Amino acid dipepetide frequency for Streptococcus satellite phage Javan742

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.819AlaAla: 0.819 ± 0.495
0.546AlaCys: 0.546 ± 0.325
1.365AlaAsp: 1.365 ± 0.552
6.008AlaGlu: 6.008 ± 1.174
3.55AlaPhe: 3.55 ± 0.854
3.277AlaGly: 3.277 ± 0.884
0.819AlaHis: 0.819 ± 0.422
3.823AlaIle: 3.823 ± 0.762
4.642AlaLys: 4.642 ± 0.853
4.369AlaLeu: 4.369 ± 0.63
2.731AlaMet: 2.731 ± 1.066
2.458AlaAsn: 2.458 ± 0.916
0.819AlaPro: 0.819 ± 0.469
1.365AlaGln: 1.365 ± 0.43
4.642AlaArg: 4.642 ± 1.175
2.185AlaSer: 2.185 ± 0.726
3.823AlaThr: 3.823 ± 0.874
3.823AlaVal: 3.823 ± 0.66
0.819AlaTrp: 0.819 ± 0.399
1.365AlaTyr: 1.365 ± 0.441
0.0AlaXaa: 0.0 ± 0.0
Cys
0.273CysAla: 0.273 ± 0.247
0.0CysCys: 0.0 ± 0.0
0.546CysAsp: 0.546 ± 0.366
0.0CysGlu: 0.0 ± 0.0
0.273CysPhe: 0.273 ± 0.27
0.546CysGly: 0.546 ± 0.346
0.273CysHis: 0.273 ± 0.252
0.0CysIle: 0.0 ± 0.0
0.546CysLys: 0.546 ± 0.383
1.638CysLeu: 1.638 ± 0.507
0.0CysMet: 0.0 ± 0.0
0.546CysAsn: 0.546 ± 0.442
0.273CysPro: 0.273 ± 0.252
0.273CysGln: 0.273 ± 0.266
0.273CysArg: 0.273 ± 0.292
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.546CysVal: 0.546 ± 0.377
0.0CysTrp: 0.0 ± 0.0
0.273CysTyr: 0.273 ± 0.297
0.0CysXaa: 0.0 ± 0.0
Asp
0.819AspAla: 0.819 ± 0.429
0.546AspCys: 0.546 ± 0.347
2.458AspAsp: 2.458 ± 0.888
3.004AspGlu: 3.004 ± 0.941
4.369AspPhe: 4.369 ± 1.067
2.185AspGly: 2.185 ± 0.69
0.273AspHis: 0.273 ± 0.302
5.461AspIle: 5.461 ± 1.181
5.461AspLys: 5.461 ± 1.009
7.646AspLeu: 7.646 ± 2.024
1.638AspMet: 1.638 ± 0.569
3.004AspAsn: 3.004 ± 0.881
0.546AspPro: 0.546 ± 0.473
0.273AspGln: 0.273 ± 0.238
2.458AspArg: 2.458 ± 0.75
3.004AspSer: 3.004 ± 0.89
3.004AspThr: 3.004 ± 0.603
2.731AspVal: 2.731 ± 0.881
0.273AspTrp: 0.273 ± 0.221
4.096AspTyr: 4.096 ± 0.871
0.0AspXaa: 0.0 ± 0.0
Glu
6.827GluAla: 6.827 ± 1.791
0.819GluCys: 0.819 ± 0.432
4.096GluAsp: 4.096 ± 1.035
6.281GluGlu: 6.281 ± 1.072
1.638GluPhe: 1.638 ± 0.672
2.458GluGly: 2.458 ± 0.785
2.731GluHis: 2.731 ± 0.615
7.919GluIle: 7.919 ± 1.413
10.377GluLys: 10.377 ± 1.284
9.558GluLeu: 9.558 ± 1.767
3.004GluMet: 3.004 ± 0.866
4.915GluAsn: 4.915 ± 1.066
2.458GluPro: 2.458 ± 0.828
4.369GluGln: 4.369 ± 0.734
5.735GluArg: 5.735 ± 1.402
3.823GluSer: 3.823 ± 1.229
3.55GluThr: 3.55 ± 1.039
3.823GluVal: 3.823 ± 0.934
0.546GluTrp: 0.546 ± 0.442
5.188GluTyr: 5.188 ± 0.946
0.0GluXaa: 0.0 ± 0.0
Phe
1.638PheAla: 1.638 ± 0.723
0.273PheCys: 0.273 ± 0.238
2.458PheAsp: 2.458 ± 0.646
6.827PheGlu: 6.827 ± 1.47
2.185PhePhe: 2.185 ± 0.938
2.185PheGly: 2.185 ± 0.623
0.819PheHis: 0.819 ± 0.432
3.277PheIle: 3.277 ± 0.749
4.096PheLys: 4.096 ± 1.066
4.096PheLeu: 4.096 ± 0.905
0.546PheMet: 0.546 ± 0.444
4.096PheAsn: 4.096 ± 1.057
0.273PhePro: 0.273 ± 0.266
2.185PheGln: 2.185 ± 0.837
1.912PheArg: 1.912 ± 0.751
3.823PheSer: 3.823 ± 0.783
3.004PheThr: 3.004 ± 0.889
0.546PheVal: 0.546 ± 0.364
0.546PheTrp: 0.546 ± 0.312
2.185PheTyr: 2.185 ± 0.701
0.0PheXaa: 0.0 ± 0.0
Gly
1.912GlyAla: 1.912 ± 0.647
0.546GlyCys: 0.546 ± 0.379
3.004GlyAsp: 3.004 ± 1.075
3.823GlyGlu: 3.823 ± 1.064
1.092GlyPhe: 1.092 ± 0.517
3.55GlyGly: 3.55 ± 0.891
1.092GlyHis: 1.092 ± 0.426
4.096GlyIle: 4.096 ± 0.931
3.277GlyLys: 3.277 ± 0.911
5.461GlyLeu: 5.461 ± 1.105
1.365GlyMet: 1.365 ± 0.548
1.912GlyAsn: 1.912 ± 0.606
0.273GlyPro: 0.273 ± 0.252
1.638GlyGln: 1.638 ± 0.459
2.185GlyArg: 2.185 ± 0.749
1.638GlySer: 1.638 ± 0.587
3.277GlyThr: 3.277 ± 0.967
3.004GlyVal: 3.004 ± 1.07
0.819GlyTrp: 0.819 ± 0.47
3.004GlyTyr: 3.004 ± 0.785
0.0GlyXaa: 0.0 ± 0.0
His
2.185HisAla: 2.185 ± 0.783
0.0HisCys: 0.0 ± 0.0
0.819HisAsp: 0.819 ± 0.38
1.092HisGlu: 1.092 ± 0.469
0.819HisPhe: 0.819 ± 0.382
1.092HisGly: 1.092 ± 0.494
0.0HisHis: 0.0 ± 0.0
0.273HisIle: 0.273 ± 0.252
1.912HisLys: 1.912 ± 0.85
2.458HisLeu: 2.458 ± 0.749
0.273HisMet: 0.273 ± 0.242
1.092HisAsn: 1.092 ± 0.604
1.092HisPro: 1.092 ± 0.428
0.273HisGln: 0.273 ± 0.297
1.638HisArg: 1.638 ± 0.661
1.365HisSer: 1.365 ± 0.349
1.365HisThr: 1.365 ± 0.579
0.273HisVal: 0.273 ± 0.243
0.0HisTrp: 0.0 ± 0.0
1.092HisTyr: 1.092 ± 0.426
0.0HisXaa: 0.0 ± 0.0
Ile
3.823IleAla: 3.823 ± 0.904
0.273IleCys: 0.273 ± 0.302
7.373IleAsp: 7.373 ± 2.339
9.011IleGlu: 9.011 ± 1.806
4.096IlePhe: 4.096 ± 0.893
2.731IleGly: 2.731 ± 0.481
0.819IleHis: 0.819 ± 0.655
4.642IleIle: 4.642 ± 0.83
5.461IleLys: 5.461 ± 1.15
5.188IleLeu: 5.188 ± 0.742
0.273IleMet: 0.273 ± 0.221
4.642IleAsn: 4.642 ± 1.078
3.004IlePro: 3.004 ± 0.9
2.185IleGln: 2.185 ± 0.804
3.55IleArg: 3.55 ± 0.933
5.735IleSer: 5.735 ± 0.884
3.823IleThr: 3.823 ± 0.824
4.096IleVal: 4.096 ± 0.697
0.0IleTrp: 0.0 ± 0.0
2.185IleTyr: 2.185 ± 0.607
0.0IleXaa: 0.0 ± 0.0
Lys
5.461LysAla: 5.461 ± 1.171
0.0LysCys: 0.0 ± 0.0
3.004LysAsp: 3.004 ± 1.145
9.831LysGlu: 9.831 ± 1.549
3.277LysPhe: 3.277 ± 0.924
5.188LysGly: 5.188 ± 1.004
3.823LysHis: 3.823 ± 1.017
7.373LysIle: 7.373 ± 1.697
5.461LysLys: 5.461 ± 1.203
7.373LysLeu: 7.373 ± 1.152
2.185LysMet: 2.185 ± 0.639
4.915LysAsn: 4.915 ± 0.824
3.277LysPro: 3.277 ± 1.254
2.731LysGln: 2.731 ± 0.534
6.008LysArg: 6.008 ± 1.12
5.188LysSer: 5.188 ± 1.033
6.827LysThr: 6.827 ± 1.735
5.188LysVal: 5.188 ± 0.602
1.092LysTrp: 1.092 ± 0.438
2.731LysTyr: 2.731 ± 1.022
0.0LysXaa: 0.0 ± 0.0
Leu
6.008LeuAla: 6.008 ± 1.306
0.273LeuCys: 0.273 ± 0.221
9.831LeuAsp: 9.831 ± 1.903
9.011LeuGlu: 9.011 ± 1.571
2.458LeuPhe: 2.458 ± 0.937
2.185LeuGly: 2.185 ± 0.894
1.365LeuHis: 1.365 ± 0.593
5.188LeuIle: 5.188 ± 0.911
8.738LeuLys: 8.738 ± 1.587
9.558LeuLeu: 9.558 ± 1.107
2.458LeuMet: 2.458 ± 0.621
7.646LeuAsn: 7.646 ± 1.436
2.731LeuPro: 2.731 ± 0.855
4.096LeuGln: 4.096 ± 0.804
4.096LeuArg: 4.096 ± 0.676
6.827LeuSer: 6.827 ± 1.07
6.281LeuThr: 6.281 ± 1.473
6.281LeuVal: 6.281 ± 1.002
0.546LeuTrp: 0.546 ± 0.377
3.823LeuTyr: 3.823 ± 0.918
0.0LeuXaa: 0.0 ± 0.0
Met
2.185MetAla: 2.185 ± 0.814
0.0MetCys: 0.0 ± 0.0
1.638MetAsp: 1.638 ± 0.553
3.823MetGlu: 3.823 ± 0.81
1.365MetPhe: 1.365 ± 0.541
1.638MetGly: 1.638 ± 0.535
0.546MetHis: 0.546 ± 0.379
1.365MetIle: 1.365 ± 0.469
1.638MetLys: 1.638 ± 0.68
1.638MetLeu: 1.638 ± 0.745
0.273MetMet: 0.273 ± 0.297
2.185MetAsn: 2.185 ± 0.786
0.546MetPro: 0.546 ± 0.299
1.092MetGln: 1.092 ± 0.651
1.365MetArg: 1.365 ± 0.487
1.638MetSer: 1.638 ± 0.623
3.277MetThr: 3.277 ± 0.949
0.819MetVal: 0.819 ± 0.464
0.0MetTrp: 0.0 ± 0.0
0.273MetTyr: 0.273 ± 0.243
0.0MetXaa: 0.0 ± 0.0
Asn
3.277AsnAla: 3.277 ± 1.154
0.0AsnCys: 0.0 ± 0.0
3.004AsnAsp: 3.004 ± 0.961
3.55AsnGlu: 3.55 ± 1.013
1.638AsnPhe: 1.638 ± 0.622
4.369AsnGly: 4.369 ± 0.767
1.092AsnHis: 1.092 ± 0.394
3.55AsnIle: 3.55 ± 1.018
6.554AsnLys: 6.554 ± 0.845
3.823AsnLeu: 3.823 ± 0.913
1.092AsnMet: 1.092 ± 0.457
3.823AsnAsn: 3.823 ± 1.356
2.458AsnPro: 2.458 ± 0.806
3.277AsnGln: 3.277 ± 0.793
2.185AsnArg: 2.185 ± 0.632
4.369AsnSer: 4.369 ± 1.054
3.55AsnThr: 3.55 ± 0.727
3.55AsnVal: 3.55 ± 0.876
0.273AsnTrp: 0.273 ± 0.252
1.365AsnTyr: 1.365 ± 0.456
0.0AsnXaa: 0.0 ± 0.0
Pro
1.912ProAla: 1.912 ± 0.621
0.0ProCys: 0.0 ± 0.0
1.638ProAsp: 1.638 ± 0.836
1.912ProGlu: 1.912 ± 0.833
2.458ProPhe: 2.458 ± 0.832
1.092ProGly: 1.092 ± 0.449
0.273ProHis: 0.273 ± 0.243
1.638ProIle: 1.638 ± 0.478
3.004ProLys: 3.004 ± 1.029
1.365ProLeu: 1.365 ± 0.505
0.819ProMet: 0.819 ± 0.416
1.912ProAsn: 1.912 ± 1.062
1.092ProPro: 1.092 ± 0.632
1.092ProGln: 1.092 ± 0.68
2.458ProArg: 2.458 ± 0.787
1.912ProSer: 1.912 ± 0.755
0.819ProThr: 0.819 ± 0.362
1.638ProVal: 1.638 ± 0.674
0.273ProTrp: 0.273 ± 0.221
1.092ProTyr: 1.092 ± 0.463
0.0ProXaa: 0.0 ± 0.0
Gln
3.277GlnAla: 3.277 ± 1.018
0.0GlnCys: 0.0 ± 0.0
1.092GlnAsp: 1.092 ± 0.632
3.277GlnGlu: 3.277 ± 0.862
1.092GlnPhe: 1.092 ± 0.402
1.912GlnGly: 1.912 ± 0.999
0.273GlnHis: 0.273 ± 0.221
3.277GlnIle: 3.277 ± 0.756
3.55GlnLys: 3.55 ± 0.923
3.55GlnLeu: 3.55 ± 0.808
0.819GlnMet: 0.819 ± 0.465
1.638GlnAsn: 1.638 ± 0.615
0.546GlnPro: 0.546 ± 0.498
1.092GlnGln: 1.092 ± 0.456
3.55GlnArg: 3.55 ± 0.796
1.092GlnSer: 1.092 ± 0.404
1.365GlnThr: 1.365 ± 0.546
3.004GlnVal: 3.004 ± 0.966
0.546GlnTrp: 0.546 ± 0.367
0.819GlnTyr: 0.819 ± 0.411
0.0GlnXaa: 0.0 ± 0.0
Arg
2.731ArgAla: 2.731 ± 0.69
0.273ArgCys: 0.273 ± 0.254
2.458ArgAsp: 2.458 ± 0.793
5.735ArgGlu: 5.735 ± 1.612
2.731ArgPhe: 2.731 ± 0.687
2.731ArgGly: 2.731 ± 0.954
0.546ArgHis: 0.546 ± 0.332
3.823ArgIle: 3.823 ± 0.877
3.55ArgLys: 3.55 ± 0.693
6.554ArgLeu: 6.554 ± 1.485
1.638ArgMet: 1.638 ± 0.808
2.185ArgAsn: 2.185 ± 0.747
0.819ArgPro: 0.819 ± 0.377
2.458ArgGln: 2.458 ± 0.765
1.912ArgArg: 1.912 ± 0.772
2.185ArgSer: 2.185 ± 0.609
2.731ArgThr: 2.731 ± 0.937
3.823ArgVal: 3.823 ± 0.767
0.546ArgTrp: 0.546 ± 0.449
3.004ArgTyr: 3.004 ± 1.097
0.0ArgXaa: 0.0 ± 0.0
Ser
2.458SerAla: 2.458 ± 0.764
0.546SerCys: 0.546 ± 0.389
3.277SerAsp: 3.277 ± 0.797
4.369SerGlu: 4.369 ± 1.189
4.096SerPhe: 4.096 ± 1.099
3.277SerGly: 3.277 ± 0.658
1.092SerHis: 1.092 ± 0.652
5.188SerIle: 5.188 ± 0.864
4.915SerLys: 4.915 ± 0.929
5.188SerLeu: 5.188 ± 0.817
1.365SerMet: 1.365 ± 0.65
3.004SerAsn: 3.004 ± 0.699
1.092SerPro: 1.092 ± 0.379
1.912SerGln: 1.912 ± 0.608
1.912SerArg: 1.912 ± 0.839
4.369SerSer: 4.369 ± 1.048
3.55SerThr: 3.55 ± 0.881
2.458SerVal: 2.458 ± 0.657
0.273SerTrp: 0.273 ± 0.221
2.185SerTyr: 2.185 ± 0.812
0.0SerXaa: 0.0 ± 0.0
Thr
2.185ThrAla: 2.185 ± 0.554
0.546ThrCys: 0.546 ± 0.407
1.912ThrAsp: 1.912 ± 0.769
4.096ThrGlu: 4.096 ± 0.752
4.369ThrPhe: 4.369 ± 1.795
2.731ThrGly: 2.731 ± 0.654
1.092ThrHis: 1.092 ± 0.403
3.823ThrIle: 3.823 ± 0.797
5.461ThrLys: 5.461 ± 1.027
7.919ThrLeu: 7.919 ± 1.09
2.731ThrMet: 2.731 ± 0.636
2.185ThrAsn: 2.185 ± 1.5
2.185ThrPro: 2.185 ± 0.667
1.365ThrGln: 1.365 ± 0.503
2.185ThrArg: 2.185 ± 0.613
3.004ThrSer: 3.004 ± 0.712
2.731ThrThr: 2.731 ± 0.789
4.096ThrVal: 4.096 ± 1.35
0.546ThrTrp: 0.546 ± 0.318
3.823ThrTyr: 3.823 ± 1.371
0.0ThrXaa: 0.0 ± 0.0
Val
3.823ValAla: 3.823 ± 1.055
0.546ValCys: 0.546 ± 0.383
1.912ValAsp: 1.912 ± 0.663
4.369ValGlu: 4.369 ± 1.265
2.731ValPhe: 2.731 ± 1.099
2.185ValGly: 2.185 ± 0.869
0.546ValHis: 0.546 ± 0.477
2.731ValIle: 2.731 ± 0.835
6.281ValLys: 6.281 ± 1.108
6.827ValLeu: 6.827 ± 1.467
1.912ValMet: 1.912 ± 0.698
3.004ValAsn: 3.004 ± 0.808
3.004ValPro: 3.004 ± 1.052
1.638ValGln: 1.638 ± 0.672
2.185ValArg: 2.185 ± 0.763
2.185ValSer: 2.185 ± 0.711
3.823ValThr: 3.823 ± 0.875
2.185ValVal: 2.185 ± 0.824
0.273ValTrp: 0.273 ± 0.257
2.185ValTyr: 2.185 ± 0.722
0.0ValXaa: 0.0 ± 0.0
Trp
0.273TrpAla: 0.273 ± 0.252
0.0TrpCys: 0.0 ± 0.0
0.546TrpAsp: 0.546 ± 0.303
1.092TrpGlu: 1.092 ± 0.562
0.0TrpPhe: 0.0 ± 0.0
0.273TrpGly: 0.273 ± 0.257
0.273TrpHis: 0.273 ± 0.221
0.819TrpIle: 0.819 ± 0.436
0.273TrpLys: 0.273 ± 0.297
0.819TrpLeu: 0.819 ± 0.381
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.273TrpPro: 0.273 ± 0.221
0.546TrpGln: 0.546 ± 0.339
0.273TrpArg: 0.273 ± 0.221
0.819TrpSer: 0.819 ± 0.438
0.273TrpThr: 0.273 ± 0.292
0.819TrpVal: 0.819 ± 0.354
0.0TrpTrp: 0.0 ± 0.0
0.273TrpTyr: 0.273 ± 0.221
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.638TyrAla: 1.638 ± 0.541
1.092TyrCys: 1.092 ± 0.456
0.819TyrAsp: 0.819 ± 0.311
3.004TyrGlu: 3.004 ± 0.838
2.731TyrPhe: 2.731 ± 0.888
1.365TyrGly: 1.365 ± 0.514
1.365TyrHis: 1.365 ± 0.432
4.642TyrIle: 4.642 ± 1.006
5.735TyrLys: 5.735 ± 1.505
4.369TyrLeu: 4.369 ± 1.188
1.912TyrMet: 1.912 ± 0.651
1.638TyrAsn: 1.638 ± 0.507
1.638TyrPro: 1.638 ± 0.745
1.912TyrGln: 1.912 ± 0.734
1.912TyrArg: 1.912 ± 0.646
1.365TyrSer: 1.365 ± 0.457
1.912TyrThr: 1.912 ± 0.686
1.638TyrVal: 1.638 ± 0.637
0.273TyrTrp: 0.273 ± 0.266
1.638TyrTyr: 1.638 ± 0.656
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 23 proteins (3663 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski