Amino acid dipepetide frequency for Thermus virus P23-77

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.1AlaAla: 12.1 ± 1.875
1.423AlaCys: 1.423 ± 0.579
2.669AlaAsp: 2.669 ± 0.844
3.737AlaGlu: 3.737 ± 0.961
3.559AlaPhe: 3.559 ± 0.704
9.075AlaGly: 9.075 ± 1.407
1.246AlaHis: 1.246 ± 0.417
2.313AlaIle: 2.313 ± 0.559
4.982AlaLys: 4.982 ± 1.218
16.192AlaLeu: 16.192 ± 1.719
3.025AlaMet: 3.025 ± 0.671
2.135AlaAsn: 2.135 ± 0.596
6.94AlaPro: 6.94 ± 1.251
6.406AlaGln: 6.406 ± 1.257
7.651AlaArg: 7.651 ± 1.122
4.448AlaSer: 4.448 ± 0.895
5.338AlaThr: 5.338 ± 0.879
11.566AlaVal: 11.566 ± 1.85
2.135AlaTrp: 2.135 ± 0.897
4.27AlaTyr: 4.27 ± 0.822
0.0AlaXaa: 0.0 ± 0.0
Cys
0.534CysAla: 0.534 ± 0.416
0.0CysCys: 0.0 ± 0.0
0.712CysAsp: 0.712 ± 0.37
0.178CysGlu: 0.178 ± 0.225
0.178CysPhe: 0.178 ± 0.189
0.534CysGly: 0.534 ± 0.287
0.0CysHis: 0.0 ± 0.0
0.178CysIle: 0.178 ± 0.155
0.0CysLys: 0.0 ± 0.0
0.534CysLeu: 0.534 ± 0.388
0.534CysMet: 0.534 ± 0.328
0.0CysAsn: 0.0 ± 0.0
0.89CysPro: 0.89 ± 0.427
0.356CysGln: 0.356 ± 0.23
0.534CysArg: 0.534 ± 0.274
0.89CysSer: 0.89 ± 0.388
0.712CysThr: 0.712 ± 0.345
0.356CysVal: 0.356 ± 0.253
0.178CysTrp: 0.178 ± 0.148
0.178CysTyr: 0.178 ± 0.175
0.0CysXaa: 0.0 ± 0.0
Asp
3.737AspAla: 3.737 ± 0.866
0.356AspCys: 0.356 ± 0.256
1.246AspAsp: 1.246 ± 0.423
0.712AspGlu: 0.712 ± 0.333
1.068AspPhe: 1.068 ± 0.39
4.448AspGly: 4.448 ± 0.807
0.0AspHis: 0.0 ± 0.0
1.957AspIle: 1.957 ± 0.603
0.89AspLys: 0.89 ± 0.316
6.05AspLeu: 6.05 ± 0.903
0.89AspMet: 0.89 ± 0.293
0.356AspAsn: 0.356 ± 0.249
5.16AspPro: 5.16 ± 1.033
1.423AspGln: 1.423 ± 0.475
2.313AspArg: 2.313 ± 0.616
1.601AspSer: 1.601 ± 0.437
2.135AspThr: 2.135 ± 0.529
3.025AspVal: 3.025 ± 0.838
0.534AspTrp: 0.534 ± 0.409
1.068AspTyr: 1.068 ± 0.377
0.0AspXaa: 0.0 ± 0.0
Glu
8.363GluAla: 8.363 ± 1.539
0.534GluCys: 0.534 ± 0.28
1.779GluAsp: 1.779 ± 0.48
5.872GluGlu: 5.872 ± 1.613
1.957GluPhe: 1.957 ± 0.692
4.448GluGly: 4.448 ± 1.06
0.356GluHis: 0.356 ± 0.216
1.601GluIle: 1.601 ± 0.587
1.068GluLys: 1.068 ± 0.544
4.982GluLeu: 4.982 ± 0.796
1.423GluMet: 1.423 ± 0.418
1.068GluAsn: 1.068 ± 0.424
2.135GluPro: 2.135 ± 0.522
1.779GluGln: 1.779 ± 0.549
5.338GluArg: 5.338 ± 1.139
1.068GluSer: 1.068 ± 0.386
2.669GluThr: 2.669 ± 0.702
6.762GluVal: 6.762 ± 0.989
2.491GluTrp: 2.491 ± 0.641
1.068GluTyr: 1.068 ± 0.393
0.0GluXaa: 0.0 ± 0.0
Phe
2.669PheAla: 2.669 ± 0.546
0.178PheCys: 0.178 ± 0.155
1.246PheAsp: 1.246 ± 0.393
0.356PheGlu: 0.356 ± 0.264
0.356PhePhe: 0.356 ± 0.266
3.381PheGly: 3.381 ± 0.754
0.356PheHis: 0.356 ± 0.241
0.712PheIle: 0.712 ± 0.311
0.356PheLys: 0.356 ± 0.24
3.025PheLeu: 3.025 ± 0.721
0.178PheMet: 0.178 ± 0.175
0.712PheAsn: 0.712 ± 0.355
2.313PhePro: 2.313 ± 0.769
1.779PheGln: 1.779 ± 0.827
2.135PheArg: 2.135 ± 0.829
1.601PheSer: 1.601 ± 0.65
2.135PheThr: 2.135 ± 0.826
1.601PheVal: 1.601 ± 0.546
0.534PheTrp: 0.534 ± 0.381
0.356PheTyr: 0.356 ± 0.224
0.0PheXaa: 0.0 ± 0.0
Gly
8.719GlyAla: 8.719 ± 1.322
0.712GlyCys: 0.712 ± 0.365
3.737GlyAsp: 3.737 ± 0.748
4.626GlyGlu: 4.626 ± 0.983
2.847GlyPhe: 2.847 ± 0.685
13.701GlyGly: 13.701 ± 2.33
2.135GlyHis: 2.135 ± 0.549
4.27GlyIle: 4.27 ± 0.817
3.203GlyLys: 3.203 ± 0.658
9.786GlyLeu: 9.786 ± 1.237
0.89GlyMet: 0.89 ± 0.458
1.957GlyAsn: 1.957 ± 0.544
7.117GlyPro: 7.117 ± 1.099
4.27GlyGln: 4.27 ± 1.035
7.295GlyArg: 7.295 ± 1.262
5.516GlySer: 5.516 ± 0.972
5.694GlyThr: 5.694 ± 1.554
9.431GlyVal: 9.431 ± 1.1
1.601GlyTrp: 1.601 ± 0.56
2.491GlyTyr: 2.491 ± 0.678
0.0GlyXaa: 0.0 ± 0.0
His
0.712HisAla: 0.712 ± 0.329
0.0HisCys: 0.0 ± 0.0
0.89HisAsp: 0.89 ± 0.311
0.0HisGlu: 0.0 ± 0.0
0.534HisPhe: 0.534 ± 0.312
1.423HisGly: 1.423 ± 0.577
0.534HisHis: 0.534 ± 0.354
0.534HisIle: 0.534 ± 0.268
0.0HisLys: 0.0 ± 0.0
1.601HisLeu: 1.601 ± 0.792
0.178HisMet: 0.178 ± 0.164
0.534HisAsn: 0.534 ± 0.288
0.712HisPro: 0.712 ± 0.345
0.89HisGln: 0.89 ± 0.356
0.712HisArg: 0.712 ± 0.478
0.534HisSer: 0.534 ± 0.258
0.178HisThr: 0.178 ± 0.175
1.601HisVal: 1.601 ± 0.505
0.534HisTrp: 0.534 ± 0.356
0.178HisTyr: 0.178 ± 0.193
0.0HisXaa: 0.0 ± 0.0
Ile
4.804IleAla: 4.804 ± 1.089
0.712IleCys: 0.712 ± 0.337
1.068IleAsp: 1.068 ± 0.393
2.135IleGlu: 2.135 ± 0.726
1.246IlePhe: 1.246 ± 0.369
2.847IleGly: 2.847 ± 0.67
0.534IleHis: 0.534 ± 0.271
1.601IleIle: 1.601 ± 0.492
1.068IleLys: 1.068 ± 0.45
3.737IleLeu: 3.737 ± 1.044
0.0IleMet: 0.0 ± 0.0
0.534IleAsn: 0.534 ± 0.273
3.025IlePro: 3.025 ± 0.864
0.89IleGln: 0.89 ± 0.469
4.804IleArg: 4.804 ± 1.363
0.89IleSer: 0.89 ± 0.304
1.068IleThr: 1.068 ± 0.453
2.135IleVal: 2.135 ± 0.524
0.534IleTrp: 0.534 ± 0.295
0.712IleTyr: 0.712 ± 0.433
0.0IleXaa: 0.0 ± 0.0
Lys
2.669LysAla: 2.669 ± 0.586
0.178LysCys: 0.178 ± 0.225
1.779LysAsp: 1.779 ± 0.574
3.915LysGlu: 3.915 ± 0.977
0.534LysPhe: 0.534 ± 0.277
3.381LysGly: 3.381 ± 0.899
0.0LysHis: 0.0 ± 0.0
0.0LysIle: 0.0 ± 0.0
1.246LysLys: 1.246 ± 0.576
1.957LysLeu: 1.957 ± 0.574
0.534LysMet: 0.534 ± 0.283
0.712LysAsn: 0.712 ± 0.314
2.135LysPro: 2.135 ± 0.73
1.068LysGln: 1.068 ± 0.46
3.737LysArg: 3.737 ± 1.154
1.957LysSer: 1.957 ± 0.601
1.246LysThr: 1.246 ± 0.403
3.381LysVal: 3.381 ± 0.898
0.356LysTrp: 0.356 ± 0.228
0.178LysTyr: 0.178 ± 0.173
0.0LysXaa: 0.0 ± 0.0
Leu
14.413LeuAla: 14.413 ± 1.976
0.534LeuCys: 0.534 ± 0.344
4.27LeuAsp: 4.27 ± 0.653
6.94LeuGlu: 6.94 ± 1.192
1.957LeuPhe: 1.957 ± 0.49
13.523LeuGly: 13.523 ± 2.254
1.423LeuHis: 1.423 ± 0.538
2.847LeuIle: 2.847 ± 1.017
4.448LeuLys: 4.448 ± 0.883
10.32LeuLeu: 10.32 ± 1.688
2.313LeuMet: 2.313 ± 0.664
2.491LeuAsn: 2.491 ± 0.566
6.228LeuPro: 6.228 ± 1.15
4.093LeuGln: 4.093 ± 0.927
8.363LeuArg: 8.363 ± 1.593
5.16LeuSer: 5.16 ± 0.709
4.093LeuThr: 4.093 ± 1.295
7.473LeuVal: 7.473 ± 1.136
1.246LeuTrp: 1.246 ± 0.456
3.203LeuTyr: 3.203 ± 0.837
0.0LeuXaa: 0.0 ± 0.0
Met
2.313MetAla: 2.313 ± 0.663
0.178MetCys: 0.178 ± 0.193
0.534MetAsp: 0.534 ± 0.279
1.779MetGlu: 1.779 ± 0.64
0.356MetPhe: 0.356 ± 0.276
3.025MetGly: 3.025 ± 0.682
0.356MetHis: 0.356 ± 0.254
0.356MetIle: 0.356 ± 0.249
0.89MetLys: 0.89 ± 0.347
1.779MetLeu: 1.779 ± 0.442
0.178MetMet: 0.178 ± 0.225
0.356MetAsn: 0.356 ± 0.296
0.712MetPro: 0.712 ± 0.369
0.712MetGln: 0.712 ± 0.39
3.203MetArg: 3.203 ± 0.705
0.89MetSer: 0.89 ± 0.35
0.712MetThr: 0.712 ± 0.308
1.068MetVal: 1.068 ± 0.433
0.178MetTrp: 0.178 ± 0.172
0.178MetTyr: 0.178 ± 0.202
0.0MetXaa: 0.0 ± 0.0
Asn
0.89AsnAla: 0.89 ± 0.501
0.178AsnCys: 0.178 ± 0.148
0.356AsnAsp: 0.356 ± 0.233
0.89AsnGlu: 0.89 ± 0.47
0.178AsnPhe: 0.178 ± 0.155
0.712AsnGly: 0.712 ± 0.39
0.0AsnHis: 0.0 ± 0.0
1.246AsnIle: 1.246 ± 0.431
0.534AsnLys: 0.534 ± 0.28
3.915AsnLeu: 3.915 ± 1.082
0.0AsnMet: 0.0 ± 0.0
0.89AsnAsn: 0.89 ± 0.401
2.847AsnPro: 2.847 ± 0.69
0.534AsnGln: 0.534 ± 0.277
2.135AsnArg: 2.135 ± 0.592
1.068AsnSer: 1.068 ± 0.387
0.712AsnThr: 0.712 ± 0.387
1.068AsnVal: 1.068 ± 0.36
0.178AsnTrp: 0.178 ± 0.173
1.068AsnTyr: 1.068 ± 0.544
0.0AsnXaa: 0.0 ± 0.0
Pro
10.676ProAla: 10.676 ± 1.681
0.89ProCys: 0.89 ± 0.413
3.025ProAsp: 3.025 ± 0.758
3.025ProGlu: 3.025 ± 0.796
2.135ProPhe: 2.135 ± 0.464
7.651ProGly: 7.651 ± 0.868
1.423ProHis: 1.423 ± 0.499
1.423ProIle: 1.423 ± 0.493
2.313ProLys: 2.313 ± 0.755
5.16ProLeu: 5.16 ± 0.996
1.779ProMet: 1.779 ± 0.47
0.712ProAsn: 0.712 ± 0.308
8.363ProPro: 8.363 ± 2.167
5.516ProGln: 5.516 ± 1.143
4.626ProArg: 4.626 ± 0.912
7.651ProSer: 7.651 ± 1.0
6.228ProThr: 6.228 ± 1.54
4.982ProVal: 4.982 ± 1.218
1.068ProTrp: 1.068 ± 0.436
1.601ProTyr: 1.601 ± 0.406
0.0ProXaa: 0.0 ± 0.0
Gln
6.584GlnAla: 6.584 ± 1.09
0.178GlnCys: 0.178 ± 0.175
2.313GlnAsp: 2.313 ± 0.868
3.381GlnGlu: 3.381 ± 0.676
1.068GlnPhe: 1.068 ± 0.379
2.669GlnGly: 2.669 ± 0.686
0.534GlnHis: 0.534 ± 0.333
2.313GlnIle: 2.313 ± 0.544
2.135GlnLys: 2.135 ± 0.635
2.669GlnLeu: 2.669 ± 0.854
1.068GlnMet: 1.068 ± 0.458
0.712GlnAsn: 0.712 ± 0.315
3.915GlnPro: 3.915 ± 1.008
1.068GlnGln: 1.068 ± 0.407
3.203GlnArg: 3.203 ± 0.622
2.135GlnSer: 2.135 ± 0.548
2.313GlnThr: 2.313 ± 0.651
3.915GlnVal: 3.915 ± 0.785
0.356GlnTrp: 0.356 ± 0.226
0.89GlnTyr: 0.89 ± 0.361
0.0GlnXaa: 0.0 ± 0.0
Arg
9.431ArgAla: 9.431 ± 1.535
0.356ArgCys: 0.356 ± 0.224
4.448ArgAsp: 4.448 ± 1.127
5.872ArgGlu: 5.872 ± 1.079
2.491ArgPhe: 2.491 ± 0.96
6.05ArgGly: 6.05 ± 0.999
0.89ArgHis: 0.89 ± 0.421
5.694ArgIle: 5.694 ± 1.024
3.381ArgLys: 3.381 ± 0.729
8.007ArgLeu: 8.007 ± 1.496
2.491ArgMet: 2.491 ± 0.751
1.246ArgAsn: 1.246 ± 0.539
6.228ArgPro: 6.228 ± 1.293
2.669ArgGln: 2.669 ± 0.723
7.473ArgArg: 7.473 ± 1.501
2.847ArgSer: 2.847 ± 0.544
3.381ArgThr: 3.381 ± 0.703
6.228ArgVal: 6.228 ± 1.272
1.068ArgTrp: 1.068 ± 0.368
2.847ArgTyr: 2.847 ± 0.652
0.0ArgXaa: 0.0 ± 0.0
Ser
3.381SerAla: 3.381 ± 0.744
0.534SerCys: 0.534 ± 0.388
2.135SerAsp: 2.135 ± 0.588
2.135SerGlu: 2.135 ± 0.427
1.068SerPhe: 1.068 ± 0.446
6.228SerGly: 6.228 ± 1.035
0.178SerHis: 0.178 ± 0.203
1.246SerIle: 1.246 ± 0.567
0.712SerLys: 0.712 ± 0.298
3.737SerLeu: 3.737 ± 1.008
1.246SerMet: 1.246 ± 0.426
1.246SerAsn: 1.246 ± 0.545
6.228SerPro: 6.228 ± 1.007
2.135SerGln: 2.135 ± 0.603
3.025SerArg: 3.025 ± 0.662
4.093SerSer: 4.093 ± 1.242
3.025SerThr: 3.025 ± 0.878
2.847SerVal: 2.847 ± 0.72
1.423SerTrp: 1.423 ± 0.533
2.313SerTyr: 2.313 ± 0.727
0.0SerXaa: 0.0 ± 0.0
Thr
4.27ThrAla: 4.27 ± 0.986
0.356ThrCys: 0.356 ± 0.237
1.246ThrAsp: 1.246 ± 0.459
3.559ThrGlu: 3.559 ± 0.774
1.601ThrPhe: 1.601 ± 0.888
6.584ThrGly: 6.584 ± 1.729
0.89ThrHis: 0.89 ± 0.437
0.534ThrIle: 0.534 ± 0.283
0.712ThrLys: 0.712 ± 0.303
6.406ThrLeu: 6.406 ± 0.838
0.712ThrMet: 0.712 ± 0.481
0.534ThrAsn: 0.534 ± 0.247
5.872ThrPro: 5.872 ± 1.436
1.601ThrGln: 1.601 ± 0.53
3.737ThrArg: 3.737 ± 0.789
2.491ThrSer: 2.491 ± 0.675
2.669ThrThr: 2.669 ± 0.547
2.313ThrVal: 2.313 ± 0.61
1.068ThrTrp: 1.068 ± 0.44
1.779ThrTyr: 1.779 ± 0.555
0.0ThrXaa: 0.0 ± 0.0
Val
9.964ValAla: 9.964 ± 1.238
0.178ValCys: 0.178 ± 0.148
2.847ValAsp: 2.847 ± 0.559
3.381ValGlu: 3.381 ± 0.849
2.313ValPhe: 2.313 ± 0.811
6.584ValGly: 6.584 ± 0.849
0.89ValHis: 0.89 ± 0.379
2.313ValIle: 2.313 ± 0.681
1.957ValLys: 1.957 ± 0.548
9.786ValLeu: 9.786 ± 1.256
1.423ValMet: 1.423 ± 0.53
2.135ValAsn: 2.135 ± 0.598
6.406ValPro: 6.406 ± 0.941
3.737ValGln: 3.737 ± 0.73
6.762ValArg: 6.762 ± 1.048
2.847ValSer: 2.847 ± 0.61
3.025ValThr: 3.025 ± 0.735
9.786ValVal: 9.786 ± 2.055
3.737ValTrp: 3.737 ± 0.715
2.847ValTyr: 2.847 ± 0.644
0.0ValXaa: 0.0 ± 0.0
Trp
2.135TrpAla: 2.135 ± 0.66
0.0TrpCys: 0.0 ± 0.0
1.068TrpAsp: 1.068 ± 0.37
2.135TrpGlu: 2.135 ± 1.065
0.178TrpPhe: 0.178 ± 0.178
1.601TrpGly: 1.601 ± 0.491
0.0TrpHis: 0.0 ± 0.0
0.534TrpIle: 0.534 ± 0.258
0.178TrpLys: 0.178 ± 0.169
2.847TrpLeu: 2.847 ± 0.693
0.356TrpMet: 0.356 ± 0.242
0.534TrpAsn: 0.534 ± 0.321
0.89TrpPro: 0.89 ± 0.402
1.246TrpGln: 1.246 ± 0.311
3.025TrpArg: 3.025 ± 0.784
0.178TrpSer: 0.178 ± 0.148
0.178TrpThr: 0.178 ± 0.173
1.779TrpVal: 1.779 ± 0.634
0.534TrpTrp: 0.534 ± 0.371
0.89TrpTyr: 0.89 ± 0.353
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.847TyrAla: 2.847 ± 0.749
0.0TyrCys: 0.0 ± 0.0
1.601TyrAsp: 1.601 ± 0.647
2.135TyrGlu: 2.135 ± 0.557
0.356TyrPhe: 0.356 ± 0.238
2.135TyrGly: 2.135 ± 0.658
0.534TyrHis: 0.534 ± 0.291
2.669TyrIle: 2.669 ± 0.652
0.89TyrLys: 0.89 ± 0.505
2.847TyrLeu: 2.847 ± 0.586
0.356TyrMet: 0.356 ± 0.235
0.534TyrAsn: 0.534 ± 0.353
2.135TyrPro: 2.135 ± 0.745
1.246TyrGln: 1.246 ± 0.444
3.025TyrArg: 3.025 ± 0.67
1.068TyrSer: 1.068 ± 0.357
1.423TyrThr: 1.423 ± 0.507
1.779TyrVal: 1.779 ± 0.449
0.534TyrTrp: 0.534 ± 0.394
1.601TyrTyr: 1.601 ± 0.727
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 37 proteins (5621 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski