Amino acid dipepetide frequency for Sphingobium amiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.142AlaAla: 19.142 ± 0.187	1.058AlaCys: 1.058 ± 0.033	7.839AlaAsp: 7.839 ± 0.087	7.125AlaGlu: 7.125 ± 0.095	4.403AlaPhe: 4.403 ± 0.071	11.284AlaGly: 11.284 ± 0.113	2.425AlaHis: 2.425 ± 0.049	6.675AlaIle: 6.675 ± 0.083	3.922AlaLys: 3.922 ± 0.063	14.242AlaLeu: 14.242 ± 0.136	4.042AlaMet: 4.042 ± 0.06	2.998AlaAsn: 2.998 ± 0.055	6.461AlaPro: 6.461 ± 0.088	5.02AlaGln: 5.02 ± 0.073	10.121AlaArg: 10.121 ± 0.111	6.807AlaSer: 6.807 ± 0.075	6.351AlaThr: 6.351 ± 0.066	8.475AlaVal: 8.475 ± 0.086	1.615AlaTrp: 1.615 ± 0.037	2.763AlaTyr: 2.763 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.069CysAla: 1.069 ± 0.033	0.099CysCys: 0.099 ± 0.008	0.515CysAsp: 0.515 ± 0.023	0.401CysGlu: 0.401 ± 0.016	0.327CysPhe: 0.327 ± 0.017	0.846CysGly: 0.846 ± 0.026	0.201CysHis: 0.201 ± 0.013	0.378CysIle: 0.378 ± 0.017	0.165CysLys: 0.165 ± 0.013	0.765CysLeu: 0.765 ± 0.028	0.172CysMet: 0.172 ± 0.009	0.182CysAsn: 0.182 ± 0.012	0.448CysPro: 0.448 ± 0.02	0.188CysGln: 0.188 ± 0.012	0.586CysArg: 0.586 ± 0.023	0.427CysSer: 0.427 ± 0.019	0.383CysThr: 0.383 ± 0.015	0.505CysVal: 0.505 ± 0.02	0.13CysTrp: 0.13 ± 0.01	0.166CysTyr: 0.166 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.932AspAla: 7.932 ± 0.091	0.459AspCys: 0.459 ± 0.022	3.304AspAsp: 3.304 ± 0.062	3.399AspGlu: 3.399 ± 0.061	2.16AspPhe: 2.16 ± 0.043	5.715AspGly: 5.715 ± 0.071	1.471AspHis: 1.471 ± 0.037	3.13AspIle: 3.13 ± 0.052	1.481AspLys: 1.481 ± 0.035	5.909AspLeu: 5.909 ± 0.068	1.595AspMet: 1.595 ± 0.039	1.29AspAsn: 1.29 ± 0.031	3.856AspPro: 3.856 ± 0.053	1.807AspGln: 1.807 ± 0.044	5.385AspArg: 5.385 ± 0.073	2.337AspSer: 2.337 ± 0.041	2.477AspThr: 2.477 ± 0.044	4.017AspVal: 4.017 ± 0.062	1.15AspTrp: 1.15 ± 0.026	1.673AspTyr: 1.673 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.729GluAla: 7.729 ± 0.109	0.295GluCys: 0.295 ± 0.013	2.78GluAsp: 2.78 ± 0.052	2.957GluGlu: 2.957 ± 0.062	1.36GluPhe: 1.36 ± 0.029	4.603GluGly: 4.603 ± 0.061	1.097GluHis: 1.097 ± 0.03	2.846GluIle: 2.846 ± 0.048	2.075GluLys: 2.075 ± 0.042	4.658GluLeu: 4.658 ± 0.066	1.424GluMet: 1.424 ± 0.039	1.339GluAsn: 1.339 ± 0.033	2.467GluPro: 2.467 ± 0.05	2.067GluGln: 2.067 ± 0.04	4.955GluArg: 4.955 ± 0.07	2.331GluSer: 2.331 ± 0.037	2.969GluThr: 2.969 ± 0.045	3.367GluVal: 3.367 ± 0.059	0.768GluTrp: 0.768 ± 0.024	0.93GluTyr: 0.93 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.717PheAla: 4.717 ± 0.067	0.338PheCys: 0.338 ± 0.016	2.695PheAsp: 2.695 ± 0.049	1.882PheGlu: 1.882 ± 0.035	1.292PhePhe: 1.292 ± 0.034	3.466PheGly: 3.466 ± 0.052	0.771PheHis: 0.771 ± 0.023	1.45PheIle: 1.45 ± 0.04	0.795PheLys: 0.795 ± 0.028	3.192PheLeu: 3.192 ± 0.054	0.786PheMet: 0.786 ± 0.027	0.987PheAsn: 0.987 ± 0.03	1.534PhePro: 1.534 ± 0.037	0.867PheGln: 0.867 ± 0.025	2.373PheArg: 2.373 ± 0.046	2.131PheSer: 2.131 ± 0.046	1.985PheThr: 1.985 ± 0.044	2.449PheVal: 2.449 ± 0.049	0.525PheTrp: 0.525 ± 0.022	0.884PheTyr: 0.884 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.953GlyAla: 9.953 ± 0.091	0.807GlyCys: 0.807 ± 0.025	4.887GlyAsp: 4.887 ± 0.069	4.895GlyGlu: 4.895 ± 0.059	3.594GlyPhe: 3.594 ± 0.045	7.919GlyGly: 7.919 ± 0.103	1.966GlyHis: 1.966 ± 0.038	4.42GlyIle: 4.42 ± 0.057	3.15GlyLys: 3.15 ± 0.055	8.639GlyLeu: 8.639 ± 0.098	2.332GlyMet: 2.332 ± 0.036	2.183GlyAsn: 2.183 ± 0.051	3.663GlyPro: 3.663 ± 0.054	3.108GlyGln: 3.108 ± 0.047	6.913GlyArg: 6.913 ± 0.094	4.723GlySer: 4.723 ± 0.066	4.532GlyThr: 4.532 ± 0.07	6.239GlyVal: 6.239 ± 0.07	1.62GlyTrp: 1.62 ± 0.041	2.361GlyTyr: 2.361 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.454HisAla: 2.454 ± 0.045	0.222HisCys: 0.222 ± 0.014	1.295HisAsp: 1.295 ± 0.03	0.989HisGlu: 0.989 ± 0.027	0.857HisPhe: 0.857 ± 0.026	2.041HisGly: 2.041 ± 0.041	0.631HisHis: 0.631 ± 0.023	1.019HisIle: 1.019 ± 0.028	0.459HisLys: 0.459 ± 0.02	2.048HisLeu: 2.048 ± 0.044	0.534HisMet: 0.534 ± 0.02	0.456HisAsn: 0.456 ± 0.018	1.334HisPro: 1.334 ± 0.036	0.595HisGln: 0.595 ± 0.02	1.584HisArg: 1.584 ± 0.041	1.0HisSer: 1.0 ± 0.028	0.655HisThr: 0.655 ± 0.022	1.6HisVal: 1.6 ± 0.04	0.384HisTrp: 0.384 ± 0.016	0.619HisTyr: 0.619 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.754IleAla: 7.754 ± 0.09	0.432IleCys: 0.432 ± 0.018	3.873IleAsp: 3.873 ± 0.052	3.313IleGlu: 3.313 ± 0.056	1.66IlePhe: 1.66 ± 0.036	4.932IleGly: 4.932 ± 0.063	0.891IleHis: 0.891 ± 0.026	2.002IleIle: 2.002 ± 0.043	1.115IleLys: 1.115 ± 0.032	4.357IleLeu: 4.357 ± 0.067	0.966IleMet: 0.966 ± 0.028	1.304IleAsn: 1.304 ± 0.031	2.239IlePro: 2.239 ± 0.036	1.146IleGln: 1.146 ± 0.03	3.348IleArg: 3.348 ± 0.044	2.662IleSer: 2.662 ± 0.045	2.345IleThr: 2.345 ± 0.044	4.141IleVal: 4.141 ± 0.062	0.623IleTrp: 0.623 ± 0.021	1.031IleTyr: 1.031 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	4.158LysAla: 4.158 ± 0.063	0.14LysCys: 0.14 ± 0.01	1.624LysAsp: 1.624 ± 0.04	1.238LysGlu: 1.238 ± 0.034	0.773LysPhe: 0.773 ± 0.025	2.743LysGly: 2.743 ± 0.053	0.472LysHis: 0.472 ± 0.019	1.365LysIle: 1.365 ± 0.035	0.964LysLys: 0.964 ± 0.036	2.995LysLeu: 2.995 ± 0.051	0.702LysMet: 0.702 ± 0.025	0.698LysAsn: 0.698 ± 0.026	1.908LysPro: 1.908 ± 0.041	0.886LysGln: 0.886 ± 0.027	2.154LysArg: 2.154 ± 0.041	1.554LysSer: 1.554 ± 0.038	1.558LysThr: 1.558 ± 0.042	2.07LysVal: 2.07 ± 0.047	0.39LysTrp: 0.39 ± 0.018	0.569LysTyr: 0.569 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.799LeuAla: 13.799 ± 0.126	0.895LeuCys: 0.895 ± 0.025	6.141LeuAsp: 6.141 ± 0.075	4.675LeuGlu: 4.675 ± 0.062	3.765LeuPhe: 3.765 ± 0.063	8.026LeuGly: 8.026 ± 0.088	1.948LeuHis: 1.948 ± 0.04	4.945LeuIle: 4.945 ± 0.07	2.929LeuLys: 2.929 ± 0.044	9.935LeuLeu: 9.935 ± 0.119	2.24LeuMet: 2.24 ± 0.04	2.397LeuAsn: 2.397 ± 0.047	5.928LeuPro: 5.928 ± 0.073	2.5LeuGln: 2.5 ± 0.042	7.331LeuArg: 7.331 ± 0.094	6.418LeuSer: 6.418 ± 0.07	5.657LeuThr: 5.657 ± 0.065	6.864LeuVal: 6.864 ± 0.075	1.349LeuTrp: 1.349 ± 0.036	2.049LeuTyr: 2.049 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	3.489MetAla: 3.489 ± 0.046	0.152MetCys: 0.152 ± 0.01	1.22MetAsp: 1.22 ± 0.029	1.181MetGlu: 1.181 ± 0.034	0.705MetPhe: 0.705 ± 0.023	1.976MetGly: 1.976 ± 0.041	0.434MetHis: 0.434 ± 0.02	1.341MetIle: 1.341 ± 0.032	0.94MetLys: 0.94 ± 0.024	2.743MetLeu: 2.743 ± 0.05	0.684MetMet: 0.684 ± 0.022	0.676MetAsn: 0.676 ± 0.026	1.537MetPro: 1.537 ± 0.038	0.786MetGln: 0.786 ± 0.028	1.833MetArg: 1.833 ± 0.039	1.478MetSer: 1.478 ± 0.035	1.792MetThr: 1.792 ± 0.032	1.681MetVal: 1.681 ± 0.038	0.207MetTrp: 0.207 ± 0.012	0.26MetTyr: 0.26 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.201AsnAla: 3.201 ± 0.056	0.206AsnCys: 0.206 ± 0.013	1.392AsnAsp: 1.392 ± 0.031	1.119AsnGlu: 1.119 ± 0.032	0.865AsnPhe: 0.865 ± 0.026	2.351AsnGly: 2.351 ± 0.058	0.46AsnHis: 0.46 ± 0.019	1.322AsnIle: 1.322 ± 0.038	0.61AsnLys: 0.61 ± 0.023	2.445AsnLeu: 2.445 ± 0.051	0.557AsnMet: 0.557 ± 0.02	0.63AsnAsn: 0.63 ± 0.027	1.674AsnPro: 1.674 ± 0.042	0.761AsnGln: 0.761 ± 0.025	1.897AsnArg: 1.897 ± 0.035	1.229AsnSer: 1.229 ± 0.037	0.92AsnThr: 0.92 ± 0.026	1.817AsnVal: 1.817 ± 0.041	0.418AsnTrp: 0.418 ± 0.019	0.68AsnTyr: 0.68 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.18ProAla: 7.18 ± 0.094	0.355ProCys: 0.355 ± 0.016	4.002ProAsp: 4.002 ± 0.057	3.298ProGlu: 3.298 ± 0.053	1.963ProPhe: 1.963 ± 0.041	4.68ProGly: 4.68 ± 0.069	1.103ProHis: 1.103 ± 0.032	2.368ProIle: 2.368 ± 0.044	1.459ProLys: 1.459 ± 0.036	5.126ProLeu: 5.126 ± 0.066	1.293ProMet: 1.293 ± 0.033	1.151ProAsn: 1.151 ± 0.031	3.029ProPro: 3.029 ± 0.068	1.853ProGln: 1.853 ± 0.038	3.13ProArg: 3.13 ± 0.049	2.752ProSer: 2.752 ± 0.052	2.528ProThr: 2.528 ± 0.044	4.557ProVal: 4.557 ± 0.058	0.728ProTrp: 0.728 ± 0.024	1.164ProTyr: 1.164 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.469GlnAla: 4.469 ± 0.071	0.243GlnCys: 0.243 ± 0.014	1.59GlnAsp: 1.59 ± 0.03	1.424GlnGlu: 1.424 ± 0.032	1.066GlnPhe: 1.066 ± 0.025	2.658GlnGly: 2.658 ± 0.042	0.62GlnHis: 0.62 ± 0.021	1.847GlnIle: 1.847 ± 0.036	0.947GlnLys: 0.947 ± 0.028	2.999GlnLeu: 2.999 ± 0.049	0.897GlnMet: 0.897 ± 0.029	0.762GlnAsn: 0.762 ± 0.026	1.908GlnPro: 1.908 ± 0.039	1.271GlnGln: 1.271 ± 0.034	2.568GlnArg: 2.568 ± 0.05	1.793GlnSer: 1.793 ± 0.038	1.636GlnThr: 1.636 ± 0.036	2.371GlnVal: 2.371 ± 0.046	0.529GlnTrp: 0.529 ± 0.022	0.637GlnTyr: 0.637 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	9.187ArgAla: 9.187 ± 0.102	0.554ArgCys: 0.554 ± 0.022	4.612ArgAsp: 4.612 ± 0.063	4.037ArgGlu: 4.037 ± 0.062	3.172ArgPhe: 3.172 ± 0.054	5.219ArgGly: 5.219 ± 0.066	1.905ArgHis: 1.905 ± 0.034	4.256ArgIle: 4.256 ± 0.048	2.156ArgLys: 2.156 ± 0.047	8.546ArgLeu: 8.546 ± 0.084	1.968ArgMet: 1.968 ± 0.038	1.941ArgAsn: 1.941 ± 0.038	3.925ArgPro: 3.925 ± 0.054	2.789ArgGln: 2.789 ± 0.051	6.24ArgArg: 6.24 ± 0.099	3.948ArgSer: 3.948 ± 0.058	3.659ArgThr: 3.659 ± 0.056	4.816ArgVal: 4.816 ± 0.068	1.304ArgTrp: 1.304 ± 0.031	1.989ArgTyr: 1.989 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	6.628SerAla: 6.628 ± 0.069	0.413SerCys: 0.413 ± 0.019	3.165SerAsp: 3.165 ± 0.05	2.526SerGlu: 2.526 ± 0.044	2.242SerPhe: 2.242 ± 0.046	5.504SerGly: 5.504 ± 0.063	1.093SerHis: 1.093 ± 0.033	2.775SerIle: 2.775 ± 0.047	1.386SerLys: 1.386 ± 0.036	5.302SerLeu: 5.302 ± 0.058	1.242SerMet: 1.242 ± 0.029	1.319SerAsn: 1.319 ± 0.035	2.878SerPro: 2.878 ± 0.046	1.582SerGln: 1.582 ± 0.036	3.693SerArg: 3.693 ± 0.059	2.802SerSer: 2.802 ± 0.062	2.542SerThr: 2.542 ± 0.049	3.783SerVal: 3.783 ± 0.07	0.779SerTrp: 0.779 ± 0.025	1.387SerTyr: 1.387 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.185ThrAla: 6.185 ± 0.081	0.377ThrCys: 0.377 ± 0.017	2.886ThrAsp: 2.886 ± 0.046	2.168ThrGlu: 2.168 ± 0.046	1.581ThrPhe: 1.581 ± 0.039	5.259ThrGly: 5.259 ± 0.075	1.003ThrHis: 1.003 ± 0.027	2.815ThrIle: 2.815 ± 0.044	1.306ThrLys: 1.306 ± 0.033	5.73ThrLeu: 5.73 ± 0.069	1.182ThrMet: 1.182 ± 0.029	1.184ThrAsn: 1.184 ± 0.036	3.353ThrPro: 3.353 ± 0.054	1.527ThrGln: 1.527 ± 0.04	3.461ThrArg: 3.461 ± 0.051	2.51ThrSer: 2.51 ± 0.049	2.454ThrThr: 2.454 ± 0.052	4.077ThrVal: 4.077 ± 0.057	0.567ThrTrp: 0.567 ± 0.024	1.158ThrTyr: 1.158 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	9.569ValAla: 9.569 ± 0.094	0.531ValCys: 0.531 ± 0.023	4.411ValAsp: 4.411 ± 0.056	4.566ValGlu: 4.566 ± 0.067	1.953ValPhe: 1.953 ± 0.045	5.509ValGly: 5.509 ± 0.071	1.379ValHis: 1.379 ± 0.032	3.582ValIle: 3.582 ± 0.058	2.039ValLys: 2.039 ± 0.043	6.173ValLeu: 6.173 ± 0.066	1.678ValMet: 1.678 ± 0.031	1.952ValAsn: 1.952 ± 0.042	3.849ValPro: 3.849 ± 0.054	2.151ValGln: 2.151 ± 0.045	5.258ValArg: 5.258 ± 0.062	4.001ValSer: 4.001 ± 0.061	4.475ValThr: 4.475 ± 0.064	4.967ValVal: 4.967 ± 0.071	0.796ValTrp: 0.796 ± 0.028	1.397ValTyr: 1.397 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.47TrpAla: 1.47 ± 0.035	0.124TrpCys: 0.124 ± 0.009	0.73TrpAsp: 0.73 ± 0.024	0.647TrpGlu: 0.647 ± 0.024	0.531TrpPhe: 0.531 ± 0.024	0.987TrpGly: 0.987 ± 0.031	0.366TrpHis: 0.366 ± 0.018	0.698TrpIle: 0.698 ± 0.024	0.471TrpLys: 0.471 ± 0.018	1.782TrpLeu: 1.782 ± 0.045	0.378TrpMet: 0.378 ± 0.016	0.482TrpAsn: 0.482 ± 0.022	0.683TrpPro: 0.683 ± 0.021	0.621TrpGln: 0.621 ± 0.022	1.362TrpArg: 1.362 ± 0.036	0.932TrpSer: 0.932 ± 0.029	0.866TrpThr: 0.866 ± 0.028	0.829TrpVal: 0.829 ± 0.025	0.279TrpTrp: 0.279 ± 0.015	0.259TrpTyr: 0.259 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.683TyrAla: 2.683 ± 0.047	0.252TyrCys: 0.252 ± 0.015	1.588TyrAsp: 1.588 ± 0.038	1.178TyrGlu: 1.178 ± 0.032	0.851TyrPhe: 0.851 ± 0.025	2.187TyrGly: 2.187 ± 0.047	0.541TyrHis: 0.541 ± 0.022	0.9TyrIle: 0.9 ± 0.027	0.592TyrLys: 0.592 ± 0.023	2.208TyrLeu: 2.208 ± 0.045	0.443TyrMet: 0.443 ± 0.019	0.622TyrAsn: 0.622 ± 0.025	1.043TyrPro: 1.043 ± 0.031	0.71TyrGln: 0.71 ± 0.022	2.028TyrArg: 2.028 ± 0.041	1.206TyrSer: 1.206 ± 0.039	0.999TyrThr: 0.999 ± 0.027	1.612TyrVal: 1.612 ± 0.038	0.333TyrTrp: 0.333 ± 0.014	0.647TyrTyr: 0.647 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3954 proteins (1349417 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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