Amino acid dipepetide frequency for Clostridium sp. CAG:762

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.294AlaAla: 1.294 ± 0.086
0.468AlaCys: 0.468 ± 0.032
2.064AlaAsp: 2.064 ± 0.078
1.89AlaGlu: 1.89 ± 0.1
1.777AlaPhe: 1.777 ± 0.079
2.226AlaGly: 2.226 ± 0.111
0.67AlaHis: 0.67 ± 0.052
4.336AlaIle: 4.336 ± 0.136
4.147AlaLys: 4.147 ± 0.105
4.199AlaLeu: 4.199 ± 0.115
1.018AlaMet: 1.018 ± 0.057
2.679AlaAsn: 2.679 ± 0.103
0.884AlaPro: 0.884 ± 0.05
0.838AlaGln: 0.838 ± 0.051
1.657AlaArg: 1.657 ± 0.089
3.232AlaSer: 3.232 ± 0.108
2.309AlaThr: 2.309 ± 0.085
2.18AlaVal: 2.18 ± 0.091
0.223AlaTrp: 0.223 ± 0.025
2.107AlaTyr: 2.107 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.468CysAla: 0.468 ± 0.038
0.153CysCys: 0.153 ± 0.027
0.813CysAsp: 0.813 ± 0.059
0.709CysGlu: 0.709 ± 0.044
0.492CysPhe: 0.492 ± 0.036
0.878CysGly: 0.878 ± 0.059
0.183CysHis: 0.183 ± 0.026
0.807CysIle: 0.807 ± 0.051
0.896CysLys: 0.896 ± 0.061
0.93CysLeu: 0.93 ± 0.051
0.226CysMet: 0.226 ± 0.025
0.746CysAsn: 0.746 ± 0.058
0.44CysPro: 0.44 ± 0.04
0.239CysGln: 0.239 ± 0.028
0.306CysArg: 0.306 ± 0.032
0.657CysSer: 0.657 ± 0.051
0.422CysThr: 0.422 ± 0.038
0.508CysVal: 0.508 ± 0.037
0.043CysTrp: 0.043 ± 0.013
0.514CysTyr: 0.514 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
2.517AspAla: 2.517 ± 0.102
0.434AspCys: 0.434 ± 0.036
3.0AspAsp: 3.0 ± 0.101
3.584AspGlu: 3.584 ± 0.107
2.624AspPhe: 2.624 ± 0.09
3.031AspGly: 3.031 ± 0.113
0.483AspHis: 0.483 ± 0.041
7.128AspIle: 7.128 ± 0.159
7.037AspLys: 7.037 ± 0.164
4.826AspLeu: 4.826 ± 0.123
1.477AspMet: 1.477 ± 0.072
5.532AspAsn: 5.532 ± 0.157
1.003AspPro: 1.003 ± 0.053
0.575AspGln: 0.575 ± 0.035
1.605AspArg: 1.605 ± 0.07
3.242AspSer: 3.242 ± 0.092
3.242AspThr: 3.242 ± 0.097
3.719AspVal: 3.719 ± 0.12
0.251AspTrp: 0.251 ± 0.031
4.144AspTyr: 4.144 ± 0.125
0.0AspXaa: 0.0 ± 0.0
Glu
2.942GluAla: 2.942 ± 0.11
0.691GluCys: 0.691 ± 0.05
4.006GluAsp: 4.006 ± 0.122
6.251GluGlu: 6.251 ± 0.173
2.404GluPhe: 2.404 ± 0.092
2.914GluGly: 2.914 ± 0.121
0.862GluHis: 0.862 ± 0.059
7.024GluIle: 7.024 ± 0.143
7.456GluLys: 7.456 ± 0.161
6.801GluLeu: 6.801 ± 0.153
1.685GluMet: 1.685 ± 0.064
5.657GluAsn: 5.657 ± 0.133
1.235GluPro: 1.235 ± 0.063
1.547GluGln: 1.547 ± 0.077
2.19GluArg: 2.19 ± 0.106
3.092GluSer: 3.092 ± 0.093
3.407GluThr: 3.407 ± 0.104
4.56GluVal: 4.56 ± 0.13
0.443GluTrp: 0.443 ± 0.034
3.639GluTyr: 3.639 ± 0.116
0.0GluXaa: 0.0 ± 0.0
Phe
1.685PheAla: 1.685 ± 0.076
0.44PheCys: 0.44 ± 0.032
2.755PheAsp: 2.755 ± 0.094
2.52PheGlu: 2.52 ± 0.083
1.593PhePhe: 1.593 ± 0.079
2.294PheGly: 2.294 ± 0.091
0.434PheHis: 0.434 ± 0.037
4.501PheIle: 4.501 ± 0.129
3.875PheLys: 3.875 ± 0.121
3.85PheLeu: 3.85 ± 0.113
0.96PheMet: 0.96 ± 0.048
3.37PheAsn: 3.37 ± 0.109
1.031PhePro: 1.031 ± 0.052
0.804PheGln: 0.804 ± 0.054
1.086PheArg: 1.086 ± 0.061
2.743PheSer: 2.743 ± 0.102
2.235PheThr: 2.235 ± 0.078
2.41PheVal: 2.41 ± 0.092
0.211PheTrp: 0.211 ± 0.027
1.951PheTyr: 1.951 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
2.483GlyAla: 2.483 ± 0.102
0.621GlyCys: 0.621 ± 0.048
2.737GlyAsp: 2.737 ± 0.095
3.119GlyGlu: 3.119 ± 0.116
2.232GlyPhe: 2.232 ± 0.098
3.226GlyGly: 3.226 ± 0.137
0.868GlyHis: 0.868 ± 0.05
6.009GlyIle: 6.009 ± 0.148
4.67GlyLys: 4.67 ± 0.132
4.358GlyLeu: 4.358 ± 0.125
1.373GlyMet: 1.373 ± 0.071
3.569GlyAsn: 3.569 ± 0.118
1.0GlyPro: 1.0 ± 0.082
0.972GlyGln: 0.972 ± 0.057
1.618GlyArg: 1.618 ± 0.093
3.119GlySer: 3.119 ± 0.101
3.342GlyThr: 3.342 ± 0.13
3.373GlyVal: 3.373 ± 0.124
0.294GlyTrp: 0.294 ± 0.032
3.171GlyTyr: 3.171 ± 0.096
0.0GlyXaa: 0.0 ± 0.0
His
0.63HisAla: 0.63 ± 0.047
0.196HisCys: 0.196 ± 0.027
0.749HisAsp: 0.749 ± 0.05
0.905HisGlu: 0.905 ± 0.051
0.578HisPhe: 0.578 ± 0.041
0.905HisGly: 0.905 ± 0.065
0.254HisHis: 0.254 ± 0.028
1.367HisIle: 1.367 ± 0.057
1.006HisLys: 1.006 ± 0.052
1.171HisLeu: 1.171 ± 0.058
0.339HisMet: 0.339 ± 0.03
0.902HisAsn: 0.902 ± 0.061
0.627HisPro: 0.627 ± 0.046
0.3HisGln: 0.3 ± 0.033
0.413HisArg: 0.413 ± 0.035
0.664HisSer: 0.664 ± 0.047
0.737HisThr: 0.737 ± 0.047
0.731HisVal: 0.731 ± 0.05
0.055HisTrp: 0.055 ± 0.011
0.713HisTyr: 0.713 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
4.407IleAla: 4.407 ± 0.128
1.22IleCys: 1.22 ± 0.068
7.128IleAsp: 7.128 ± 0.155
6.945IleGlu: 6.945 ± 0.167
4.315IlePhe: 4.315 ± 0.131
4.917IleGly: 4.917 ± 0.135
1.187IleHis: 1.187 ± 0.063
12.156IleIle: 12.156 ± 0.285
11.092IleLys: 11.092 ± 0.229
10.217IleLeu: 10.217 ± 0.235
2.367IleMet: 2.367 ± 0.078
8.761IleAsn: 8.761 ± 0.193
3.15IlePro: 3.15 ± 0.104
1.572IleGln: 1.572 ± 0.071
2.982IleArg: 2.982 ± 0.104
7.043IleSer: 7.043 ± 0.177
6.263IleThr: 6.263 ± 0.157
6.107IleVal: 6.107 ± 0.17
0.554IleTrp: 0.554 ± 0.039
5.0IleTyr: 5.0 ± 0.151
0.0IleXaa: 0.0 ± 0.0
Lys
3.272LysAla: 3.272 ± 0.115
0.936LysCys: 0.936 ± 0.057
6.63LysAsp: 6.63 ± 0.15
10.333LysGlu: 10.333 ± 0.225
3.055LysPhe: 3.055 ± 0.104
4.293LysGly: 4.293 ± 0.123
1.22LysHis: 1.22 ± 0.07
10.44LysIle: 10.44 ± 0.201
11.296LysLys: 11.296 ± 0.238
8.602LysLeu: 8.602 ± 0.17
2.957LysMet: 2.957 ± 0.096
8.74LysAsn: 8.74 ± 0.175
1.933LysPro: 1.933 ± 0.074
2.339LysGln: 2.339 ± 0.087
3.41LysArg: 3.41 ± 0.102
4.486LysSer: 4.486 ± 0.139
5.193LysThr: 5.193 ± 0.117
5.985LysVal: 5.985 ± 0.141
0.563LysTrp: 0.563 ± 0.04
6.144LysTyr: 6.144 ± 0.156
0.0LysXaa: 0.0 ± 0.0
Leu
3.716LeuAla: 3.716 ± 0.115
1.028LeuCys: 1.028 ± 0.058
5.926LeuAsp: 5.926 ± 0.138
6.575LeuGlu: 6.575 ± 0.171
4.095LeuPhe: 4.095 ± 0.125
5.287LeuGly: 5.287 ± 0.137
1.07LeuHis: 1.07 ± 0.065
9.602LeuIle: 9.602 ± 0.212
8.981LeuLys: 8.981 ± 0.18
8.0LeuLeu: 8.0 ± 0.216
1.798LeuMet: 1.798 ± 0.07
7.089LeuAsn: 7.089 ± 0.155
2.52LeuPro: 2.52 ± 0.091
1.648LeuGln: 1.648 ± 0.079
2.612LeuArg: 2.612 ± 0.102
6.416LeuSer: 6.416 ± 0.134
5.141LeuThr: 5.141 ± 0.123
5.648LeuVal: 5.648 ± 0.151
0.434LeuTrp: 0.434 ± 0.038
4.089LeuTyr: 4.089 ± 0.128
0.0LeuXaa: 0.0 ± 0.0
Met
1.266MetAla: 1.266 ± 0.061
0.275MetCys: 0.275 ± 0.03
1.147MetAsp: 1.147 ± 0.059
1.544MetGlu: 1.544 ± 0.077
1.116MetPhe: 1.116 ± 0.06
1.315MetGly: 1.315 ± 0.059
0.349MetHis: 0.349 ± 0.033
2.208MetIle: 2.208 ± 0.098
2.523MetLys: 2.523 ± 0.09
2.235MetLeu: 2.235 ± 0.082
0.56MetMet: 0.56 ± 0.046
1.939MetAsn: 1.939 ± 0.067
0.868MetPro: 0.868 ± 0.064
0.599MetGln: 0.599 ± 0.04
0.722MetArg: 0.722 ± 0.045
1.33MetSer: 1.33 ± 0.068
1.092MetThr: 1.092 ± 0.056
1.339MetVal: 1.339 ± 0.065
0.174MetTrp: 0.174 ± 0.024
1.125MetTyr: 1.125 ± 0.054
0.0MetXaa: 0.0 ± 0.0
Asn
2.979AsnAla: 2.979 ± 0.108
0.725AsnCys: 0.725 ± 0.048
5.009AsnAsp: 5.009 ± 0.14
5.697AsnGlu: 5.697 ± 0.13
2.7AsnPhe: 2.7 ± 0.092
3.758AsnGly: 3.758 ± 0.12
1.07AsnHis: 1.07 ± 0.056
9.575AsnIle: 9.575 ± 0.22
9.367AsnLys: 9.367 ± 0.187
6.694AsnLeu: 6.694 ± 0.167
2.083AsnMet: 2.083 ± 0.081
8.459AsnAsn: 8.459 ± 0.269
1.838AsnPro: 1.838 ± 0.081
1.875AsnGln: 1.875 ± 0.084
2.049AsnArg: 2.049 ± 0.076
4.205AsnSer: 4.205 ± 0.137
4.144AsnThr: 4.144 ± 0.138
4.082AsnVal: 4.082 ± 0.12
0.355AsnTrp: 0.355 ± 0.036
5.315AsnTyr: 5.315 ± 0.145
0.0AsnXaa: 0.0 ± 0.0
Pro
0.924ProAla: 0.924 ± 0.052
0.272ProCys: 0.272 ± 0.034
1.187ProAsp: 1.187 ± 0.06
1.489ProGlu: 1.489 ± 0.072
1.26ProPhe: 1.26 ± 0.059
1.144ProGly: 1.144 ± 0.059
0.391ProHis: 0.391 ± 0.035
2.428ProIle: 2.428 ± 0.087
2.138ProLys: 2.138 ± 0.082
2.04ProLeu: 2.04 ± 0.079
0.569ProMet: 0.569 ± 0.037
1.945ProAsn: 1.945 ± 0.084
0.398ProPro: 0.398 ± 0.037
0.55ProGln: 0.55 ± 0.047
0.679ProArg: 0.679 ± 0.046
1.792ProSer: 1.792 ± 0.088
1.55ProThr: 1.55 ± 0.076
1.56ProVal: 1.56 ± 0.085
0.229ProTrp: 0.229 ± 0.025
1.532ProTyr: 1.532 ± 0.069
0.0ProXaa: 0.0 ± 0.0
Gln
1.012GlnAla: 1.012 ± 0.061
0.162GlnCys: 0.162 ± 0.023
1.156GlnAsp: 1.156 ± 0.065
1.627GlnGlu: 1.627 ± 0.086
0.713GlnPhe: 0.713 ± 0.045
1.101GlnGly: 1.101 ± 0.063
0.128GlnHis: 0.128 ± 0.02
2.073GlnIle: 2.073 ± 0.073
2.006GlnLys: 2.006 ± 0.076
1.538GlnLeu: 1.538 ± 0.062
0.529GlnMet: 0.529 ± 0.043
1.633GlnAsn: 1.633 ± 0.071
0.41GlnPro: 0.41 ± 0.048
0.379GlnGln: 0.379 ± 0.038
0.731GlnArg: 0.731 ± 0.053
1.202GlnSer: 1.202 ± 0.067
1.199GlnThr: 1.199 ± 0.068
1.235GlnVal: 1.235 ± 0.062
0.073GlnTrp: 0.073 ± 0.018
0.801GlnTyr: 0.801 ± 0.052
0.0GlnXaa: 0.0 ± 0.0
Arg
1.098ArgAla: 1.098 ± 0.061
0.37ArgCys: 0.37 ± 0.034
1.664ArgAsp: 1.664 ± 0.069
2.211ArgGlu: 2.211 ± 0.089
1.125ArgPhe: 1.125 ± 0.047
1.627ArgGly: 1.627 ± 0.076
0.477ArgHis: 0.477 ± 0.041
3.046ArgIle: 3.046 ± 0.094
3.095ArgLys: 3.095 ± 0.106
2.777ArgLeu: 2.777 ± 0.098
0.878ArgMet: 0.878 ± 0.055
2.248ArgAsn: 2.248 ± 0.075
0.719ArgPro: 0.719 ± 0.055
0.768ArgGln: 0.768 ± 0.051
1.125ArgArg: 1.125 ± 0.063
1.547ArgSer: 1.547 ± 0.062
1.352ArgThr: 1.352 ± 0.07
1.878ArgVal: 1.878 ± 0.088
0.22ArgTrp: 0.22 ± 0.026
1.67ArgTyr: 1.67 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
2.171SerAla: 2.171 ± 0.089
0.596SerCys: 0.596 ± 0.044
2.716SerAsp: 2.716 ± 0.087
2.905SerGlu: 2.905 ± 0.114
2.914SerPhe: 2.914 ± 0.098
3.443SerGly: 3.443 ± 0.126
0.93SerHis: 0.93 ± 0.05
6.605SerIle: 6.605 ± 0.16
6.211SerLys: 6.211 ± 0.145
6.095SerLeu: 6.095 ± 0.15
1.342SerMet: 1.342 ± 0.071
5.33SerAsn: 5.33 ± 0.138
1.29SerPro: 1.29 ± 0.068
1.138SerGln: 1.138 ± 0.063
1.716SerArg: 1.716 ± 0.076
4.26SerSer: 4.26 ± 0.137
3.284SerThr: 3.284 ± 0.099
3.425SerVal: 3.425 ± 0.096
0.321SerTrp: 0.321 ± 0.036
3.657SerTyr: 3.657 ± 0.113
0.0SerXaa: 0.0 ± 0.0
Thr
2.052ThrAla: 2.052 ± 0.092
0.599ThrCys: 0.599 ± 0.043
3.113ThrAsp: 3.113 ± 0.096
2.92ThrGlu: 2.92 ± 0.095
2.501ThrPhe: 2.501 ± 0.089
3.428ThrGly: 3.428 ± 0.136
0.81ThrHis: 0.81 ± 0.05
5.926ThrIle: 5.926 ± 0.151
5.394ThrLys: 5.394 ± 0.142
5.052ThrLeu: 5.052 ± 0.134
1.07ThrMet: 1.07 ± 0.052
4.232ThrAsn: 4.232 ± 0.126
1.682ThrPro: 1.682 ± 0.079
0.881ThrGln: 0.881 ± 0.052
1.459ThrArg: 1.459 ± 0.074
3.875ThrSer: 3.875 ± 0.111
3.242ThrThr: 3.242 ± 0.125
3.101ThrVal: 3.101 ± 0.114
0.315ThrTrp: 0.315 ± 0.035
3.131ThrTyr: 3.131 ± 0.116
0.0ThrXaa: 0.0 ± 0.0
Val
2.703ValAla: 2.703 ± 0.104
0.706ValCys: 0.706 ± 0.048
3.569ValAsp: 3.569 ± 0.116
3.462ValGlu: 3.462 ± 0.121
2.501ValPhe: 2.501 ± 0.103
3.235ValGly: 3.235 ± 0.114
0.765ValHis: 0.765 ± 0.057
6.575ValIle: 6.575 ± 0.156
5.199ValLys: 5.199 ± 0.127
5.813ValLeu: 5.813 ± 0.144
1.324ValMet: 1.324 ± 0.067
4.342ValAsn: 4.342 ± 0.118
1.581ValPro: 1.581 ± 0.073
0.884ValGln: 0.884 ± 0.052
1.801ValArg: 1.801 ± 0.08
4.165ValSer: 4.165 ± 0.105
3.456ValThr: 3.456 ± 0.11
3.792ValVal: 3.792 ± 0.13
0.391ValTrp: 0.391 ± 0.037
2.703ValTyr: 2.703 ± 0.088
0.0ValXaa: 0.0 ± 0.0
Trp
0.281TrpAla: 0.281 ± 0.029
0.089TrpCys: 0.089 ± 0.016
0.318TrpAsp: 0.318 ± 0.031
0.284TrpGlu: 0.284 ± 0.031
0.346TrpPhe: 0.346 ± 0.034
0.312TrpGly: 0.312 ± 0.029
0.092TrpHis: 0.092 ± 0.018
0.459TrpIle: 0.459 ± 0.042
0.394TrpLys: 0.394 ± 0.034
0.538TrpLeu: 0.538 ± 0.038
0.131TrpMet: 0.131 ± 0.021
0.349TrpAsn: 0.349 ± 0.033
0.15TrpPro: 0.15 ± 0.02
0.177TrpGln: 0.177 ± 0.027
0.144TrpArg: 0.144 ± 0.02
0.306TrpSer: 0.306 ± 0.035
0.217TrpThr: 0.217 ± 0.029
0.312TrpVal: 0.312 ± 0.033
0.046TrpTrp: 0.046 ± 0.011
0.483TrpTyr: 0.483 ± 0.047
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.3TyrAla: 2.3 ± 0.09
0.45TyrCys: 0.45 ± 0.041
3.764TyrAsp: 3.764 ± 0.13
3.838TyrGlu: 3.838 ± 0.118
2.407TyrPhe: 2.407 ± 0.094
2.82TyrGly: 2.82 ± 0.1
0.997TyrHis: 0.997 ± 0.057
5.113TyrIle: 5.113 ± 0.135
5.046TyrLys: 5.046 ± 0.149
5.939TyrLeu: 5.939 ± 0.172
1.037TyrMet: 1.037 ± 0.058
4.456TyrAsn: 4.456 ± 0.122
1.318TyrPro: 1.318 ± 0.06
1.624TyrGln: 1.624 ± 0.075
1.59TyrArg: 1.59 ± 0.071
2.975TyrSer: 2.975 ± 0.095
2.96TyrThr: 2.96 ± 0.116
3.024TyrVal: 3.024 ± 0.084
0.232TyrTrp: 0.232 ± 0.031
3.284TyrTyr: 3.284 ± 0.129
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1127 proteins (327007 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski