Amino acid dipepetide frequency for Mycobacterium grossiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.191AlaAla: 22.191 ± 0.184
0.97AlaCys: 0.97 ± 0.026
9.504AlaAsp: 9.504 ± 0.08
7.854AlaGlu: 7.854 ± 0.095
3.709AlaPhe: 3.709 ± 0.047
12.158AlaGly: 12.158 ± 0.072
2.745AlaHis: 2.745 ± 0.043
5.109AlaIle: 5.109 ± 0.054
2.842AlaLys: 2.842 ± 0.047
13.945AlaLeu: 13.945 ± 0.113
2.881AlaMet: 2.881 ± 0.047
2.46AlaAsn: 2.46 ± 0.041
6.795AlaPro: 6.795 ± 0.078
3.625AlaGln: 3.625 ± 0.051
9.396AlaArg: 9.396 ± 0.099
6.22AlaSer: 6.22 ± 0.066
8.109AlaThr: 8.109 ± 0.069
12.789AlaVal: 12.789 ± 0.115
1.814AlaTrp: 1.814 ± 0.034
2.416AlaTyr: 2.416 ± 0.031
0.0AlaXaa: 0.0 ± 0.0
Cys
1.048CysAla: 1.048 ± 0.028
0.085CysCys: 0.085 ± 0.008
0.497CysAsp: 0.497 ± 0.017
0.355CysGlu: 0.355 ± 0.014
0.215CysPhe: 0.215 ± 0.012
0.86CysGly: 0.86 ± 0.024
0.171CysHis: 0.171 ± 0.011
0.245CysIle: 0.245 ± 0.012
0.091CysLys: 0.091 ± 0.007
0.641CysLeu: 0.641 ± 0.019
0.112CysMet: 0.112 ± 0.008
0.133CysAsn: 0.133 ± 0.009
0.47CysPro: 0.47 ± 0.015
0.183CysGln: 0.183 ± 0.013
0.548CysArg: 0.548 ± 0.017
0.437CysSer: 0.437 ± 0.017
0.502CysThr: 0.502 ± 0.018
0.643CysVal: 0.643 ± 0.019
0.128CysTrp: 0.128 ± 0.01
0.177CysTyr: 0.177 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
9.473AspAla: 9.473 ± 0.095
0.443AspCys: 0.443 ± 0.016
4.92AspAsp: 4.92 ± 0.071
4.224AspGlu: 4.224 ± 0.055
1.832AspPhe: 1.832 ± 0.031
6.682AspGly: 6.682 ± 0.077
1.516AspHis: 1.516 ± 0.03
1.972AspIle: 1.972 ± 0.033
1.014AspLys: 1.014 ± 0.029
6.615AspLeu: 6.615 ± 0.07
0.997AspMet: 0.997 ± 0.024
0.955AspAsn: 0.955 ± 0.025
4.627AspPro: 4.627 ± 0.056
1.627AspGln: 1.627 ± 0.033
4.909AspArg: 4.909 ± 0.055
2.394AspSer: 2.394 ± 0.043
3.273AspThr: 3.273 ± 0.045
6.882AspVal: 6.882 ± 0.074
0.972AspTrp: 0.972 ± 0.029
1.5AspTyr: 1.5 ± 0.033
0.0AspXaa: 0.0 ± 0.0
Glu
6.124GluAla: 6.124 ± 0.071
0.343GluCys: 0.343 ± 0.014
2.562GluAsp: 2.562 ± 0.047
2.404GluGlu: 2.404 ± 0.048
1.665GluPhe: 1.665 ± 0.034
3.262GluGly: 3.262 ± 0.046
1.501GluHis: 1.501 ± 0.031
2.363GluIle: 2.363 ± 0.04
1.229GluLys: 1.229 ± 0.027
5.707GluLeu: 5.707 ± 0.072
1.013GluMet: 1.013 ± 0.025
0.986GluAsn: 0.986 ± 0.024
2.945GluPro: 2.945 ± 0.044
1.994GluGln: 1.994 ± 0.036
4.678GluArg: 4.678 ± 0.056
2.403GluSer: 2.403 ± 0.038
2.645GluThr: 2.645 ± 0.043
4.536GluVal: 4.536 ± 0.058
0.731GluTrp: 0.731 ± 0.019
1.075GluTyr: 1.075 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.212PheAla: 4.212 ± 0.051
0.304PheCys: 0.304 ± 0.013
2.522PheAsp: 2.522 ± 0.038
1.381PheGlu: 1.381 ± 0.029
0.956PhePhe: 0.956 ± 0.026
3.44PheGly: 3.44 ± 0.057
0.621PheHis: 0.621 ± 0.02
0.962PheIle: 0.962 ± 0.024
0.456PheLys: 0.456 ± 0.019
2.543PheLeu: 2.543 ± 0.042
0.467PheMet: 0.467 ± 0.019
0.643PheAsn: 0.643 ± 0.018
1.37PhePro: 1.37 ± 0.03
0.618PheGln: 0.618 ± 0.019
1.662PheArg: 1.662 ± 0.03
1.548PheSer: 1.548 ± 0.031
2.139PheThr: 2.139 ± 0.04
2.683PheVal: 2.683 ± 0.046
0.452PheTrp: 0.452 ± 0.015
0.676PheTyr: 0.676 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
10.817GlyAla: 10.817 ± 0.099
0.774GlyCys: 0.774 ± 0.021
5.507GlyAsp: 5.507 ± 0.048
4.308GlyGlu: 4.308 ± 0.054
2.988GlyPhe: 2.988 ± 0.042
8.119GlyGly: 8.119 ± 0.101
2.077GlyHis: 2.077 ± 0.039
3.943GlyIle: 3.943 ± 0.05
1.966GlyLys: 1.966 ± 0.039
8.725GlyLeu: 8.725 ± 0.083
2.105GlyMet: 2.105 ± 0.036
1.839GlyAsn: 1.839 ± 0.04
4.575GlyPro: 4.575 ± 0.058
2.63GlyGln: 2.63 ± 0.037
6.728GlyArg: 6.728 ± 0.063
5.006GlySer: 5.006 ± 0.057
5.807GlyThr: 5.807 ± 0.079
7.987GlyVal: 7.987 ± 0.072
1.67GlyTrp: 1.67 ± 0.03
2.338GlyTyr: 2.338 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.642HisAla: 2.642 ± 0.043
0.205HisCys: 0.205 ± 0.011
1.528HisAsp: 1.528 ± 0.028
0.967HisGlu: 0.967 ± 0.027
0.653HisPhe: 0.653 ± 0.018
2.273HisGly: 2.273 ± 0.039
0.68HisHis: 0.68 ± 0.023
0.583HisIle: 0.583 ± 0.02
0.265HisLys: 0.265 ± 0.013
2.222HisLeu: 2.222 ± 0.038
0.325HisMet: 0.325 ± 0.014
0.366HisAsn: 0.366 ± 0.014
1.708HisPro: 1.708 ± 0.03
0.628HisGln: 0.628 ± 0.02
2.017HisArg: 2.017 ± 0.039
0.913HisSer: 0.913 ± 0.022
1.099HisThr: 1.099 ± 0.026
2.096HisVal: 2.096 ± 0.035
0.371HisTrp: 0.371 ± 0.014
0.531HisTyr: 0.531 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
6.12IleAla: 6.12 ± 0.058
0.306IleCys: 0.306 ± 0.015
3.184IleAsp: 3.184 ± 0.04
2.249IleGlu: 2.249 ± 0.041
0.895IlePhe: 0.895 ± 0.027
4.266IleGly: 4.266 ± 0.056
0.644IleHis: 0.644 ± 0.019
1.193IleIle: 1.193 ± 0.033
0.746IleLys: 0.746 ± 0.024
2.803IleLeu: 2.803 ± 0.039
0.5IleMet: 0.5 ± 0.017
0.927IleAsn: 0.927 ± 0.025
2.092IlePro: 2.092 ± 0.039
0.792IleGln: 0.792 ± 0.023
2.449IleArg: 2.449 ± 0.035
1.862IleSer: 1.862 ± 0.031
2.588IleThr: 2.588 ± 0.035
3.57IleVal: 3.57 ± 0.048
0.408IleTrp: 0.408 ± 0.017
0.653IleTyr: 0.653 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.471LysAla: 2.471 ± 0.052
0.102LysCys: 0.102 ± 0.008
1.083LysAsp: 1.083 ± 0.026
0.837LysGlu: 0.837 ± 0.027
0.487LysPhe: 0.487 ± 0.02
1.409LysGly: 1.409 ± 0.031
0.408LysHis: 0.408 ± 0.015
0.832LysIle: 0.832 ± 0.026
0.593LysLys: 0.593 ± 0.027
1.895LysLeu: 1.895 ± 0.039
0.39LysMet: 0.39 ± 0.016
0.424LysAsn: 0.424 ± 0.017
1.234LysPro: 1.234 ± 0.028
0.625LysGln: 0.625 ± 0.02
1.425LysArg: 1.425 ± 0.034
1.058LysSer: 1.058 ± 0.025
1.28LysThr: 1.28 ± 0.031
1.72LysVal: 1.72 ± 0.034
0.264LysTrp: 0.264 ± 0.013
0.41LysTyr: 0.41 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
14.63LeuAla: 14.63 ± 0.114
0.733LeuCys: 0.733 ± 0.022
6.855LeuAsp: 6.855 ± 0.069
4.238LeuGlu: 4.238 ± 0.056
2.646LeuPhe: 2.646 ± 0.045
9.03LeuGly: 9.03 ± 0.088
2.08LeuHis: 2.08 ± 0.037
3.683LeuIle: 3.683 ± 0.047
1.599LeuLys: 1.599 ± 0.032
9.869LeuLeu: 9.869 ± 0.115
1.557LeuMet: 1.557 ± 0.028
1.92LeuAsn: 1.92 ± 0.033
5.865LeuPro: 5.865 ± 0.067
2.333LeuGln: 2.333 ± 0.038
7.922LeuArg: 7.922 ± 0.077
5.248LeuSer: 5.248 ± 0.054
6.535LeuThr: 6.535 ± 0.075
8.869LeuVal: 8.869 ± 0.084
1.219LeuTrp: 1.219 ± 0.026
1.629LeuTyr: 1.629 ± 0.031
0.0LeuXaa: 0.0 ± 0.0
Met
2.57MetAla: 2.57 ± 0.041
0.158MetCys: 0.158 ± 0.009
0.842MetAsp: 0.842 ± 0.022
0.636MetGlu: 0.636 ± 0.022
0.566MetPhe: 0.566 ± 0.019
1.433MetGly: 1.433 ± 0.029
0.399MetHis: 0.399 ± 0.015
0.813MetIle: 0.813 ± 0.024
0.388MetLys: 0.388 ± 0.015
1.946MetLeu: 1.946 ± 0.038
0.387MetMet: 0.387 ± 0.016
0.449MetAsn: 0.449 ± 0.016
1.184MetPro: 1.184 ± 0.029
0.496MetGln: 0.496 ± 0.019
1.475MetArg: 1.475 ± 0.032
1.487MetSer: 1.487 ± 0.029
1.835MetThr: 1.835 ± 0.034
1.544MetVal: 1.544 ± 0.032
0.241MetTrp: 0.241 ± 0.013
0.312MetTyr: 0.312 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.627AsnAla: 2.627 ± 0.043
0.155AsnCys: 0.155 ± 0.01
1.222AsnAsp: 1.222 ± 0.029
0.857AsnGlu: 0.857 ± 0.025
0.559AsnPhe: 0.559 ± 0.02
1.926AsnGly: 1.926 ± 0.038
0.415AsnHis: 0.415 ± 0.016
0.657AsnIle: 0.657 ± 0.021
0.379AsnLys: 0.379 ± 0.014
1.913AsnLeu: 1.913 ± 0.034
0.345AsnMet: 0.345 ± 0.014
0.447AsnAsn: 0.447 ± 0.019
1.536AsnPro: 1.536 ± 0.033
0.571AsnGln: 0.571 ± 0.019
1.398AsnArg: 1.398 ± 0.029
0.877AsnSer: 0.877 ± 0.025
1.183AsnThr: 1.183 ± 0.027
1.842AsnVal: 1.842 ± 0.032
0.316AsnTrp: 0.316 ± 0.014
0.502AsnTyr: 0.502 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
7.636ProAla: 7.636 ± 0.078
0.313ProCys: 0.313 ± 0.014
4.576ProAsp: 4.576 ± 0.053
3.462ProGlu: 3.462 ± 0.049
1.667ProPhe: 1.667 ± 0.031
5.648ProGly: 5.648 ± 0.063
1.316ProHis: 1.316 ± 0.026
1.951ProIle: 1.951 ± 0.034
1.088ProLys: 1.088 ± 0.024
5.025ProLeu: 5.025 ± 0.06
1.164ProMet: 1.164 ± 0.026
1.21ProAsn: 1.21 ± 0.026
3.802ProPro: 3.802 ± 0.076
1.602ProGln: 1.602 ± 0.033
3.591ProArg: 3.591 ± 0.045
3.131ProSer: 3.131 ± 0.047
3.697ProThr: 3.697 ± 0.058
5.182ProVal: 5.182 ± 0.065
0.884ProTrp: 0.884 ± 0.025
1.119ProTyr: 1.119 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.331GlnAla: 3.331 ± 0.053
0.203GlnCys: 0.203 ± 0.011
1.188GlnAsp: 1.188 ± 0.027
1.026GlnGlu: 1.026 ± 0.025
0.893GlnPhe: 0.893 ± 0.022
1.892GlnGly: 1.892 ± 0.036
0.643GlnHis: 0.643 ± 0.016
1.274GlnIle: 1.274 ± 0.025
0.541GlnLys: 0.541 ± 0.019
3.022GlnLeu: 3.022 ± 0.04
0.595GlnMet: 0.595 ± 0.02
0.578GlnAsn: 0.578 ± 0.015
1.713GlnPro: 1.713 ± 0.033
1.216GlnGln: 1.216 ± 0.031
2.712GlnArg: 2.712 ± 0.042
1.344GlnSer: 1.344 ± 0.03
1.504GlnThr: 1.504 ± 0.032
2.22GlnVal: 2.22 ± 0.038
0.57GlnTrp: 0.57 ± 0.02
0.654GlnTyr: 0.654 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.933ArgAla: 8.933 ± 0.088
0.559ArgCys: 0.559 ± 0.018
4.714ArgAsp: 4.714 ± 0.058
3.813ArgGlu: 3.813 ± 0.047
2.452ArgPhe: 2.452 ± 0.038
5.418ArgGly: 5.418 ± 0.062
1.887ArgHis: 1.887 ± 0.038
3.497ArgIle: 3.497 ± 0.047
1.382ArgLys: 1.382 ± 0.036
7.584ArgLeu: 7.584 ± 0.081
1.785ArgMet: 1.785 ± 0.028
1.54ArgAsn: 1.54 ± 0.03
4.183ArgPro: 4.183 ± 0.052
2.255ArgGln: 2.255 ± 0.037
7.289ArgArg: 7.289 ± 0.091
4.044ArgSer: 4.044 ± 0.045
4.765ArgThr: 4.765 ± 0.053
5.928ArgVal: 5.928 ± 0.068
1.35ArgTrp: 1.35 ± 0.029
1.821ArgTyr: 1.821 ± 0.035
0.0ArgXaa: 0.0 ± 0.0
Ser
6.891SerAla: 6.891 ± 0.065
0.38SerCys: 0.38 ± 0.016
3.162SerAsp: 3.162 ± 0.048
2.302SerGlu: 2.302 ± 0.035
1.569SerPhe: 1.569 ± 0.031
5.463SerGly: 5.463 ± 0.054
0.973SerHis: 0.973 ± 0.023
2.024SerIle: 2.024 ± 0.035
1.005SerLys: 1.005 ± 0.022
4.43SerLeu: 4.43 ± 0.055
1.235SerMet: 1.235 ± 0.028
0.963SerAsn: 0.963 ± 0.023
2.915SerPro: 2.915 ± 0.042
1.32SerGln: 1.32 ± 0.031
3.542SerArg: 3.542 ± 0.042
3.022SerSer: 3.022 ± 0.057
3.406SerThr: 3.406 ± 0.055
4.332SerVal: 4.332 ± 0.053
0.86SerTrp: 0.86 ± 0.021
1.125SerTyr: 1.125 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
8.674ThrAla: 8.674 ± 0.079
0.402ThrCys: 0.402 ± 0.016
4.079ThrAsp: 4.079 ± 0.047
3.09ThrGlu: 3.09 ± 0.043
1.92ThrPhe: 1.92 ± 0.039
6.048ThrGly: 6.048 ± 0.075
1.238ThrHis: 1.238 ± 0.027
2.352ThrIle: 2.352 ± 0.043
1.172ThrLys: 1.172 ± 0.033
5.854ThrLeu: 5.854 ± 0.06
1.183ThrMet: 1.183 ± 0.028
1.161ThrAsn: 1.161 ± 0.026
4.179ThrPro: 4.179 ± 0.053
1.392ThrGln: 1.392 ± 0.031
3.986ThrArg: 3.986 ± 0.055
3.42ThrSer: 3.42 ± 0.049
4.232ThrThr: 4.232 ± 0.075
6.456ThrVal: 6.456 ± 0.078
0.931ThrTrp: 0.931 ± 0.025
1.34ThrTyr: 1.34 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
12.918ValAla: 12.918 ± 0.116
0.737ValCys: 0.737 ± 0.025
6.553ValAsp: 6.553 ± 0.07
4.527ValGlu: 4.527 ± 0.054
2.704ValPhe: 2.704 ± 0.042
7.498ValGly: 7.498 ± 0.079
1.946ValHis: 1.946 ± 0.037
3.716ValIle: 3.716 ± 0.055
1.566ValLys: 1.566 ± 0.04
9.688ValLeu: 9.688 ± 0.081
1.549ValMet: 1.549 ± 0.033
1.933ValAsn: 1.933 ± 0.037
4.881ValPro: 4.881 ± 0.055
1.954ValGln: 1.954 ± 0.034
6.38ValArg: 6.38 ± 0.068
4.598ValSer: 4.598 ± 0.053
6.378ValThr: 6.378 ± 0.089
9.43ValVal: 9.43 ± 0.088
1.055ValTrp: 1.055 ± 0.026
1.667ValTyr: 1.667 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.618TrpAla: 1.618 ± 0.031
0.158TrpCys: 0.158 ± 0.01
0.85TrpAsp: 0.85 ± 0.03
0.613TrpGlu: 0.613 ± 0.02
0.539TrpPhe: 0.539 ± 0.019
0.991TrpGly: 0.991 ± 0.025
0.368TrpHis: 0.368 ± 0.016
0.611TrpIle: 0.611 ± 0.02
0.288TrpLys: 0.288 ± 0.012
1.773TrpLeu: 1.773 ± 0.039
0.31TrpMet: 0.31 ± 0.015
0.409TrpAsn: 0.409 ± 0.016
0.85TrpPro: 0.85 ± 0.023
0.596TrpGln: 0.596 ± 0.016
1.297TrpArg: 1.297 ± 0.028
0.925TrpSer: 0.925 ± 0.023
0.957TrpThr: 0.957 ± 0.024
1.107TrpVal: 1.107 ± 0.025
0.354TrpTrp: 0.354 ± 0.017
0.316TrpTyr: 0.316 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.607TyrAla: 2.607 ± 0.038
0.21TyrCys: 0.21 ± 0.01
1.48TyrAsp: 1.48 ± 0.034
1.023TyrGlu: 1.023 ± 0.024
0.744TyrPhe: 0.744 ± 0.021
2.094TyrGly: 2.094 ± 0.039
0.443TyrHis: 0.443 ± 0.016
0.468TyrIle: 0.468 ± 0.016
0.338TyrLys: 0.338 ± 0.014
2.259TyrLeu: 2.259 ± 0.041
0.264TyrMet: 0.264 ± 0.011
0.382TyrAsn: 0.382 ± 0.016
1.139TyrPro: 1.139 ± 0.032
0.66TyrGln: 0.66 ± 0.025
1.796TyrArg: 1.796 ± 0.035
0.985TyrSer: 0.985 ± 0.025
1.172TyrThr: 1.172 ± 0.03
1.857TyrVal: 1.857 ± 0.031
0.342TyrTrp: 0.342 ± 0.013
0.477TyrTyr: 0.477 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5542 proteins (1755592 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski