106ValPhe: 3.106 ± 0.055	4.225ValGly: 4.225 ± 0.078	0.892ValHis: 0.892 ± 0.034	5.984ValIle: 5.984 ± 0.092	5.654ValLys: 5.654 ± 0.089	6.095ValLeu: 6.095 ± 0.084	2.023ValMet: 2.023 ± 0.047	3.622ValAsn: 3.622 ± 0.077	2.029ValPro: 2.029 ± 0.052	1.652ValGln: 1.652 ± 0.046	2.236ValArg: 2.236 ± 0.051	4.416ValSer: 4.416 ± 0.08	3.498ValThr: 3.498 ± 0.075	4.944ValVal: 4.944 ± 0.095	0.444ValTrp: 0.444 ± 0.022	2.553ValTyr: 2.553 ± 0.069	0.0ValXaa: 0.0 ± 0.0
Trp	0.396TrpAla: 0.396 ± 0.023	0.118TrpCys: 0.118 ± 0.01	0.397TrpAsp: 0.397 ± 0.026	0.437TrpGlu: 0.437 ± 0.025	0.323TrpPhe: 0.323 ± 0.019	0.474TrpGly: 0.474 ± 0.025	0.119TrpHis: 0.119 ± 0.012	0.529TrpIle: 0.529 ± 0.029	0.543TrpLys: 0.543 ± 0.03	0.558TrpLeu: 0.558 ± 0.027	0.229TrpMet: 0.229 ± 0.017	0.442TrpAsn: 0.442 ± 0.022	0.156TrpPro: 0.156 ± 0.014	0.265TrpGln: 0.265 ± 0.018	0.293TrpArg: 0.293 ± 0.02	0.417TrpSer: 0.417 ± 0.021	0.324TrpThr: 0.324 ± 0.022	0.393TrpVal: 0.393 ± 0.023	0.084TrpTrp: 0.084 ± 0.01	0.273TrpTyr: 0.273 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.046TyrAla: 2.046 ± 0.045	0.654TyrCys: 0.654 ± 0.029	2.657TyrAsp: 2.657 ± 0.075	2.967TyrGlu: 2.967 ± 0.069	2.041TyrPhe: 2.041 ± 0.051	2.629TyrGly: 2.629 ± 0.06	0.672TyrHis: 0.672 ± 0.034	3.839TyrIle: 3.839 ± 0.078	3.601TyrLys: 3.601 ± 0.066	3.494TyrLeu: 3.494 ± 0.078	1.216TyrMet: 1.216 ± 0.039	2.853TyrAsn: 2.853 ± 0.066	1.169TyrPro: 1.169 ± 0.039	0.815TyrGln: 0.815 ± 0.033	1.598TyrArg: 1.598 ± 0.051	2.619TyrSer: 2.619 ± 0.058	2.136TyrThr: 2.136 ± 0.053	2.603TyrVal: 2.603 ± 0.057	0.294TyrTrp: 0.294 ± 0.02	1.896TyrTyr: 1.896 ± 0.057	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2678 proteins (832864 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---