Amino acid dipepetide frequency for Gordonia phage Rabbitrun

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.794AlaAla: 11.794 ± 1.063
0.836AlaCys: 0.836 ± 0.175
6.357AlaAsp: 6.357 ± 0.594
6.775AlaGlu: 6.775 ± 0.649
3.095AlaPhe: 3.095 ± 0.396
8.155AlaGly: 8.155 ± 0.652
2.133AlaHis: 2.133 ± 0.349
3.973AlaIle: 3.973 ± 0.476
4.517AlaLys: 4.517 ± 0.512
9.41AlaLeu: 9.41 ± 0.687
3.053AlaMet: 3.053 ± 0.38
3.429AlaAsn: 3.429 ± 0.47
4.6AlaPro: 4.6 ± 0.569
3.429AlaGln: 3.429 ± 0.391
6.942AlaArg: 6.942 ± 0.602
5.395AlaSer: 5.395 ± 0.48
7.11AlaThr: 7.11 ± 0.595
7.277AlaVal: 7.277 ± 0.54
2.3AlaTrp: 2.3 ± 0.3
2.175AlaTyr: 2.175 ± 0.322
0.0AlaXaa: 0.0 ± 0.0
Cys
0.878CysAla: 0.878 ± 0.187
0.293CysCys: 0.293 ± 0.142
0.669CysAsp: 0.669 ± 0.179
0.376CysGlu: 0.376 ± 0.132
0.084CysPhe: 0.084 ± 0.065
1.296CysGly: 1.296 ± 0.237
0.167CysHis: 0.167 ± 0.097
0.46CysIle: 0.46 ± 0.14
0.293CysLys: 0.293 ± 0.115
0.502CysLeu: 0.502 ± 0.171
0.335CysMet: 0.335 ± 0.118
0.209CysAsn: 0.209 ± 0.094
0.544CysPro: 0.544 ± 0.165
0.335CysGln: 0.335 ± 0.126
0.962CysArg: 0.962 ± 0.218
0.376CysSer: 0.376 ± 0.109
0.376CysThr: 0.376 ± 0.116
0.544CysVal: 0.544 ± 0.16
0.167CysTrp: 0.167 ± 0.117
0.376CysTyr: 0.376 ± 0.138
0.0CysXaa: 0.0 ± 0.0
Asp
6.901AspAla: 6.901 ± 0.531
0.753AspCys: 0.753 ± 0.207
6.106AspAsp: 6.106 ± 0.839
4.893AspGlu: 4.893 ± 0.607
1.757AspPhe: 1.757 ± 0.301
5.855AspGly: 5.855 ± 0.465
1.422AspHis: 1.422 ± 0.245
3.011AspIle: 3.011 ± 0.353
2.258AspLys: 2.258 ± 0.418
4.893AspLeu: 4.893 ± 0.46
1.464AspMet: 1.464 ± 0.289
2.049AspAsn: 2.049 ± 0.27
4.726AspPro: 4.726 ± 0.46
2.175AspGln: 2.175 ± 0.316
3.973AspArg: 3.973 ± 0.424
3.889AspSer: 3.889 ± 0.408
3.638AspThr: 3.638 ± 0.396
4.935AspVal: 4.935 ± 0.436
1.631AspTrp: 1.631 ± 0.273
2.049AspTyr: 2.049 ± 0.301
0.0AspXaa: 0.0 ± 0.0
Glu
5.939GluAla: 5.939 ± 0.648
0.711GluCys: 0.711 ± 0.165
3.68GluAsp: 3.68 ± 0.427
3.095GluGlu: 3.095 ± 0.359
3.262GluPhe: 3.262 ± 0.333
3.973GluGly: 3.973 ± 0.392
1.966GluHis: 1.966 ± 0.336
3.137GluIle: 3.137 ± 0.33
2.593GluLys: 2.593 ± 0.306
5.855GluLeu: 5.855 ± 0.604
1.38GluMet: 1.38 ± 0.227
2.133GluAsn: 2.133 ± 0.298
3.388GluPro: 3.388 ± 0.643
2.426GluGln: 2.426 ± 0.297
3.848GluArg: 3.848 ± 0.464
3.22GluSer: 3.22 ± 0.386
3.262GluThr: 3.262 ± 0.353
4.391GluVal: 4.391 ± 0.557
1.631GluTrp: 1.631 ± 0.265
1.798GluTyr: 1.798 ± 0.333
0.0GluXaa: 0.0 ± 0.0
Phe
3.011PheAla: 3.011 ± 0.388
0.376PheCys: 0.376 ± 0.109
2.133PheAsp: 2.133 ± 0.265
2.3PheGlu: 2.3 ± 0.275
0.795PhePhe: 0.795 ± 0.182
3.429PheGly: 3.429 ± 0.37
0.502PheHis: 0.502 ± 0.145
1.673PheIle: 1.673 ± 0.313
1.589PheLys: 1.589 ± 0.259
2.509PheLeu: 2.509 ± 0.332
1.046PheMet: 1.046 ± 0.197
1.464PheAsn: 1.464 ± 0.259
1.547PhePro: 1.547 ± 0.249
1.547PheGln: 1.547 ± 0.221
1.966PheArg: 1.966 ± 0.302
2.426PheSer: 2.426 ± 0.355
2.3PheThr: 2.3 ± 0.382
2.635PheVal: 2.635 ± 0.396
0.586PheTrp: 0.586 ± 0.171
0.753PheTyr: 0.753 ± 0.222
0.0PheXaa: 0.0 ± 0.0
Gly
6.524GlyAla: 6.524 ± 0.651
0.544GlyCys: 0.544 ± 0.159
5.102GlyAsp: 5.102 ± 0.473
5.228GlyGlu: 5.228 ± 0.542
3.304GlyPhe: 3.304 ± 0.43
7.779GlyGly: 7.779 ± 0.794
1.882GlyHis: 1.882 ± 0.327
4.475GlyIle: 4.475 ± 0.413
4.224GlyLys: 4.224 ± 0.466
5.479GlyLeu: 5.479 ± 0.457
2.802GlyMet: 2.802 ± 0.298
2.551GlyAsn: 2.551 ± 0.432
3.471GlyPro: 3.471 ± 0.47
2.802GlyGln: 2.802 ± 0.447
5.102GlyArg: 5.102 ± 0.553
6.441GlySer: 6.441 ± 0.589
4.851GlyThr: 4.851 ± 0.476
6.775GlyVal: 6.775 ± 0.51
1.924GlyTrp: 1.924 ± 0.318
3.471GlyTyr: 3.471 ± 0.367
0.0GlyXaa: 0.0 ± 0.0
His
1.255HisAla: 1.255 ± 0.234
0.209HisCys: 0.209 ± 0.095
1.213HisAsp: 1.213 ± 0.27
1.129HisGlu: 1.129 ± 0.2
0.753HisPhe: 0.753 ± 0.164
2.049HisGly: 2.049 ± 0.337
0.586HisHis: 0.586 ± 0.206
1.171HisIle: 1.171 ± 0.175
1.004HisLys: 1.004 ± 0.202
1.798HisLeu: 1.798 ± 0.269
0.711HisMet: 0.711 ± 0.203
0.753HisAsn: 0.753 ± 0.209
0.92HisPro: 0.92 ± 0.197
0.418HisGln: 0.418 ± 0.12
1.296HisArg: 1.296 ± 0.29
1.464HisSer: 1.464 ± 0.232
1.129HisThr: 1.129 ± 0.247
1.631HisVal: 1.631 ± 0.291
0.586HisTrp: 0.586 ± 0.173
0.753HisTyr: 0.753 ± 0.177
0.0HisXaa: 0.0 ± 0.0
Ile
5.479IleAla: 5.479 ± 0.438
0.795IleCys: 0.795 ± 0.223
2.928IleAsp: 2.928 ± 0.325
3.973IleGlu: 3.973 ± 0.402
1.38IlePhe: 1.38 ± 0.215
3.638IleGly: 3.638 ± 0.445
0.836IleHis: 0.836 ± 0.192
1.798IleIle: 1.798 ± 0.268
1.547IleLys: 1.547 ± 0.25
2.426IleLeu: 2.426 ± 0.337
0.627IleMet: 0.627 ± 0.167
1.506IleAsn: 1.506 ± 0.24
2.844IlePro: 2.844 ± 0.386
1.673IleGln: 1.673 ± 0.237
3.638IleArg: 3.638 ± 0.463
1.966IleSer: 1.966 ± 0.334
2.802IleThr: 2.802 ± 0.321
3.513IleVal: 3.513 ± 0.341
0.627IleTrp: 0.627 ± 0.133
1.171IleTyr: 1.171 ± 0.192
0.0IleXaa: 0.0 ± 0.0
Lys
4.81LysAla: 4.81 ± 0.558
0.293LysCys: 0.293 ± 0.121
2.3LysAsp: 2.3 ± 0.334
2.133LysGlu: 2.133 ± 0.336
1.757LysPhe: 1.757 ± 0.256
2.677LysGly: 2.677 ± 0.335
1.255LysHis: 1.255 ± 0.195
1.464LysIle: 1.464 ± 0.25
2.76LysLys: 2.76 ± 0.449
4.517LysLeu: 4.517 ± 0.41
1.213LysMet: 1.213 ± 0.234
1.464LysAsn: 1.464 ± 0.274
2.718LysPro: 2.718 ± 0.447
1.046LysGln: 1.046 ± 0.197
2.551LysArg: 2.551 ± 0.354
2.76LysSer: 2.76 ± 0.309
2.217LysThr: 2.217 ± 0.339
3.513LysVal: 3.513 ± 0.435
0.544LysTrp: 0.544 ± 0.131
1.046LysTyr: 1.046 ± 0.22
0.0LysXaa: 0.0 ± 0.0
Leu
8.573LeuAla: 8.573 ± 0.647
0.586LeuCys: 0.586 ± 0.173
5.688LeuAsp: 5.688 ± 0.499
3.722LeuGlu: 3.722 ± 0.41
2.509LeuPhe: 2.509 ± 0.33
6.357LeuGly: 6.357 ± 0.591
1.547LeuHis: 1.547 ± 0.284
4.182LeuIle: 4.182 ± 0.375
3.513LeuLys: 3.513 ± 0.45
6.942LeuLeu: 6.942 ± 0.646
1.966LeuMet: 1.966 ± 0.296
2.969LeuAsn: 2.969 ± 0.336
4.14LeuPro: 4.14 ± 0.354
2.091LeuGln: 2.091 ± 0.278
5.311LeuArg: 5.311 ± 0.478
4.893LeuSer: 4.893 ± 0.549
4.851LeuThr: 4.851 ± 0.539
5.604LeuVal: 5.604 ± 0.413
1.924LeuTrp: 1.924 ± 0.27
1.924LeuTyr: 1.924 ± 0.303
0.0LeuXaa: 0.0 ± 0.0
Met
2.886MetAla: 2.886 ± 0.37
0.167MetCys: 0.167 ± 0.081
0.962MetAsp: 0.962 ± 0.204
1.129MetGlu: 1.129 ± 0.203
0.92MetPhe: 0.92 ± 0.191
2.342MetGly: 2.342 ± 0.424
0.502MetHis: 0.502 ± 0.142
0.795MetIle: 0.795 ± 0.183
1.046MetLys: 1.046 ± 0.248
1.589MetLeu: 1.589 ± 0.246
0.502MetMet: 0.502 ± 0.163
0.753MetAsn: 0.753 ± 0.181
1.924MetPro: 1.924 ± 0.244
0.46MetGln: 0.46 ± 0.139
1.589MetArg: 1.589 ± 0.229
2.76MetSer: 2.76 ± 0.35
2.3MetThr: 2.3 ± 0.291
1.338MetVal: 1.338 ± 0.231
0.251MetTrp: 0.251 ± 0.098
0.544MetTyr: 0.544 ± 0.147
0.0MetXaa: 0.0 ± 0.0
Asn
3.597AsnAla: 3.597 ± 0.487
0.167AsnCys: 0.167 ± 0.076
2.3AsnAsp: 2.3 ± 0.283
2.049AsnGlu: 2.049 ± 0.298
1.255AsnPhe: 1.255 ± 0.22
3.555AsnGly: 3.555 ± 0.411
0.46AsnHis: 0.46 ± 0.139
1.38AsnIle: 1.38 ± 0.223
1.422AsnLys: 1.422 ± 0.265
3.262AsnLeu: 3.262 ± 0.394
0.753AsnMet: 0.753 ± 0.165
0.878AsnAsn: 0.878 ± 0.213
2.551AsnPro: 2.551 ± 0.386
0.962AsnGln: 0.962 ± 0.205
2.342AsnArg: 2.342 ± 0.314
1.84AsnSer: 1.84 ± 0.263
1.798AsnThr: 1.798 ± 0.26
2.175AsnVal: 2.175 ± 0.292
0.376AsnTrp: 0.376 ± 0.143
1.422AsnTyr: 1.422 ± 0.249
0.0AsnXaa: 0.0 ± 0.0
Pro
5.604ProAla: 5.604 ± 0.484
0.627ProCys: 0.627 ± 0.194
4.224ProAsp: 4.224 ± 0.516
4.057ProGlu: 4.057 ± 0.553
1.338ProPhe: 1.338 ± 0.221
3.68ProGly: 3.68 ± 0.509
0.795ProHis: 0.795 ± 0.22
2.342ProIle: 2.342 ± 0.288
2.509ProLys: 2.509 ± 0.375
3.513ProLeu: 3.513 ± 0.383
1.171ProMet: 1.171 ± 0.223
2.467ProAsn: 2.467 ± 0.325
2.133ProPro: 2.133 ± 0.318
1.673ProGln: 1.673 ± 0.255
2.3ProArg: 2.3 ± 0.305
2.677ProSer: 2.677 ± 0.355
4.099ProThr: 4.099 ± 0.526
3.471ProVal: 3.471 ± 0.526
1.589ProTrp: 1.589 ± 0.271
1.506ProTyr: 1.506 ± 0.277
0.0ProXaa: 0.0 ± 0.0
Gln
4.935GlnAla: 4.935 ± 0.414
0.167GlnCys: 0.167 ± 0.082
1.798GlnAsp: 1.798 ± 0.256
1.798GlnGlu: 1.798 ± 0.285
1.589GlnPhe: 1.589 ± 0.299
2.718GlnGly: 2.718 ± 0.376
0.711GlnHis: 0.711 ± 0.204
1.673GlnIle: 1.673 ± 0.255
1.38GlnLys: 1.38 ± 0.289
3.178GlnLeu: 3.178 ± 0.309
1.506GlnMet: 1.506 ± 0.23
1.087GlnAsn: 1.087 ± 0.224
1.213GlnPro: 1.213 ± 0.242
1.296GlnGln: 1.296 ± 0.224
2.049GlnArg: 2.049 ± 0.328
1.547GlnSer: 1.547 ± 0.198
1.673GlnThr: 1.673 ± 0.274
2.467GlnVal: 2.467 ± 0.259
0.376GlnTrp: 0.376 ± 0.163
1.087GlnTyr: 1.087 ± 0.244
0.0GlnXaa: 0.0 ± 0.0
Arg
5.981ArgAla: 5.981 ± 0.555
0.46ArgCys: 0.46 ± 0.144
5.06ArgAsp: 5.06 ± 0.459
4.642ArgGlu: 4.642 ± 0.521
2.049ArgPhe: 2.049 ± 0.268
4.433ArgGly: 4.433 ± 0.466
1.171ArgHis: 1.171 ± 0.22
3.053ArgIle: 3.053 ± 0.341
3.053ArgLys: 3.053 ± 0.375
5.27ArgLeu: 5.27 ± 0.481
1.715ArgMet: 1.715 ± 0.267
2.3ArgAsn: 2.3 ± 0.344
2.384ArgPro: 2.384 ± 0.32
2.969ArgGln: 2.969 ± 0.39
4.057ArgArg: 4.057 ± 0.555
3.638ArgSer: 3.638 ± 0.465
3.178ArgThr: 3.178 ± 0.343
4.726ArgVal: 4.726 ± 0.483
1.38ArgTrp: 1.38 ± 0.309
1.757ArgTyr: 1.757 ± 0.231
0.0ArgXaa: 0.0 ± 0.0
Ser
5.688SerAla: 5.688 ± 0.438
0.544SerCys: 0.544 ± 0.185
4.015SerAsp: 4.015 ± 0.382
2.635SerGlu: 2.635 ± 0.354
2.175SerPhe: 2.175 ± 0.331
6.524SerGly: 6.524 ± 0.701
1.171SerHis: 1.171 ± 0.222
2.886SerIle: 2.886 ± 0.335
2.217SerLys: 2.217 ± 0.346
4.559SerLeu: 4.559 ± 0.469
1.589SerMet: 1.589 ± 0.3
1.798SerAsn: 1.798 ± 0.308
2.718SerPro: 2.718 ± 0.347
2.426SerGln: 2.426 ± 0.324
3.722SerArg: 3.722 ± 0.509
4.099SerSer: 4.099 ± 0.538
3.68SerThr: 3.68 ± 0.498
4.266SerVal: 4.266 ± 0.359
1.129SerTrp: 1.129 ± 0.221
1.506SerTyr: 1.506 ± 0.262
0.0SerXaa: 0.0 ± 0.0
Thr
5.479ThrAla: 5.479 ± 0.667
0.293ThrCys: 0.293 ± 0.114
3.973ThrAsp: 3.973 ± 0.333
3.471ThrGlu: 3.471 ± 0.47
2.467ThrPhe: 2.467 ± 0.348
6.273ThrGly: 6.273 ± 0.649
1.046ThrHis: 1.046 ± 0.204
2.593ThrIle: 2.593 ± 0.371
2.718ThrLys: 2.718 ± 0.323
4.433ThrLeu: 4.433 ± 0.451
0.92ThrMet: 0.92 ± 0.154
2.3ThrAsn: 2.3 ± 0.291
4.015ThrPro: 4.015 ± 0.432
1.798ThrGln: 1.798 ± 0.295
3.513ThrArg: 3.513 ± 0.352
2.677ThrSer: 2.677 ± 0.396
3.513ThrThr: 3.513 ± 0.362
5.437ThrVal: 5.437 ± 0.56
0.92ThrTrp: 0.92 ± 0.211
1.798ThrTyr: 1.798 ± 0.301
0.0ThrXaa: 0.0 ± 0.0
Val
8.197ValAla: 8.197 ± 0.769
1.046ValCys: 1.046 ± 0.228
6.19ValAsp: 6.19 ± 0.551
4.768ValGlu: 4.768 ± 0.526
2.551ValPhe: 2.551 ± 0.298
5.646ValGly: 5.646 ± 0.445
1.84ValHis: 1.84 ± 0.266
3.304ValIle: 3.304 ± 0.319
2.509ValLys: 2.509 ± 0.338
5.144ValLeu: 5.144 ± 0.447
1.338ValMet: 1.338 ± 0.209
2.258ValAsn: 2.258 ± 0.228
3.973ValPro: 3.973 ± 0.497
2.677ValGln: 2.677 ± 0.393
4.851ValArg: 4.851 ± 0.503
4.642ValSer: 4.642 ± 0.433
3.806ValThr: 3.806 ± 0.447
5.855ValVal: 5.855 ± 0.526
1.213ValTrp: 1.213 ± 0.248
2.091ValTyr: 2.091 ± 0.29
0.0ValXaa: 0.0 ± 0.0
Trp
2.091TrpAla: 2.091 ± 0.273
0.209TrpCys: 0.209 ± 0.093
1.296TrpAsp: 1.296 ± 0.205
1.338TrpGlu: 1.338 ± 0.27
0.627TrpPhe: 0.627 ± 0.189
1.464TrpGly: 1.464 ± 0.269
0.335TrpHis: 0.335 ± 0.1
1.046TrpIle: 1.046 ± 0.222
0.795TrpLys: 0.795 ± 0.185
1.882TrpLeu: 1.882 ± 0.272
0.46TrpMet: 0.46 ± 0.149
0.92TrpAsn: 0.92 ± 0.2
0.92TrpPro: 0.92 ± 0.234
0.753TrpGln: 0.753 ± 0.208
1.506TrpArg: 1.506 ± 0.265
1.087TrpSer: 1.087 ± 0.218
1.338TrpThr: 1.338 ± 0.297
1.255TrpVal: 1.255 ± 0.237
0.544TrpTrp: 0.544 ± 0.136
0.335TrpTyr: 0.335 ± 0.109
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.137TyrAla: 3.137 ± 0.328
0.167TyrCys: 0.167 ± 0.081
2.384TyrAsp: 2.384 ± 0.371
2.175TyrGlu: 2.175 ± 0.317
0.92TyrPhe: 0.92 ± 0.198
2.886TyrGly: 2.886 ± 0.336
0.502TyrHis: 0.502 ± 0.167
0.753TyrIle: 0.753 ± 0.165
1.087TyrLys: 1.087 ± 0.211
2.133TyrLeu: 2.133 ± 0.316
0.167TyrMet: 0.167 ± 0.084
1.255TyrAsn: 1.255 ± 0.227
1.046TyrPro: 1.046 ± 0.197
1.296TyrGln: 1.296 ± 0.21
1.757TyrArg: 1.757 ± 0.339
1.547TyrSer: 1.547 ± 0.277
1.715TyrThr: 1.715 ± 0.288
2.091TyrVal: 2.091 ± 0.296
0.544TyrTrp: 0.544 ± 0.161
1.046TyrTyr: 1.046 ± 0.259
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 132 proteins (23912 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski