Amino acid dipepetide frequency for Glycocaulis alkaliphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.766AlaAla: 18.766 ± 0.22	1.207AlaCys: 1.207 ± 0.041	7.78AlaAsp: 7.78 ± 0.097	8.327AlaGlu: 8.327 ± 0.127	5.056AlaPhe: 5.056 ± 0.08	13.099AlaGly: 13.099 ± 0.154	2.535AlaHis: 2.535 ± 0.061	6.275AlaIle: 6.275 ± 0.104	3.293AlaLys: 3.293 ± 0.084	15.633AlaLeu: 15.633 ± 0.193	3.641AlaMet: 3.641 ± 0.067	3.038AlaAsn: 3.038 ± 0.064	6.316AlaPro: 6.316 ± 0.113	4.036AlaGln: 4.036 ± 0.076	11.377AlaArg: 11.377 ± 0.147	7.521AlaSer: 7.521 ± 0.104	4.86AlaThr: 4.86 ± 0.089	8.884AlaVal: 8.884 ± 0.108	1.518AlaTrp: 1.518 ± 0.05	2.622AlaTyr: 2.622 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.977CysAla: 0.977 ± 0.035	0.073CysCys: 0.073 ± 0.009	0.462CysAsp: 0.462 ± 0.022	0.465CysGlu: 0.465 ± 0.023	0.258CysPhe: 0.258 ± 0.017	0.8CysGly: 0.8 ± 0.032	0.166CysHis: 0.166 ± 0.014	0.28CysIle: 0.28 ± 0.017	0.147CysLys: 0.147 ± 0.013	0.676CysLeu: 0.676 ± 0.026	0.12CysMet: 0.12 ± 0.012	0.18CysAsn: 0.18 ± 0.016	0.432CysPro: 0.432 ± 0.022	0.212CysGln: 0.212 ± 0.016	0.479CysArg: 0.479 ± 0.022	0.392CysSer: 0.392 ± 0.018	0.341CysThr: 0.341 ± 0.021	0.598CysVal: 0.598 ± 0.024	0.092CysTrp: 0.092 ± 0.011	0.14CysTyr: 0.14 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.921AspAla: 7.921 ± 0.1	0.42AspCys: 0.42 ± 0.025	3.279AspAsp: 3.279 ± 0.072	3.948AspGlu: 3.948 ± 0.076	2.148AspPhe: 2.148 ± 0.048	5.782AspGly: 5.782 ± 0.091	1.204AspHis: 1.204 ± 0.043	2.967AspIle: 2.967 ± 0.054	1.2AspLys: 1.2 ± 0.04	5.407AspLeu: 5.407 ± 0.082	1.524AspMet: 1.524 ± 0.043	1.282AspAsn: 1.282 ± 0.041	3.735AspPro: 3.735 ± 0.062	1.564AspGln: 1.564 ± 0.041	4.102AspArg: 4.102 ± 0.069	2.426AspSer: 2.426 ± 0.05	3.01AspThr: 3.01 ± 0.061	4.135AspVal: 4.135 ± 0.074	1.009AspTrp: 1.009 ± 0.034	1.502AspTyr: 1.502 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	9.935GluAla: 9.935 ± 0.138	0.3GluCys: 0.3 ± 0.016	3.344GluAsp: 3.344 ± 0.076	3.792GluGlu: 3.792 ± 0.078	1.823GluPhe: 1.823 ± 0.044	5.371GluGly: 5.371 ± 0.081	1.212GluHis: 1.212 ± 0.033	3.384GluIle: 3.384 ± 0.072	1.888GluLys: 1.888 ± 0.052	5.754GluLeu: 5.754 ± 0.09	1.568GluMet: 1.568 ± 0.042	1.619GluAsn: 1.619 ± 0.044	3.065GluPro: 3.065 ± 0.076	1.958GluGln: 1.958 ± 0.055	5.98GluArg: 5.98 ± 0.103	2.676GluSer: 2.676 ± 0.061	4.062GluThr: 4.062 ± 0.08	3.716GluVal: 3.716 ± 0.075	0.77GluTrp: 0.77 ± 0.027	1.135GluTyr: 1.135 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	5.091PheAla: 5.091 ± 0.084	0.306PheCys: 0.306 ± 0.02	2.82PheAsp: 2.82 ± 0.064	2.465PheGlu: 2.465 ± 0.056	1.371PhePhe: 1.371 ± 0.05	3.516PheGly: 3.516 ± 0.067	0.724PheHis: 0.724 ± 0.028	1.771PheIle: 1.771 ± 0.042	0.812PheLys: 0.812 ± 0.032	3.34PheLeu: 3.34 ± 0.061	0.795PheMet: 0.795 ± 0.03	1.141PheAsn: 1.141 ± 0.038	1.508PhePro: 1.508 ± 0.04	0.941PheGln: 0.941 ± 0.031	2.109PheArg: 2.109 ± 0.049	2.252PheSer: 2.252 ± 0.054	2.202PheThr: 2.202 ± 0.048	2.609PheVal: 2.609 ± 0.059	0.504PheTrp: 0.504 ± 0.026	0.821PheTyr: 0.821 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	10.889GlyAla: 10.889 ± 0.146	0.646GlyCys: 0.646 ± 0.03	4.919GlyAsp: 4.919 ± 0.08	6.298GlyGlu: 6.298 ± 0.096	3.879GlyPhe: 3.879 ± 0.073	8.143GlyGly: 8.143 ± 0.214	1.936GlyHis: 1.936 ± 0.058	4.066GlyIle: 4.066 ± 0.073	2.679GlyLys: 2.679 ± 0.067	9.25GlyLeu: 9.25 ± 0.124	2.264GlyMet: 2.264 ± 0.057	2.07GlyAsn: 2.07 ± 0.063	3.938GlyPro: 3.938 ± 0.078	2.992GlyGln: 2.992 ± 0.061	6.541GlyArg: 6.541 ± 0.103	4.775GlySer: 4.775 ± 0.092	4.185GlyThr: 4.185 ± 0.088	6.684GlyVal: 6.684 ± 0.098	1.527GlyTrp: 1.527 ± 0.044	2.183GlyTyr: 2.183 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.583HisAla: 2.583 ± 0.065	0.194HisCys: 0.194 ± 0.013	1.21HisAsp: 1.21 ± 0.043	1.101HisGlu: 1.101 ± 0.032	0.797HisPhe: 0.797 ± 0.032	1.917HisGly: 1.917 ± 0.059	0.503HisHis: 0.503 ± 0.025	0.921HisIle: 0.921 ± 0.033	0.425HisLys: 0.425 ± 0.022	1.857HisLeu: 1.857 ± 0.045	0.444HisMet: 0.444 ± 0.024	0.463HisAsn: 0.463 ± 0.019	1.209HisPro: 1.209 ± 0.04	0.534HisGln: 0.534 ± 0.026	1.285HisArg: 1.285 ± 0.04	0.891HisSer: 0.891 ± 0.031	0.933HisThr: 0.933 ± 0.034	1.444HisVal: 1.444 ± 0.044	0.296HisTrp: 0.296 ± 0.021	0.545HisTyr: 0.545 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.52IleAla: 7.52 ± 0.101	0.448IleCys: 0.448 ± 0.021	3.218IleAsp: 3.218 ± 0.06	3.539IleGlu: 3.539 ± 0.068	1.574IlePhe: 1.574 ± 0.042	4.419IleGly: 4.419 ± 0.1	0.933IleHis: 0.933 ± 0.034	2.5IleIle: 2.5 ± 0.062	1.079IleLys: 1.079 ± 0.039	4.226IleLeu: 4.226 ± 0.072	0.92IleMet: 0.92 ± 0.034	1.401IleAsn: 1.401 ± 0.041	2.066IlePro: 2.066 ± 0.047	1.061IleGln: 1.061 ± 0.034	3.167IleArg: 3.167 ± 0.061	2.846IleSer: 2.846 ± 0.056	2.795IleThr: 2.795 ± 0.06	3.667IleVal: 3.667 ± 0.064	0.583IleTrp: 0.583 ± 0.024	1.009IleTyr: 1.009 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.055LysAla: 4.055 ± 0.097	0.101LysCys: 0.101 ± 0.011	1.435LysAsp: 1.435 ± 0.049	1.282LysGlu: 1.282 ± 0.048	0.669LysPhe: 0.669 ± 0.025	2.339LysGly: 2.339 ± 0.061	0.475LysHis: 0.475 ± 0.025	1.21LysIle: 1.21 ± 0.041	1.058LysLys: 1.058 ± 0.044	2.45LysLeu: 2.45 ± 0.065	0.554LysMet: 0.554 ± 0.027	0.573LysAsn: 0.573 ± 0.028	1.727LysPro: 1.727 ± 0.051	0.625LysGln: 0.625 ± 0.031	2.083LysArg: 2.083 ± 0.056	1.531LysSer: 1.531 ± 0.042	1.534LysThr: 1.534 ± 0.048	1.658LysVal: 1.658 ± 0.05	0.28LysTrp: 0.28 ± 0.016	0.437LysTyr: 0.437 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.729LeuAla: 14.729 ± 0.179	0.715LeuCys: 0.715 ± 0.027	6.27LeuAsp: 6.27 ± 0.095	6.444LeuGlu: 6.444 ± 0.108	3.565LeuPhe: 3.565 ± 0.075	7.846LeuGly: 7.846 ± 0.118	1.849LeuHis: 1.849 ± 0.048	5.219LeuIle: 5.219 ± 0.09	3.233LeuLys: 3.233 ± 0.072	8.244LeuLeu: 8.244 ± 0.113	2.352LeuMet: 2.352 ± 0.05	2.669LeuAsn: 2.669 ± 0.067	5.12LeuPro: 5.12 ± 0.078	2.726LeuGln: 2.726 ± 0.066	6.626LeuArg: 6.626 ± 0.083	6.316LeuSer: 6.316 ± 0.089	5.544LeuThr: 5.544 ± 0.081	7.18LeuVal: 7.18 ± 0.115	1.098LeuTrp: 1.098 ± 0.042	2.015LeuTyr: 2.015 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	3.435MetAla: 3.435 ± 0.063	0.148MetCys: 0.148 ± 0.013	1.302MetAsp: 1.302 ± 0.043	1.405MetGlu: 1.405 ± 0.042	0.617MetPhe: 0.617 ± 0.029	1.872MetGly: 1.872 ± 0.053	0.4MetHis: 0.4 ± 0.023	1.19MetIle: 1.19 ± 0.036	0.9MetLys: 0.9 ± 0.035	2.232MetLeu: 2.232 ± 0.054	0.71MetMet: 0.71 ± 0.035	0.775MetAsn: 0.775 ± 0.028	1.339MetPro: 1.339 ± 0.043	0.695MetGln: 0.695 ± 0.027	1.912MetArg: 1.912 ± 0.052	1.667MetSer: 1.667 ± 0.041	1.648MetThr: 1.648 ± 0.046	1.497MetVal: 1.497 ± 0.048	0.208MetTrp: 0.208 ± 0.015	0.296MetTyr: 0.296 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.529AsnAla: 3.529 ± 0.069	0.189AsnCys: 0.189 ± 0.016	1.304AsnAsp: 1.304 ± 0.042	1.234AsnGlu: 1.234 ± 0.038	0.892AsnPhe: 0.892 ± 0.035	2.264AsnGly: 2.264 ± 0.055	0.46AsnHis: 0.46 ± 0.023	1.28AsnIle: 1.28 ± 0.038	0.451AsnLys: 0.451 ± 0.024	2.431AsnLeu: 2.431 ± 0.058	0.607AsnMet: 0.607 ± 0.021	0.688AsnAsn: 0.688 ± 0.034	1.824AsnPro: 1.824 ± 0.047	0.684AsnGln: 0.684 ± 0.031	1.763AsnArg: 1.763 ± 0.038	1.121AsnSer: 1.121 ± 0.045	1.334AsnThr: 1.334 ± 0.05	1.771AsnVal: 1.771 ± 0.05	0.426AsnTrp: 0.426 ± 0.024	0.614AsnTyr: 0.614 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	7.029ProAla: 7.029 ± 0.1	0.313ProCys: 0.313 ± 0.018	4.017ProAsp: 4.017 ± 0.078	4.001ProGlu: 4.001 ± 0.078	1.968ProPhe: 1.968 ± 0.042	5.24ProGly: 5.24 ± 0.086	0.973ProHis: 0.973 ± 0.033	1.749ProIle: 1.749 ± 0.04	1.218ProLys: 1.218 ± 0.045	4.643ProLeu: 4.643 ± 0.09	1.117ProMet: 1.117 ± 0.035	1.039ProAsn: 1.039 ± 0.038	2.363ProPro: 2.363 ± 0.066	1.548ProGln: 1.548 ± 0.044	3.009ProArg: 3.009 ± 0.059	2.758ProSer: 2.758 ± 0.06	1.558ProThr: 1.558 ± 0.041	4.636ProVal: 4.636 ± 0.084	0.605ProTrp: 0.605 ± 0.03	1.062ProTyr: 1.062 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.142GlnAla: 4.142 ± 0.072	0.169GlnCys: 0.169 ± 0.011	1.309GlnAsp: 1.309 ± 0.039	1.47GlnGlu: 1.47 ± 0.046	1.006GlnPhe: 1.006 ± 0.034	2.564GlnGly: 2.564 ± 0.056	0.505GlnHis: 0.505 ± 0.024	1.636GlnIle: 1.636 ± 0.043	0.662GlnLys: 0.662 ± 0.03	2.831GlnLeu: 2.831 ± 0.065	0.795GlnMet: 0.795 ± 0.025	0.713GlnAsn: 0.713 ± 0.034	1.689GlnPro: 1.689 ± 0.051	0.939GlnGln: 0.939 ± 0.042	2.435GlnArg: 2.435 ± 0.065	1.816GlnSer: 1.816 ± 0.051	1.84GlnThr: 1.84 ± 0.052	1.957GlnVal: 1.957 ± 0.055	0.371GlnTrp: 0.371 ± 0.022	0.558GlnTyr: 0.558 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	9.752ArgAla: 9.752 ± 0.147	0.454ArgCys: 0.454 ± 0.026	4.152ArgAsp: 4.152 ± 0.076	5.034ArgGlu: 5.034 ± 0.094	3.353ArgPhe: 3.353 ± 0.066	5.111ArgGly: 5.111 ± 0.082	1.597ArgHis: 1.597 ± 0.047	3.989ArgIle: 3.989 ± 0.064	1.975ArgLys: 1.975 ± 0.063	8.647ArgLeu: 8.647 ± 0.11	1.926ArgMet: 1.926 ± 0.049	1.798ArgAsn: 1.798 ± 0.047	3.568ArgPro: 3.568 ± 0.065	2.502ArgGln: 2.502 ± 0.049	5.653ArgArg: 5.653 ± 0.093	3.743ArgSer: 3.743 ± 0.06	3.602ArgThr: 3.602 ± 0.065	4.991ArgVal: 4.991 ± 0.082	1.11ArgTrp: 1.11 ± 0.037	1.866ArgTyr: 1.866 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	7.547SerAla: 7.547 ± 0.114	0.329SerCys: 0.329 ± 0.02	3.198SerAsp: 3.198 ± 0.066	3.152SerGlu: 3.152 ± 0.066	2.128SerPhe: 2.128 ± 0.048	6.168SerGly: 6.168 ± 0.106	0.977SerHis: 0.977 ± 0.03	2.39SerIle: 2.39 ± 0.061	1.271SerLys: 1.271 ± 0.043	5.511SerLeu: 5.511 ± 0.084	1.239SerMet: 1.239 ± 0.039	1.292SerAsn: 1.292 ± 0.042	2.738SerPro: 2.738 ± 0.058	1.637SerGln: 1.637 ± 0.044	3.858SerArg: 3.858 ± 0.067	2.714SerSer: 2.714 ± 0.069	2.455SerThr: 2.455 ± 0.057	3.986SerVal: 3.986 ± 0.072	0.841SerTrp: 0.841 ± 0.031	1.157SerTyr: 1.157 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.326ThrAla: 6.326 ± 0.088	0.365ThrCys: 0.365 ± 0.024	2.612ThrAsp: 2.612 ± 0.054	2.511ThrGlu: 2.511 ± 0.05	1.622ThrPhe: 1.622 ± 0.043	5.818ThrGly: 5.818 ± 0.108	1.047ThrHis: 1.047 ± 0.036	2.48ThrIle: 2.48 ± 0.059	0.931ThrLys: 0.931 ± 0.035	5.835ThrLeu: 5.835 ± 0.093	0.929ThrMet: 0.929 ± 0.031	1.194ThrAsn: 1.194 ± 0.041	3.277ThrPro: 3.277 ± 0.063	1.456ThrGln: 1.456 ± 0.04	3.754ThrArg: 3.754 ± 0.062	2.561ThrSer: 2.561 ± 0.056	2.241ThrThr: 2.241 ± 0.051	3.675ThrVal: 3.675 ± 0.065	0.493ThrTrp: 0.493 ± 0.025	1.068ThrTyr: 1.068 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.488ValAla: 7.488 ± 0.111	0.626ValCys: 0.626 ± 0.027	3.905ValAsp: 3.905 ± 0.066	4.842ValGlu: 4.842 ± 0.086	2.99ValPhe: 2.99 ± 0.056	4.612ValGly: 4.612 ± 0.087	1.336ValHis: 1.336 ± 0.039	4.175ValIle: 4.175 ± 0.073	2.031ValLys: 2.031 ± 0.058	7.18ValLeu: 7.18 ± 0.097	1.964ValMet: 1.964 ± 0.05	1.958ValAsn: 1.958 ± 0.051	3.302ValPro: 3.302 ± 0.062	2.016ValGln: 2.016 ± 0.05	5.595ValArg: 5.595 ± 0.084	4.664ValSer: 4.664 ± 0.072	4.198ValThr: 4.198 ± 0.063	4.654ValVal: 4.654 ± 0.082	1.08ValTrp: 1.08 ± 0.035	1.491ValTyr: 1.491 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.306TrpAla: 1.306 ± 0.041	0.104TrpCys: 0.104 ± 0.011	0.626TrpAsp: 0.626 ± 0.029	0.639TrpGlu: 0.639 ± 0.028	0.535TrpPhe: 0.535 ± 0.026	0.898TrpGly: 0.898 ± 0.033	0.292TrpHis: 0.292 ± 0.018	0.637TrpIle: 0.637 ± 0.028	0.35TrpLys: 0.35 ± 0.02	1.583TrpLeu: 1.583 ± 0.044	0.343TrpMet: 0.343 ± 0.021	0.418TrpAsn: 0.418 ± 0.022	0.657TrpPro: 0.657 ± 0.025	0.582TrpGln: 0.582 ± 0.026	1.423TrpArg: 1.423 ± 0.041	0.856TrpSer: 0.856 ± 0.037	0.796TrpThr: 0.796 ± 0.028	0.837TrpVal: 0.837 ± 0.032	0.198TrpTrp: 0.198 ± 0.017	0.253TrpTyr: 0.253 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.763TyrAla: 2.763 ± 0.055	0.183TyrCys: 0.183 ± 0.016	1.402TyrAsp: 1.402 ± 0.047	1.405TyrGlu: 1.405 ± 0.04	0.851TyrPhe: 0.851 ± 0.034	2.086TyrGly: 2.086 ± 0.052	0.428TyrHis: 0.428 ± 0.021	0.851TyrIle: 0.851 ± 0.034	0.473TyrLys: 0.473 ± 0.024	2.033TyrLeu: 2.033 ± 0.048	0.437TyrMet: 0.437 ± 0.022	0.554TyrAsn: 0.554 ± 0.025	0.976TyrPro: 0.976 ± 0.03	0.699TyrGln: 0.699 ± 0.03	1.669TyrArg: 1.669 ± 0.05	1.061TyrSer: 1.061 ± 0.041	1.053TyrThr: 1.053 ± 0.04	1.524TyrVal: 1.524 ± 0.046	0.324TyrTrp: 0.324 ± 0.021	0.507TyrTyr: 0.507 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2866 proteins (900943 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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