Amino acid dipepetide frequency for Paraprevotella clara CAG:116

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.331AlaAla: 6.331 ± 0.101	1.31AlaCys: 1.31 ± 0.041	4.854AlaAsp: 4.854 ± 0.071	5.154AlaGlu: 5.154 ± 0.073	3.305AlaPhe: 3.305 ± 0.067	5.58AlaGly: 5.58 ± 0.075	1.463AlaHis: 1.463 ± 0.039	4.031AlaIle: 4.031 ± 0.065	3.587AlaLys: 3.587 ± 0.065	7.149AlaLeu: 7.149 ± 0.095	2.047AlaMet: 2.047 ± 0.046	2.861AlaAsn: 2.861 ± 0.058	2.509AlaPro: 2.509 ± 0.054	2.894AlaGln: 2.894 ± 0.049	3.773AlaArg: 3.773 ± 0.07	4.342AlaSer: 4.342 ± 0.078	3.932AlaThr: 3.932 ± 0.081	5.65AlaVal: 5.65 ± 0.073	1.024AlaTrp: 1.024 ± 0.032	3.426AlaTyr: 3.426 ± 0.062	0.001AlaXaa: 0.001 ± 0.001
Cys	0.977CysAla: 0.977 ± 0.031	0.265CysCys: 0.265 ± 0.018	0.713CysAsp: 0.713 ± 0.023	0.724CysGlu: 0.724 ± 0.027	0.691CysPhe: 0.691 ± 0.028	1.254CysGly: 1.254 ± 0.033	0.384CysHis: 0.384 ± 0.015	0.856CysIle: 0.856 ± 0.03	0.632CysLys: 0.632 ± 0.026	1.224CysLeu: 1.224 ± 0.038	0.418CysMet: 0.418 ± 0.018	0.59CysAsn: 0.59 ± 0.025	0.626CysPro: 0.626 ± 0.027	0.36CysGln: 0.36 ± 0.018	0.915CysArg: 0.915 ± 0.034	0.765CysSer: 0.765 ± 0.028	0.826CysThr: 0.826 ± 0.032	0.929CysVal: 0.929 ± 0.034	0.197CysTrp: 0.197 ± 0.013	0.621CysTyr: 0.621 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.358AspAla: 4.358 ± 0.062	0.745AspCys: 0.745 ± 0.023	2.87AspAsp: 2.87 ± 0.064	4.216AspGlu: 4.216 ± 0.064	3.34AspPhe: 3.34 ± 0.061	5.36AspGly: 5.36 ± 0.106	0.928AspHis: 0.928 ± 0.032	3.801AspIle: 3.801 ± 0.066	3.478AspLys: 3.478 ± 0.062	4.844AspLeu: 4.844 ± 0.072	1.756AspMet: 1.756 ± 0.046	2.567AspAsn: 2.567 ± 0.061	1.818AspPro: 1.818 ± 0.047	1.126AspGln: 1.126 ± 0.032	2.922AspArg: 2.922 ± 0.054	3.005AspSer: 3.005 ± 0.067	3.037AspThr: 3.037 ± 0.063	4.096AspVal: 4.096 ± 0.071	0.933AspTrp: 0.933 ± 0.027	3.002AspTyr: 3.002 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	5.478GluAla: 5.478 ± 0.093	0.679GluCys: 0.679 ± 0.025	3.792GluAsp: 3.792 ± 0.064	5.209GluGlu: 5.209 ± 0.086	2.293GluPhe: 2.293 ± 0.049	4.885GluGly: 4.885 ± 0.084	1.333GluHis: 1.333 ± 0.04	3.985GluIle: 3.985 ± 0.06	4.522GluLys: 4.522 ± 0.07	5.586GluLeu: 5.586 ± 0.08	2.008GluMet: 2.008 ± 0.044	3.384GluAsn: 3.384 ± 0.054	1.881GluPro: 1.881 ± 0.042	2.476GluGln: 2.476 ± 0.05	3.733GluArg: 3.733 ± 0.07	3.068GluSer: 3.068 ± 0.055	3.646GluThr: 3.646 ± 0.057	4.403GluVal: 4.403 ± 0.073	0.929GluTrp: 0.929 ± 0.03	2.652GluTyr: 2.652 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.053PheAla: 3.053 ± 0.052	0.82PheCys: 0.82 ± 0.027	2.82PheAsp: 2.82 ± 0.056	2.451PheGlu: 2.451 ± 0.058	2.154PhePhe: 2.154 ± 0.056	3.263PheGly: 3.263 ± 0.058	0.947PheHis: 0.947 ± 0.033	2.722PheIle: 2.722 ± 0.057	2.242PheLys: 2.242 ± 0.046	3.874PheLeu: 3.874 ± 0.064	1.232PheMet: 1.232 ± 0.034	2.189PheAsn: 2.189 ± 0.048	1.673PhePro: 1.673 ± 0.04	1.216PheGln: 1.216 ± 0.032	2.581PheArg: 2.581 ± 0.051	3.275PheSer: 3.275 ± 0.064	2.809PheThr: 2.809 ± 0.057	3.028PheVal: 3.028 ± 0.048	0.566PheTrp: 0.566 ± 0.027	2.048PheTyr: 2.048 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	4.764GlyAla: 4.764 ± 0.08	1.118GlyCys: 1.118 ± 0.035	3.955GlyAsp: 3.955 ± 0.06	4.663GlyGlu: 4.663 ± 0.073	3.298GlyPhe: 3.298 ± 0.056	5.517GlyGly: 5.517 ± 0.101	1.575GlyHis: 1.575 ± 0.042	4.934GlyIle: 4.934 ± 0.067	5.093GlyLys: 5.093 ± 0.078	6.41GlyLeu: 6.41 ± 0.088	2.33GlyMet: 2.33 ± 0.045	3.556GlyAsn: 3.556 ± 0.071	1.431GlyPro: 1.431 ± 0.042	2.496GlyGln: 2.496 ± 0.04	4.061GlyArg: 4.061 ± 0.067	3.983GlySer: 3.983 ± 0.074	4.684GlyThr: 4.684 ± 0.087	5.14GlyVal: 5.14 ± 0.074	1.266GlyTrp: 1.266 ± 0.039	3.418GlyTyr: 3.418 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.376HisAla: 1.376 ± 0.036	0.295HisCys: 0.295 ± 0.018	1.04HisAsp: 1.04 ± 0.033	1.143HisGlu: 1.143 ± 0.036	1.075HisPhe: 1.075 ± 0.033	1.464HisGly: 1.464 ± 0.039	0.506HisHis: 0.506 ± 0.025	1.455HisIle: 1.455 ± 0.041	1.029HisLys: 1.029 ± 0.03	1.78HisLeu: 1.78 ± 0.045	0.333HisMet: 0.333 ± 0.018	0.837HisAsn: 0.837 ± 0.029	1.198HisPro: 1.198 ± 0.036	0.613HisGln: 0.613 ± 0.022	1.06HisArg: 1.06 ± 0.036	1.122HisSer: 1.122 ± 0.03	1.261HisThr: 1.261 ± 0.035	1.32HisVal: 1.32 ± 0.039	0.288HisTrp: 0.288 ± 0.015	1.034HisTyr: 1.034 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	4.352IleAla: 4.352 ± 0.069	0.897IleCys: 0.897 ± 0.033	3.68IleAsp: 3.68 ± 0.06	3.711IleGlu: 3.711 ± 0.071	2.339IlePhe: 2.339 ± 0.045	4.185IleGly: 4.185 ± 0.064	1.275IleHis: 1.275 ± 0.036	3.281IleIle: 3.281 ± 0.078	3.122IleLys: 3.122 ± 0.062	5.182IleLeu: 5.182 ± 0.078	1.294IleMet: 1.294 ± 0.035	2.481IleAsn: 2.481 ± 0.048	2.885IlePro: 2.885 ± 0.057	1.882IleGln: 1.882 ± 0.045	3.468IleArg: 3.468 ± 0.059	3.678IleSer: 3.678 ± 0.071	3.225IleThr: 3.225 ± 0.063	3.985IleVal: 3.985 ± 0.065	0.685IleTrp: 0.685 ± 0.022	2.46IleTyr: 2.46 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.846LysAla: 4.846 ± 0.084	0.534LysCys: 0.534 ± 0.02	3.724LysAsp: 3.724 ± 0.058	4.72LysGlu: 4.72 ± 0.076	1.96LysPhe: 1.96 ± 0.038	4.36LysGly: 4.36 ± 0.069	1.013LysHis: 1.013 ± 0.031	3.356LysIle: 3.356 ± 0.06	4.028LysLys: 4.028 ± 0.08	4.617LysLeu: 4.617 ± 0.067	1.907LysMet: 1.907 ± 0.043	2.815LysAsn: 2.815 ± 0.05	1.944LysPro: 1.944 ± 0.041	1.999LysGln: 1.999 ± 0.038	3.001LysArg: 3.001 ± 0.059	2.928LysSer: 2.928 ± 0.059	3.187LysThr: 3.187 ± 0.058	4.106LysVal: 4.106 ± 0.069	0.735LysTrp: 0.735 ± 0.026	2.423LysTyr: 2.423 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.548LeuAla: 6.548 ± 0.081	1.611LeuCys: 1.611 ± 0.043	4.726LeuAsp: 4.726 ± 0.065	4.927LeuGlu: 4.927 ± 0.068	4.192LeuPhe: 4.192 ± 0.072	5.611LeuGly: 5.611 ± 0.081	1.963LeuHis: 1.963 ± 0.048	4.489LeuIle: 4.489 ± 0.079	5.651LeuLys: 5.651 ± 0.08	8.168LeuLeu: 8.168 ± 0.109	2.52LeuMet: 2.52 ± 0.05	4.105LeuAsn: 4.105 ± 0.071	4.3LeuPro: 4.3 ± 0.067	3.45LeuGln: 3.45 ± 0.071	4.698LeuArg: 4.698 ± 0.086	6.469LeuSer: 6.469 ± 0.088	5.262LeuThr: 5.262 ± 0.068	5.275LeuVal: 5.275 ± 0.085	1.212LeuTrp: 1.212 ± 0.032	3.872LeuTyr: 3.872 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.478MetAla: 2.478 ± 0.049	0.266MetCys: 0.266 ± 0.014	1.634MetAsp: 1.634 ± 0.042	2.07MetGlu: 2.07 ± 0.048	1.034MetPhe: 1.034 ± 0.03	2.002MetGly: 2.002 ± 0.051	0.447MetHis: 0.447 ± 0.021	1.296MetIle: 1.296 ± 0.032	2.417MetLys: 2.417 ± 0.048	2.474MetLeu: 2.474 ± 0.05	0.848MetMet: 0.848 ± 0.03	1.454MetAsn: 1.454 ± 0.034	1.298MetPro: 1.298 ± 0.035	1.064MetGln: 1.064 ± 0.031	1.463MetArg: 1.463 ± 0.043	1.509MetSer: 1.509 ± 0.038	1.545MetThr: 1.545 ± 0.037	1.807MetVal: 1.807 ± 0.043	0.274MetTrp: 0.274 ± 0.014	0.886MetTyr: 0.886 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.299AsnAla: 3.299 ± 0.059	0.472AsnCys: 0.472 ± 0.022	2.486AsnAsp: 2.486 ± 0.054	2.725AsnGlu: 2.725 ± 0.053	1.899AsnPhe: 1.899 ± 0.048	4.013AsnGly: 4.013 ± 0.09	0.92AsnHis: 0.92 ± 0.027	2.862AsnIle: 2.862 ± 0.053	2.453AsnLys: 2.453 ± 0.06	3.932AsnLeu: 3.932 ± 0.065	1.309AsnMet: 1.309 ± 0.032	2.01AsnAsn: 2.01 ± 0.059	2.36AsnPro: 2.36 ± 0.047	1.331AsnGln: 1.331 ± 0.03	2.506AsnArg: 2.506 ± 0.049	2.341AsnSer: 2.341 ± 0.052	2.471AsnThr: 2.471 ± 0.058	3.084AsnVal: 3.084 ± 0.062	0.671AsnTrp: 0.671 ± 0.029	2.067AsnTyr: 2.067 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	2.853ProAla: 2.853 ± 0.06	0.453ProCys: 0.453 ± 0.022	2.876ProAsp: 2.876 ± 0.054	3.625ProGlu: 3.625 ± 0.07	1.9ProPhe: 1.9 ± 0.04	2.654ProGly: 2.654 ± 0.056	0.771ProHis: 0.771 ± 0.028	1.886ProIle: 1.886 ± 0.041	1.8ProLys: 1.8 ± 0.043	3.387ProLeu: 3.387 ± 0.06	1.047ProMet: 1.047 ± 0.029	1.462ProAsn: 1.462 ± 0.032	0.909ProPro: 0.909 ± 0.031	1.452ProGln: 1.452 ± 0.039	1.455ProArg: 1.455 ± 0.033	2.496ProSer: 2.496 ± 0.053	2.027ProThr: 2.027 ± 0.045	3.344ProVal: 3.344 ± 0.055	0.555ProTrp: 0.555 ± 0.028	1.857ProTyr: 1.857 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	2.747GlnAla: 2.747 ± 0.06	0.318GlnCys: 0.318 ± 0.018	1.767GlnAsp: 1.767 ± 0.038	2.215GlnGlu: 2.215 ± 0.048	1.253GlnPhe: 1.253 ± 0.032	2.232GlnGly: 2.232 ± 0.047	0.614GlnHis: 0.614 ± 0.022	2.087GlnIle: 2.087 ± 0.052	2.052GlnLys: 2.052 ± 0.047	2.83GlnLeu: 2.83 ± 0.051	1.053GlnMet: 1.053 ± 0.025	1.583GlnAsn: 1.583 ± 0.037	1.382GlnPro: 1.382 ± 0.035	1.44GlnGln: 1.44 ± 0.039	1.676GlnArg: 1.676 ± 0.044	1.793GlnSer: 1.793 ± 0.042	2.2GlnThr: 2.2 ± 0.052	2.177GlnVal: 2.177 ± 0.048	0.467GlnTrp: 0.467 ± 0.021	1.395GlnTyr: 1.395 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	3.251ArgAla: 3.251 ± 0.06	0.593ArgCys: 0.593 ± 0.023	2.493ArgAsp: 2.493 ± 0.055	3.42ArgGlu: 3.42 ± 0.059	2.658ArgPhe: 2.658 ± 0.053	2.936ArgGly: 2.936 ± 0.059	1.285ArgHis: 1.285 ± 0.038	3.568ArgIle: 3.568 ± 0.067	3.61ArgLys: 3.61 ± 0.066	5.277ArgLeu: 5.277 ± 0.081	1.896ArgMet: 1.896 ± 0.039	2.55ArgAsn: 2.55 ± 0.045	2.1ArgPro: 2.1 ± 0.046	2.051ArgGln: 2.051 ± 0.05	3.053ArgArg: 3.053 ± 0.082	2.612ArgSer: 2.612 ± 0.055	2.942ArgThr: 2.942 ± 0.059	3.196ArgVal: 3.196 ± 0.069	0.734ArgTrp: 0.734 ± 0.03	2.62ArgTyr: 2.62 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	4.339SerAla: 4.339 ± 0.069	0.869SerCys: 0.869 ± 0.025	3.274SerAsp: 3.274 ± 0.061	3.328SerGlu: 3.328 ± 0.06	2.985SerPhe: 2.985 ± 0.063	4.908SerGly: 4.908 ± 0.088	1.194SerHis: 1.194 ± 0.034	3.442SerIle: 3.442 ± 0.058	2.681SerLys: 2.681 ± 0.055	5.607SerLeu: 5.607 ± 0.076	1.509SerMet: 1.509 ± 0.036	2.262SerAsn: 2.262 ± 0.046	2.464SerPro: 2.464 ± 0.054	1.699SerGln: 1.699 ± 0.042	2.987SerArg: 2.987 ± 0.054	3.681SerSer: 3.681 ± 0.073	3.15SerThr: 3.15 ± 0.064	4.541SerVal: 4.541 ± 0.067	0.853SerTrp: 0.853 ± 0.03	2.702SerTyr: 2.702 ± 0.054	0.001SerXaa: 0.001 ± 0.001
Thr	4.536ThrAla: 4.536 ± 0.078	0.668ThrCys: 0.668 ± 0.027	3.791ThrAsp: 3.791 ± 0.053	3.655ThrGlu: 3.655 ± 0.052	2.769ThrPhe: 2.769 ± 0.052	4.642ThrGly: 4.642 ± 0.078	1.095ThrHis: 1.095 ± 0.032	3.016ThrIle: 3.016 ± 0.055	2.325ThrLys: 2.325 ± 0.046	5.702ThrLeu: 5.702 ± 0.088	1.252ThrMet: 1.252 ± 0.035	2.142ThrAsn: 2.142 ± 0.052	2.792ThrPro: 2.792 ± 0.054	1.764ThrGln: 1.764 ± 0.041	2.41ThrArg: 2.41 ± 0.049	3.309ThrSer: 3.309 ± 0.056	3.103ThrThr: 3.103 ± 0.069	4.732ThrVal: 4.732 ± 0.07	0.703ThrTrp: 0.703 ± 0.031	2.547ThrTyr: 2.547 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	5.174ValAla: 5.174 ± 0.075	1.209ValCys: 1.209 ± 0.034	4.121ValAsp: 4.121 ± 0.062	4.634ValGlu: 4.634 ± 0.077	3.148ValPhe: 3.148 ± 0.058	4.531ValGly: 4.531 ± 0.065	1.219ValHis: 1.219 ± 0.035	3.758ValIle: 3.758 ± 0.064	4.241ValLys: 4.241 ± 0.066	5.942ValLeu: 5.942 ± 0.078	1.747ValMet: 1.747 ± 0.045	3.258ValAsn: 3.258 ± 0.061	2.927ValPro: 2.927 ± 0.051	2.057ValGln: 2.057 ± 0.045	3.757ValArg: 3.757 ± 0.069	4.731ValSer: 4.731 ± 0.063	4.05ValThr: 4.05 ± 0.068	5.097ValVal: 5.097 ± 0.087	1.016ValTrp: 1.016 ± 0.032	3.056ValTyr: 3.056 ± 0.052	0.001ValXaa: 0.001 ± 0.001
Trp	1.017TrpAla: 1.017 ± 0.033	0.219TrpCys: 0.219 ± 0.014	0.827TrpAsp: 0.827 ± 0.035	0.77TrpGlu: 0.77 ± 0.026	0.614TrpPhe: 0.614 ± 0.024	1.115TrpGly: 1.115 ± 0.036	0.304TrpHis: 0.304 ± 0.017	0.741TrpIle: 0.741 ± 0.03	0.871TrpLys: 0.871 ± 0.03	1.185TrpLeu: 1.185 ± 0.036	0.523TrpMet: 0.523 ± 0.022	0.873TrpAsn: 0.873 ± 0.031	0.399TrpPro: 0.399 ± 0.02	0.555TrpGln: 0.555 ± 0.022	0.691TrpArg: 0.691 ± 0.026	0.763TrpSer: 0.763 ± 0.027	0.87TrpThr: 0.87 ± 0.027	0.856TrpVal: 0.856 ± 0.03	0.227TrpTrp: 0.227 ± 0.016	0.564TrpTyr: 0.564 ± 0.025	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.446TyrAla: 3.446 ± 0.062	0.629TyrCys: 0.629 ± 0.026	2.757TyrAsp: 2.757 ± 0.062	2.582TyrGlu: 2.582 ± 0.047	2.053TyrPhe: 2.053 ± 0.043	3.18TyrGly: 3.18 ± 0.059	0.994TyrHis: 0.994 ± 0.03	2.5TyrIle: 2.5 ± 0.045	2.37TyrLys: 2.37 ± 0.053	3.882TyrLeu: 3.882 ± 0.062	1.236TyrMet: 1.236 ± 0.034	2.231TyrAsn: 2.231 ± 0.056	1.91TyrPro: 1.91 ± 0.049	1.359TyrGln: 1.359 ± 0.036	2.638TyrArg: 2.638 ± 0.048	2.602TyrSer: 2.602 ± 0.054	2.724TyrThr: 2.724 ± 0.056	2.905TyrVal: 2.905 ± 0.056	0.649TyrTrp: 0.649 ± 0.027	2.307TyrTyr: 2.307 ± 0.057	0.001TyrXaa: 0.001 ± 0.001
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.002

Statistics based on 2847 proteins (1089012 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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