Amino acid dipepetide frequency for Wenzhou picorna-like virus 19

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.487AlaAla: 5.487 ± 0.177
0.323AlaCys: 0.323 ± 0.167
3.551AlaAsp: 3.551 ± 0.24
1.937AlaGlu: 1.937 ± 0.597
4.196AlaPhe: 4.196 ± 0.041
4.519AlaGly: 4.519 ± 0.859
2.26AlaHis: 2.26 ± 0.104
4.842AlaIle: 4.842 ± 1.975
2.582AlaLys: 2.582 ± 0.805
4.196AlaLeu: 4.196 ± 0.041
2.905AlaMet: 2.905 ± 0.439
3.551AlaAsn: 3.551 ± 0.294
0.968AlaPro: 0.968 ± 1.098
3.551AlaGln: 3.551 ± 0.773
4.196AlaArg: 4.196 ± 1.026
4.842AlaSer: 4.842 ± 1.758
5.81AlaThr: 5.81 ± 0.723
5.165AlaVal: 5.165 ± 0.543
1.614AlaTrp: 1.614 ± 0.764
1.614AlaTyr: 1.614 ± 0.303
0.0AlaXaa: 0.0 ± 0.0
Cys
0.968CysAla: 0.968 ± 0.502
0.0CysCys: 0.0 ± 0.0
1.291CysAsp: 1.291 ± 0.398
0.646CysGlu: 0.646 ± 0.199
0.646CysPhe: 0.646 ± 0.199
2.26CysGly: 2.26 ± 0.637
0.0CysHis: 0.0 ± 0.0
0.646CysIle: 0.646 ± 0.335
0.646CysLys: 0.646 ± 0.335
1.291CysLeu: 1.291 ± 0.669
0.323CysMet: 0.323 ± 0.167
0.646CysAsn: 0.646 ± 0.199
1.291CysPro: 1.291 ± 0.136
0.323CysGln: 0.323 ± 0.167
0.323CysArg: 0.323 ± 0.167
0.968CysSer: 0.968 ± 0.565
0.0CysThr: 0.0 ± 0.0
0.968CysVal: 0.968 ± 0.032
0.0CysTrp: 0.0 ± 0.0
1.614CysTyr: 1.614 ± 0.764
0.0CysXaa: 0.0 ± 0.0
Asp
5.165AspAla: 5.165 ± 1.076
0.968AspCys: 0.968 ± 0.565
3.228AspAsp: 3.228 ± 0.461
4.196AspGlu: 4.196 ± 0.041
3.551AspPhe: 3.551 ± 0.773
3.551AspGly: 3.551 ± 0.294
1.937AspHis: 1.937 ± 0.47
2.905AspIle: 2.905 ± 0.972
3.873AspLys: 3.873 ± 0.407
3.873AspLeu: 3.873 ± 0.94
2.905AspMet: 2.905 ± 0.095
2.582AspAsn: 2.582 ± 0.271
2.582AspPro: 2.582 ± 1.329
0.0AspGln: 0.0 ± 0.0
1.291AspArg: 1.291 ± 0.669
4.842AspSer: 4.842 ± 1.225
3.551AspThr: 3.551 ± 0.294
4.196AspVal: 4.196 ± 0.041
1.291AspTrp: 1.291 ± 0.669
3.873AspTyr: 3.873 ± 0.126
0.0AspXaa: 0.0 ± 0.0
Glu
1.937GluAla: 1.937 ± 1.13
1.291GluCys: 1.291 ± 0.669
1.937GluAsp: 1.937 ± 1.004
3.873GluGlu: 3.873 ± 1.474
2.905GluPhe: 2.905 ± 0.439
4.196GluGly: 4.196 ± 1.108
0.646GluHis: 0.646 ± 0.335
2.905GluIle: 2.905 ± 0.095
1.937GluLys: 1.937 ± 0.47
4.196GluLeu: 4.196 ± 1.641
0.323GluMet: 0.323 ± 0.366
2.26GluAsn: 2.26 ± 1.171
1.614GluPro: 1.614 ± 0.303
2.905GluGln: 2.905 ± 0.439
1.614GluArg: 1.614 ± 0.303
3.228GluSer: 3.228 ± 1.139
2.582GluThr: 2.582 ± 0.262
4.842GluVal: 4.842 ± 0.158
0.968GluTrp: 0.968 ± 0.565
3.228GluTyr: 3.228 ± 1.139
0.0GluXaa: 0.0 ± 0.0
Phe
4.196PheAla: 4.196 ± 1.559
0.968PheCys: 0.968 ± 0.565
2.905PheAsp: 2.905 ± 0.972
3.551PheGlu: 3.551 ± 0.24
2.582PhePhe: 2.582 ± 0.271
3.551PheGly: 3.551 ± 0.294
0.646PheHis: 0.646 ± 0.732
3.228PheIle: 3.228 ± 1.673
1.937PheLys: 1.937 ± 0.47
1.937PheLeu: 1.937 ± 0.063
0.968PheMet: 0.968 ± 0.032
2.905PheAsn: 2.905 ± 0.095
1.937PhePro: 1.937 ± 0.47
0.646PheGln: 0.646 ± 0.199
2.26PheArg: 2.26 ± 0.104
4.196PheSer: 4.196 ± 1.026
4.196PheThr: 4.196 ± 0.492
3.551PheVal: 3.551 ± 1.306
1.291PheTrp: 1.291 ± 0.398
2.582PheTyr: 2.582 ± 0.805
0.0PheXaa: 0.0 ± 0.0
Gly
4.842GlyAla: 4.842 ± 0.375
1.614GlyCys: 1.614 ± 0.23
4.842GlyAsp: 4.842 ± 0.909
2.582GlyGlu: 2.582 ± 0.262
4.519GlyPhe: 4.519 ± 0.325
4.519GlyGly: 4.519 ± 1.392
0.646GlyHis: 0.646 ± 0.335
4.519GlyIle: 4.519 ± 0.742
3.551GlyLys: 3.551 ± 1.84
3.551GlyLeu: 3.551 ± 0.773
0.968GlyMet: 0.968 ± 0.565
2.582GlyAsn: 2.582 ± 0.805
2.905GlyPro: 2.905 ± 0.095
2.582GlyGln: 2.582 ± 0.271
3.228GlyArg: 3.228 ± 0.072
4.196GlySer: 4.196 ± 1.559
6.133GlyThr: 6.133 ± 2.156
5.165GlyVal: 5.165 ± 1.057
1.291GlyTrp: 1.291 ± 0.398
2.582GlyTyr: 2.582 ± 1.329
0.0GlyXaa: 0.0 ± 0.0
His
1.937HisAla: 1.937 ± 0.063
0.0HisCys: 0.0 ± 0.0
1.291HisAsp: 1.291 ± 0.136
1.291HisGlu: 1.291 ± 0.136
1.291HisPhe: 1.291 ± 0.398
1.937HisGly: 1.937 ± 0.47
0.968HisHis: 0.968 ± 0.032
1.291HisIle: 1.291 ± 0.136
1.937HisLys: 1.937 ± 0.597
2.582HisLeu: 2.582 ± 0.805
0.968HisMet: 0.968 ± 0.032
1.614HisAsn: 1.614 ± 0.303
0.646HisPro: 0.646 ± 0.335
0.323HisGln: 0.323 ± 0.167
1.614HisArg: 1.614 ± 0.23
1.291HisSer: 1.291 ± 0.398
1.291HisThr: 1.291 ± 0.136
1.291HisVal: 1.291 ± 0.398
0.0HisTrp: 0.0 ± 0.0
0.968HisTyr: 0.968 ± 0.502
0.0HisXaa: 0.0 ± 0.0
Ile
4.519IleAla: 4.519 ± 1.808
0.646IleCys: 0.646 ± 0.335
4.196IleAsp: 4.196 ± 0.492
3.551IleGlu: 3.551 ± 1.306
1.614IlePhe: 1.614 ± 0.836
3.228IleGly: 3.228 ± 0.606
2.26IleHis: 2.26 ± 0.104
2.905IleIle: 2.905 ± 0.439
4.196IleLys: 4.196 ± 1.108
3.551IleLeu: 3.551 ± 1.306
1.937IleMet: 1.937 ± 0.47
3.873IleAsn: 3.873 ± 0.66
2.582IlePro: 2.582 ± 0.795
1.614IleGln: 1.614 ± 0.303
2.26IleArg: 2.26 ± 0.429
1.291IleSer: 1.291 ± 0.398
2.905IleThr: 2.905 ± 0.972
2.582IleVal: 2.582 ± 0.262
1.937IleTrp: 1.937 ± 0.063
3.551IleTyr: 3.551 ± 1.306
0.0IleXaa: 0.0 ± 0.0
Lys
2.26LysAla: 2.26 ± 0.637
0.968LysCys: 0.968 ± 0.502
3.873LysAsp: 3.873 ± 1.474
1.291LysGlu: 1.291 ± 0.136
0.968LysPhe: 0.968 ± 0.032
3.228LysGly: 3.228 ± 0.072
1.937LysHis: 1.937 ± 1.004
2.582LysIle: 2.582 ± 0.805
2.905LysLys: 2.905 ± 1.505
6.456LysLeu: 6.456 ± 0.145
1.937LysMet: 1.937 ± 0.47
1.614LysAsn: 1.614 ± 0.764
1.614LysPro: 1.614 ± 0.303
1.937LysGln: 1.937 ± 1.004
1.291LysArg: 1.291 ± 0.669
2.26LysSer: 2.26 ± 0.104
3.551LysThr: 3.551 ± 1.306
2.905LysVal: 2.905 ± 0.095
0.646LysTrp: 0.646 ± 0.199
2.26LysTyr: 2.26 ± 0.637
0.0LysXaa: 0.0 ± 0.0
Leu
5.165LeuAla: 5.165 ± 1.076
0.968LeuCys: 0.968 ± 0.502
4.196LeuAsp: 4.196 ± 0.041
3.873LeuGlu: 3.873 ± 0.94
2.582LeuPhe: 2.582 ± 0.262
3.551LeuGly: 3.551 ± 1.36
1.291LeuHis: 1.291 ± 0.136
3.873LeuIle: 3.873 ± 0.94
4.842LeuLys: 4.842 ± 0.158
4.842LeuLeu: 4.842 ± 1.975
2.905LeuMet: 2.905 ± 0.628
4.842LeuAsn: 4.842 ± 0.375
6.133LeuPro: 6.133 ± 1.622
4.196LeuGln: 4.196 ± 0.041
2.26LeuArg: 2.26 ± 0.637
5.81LeuSer: 5.81 ± 0.877
3.551LeuThr: 3.551 ± 1.306
4.196LeuVal: 4.196 ± 1.641
0.968LeuTrp: 0.968 ± 0.032
4.842LeuTyr: 4.842 ± 1.975
0.0LeuXaa: 0.0 ± 0.0
Met
2.905MetAla: 2.905 ± 1.695
0.323MetCys: 0.323 ± 0.167
2.26MetAsp: 2.26 ± 0.429
0.323MetGlu: 0.323 ± 0.167
0.0MetPhe: 0.0 ± 0.0
1.937MetGly: 1.937 ± 0.063
1.291MetHis: 1.291 ± 0.398
1.937MetIle: 1.937 ± 0.597
0.968MetLys: 0.968 ± 0.032
2.905MetLeu: 2.905 ± 0.439
0.646MetMet: 0.646 ± 0.335
1.291MetAsn: 1.291 ± 0.136
0.646MetPro: 0.646 ± 0.199
1.291MetGln: 1.291 ± 0.669
0.968MetArg: 0.968 ± 0.502
2.26MetSer: 2.26 ± 2.029
1.291MetThr: 1.291 ± 0.669
2.582MetVal: 2.582 ± 0.262
0.323MetTrp: 0.323 ± 0.167
0.646MetTyr: 0.646 ± 0.335
0.0MetXaa: 0.0 ± 0.0
Asn
2.582AsnAla: 2.582 ± 0.262
1.614AsnCys: 1.614 ± 0.764
0.968AsnAsp: 0.968 ± 0.502
4.519AsnGlu: 4.519 ± 1.275
3.551AsnPhe: 3.551 ± 0.294
2.582AsnGly: 2.582 ± 0.262
0.968AsnHis: 0.968 ± 0.502
1.937AsnIle: 1.937 ± 0.063
2.905AsnLys: 2.905 ± 0.972
3.551AsnLeu: 3.551 ± 0.294
0.968AsnMet: 0.968 ± 0.032
4.519AsnAsn: 4.519 ± 1.808
2.905AsnPro: 2.905 ± 1.161
1.614AsnGln: 1.614 ± 0.836
2.905AsnArg: 2.905 ± 0.972
2.905AsnSer: 2.905 ± 0.439
3.551AsnThr: 3.551 ± 0.24
2.26AsnVal: 2.26 ± 0.104
0.646AsnTrp: 0.646 ± 0.732
3.228AsnTyr: 3.228 ± 0.994
0.0AsnXaa: 0.0 ± 0.0
Pro
2.582ProAla: 2.582 ± 0.262
0.0ProCys: 0.0 ± 0.0
3.873ProAsp: 3.873 ± 0.407
2.582ProGlu: 2.582 ± 0.805
1.937ProPhe: 1.937 ± 0.063
2.582ProGly: 2.582 ± 0.805
1.937ProHis: 1.937 ± 0.597
1.291ProIle: 1.291 ± 0.669
1.291ProLys: 1.291 ± 0.398
4.196ProLeu: 4.196 ± 0.492
2.582ProMet: 2.582 ± 0.795
2.26ProAsn: 2.26 ± 0.429
4.519ProPro: 4.519 ± 0.859
1.614ProGln: 1.614 ± 0.764
1.291ProArg: 1.291 ± 0.669
4.842ProSer: 4.842 ± 1.225
4.842ProThr: 4.842 ± 3.891
4.842ProVal: 4.842 ± 0.158
0.968ProTrp: 0.968 ± 0.565
2.582ProTyr: 2.582 ± 2.395
0.0ProXaa: 0.0 ± 0.0
Gln
2.26GlnAla: 2.26 ± 0.637
0.646GlnCys: 0.646 ± 0.335
1.614GlnAsp: 1.614 ± 0.764
2.582GlnGlu: 2.582 ± 0.805
2.582GlnPhe: 2.582 ± 0.805
1.614GlnGly: 1.614 ± 0.303
0.968GlnHis: 0.968 ± 0.032
2.26GlnIle: 2.26 ± 0.637
1.614GlnLys: 1.614 ± 0.303
3.551GlnLeu: 3.551 ± 0.773
0.646GlnMet: 0.646 ± 0.281
1.291GlnAsn: 1.291 ± 0.398
3.228GlnPro: 3.228 ± 0.461
2.582GlnGln: 2.582 ± 0.271
1.291GlnArg: 1.291 ± 0.136
3.551GlnSer: 3.551 ± 0.294
0.968GlnThr: 0.968 ± 0.032
2.26GlnVal: 2.26 ± 0.104
1.937GlnTrp: 1.937 ± 1.004
0.646GlnTyr: 0.646 ± 0.335
0.0GlnXaa: 0.0 ± 0.0
Arg
2.582ArgAla: 2.582 ± 0.271
0.646ArgCys: 0.646 ± 0.335
2.26ArgAsp: 2.26 ± 0.637
2.582ArgGlu: 2.582 ± 0.805
1.937ArgPhe: 1.937 ± 0.47
1.614ArgGly: 1.614 ± 0.764
1.614ArgHis: 1.614 ± 0.303
2.26ArgIle: 2.26 ± 0.637
1.614ArgLys: 1.614 ± 0.836
4.196ArgLeu: 4.196 ± 0.492
1.614ArgMet: 1.614 ± 0.23
1.937ArgAsn: 1.937 ± 0.063
3.873ArgPro: 3.873 ± 0.126
1.614ArgGln: 1.614 ± 0.23
2.582ArgArg: 2.582 ± 0.805
3.873ArgSer: 3.873 ± 0.126
2.905ArgThr: 2.905 ± 0.095
1.614ArgVal: 1.614 ± 0.836
0.646ArgTrp: 0.646 ± 0.732
1.614ArgTyr: 1.614 ± 0.303
0.0ArgXaa: 0.0 ± 0.0
Ser
4.842SerAla: 4.842 ± 0.691
0.646SerCys: 0.646 ± 0.335
6.133SerAsp: 6.133 ± 0.556
2.905SerGlu: 2.905 ± 0.439
2.905SerPhe: 2.905 ± 0.628
8.07SerGly: 8.07 ± 0.085
1.291SerHis: 1.291 ± 0.669
5.165SerIle: 5.165 ± 2.658
3.551SerLys: 3.551 ± 0.773
4.519SerLeu: 4.519 ± 1.275
0.646SerMet: 0.646 ± 0.199
3.551SerAsn: 3.551 ± 0.294
4.842SerPro: 4.842 ± 0.691
1.937SerGln: 1.937 ± 0.063
3.551SerArg: 3.551 ± 1.36
5.487SerSer: 5.487 ± 0.177
5.81SerThr: 5.81 ± 3.39
3.873SerVal: 3.873 ± 3.327
0.646SerTrp: 0.646 ± 0.199
3.551SerTyr: 3.551 ± 2.427
0.0SerXaa: 0.0 ± 0.0
Thr
5.81ThrAla: 5.81 ± 1.79
1.291ThrCys: 1.291 ± 0.398
3.551ThrAsp: 3.551 ± 0.24
3.228ThrGlu: 3.228 ± 0.606
3.228ThrPhe: 3.228 ± 0.994
5.81ThrGly: 5.81 ± 0.723
1.291ThrHis: 1.291 ± 0.398
2.905ThrIle: 2.905 ± 0.439
1.614ThrLys: 1.614 ± 0.23
5.487ThrLeu: 5.487 ± 1.424
0.968ThrMet: 0.968 ± 0.032
2.582ThrAsn: 2.582 ± 0.795
6.133ThrPro: 6.133 ± 3.756
2.905ThrGln: 2.905 ± 0.628
1.291ThrArg: 1.291 ± 0.136
7.747ThrSer: 7.747 ± 1.319
3.228ThrThr: 3.228 ± 2.061
4.842ThrVal: 4.842 ± 1.758
0.646ThrTrp: 0.646 ± 0.199
2.905ThrTyr: 2.905 ± 0.439
0.0ThrXaa: 0.0 ± 0.0
Val
3.551ValAla: 3.551 ± 1.36
0.968ValCys: 0.968 ± 0.502
3.551ValAsp: 3.551 ± 0.827
0.968ValGlu: 0.968 ± 0.032
2.26ValPhe: 2.26 ± 1.171
3.873ValGly: 3.873 ± 2.26
0.646ValHis: 0.646 ± 0.199
5.81ValIle: 5.81 ± 1.411
2.582ValLys: 2.582 ± 0.271
6.779ValLeu: 6.779 ± 0.846
0.323ValMet: 0.323 ± 0.122
4.196ValAsn: 4.196 ± 1.641
3.551ValPro: 3.551 ± 1.306
3.228ValGln: 3.228 ± 0.072
4.842ValArg: 4.842 ± 0.375
6.133ValSer: 6.133 ± 1.622
6.456ValThr: 6.456 ± 3.055
3.551ValVal: 3.551 ± 0.294
0.968ValTrp: 0.968 ± 0.032
2.582ValTyr: 2.582 ± 0.795
0.0ValXaa: 0.0 ± 0.0
Trp
0.968TrpAla: 0.968 ± 0.502
0.323TrpCys: 0.323 ± 0.366
1.291TrpAsp: 1.291 ± 0.398
0.968TrpGlu: 0.968 ± 0.032
1.937TrpPhe: 1.937 ± 1.13
0.323TrpGly: 0.323 ± 0.366
0.968TrpHis: 0.968 ± 0.032
0.646TrpIle: 0.646 ± 0.732
0.323TrpLys: 0.323 ± 0.167
0.646TrpLeu: 0.646 ± 0.335
0.323TrpMet: 0.323 ± 0.366
0.323TrpAsn: 0.323 ± 0.167
0.323TrpPro: 0.323 ± 0.167
0.646TrpGln: 0.646 ± 0.335
1.614TrpArg: 1.614 ± 0.303
0.968TrpSer: 0.968 ± 0.565
0.968TrpThr: 0.968 ± 0.565
1.291TrpVal: 1.291 ± 0.669
0.0TrpTrp: 0.0 ± 0.0
2.582TrpTyr: 2.582 ± 0.795
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.551TyrAla: 3.551 ± 0.24
0.646TyrCys: 0.646 ± 0.199
3.551TyrAsp: 3.551 ± 0.294
1.937TyrGlu: 1.937 ± 1.004
4.842TyrPhe: 4.842 ± 0.375
3.873TyrGly: 3.873 ± 1.474
0.968TyrHis: 0.968 ± 0.565
1.291TyrIle: 1.291 ± 0.136
1.614TyrLys: 1.614 ± 0.836
2.582TyrLeu: 2.582 ± 0.795
1.614TyrMet: 1.614 ± 0.764
2.26TyrAsn: 2.26 ± 0.104
0.323TyrPro: 0.323 ± 0.366
2.582TyrGln: 2.582 ± 1.338
2.905TyrArg: 2.905 ± 0.095
3.228TyrSer: 3.228 ± 1.528
3.873TyrThr: 3.873 ± 2.26
5.165TyrVal: 5.165 ± 0.524
0.646TyrTrp: 0.646 ± 0.335
4.519TyrTyr: 4.519 ± 0.742
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski