Human papillomavirus type 2

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 4

Average proteome isoelectric point is 6.35

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 7 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>tr|A3F907|A3F907_9PAPI Replication protein E1 OS=Human papillomavirus type 2 OX=333751 GN=E1 PE=3 SV=1
MM1 pKa = 7.34HH2 pKa = 7.62GNRR5 pKa = 11.84PSLKK9 pKa = 10.35DD10 pKa = 2.79ITLILDD16 pKa = 4.92EE17 pKa = 4.75IPEE20 pKa = 4.32IVDD23 pKa = 3.46LHH25 pKa = 8.08CDD27 pKa = 3.39EE28 pKa = 5.02QFDD31 pKa = 4.69SSEE34 pKa = 4.2EE35 pKa = 4.14EE36 pKa = 4.09NNHH39 pKa = 5.82QLTEE43 pKa = 4.38PDD45 pKa = 3.3VQAYY49 pKa = 9.44GVVTTCCKK57 pKa = 10.11CGRR60 pKa = 11.84TVRR63 pKa = 11.84LVVEE67 pKa = 5.05CGQADD72 pKa = 3.98LRR74 pKa = 11.84EE75 pKa = 4.19LEE77 pKa = 4.1QLFLKK82 pKa = 9.87TLTLVCPHH90 pKa = 7.05CAA92 pKa = 3.32

Molecular weight: 10.37 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>tr|A3F910|A3F910_9PAPI Minor capsid protein L2 OS=Human papillomavirus type 2 OX=333751 GN=L2 PE=3 SV=1
MM1 pKa = 7.64GSPGRR6 pKa = 11.84GRR8 pKa = 11.84CTWLGLLFTIHH19 pKa = 6.77PHH21 pKa = 5.89LCLAPRR27 pKa = 11.84PAPRR31 pKa = 11.84TTNHH35 pKa = 5.79YY36 pKa = 9.8PLLEE40 pKa = 3.98LLYY43 pKa = 9.83PQSQPQSQPQQNQQEE58 pKa = 4.43QEE60 pKa = 4.06EE61 pKa = 4.34QLRR64 pKa = 11.84PPKK67 pKa = 10.22RR68 pKa = 11.84CAPPRR73 pKa = 11.84RR74 pKa = 11.84QRR76 pKa = 11.84VRR78 pKa = 11.84RR79 pKa = 11.84PSASVSSSDD88 pKa = 3.85SSIPGPTLRR97 pKa = 11.84EE98 pKa = 3.44RR99 pKa = 11.84SEE101 pKa = 3.86RR102 pKa = 11.84GKK104 pKa = 10.19WSVTTSGASVTLTAQTPGGATVTLTLCLL132 pKa = 3.75

Molecular weight: 14.53 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

7

0

7

2451

92

643

350.1

38.95

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.324 ± 0.592

2.489 ± 0.607

5.753 ± 0.446

5.467 ± 0.785

3.794 ± 0.421

6.977 ± 0.314

2.489 ± 0.216

3.754 ± 0.413

4.243 ± 0.577

8.568 ± 0.423

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.04 ± 0.221

3.142 ± 0.425

7.222 ± 1.033

4.121 ± 0.537

5.794 ± 0.363

7.834 ± 0.349

7.63 ± 0.681

7.181 ± 0.588

1.632 ± 0.382

3.55 ± 0.288
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski