Amino acid dipepetide frequency for Salmonella phage SEN1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.229AlaAla: 10.229 ± 1.924
1.1AlaCys: 1.1 ± 0.356
6.709AlaAsp: 6.709 ± 0.938
6.269AlaGlu: 6.269 ± 0.79
2.75AlaPhe: 2.75 ± 0.424
8.579AlaGly: 8.579 ± 1.419
1.32AlaHis: 1.32 ± 0.38
5.719AlaIle: 5.719 ± 0.716
5.939AlaLys: 5.939 ± 0.776
9.459AlaLeu: 9.459 ± 0.945
3.08AlaMet: 3.08 ± 0.418
2.31AlaAsn: 2.31 ± 0.639
5.499AlaPro: 5.499 ± 0.881
4.509AlaGln: 4.509 ± 0.849
5.719AlaArg: 5.719 ± 0.781
7.369AlaSer: 7.369 ± 0.952
6.379AlaThr: 6.379 ± 1.145
6.709AlaVal: 6.709 ± 0.713
1.76AlaTrp: 1.76 ± 0.423
2.75AlaTyr: 2.75 ± 0.44
0.0AlaXaa: 0.0 ± 0.0
Cys
0.99CysAla: 0.99 ± 0.278
0.33CysCys: 0.33 ± 0.209
0.44CysAsp: 0.44 ± 0.233
0.88CysGlu: 0.88 ± 0.308
0.33CysPhe: 0.33 ± 0.222
0.22CysGly: 0.22 ± 0.164
0.22CysHis: 0.22 ± 0.165
0.33CysIle: 0.33 ± 0.153
0.88CysLys: 0.88 ± 0.287
0.66CysLeu: 0.66 ± 0.246
0.22CysMet: 0.22 ± 0.145
0.44CysAsn: 0.44 ± 0.2
0.33CysPro: 0.33 ± 0.202
0.22CysGln: 0.22 ± 0.169
0.88CysArg: 0.88 ± 0.331
0.22CysSer: 0.22 ± 0.163
0.77CysThr: 0.77 ± 0.257
0.99CysVal: 0.99 ± 0.307
0.11CysTrp: 0.11 ± 0.097
0.33CysTyr: 0.33 ± 0.175
0.0CysXaa: 0.0 ± 0.0
Asp
6.269AspAla: 6.269 ± 0.85
0.44AspCys: 0.44 ± 0.259
4.07AspAsp: 4.07 ± 0.886
4.399AspGlu: 4.399 ± 0.73
2.97AspPhe: 2.97 ± 0.72
5.609AspGly: 5.609 ± 0.687
0.77AspHis: 0.77 ± 0.28
4.399AspIle: 4.399 ± 0.788
3.52AspLys: 3.52 ± 0.575
4.619AspLeu: 4.619 ± 0.596
1.32AspMet: 1.32 ± 0.369
2.2AspAsn: 2.2 ± 0.62
2.31AspPro: 2.31 ± 0.484
1.65AspGln: 1.65 ± 0.474
2.53AspArg: 2.53 ± 0.626
3.19AspSer: 3.19 ± 0.654
4.619AspThr: 4.619 ± 0.831
3.85AspVal: 3.85 ± 0.692
0.66AspTrp: 0.66 ± 0.211
1.98AspTyr: 1.98 ± 0.486
0.0AspXaa: 0.0 ± 0.0
Glu
5.939GluAla: 5.939 ± 0.923
0.88GluCys: 0.88 ± 0.303
2.53GluAsp: 2.53 ± 0.642
2.53GluGlu: 2.53 ± 0.442
1.76GluPhe: 1.76 ± 0.389
2.86GluGly: 2.86 ± 0.576
1.32GluHis: 1.32 ± 0.425
3.63GluIle: 3.63 ± 0.665
3.08GluLys: 3.08 ± 0.517
9.459GluLeu: 9.459 ± 1.098
2.09GluMet: 2.09 ± 0.461
3.08GluAsn: 3.08 ± 0.82
2.64GluPro: 2.64 ± 0.451
2.53GluGln: 2.53 ± 0.59
3.74GluArg: 3.74 ± 0.559
4.289GluSer: 4.289 ± 0.689
3.19GluThr: 3.19 ± 0.609
2.75GluVal: 2.75 ± 0.516
0.77GluTrp: 0.77 ± 0.292
1.76GluTyr: 1.76 ± 0.472
0.0GluXaa: 0.0 ± 0.0
Phe
2.75PheAla: 2.75 ± 0.474
0.44PheCys: 0.44 ± 0.189
1.54PheAsp: 1.54 ± 0.36
2.2PheGlu: 2.2 ± 0.407
1.21PhePhe: 1.21 ± 0.406
1.65PheGly: 1.65 ± 0.366
0.66PheHis: 0.66 ± 0.24
1.32PheIle: 1.32 ± 0.413
2.42PheLys: 2.42 ± 0.546
2.09PheLeu: 2.09 ± 0.463
0.99PheMet: 0.99 ± 0.273
1.65PheAsn: 1.65 ± 0.358
0.99PhePro: 0.99 ± 0.337
1.21PheGln: 1.21 ± 0.382
1.32PheArg: 1.32 ± 0.336
3.08PheSer: 3.08 ± 0.573
2.31PheThr: 2.31 ± 0.568
1.54PheVal: 1.54 ± 0.415
0.77PheTrp: 0.77 ± 0.315
0.77PheTyr: 0.77 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
6.379GlyAla: 6.379 ± 0.708
0.88GlyCys: 0.88 ± 0.343
4.839GlyAsp: 4.839 ± 0.644
4.949GlyGlu: 4.949 ± 0.755
2.53GlyPhe: 2.53 ± 0.473
5.169GlyGly: 5.169 ± 1.057
1.32GlyHis: 1.32 ± 0.378
3.96GlyIle: 3.96 ± 0.695
5.059GlyLys: 5.059 ± 0.768
4.839GlyLeu: 4.839 ± 0.517
2.31GlyMet: 2.31 ± 0.552
3.3GlyAsn: 3.3 ± 0.57
0.55GlyPro: 0.55 ± 0.256
1.76GlyGln: 1.76 ± 0.488
3.74GlyArg: 3.74 ± 0.624
3.3GlySer: 3.3 ± 0.684
4.619GlyThr: 4.619 ± 0.65
6.159GlyVal: 6.159 ± 1.153
0.77GlyTrp: 0.77 ± 0.239
1.98GlyTyr: 1.98 ± 0.458
0.0GlyXaa: 0.0 ± 0.0
His
1.54HisAla: 1.54 ± 0.461
0.33HisCys: 0.33 ± 0.162
0.88HisAsp: 0.88 ± 0.278
0.99HisGlu: 0.99 ± 0.341
0.66HisPhe: 0.66 ± 0.375
1.54HisGly: 1.54 ± 0.376
0.55HisHis: 0.55 ± 0.198
1.21HisIle: 1.21 ± 0.335
0.99HisLys: 0.99 ± 0.317
1.43HisLeu: 1.43 ± 0.372
0.66HisMet: 0.66 ± 0.255
1.1HisAsn: 1.1 ± 0.355
1.1HisPro: 1.1 ± 0.348
1.1HisGln: 1.1 ± 0.292
1.32HisArg: 1.32 ± 0.385
1.43HisSer: 1.43 ± 0.481
0.88HisThr: 0.88 ± 0.266
0.88HisVal: 0.88 ± 0.275
0.33HisTrp: 0.33 ± 0.205
1.1HisTyr: 1.1 ± 0.317
0.0HisXaa: 0.0 ± 0.0
Ile
6.159IleAla: 6.159 ± 0.815
0.33IleCys: 0.33 ± 0.185
4.839IleAsp: 4.839 ± 0.658
2.42IleGlu: 2.42 ± 0.52
2.09IlePhe: 2.09 ± 0.557
4.399IleGly: 4.399 ± 0.726
0.88IleHis: 0.88 ± 0.305
2.64IleIle: 2.64 ± 0.589
1.98IleLys: 1.98 ± 0.491
2.64IleLeu: 2.64 ± 0.437
0.99IleMet: 0.99 ± 0.309
2.31IleAsn: 2.31 ± 0.461
2.53IlePro: 2.53 ± 0.54
1.54IleGln: 1.54 ± 0.396
5.939IleArg: 5.939 ± 0.84
4.839IleSer: 4.839 ± 0.872
3.96IleThr: 3.96 ± 0.679
3.63IleVal: 3.63 ± 0.584
0.33IleTrp: 0.33 ± 0.162
0.66IleTyr: 0.66 ± 0.311
0.0IleXaa: 0.0 ± 0.0
Lys
6.709LysAla: 6.709 ± 1.022
0.11LysCys: 0.11 ± 0.107
2.42LysAsp: 2.42 ± 0.42
3.08LysGlu: 3.08 ± 0.63
1.21LysPhe: 1.21 ± 0.379
4.07LysGly: 4.07 ± 0.623
1.65LysHis: 1.65 ± 0.428
1.87LysIle: 1.87 ± 0.43
3.3LysLys: 3.3 ± 0.672
4.949LysLeu: 4.949 ± 0.711
0.99LysMet: 0.99 ± 0.287
2.64LysAsn: 2.64 ± 0.506
3.08LysPro: 3.08 ± 0.702
1.76LysGln: 1.76 ± 0.441
3.85LysArg: 3.85 ± 0.479
3.52LysSer: 3.52 ± 0.481
4.289LysThr: 4.289 ± 0.622
3.08LysVal: 3.08 ± 0.712
1.65LysTrp: 1.65 ± 0.497
2.42LysTyr: 2.42 ± 0.587
0.0LysXaa: 0.0 ± 0.0
Leu
10.999LeuAla: 10.999 ± 0.954
0.99LeuCys: 0.99 ± 0.315
6.159LeuAsp: 6.159 ± 0.911
5.169LeuGlu: 5.169 ± 0.572
1.87LeuPhe: 1.87 ± 0.519
5.609LeuGly: 5.609 ± 0.941
1.98LeuHis: 1.98 ± 0.46
4.729LeuIle: 4.729 ± 0.512
5.059LeuLys: 5.059 ± 0.635
6.379LeuLeu: 6.379 ± 0.752
2.31LeuMet: 2.31 ± 0.567
4.289LeuAsn: 4.289 ± 0.487
4.07LeuPro: 4.07 ± 0.592
4.07LeuGln: 4.07 ± 0.501
5.609LeuArg: 5.609 ± 0.903
6.599LeuSer: 6.599 ± 0.79
7.479LeuThr: 7.479 ± 1.476
4.07LeuVal: 4.07 ± 0.582
1.21LeuTrp: 1.21 ± 0.341
2.42LeuTyr: 2.42 ± 0.501
0.0LeuXaa: 0.0 ± 0.0
Met
3.19MetAla: 3.19 ± 0.593
0.11MetCys: 0.11 ± 0.11
0.77MetAsp: 0.77 ± 0.331
1.32MetGlu: 1.32 ± 0.338
1.21MetPhe: 1.21 ± 0.42
0.66MetGly: 0.66 ± 0.352
0.33MetHis: 0.33 ± 0.191
0.77MetIle: 0.77 ± 0.253
0.88MetLys: 0.88 ± 0.293
2.75MetLeu: 2.75 ± 0.566
0.33MetMet: 0.33 ± 0.199
1.32MetAsn: 1.32 ± 0.381
0.66MetPro: 0.66 ± 0.268
1.76MetGln: 1.76 ± 0.533
2.2MetArg: 2.2 ± 0.559
2.31MetSer: 2.31 ± 0.407
2.42MetThr: 2.42 ± 0.435
1.76MetVal: 1.76 ± 0.345
0.33MetTrp: 0.33 ± 0.188
0.44MetTyr: 0.44 ± 0.248
0.0MetXaa: 0.0 ± 0.0
Asn
3.3AsnAla: 3.3 ± 0.713
0.55AsnCys: 0.55 ± 0.287
1.43AsnAsp: 1.43 ± 0.323
2.64AsnGlu: 2.64 ± 0.55
1.21AsnPhe: 1.21 ± 0.295
3.85AsnGly: 3.85 ± 0.676
0.66AsnHis: 0.66 ± 0.285
3.08AsnIle: 3.08 ± 0.575
2.64AsnLys: 2.64 ± 0.589
2.97AsnLeu: 2.97 ± 0.587
1.21AsnMet: 1.21 ± 0.296
1.54AsnAsn: 1.54 ± 0.428
1.98AsnPro: 1.98 ± 0.533
1.21AsnGln: 1.21 ± 0.332
2.42AsnArg: 2.42 ± 0.464
2.31AsnSer: 2.31 ± 0.373
1.98AsnThr: 1.98 ± 0.591
2.75AsnVal: 2.75 ± 0.429
0.66AsnTrp: 0.66 ± 0.266
0.77AsnTyr: 0.77 ± 0.337
0.0AsnXaa: 0.0 ± 0.0
Pro
4.509ProAla: 4.509 ± 0.633
0.22ProCys: 0.22 ± 0.153
3.74ProAsp: 3.74 ± 0.724
4.399ProGlu: 4.399 ± 0.664
0.88ProPhe: 0.88 ± 0.445
2.42ProGly: 2.42 ± 0.584
1.54ProHis: 1.54 ± 0.477
1.98ProIle: 1.98 ± 0.481
2.2ProLys: 2.2 ± 0.563
3.96ProLeu: 3.96 ± 0.57
0.11ProMet: 0.11 ± 0.124
0.99ProAsn: 0.99 ± 0.424
2.2ProPro: 2.2 ± 0.498
1.43ProGln: 1.43 ± 0.425
1.98ProArg: 1.98 ± 0.5
2.42ProSer: 2.42 ± 0.559
0.99ProThr: 0.99 ± 0.364
4.399ProVal: 4.399 ± 0.64
0.66ProTrp: 0.66 ± 0.24
0.77ProTyr: 0.77 ± 0.348
0.0ProXaa: 0.0 ± 0.0
Gln
4.399GlnAla: 4.399 ± 1.243
0.0GlnCys: 0.0 ± 0.0
2.31GlnAsp: 2.31 ± 0.6
1.76GlnGlu: 1.76 ± 0.446
1.65GlnPhe: 1.65 ± 0.359
1.54GlnGly: 1.54 ± 0.331
0.33GlnHis: 0.33 ± 0.189
2.09GlnIle: 2.09 ± 0.632
3.3GlnLys: 3.3 ± 0.546
4.729GlnLeu: 4.729 ± 1.021
0.77GlnMet: 0.77 ± 0.328
0.77GlnAsn: 0.77 ± 0.344
1.43GlnPro: 1.43 ± 0.304
1.87GlnGln: 1.87 ± 0.514
3.41GlnArg: 3.41 ± 0.59
2.42GlnSer: 2.42 ± 0.569
2.86GlnThr: 2.86 ± 0.619
1.65GlnVal: 1.65 ± 0.434
0.88GlnTrp: 0.88 ± 0.339
1.1GlnTyr: 1.1 ± 0.424
0.0GlnXaa: 0.0 ± 0.0
Arg
5.609ArgAla: 5.609 ± 0.895
0.77ArgCys: 0.77 ± 0.261
2.97ArgAsp: 2.97 ± 0.453
4.619ArgGlu: 4.619 ± 0.681
1.65ArgPhe: 1.65 ± 0.531
3.74ArgGly: 3.74 ± 0.808
1.98ArgHis: 1.98 ± 0.452
3.85ArgIle: 3.85 ± 0.736
3.63ArgLys: 3.63 ± 0.584
7.149ArgLeu: 7.149 ± 0.959
1.65ArgMet: 1.65 ± 0.424
2.86ArgAsn: 2.86 ± 0.552
1.98ArgPro: 1.98 ± 0.508
2.53ArgGln: 2.53 ± 0.665
5.059ArgArg: 5.059 ± 0.81
2.86ArgSer: 2.86 ± 0.488
3.63ArgThr: 3.63 ± 0.642
4.509ArgVal: 4.509 ± 0.791
1.1ArgTrp: 1.1 ± 0.351
1.32ArgTyr: 1.32 ± 0.396
0.0ArgXaa: 0.0 ± 0.0
Ser
8.029SerAla: 8.029 ± 0.863
0.77SerCys: 0.77 ± 0.25
4.619SerAsp: 4.619 ± 0.657
4.289SerGlu: 4.289 ± 0.575
1.98SerPhe: 1.98 ± 0.437
5.279SerGly: 5.279 ± 0.869
1.32SerHis: 1.32 ± 0.463
1.98SerIle: 1.98 ± 0.464
3.08SerLys: 3.08 ± 0.643
5.719SerLeu: 5.719 ± 0.858
1.87SerMet: 1.87 ± 0.422
2.75SerAsn: 2.75 ± 0.598
2.2SerPro: 2.2 ± 0.459
2.64SerGln: 2.64 ± 0.474
3.96SerArg: 3.96 ± 0.652
2.75SerSer: 2.75 ± 0.628
2.86SerThr: 2.86 ± 0.474
4.07SerVal: 4.07 ± 0.66
0.99SerTrp: 0.99 ± 0.297
0.99SerTyr: 0.99 ± 0.345
0.0SerXaa: 0.0 ± 0.0
Thr
7.369ThrAla: 7.369 ± 1.214
0.66ThrCys: 0.66 ± 0.244
4.619ThrAsp: 4.619 ± 0.698
2.2ThrGlu: 2.2 ± 0.568
1.21ThrPhe: 1.21 ± 0.384
5.719ThrGly: 5.719 ± 0.72
0.66ThrHis: 0.66 ± 0.289
4.179ThrIle: 4.179 ± 0.567
3.3ThrLys: 3.3 ± 0.649
7.589ThrLeu: 7.589 ± 0.984
1.87ThrMet: 1.87 ± 0.431
2.09ThrAsn: 2.09 ± 0.395
2.75ThrPro: 2.75 ± 0.43
2.64ThrGln: 2.64 ± 0.571
3.74ThrArg: 3.74 ± 0.654
3.08ThrSer: 3.08 ± 0.633
4.729ThrThr: 4.729 ± 0.933
4.619ThrVal: 4.619 ± 0.74
1.32ThrTrp: 1.32 ± 0.404
0.88ThrTyr: 0.88 ± 0.271
0.0ThrXaa: 0.0 ± 0.0
Val
6.159ValAla: 6.159 ± 0.629
0.77ValCys: 0.77 ± 0.238
3.74ValAsp: 3.74 ± 0.606
4.179ValGlu: 4.179 ± 0.73
2.64ValPhe: 2.64 ± 0.538
3.41ValGly: 3.41 ± 0.626
0.77ValHis: 0.77 ± 0.328
4.399ValIle: 4.399 ± 0.84
4.07ValLys: 4.07 ± 0.603
4.949ValLeu: 4.949 ± 0.642
1.98ValMet: 1.98 ± 0.519
2.64ValAsn: 2.64 ± 0.458
2.53ValPro: 2.53 ± 0.537
2.64ValGln: 2.64 ± 0.575
2.64ValArg: 2.64 ± 0.561
4.729ValSer: 4.729 ± 0.574
5.279ValThr: 5.279 ± 0.602
3.74ValVal: 3.74 ± 0.783
1.1ValTrp: 1.1 ± 0.312
1.76ValTyr: 1.76 ± 0.514
0.0ValXaa: 0.0 ± 0.0
Trp
1.43TrpAla: 1.43 ± 0.365
0.0TrpCys: 0.0 ± 0.0
0.88TrpAsp: 0.88 ± 0.299
0.99TrpGlu: 0.99 ± 0.305
0.33TrpPhe: 0.33 ± 0.142
0.33TrpGly: 0.33 ± 0.203
1.21TrpHis: 1.21 ± 0.384
0.77TrpIle: 0.77 ± 0.321
0.66TrpLys: 0.66 ± 0.273
3.08TrpLeu: 3.08 ± 0.729
0.22TrpMet: 0.22 ± 0.14
0.44TrpAsn: 0.44 ± 0.227
1.21TrpPro: 1.21 ± 0.292
0.55TrpGln: 0.55 ± 0.204
1.54TrpArg: 1.54 ± 0.369
0.44TrpSer: 0.44 ± 0.285
0.44TrpThr: 0.44 ± 0.215
0.66TrpVal: 0.66 ± 0.334
0.33TrpTrp: 0.33 ± 0.17
0.44TrpTyr: 0.44 ± 0.179
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.2TyrAla: 2.2 ± 0.692
0.11TyrCys: 0.11 ± 0.097
1.87TyrAsp: 1.87 ± 0.39
1.65TyrGlu: 1.65 ± 0.437
0.77TyrPhe: 0.77 ± 0.418
1.76TyrGly: 1.76 ± 0.429
0.55TyrHis: 0.55 ± 0.246
2.2TyrIle: 2.2 ± 0.49
0.66TyrLys: 0.66 ± 0.229
1.65TyrLeu: 1.65 ± 0.402
0.44TyrMet: 0.44 ± 0.217
0.44TyrAsn: 0.44 ± 0.25
1.76TyrPro: 1.76 ± 0.371
1.65TyrGln: 1.65 ± 0.459
1.87TyrArg: 1.87 ± 0.442
0.99TyrSer: 0.99 ± 0.343
1.54TyrThr: 1.54 ± 0.468
2.31TyrVal: 2.31 ± 0.476
0.22TyrTrp: 0.22 ± 0.148
0.44TyrTyr: 0.44 ± 0.245
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (9093 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski