Amino acid dipepetide frequency for Caballeronia mineralivorans PML1(12)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.751AlaAla: 15.751 ± 0.115	1.202AlaCys: 1.202 ± 0.024	6.251AlaAsp: 6.251 ± 0.047	5.8AlaGlu: 5.8 ± 0.05	4.38AlaPhe: 4.38 ± 0.043	9.895AlaGly: 9.895 ± 0.079	2.592AlaHis: 2.592 ± 0.033	6.067AlaIle: 6.067 ± 0.055	3.921AlaLys: 3.921 ± 0.049	13.655AlaLeu: 13.655 ± 0.096	3.306AlaMet: 3.306 ± 0.04	3.322AlaAsn: 3.322 ± 0.043	5.244AlaPro: 5.244 ± 0.054	4.872AlaGln: 4.872 ± 0.051	8.072AlaArg: 8.072 ± 0.067	7.503AlaSer: 7.503 ± 0.06	6.402AlaThr: 6.402 ± 0.06	8.724AlaVal: 8.724 ± 0.063	1.517AlaTrp: 1.517 ± 0.027	2.68AlaTyr: 2.68 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.156CysAla: 1.156 ± 0.024	0.118CysCys: 0.118 ± 0.007	0.494CysAsp: 0.494 ± 0.015	0.47CysGlu: 0.47 ± 0.015	0.343CysPhe: 0.343 ± 0.011	0.974CysGly: 0.974 ± 0.018	0.242CysHis: 0.242 ± 0.012	0.413CysIle: 0.413 ± 0.013	0.212CysLys: 0.212 ± 0.01	0.789CysLeu: 0.789 ± 0.019	0.211CysMet: 0.211 ± 0.01	0.253CysAsn: 0.253 ± 0.01	0.433CysPro: 0.433 ± 0.014	0.225CysGln: 0.225 ± 0.011	0.583CysArg: 0.583 ± 0.016	0.536CysSer: 0.536 ± 0.015	0.469CysThr: 0.469 ± 0.014	0.791CysVal: 0.791 ± 0.018	0.124CysTrp: 0.124 ± 0.007	0.218CysTyr: 0.218 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.081AspAla: 7.081 ± 0.064	0.453AspCys: 0.453 ± 0.016	2.939AspAsp: 2.939 ± 0.04	3.316AspGlu: 3.316 ± 0.038	2.004AspPhe: 2.004 ± 0.032	4.417AspGly: 4.417 ± 0.043	1.179AspHis: 1.179 ± 0.019	2.699AspIle: 2.699 ± 0.036	1.681AspLys: 1.681 ± 0.027	5.257AspLeu: 5.257 ± 0.043	1.16AspMet: 1.16 ± 0.022	1.448AspAsn: 1.448 ± 0.026	2.917AspPro: 2.917 ± 0.036	1.661AspGln: 1.661 ± 0.024	3.328AspArg: 3.328 ± 0.035	2.624AspSer: 2.624 ± 0.034	2.909AspThr: 2.909 ± 0.036	4.381AspVal: 4.381 ± 0.049	0.85AspTrp: 0.85 ± 0.02	1.518AspTyr: 1.518 ± 0.021	0.0AspXaa: 0.0 ± 0.0
Glu	6.18GluAla: 6.18 ± 0.055	0.398GluCys: 0.398 ± 0.013	2.084GluAsp: 2.084 ± 0.032	2.418GluGlu: 2.418 ± 0.038	1.826GluPhe: 1.826 ± 0.028	3.369GluGly: 3.369 ± 0.038	1.412GluHis: 1.412 ± 0.026	2.914GluIle: 2.914 ± 0.043	1.867GluLys: 1.867 ± 0.03	5.394GluLeu: 5.394 ± 0.057	1.268GluMet: 1.268 ± 0.024	1.465GluAsn: 1.465 ± 0.027	2.434GluPro: 2.434 ± 0.033	2.298GluGln: 2.298 ± 0.035	4.578GluArg: 4.578 ± 0.046	2.763GluSer: 2.763 ± 0.032	2.986GluThr: 2.986 ± 0.032	3.567GluVal: 3.567 ± 0.042	0.727GluTrp: 0.727 ± 0.017	1.133GluTyr: 1.133 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.678PheAla: 4.678 ± 0.048	0.433PheCys: 0.433 ± 0.014	2.822PheAsp: 2.822 ± 0.036	2.078PheGlu: 2.078 ± 0.032	1.531PhePhe: 1.531 ± 0.026	3.757PheGly: 3.757 ± 0.042	0.766PheHis: 0.766 ± 0.019	1.788PheIle: 1.788 ± 0.027	1.158PheLys: 1.158 ± 0.02	3.172PheLeu: 3.172 ± 0.036	0.823PheMet: 0.823 ± 0.019	1.26PheAsn: 1.26 ± 0.027	1.668PhePro: 1.668 ± 0.026	1.079PheGln: 1.079 ± 0.019	2.016PheArg: 2.016 ± 0.026	2.493PheSer: 2.493 ± 0.031	2.033PheThr: 2.033 ± 0.032	3.188PheVal: 3.188 ± 0.035	0.503PheTrp: 0.503 ± 0.016	1.005PheTyr: 1.005 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	8.803GlyAla: 8.803 ± 0.067	0.825GlyCys: 0.825 ± 0.019	3.853GlyAsp: 3.853 ± 0.045	4.129GlyGlu: 4.129 ± 0.044	3.586GlyPhe: 3.586 ± 0.039	6.575GlyGly: 6.575 ± 0.091	1.893GlyHis: 1.893 ± 0.028	4.592GlyIle: 4.592 ± 0.048	3.168GlyLys: 3.168 ± 0.038	8.128GlyLeu: 8.128 ± 0.059	2.25GlyMet: 2.25 ± 0.032	2.417GlyAsn: 2.417 ± 0.044	2.906GlyPro: 2.906 ± 0.035	2.805GlyGln: 2.805 ± 0.037	5.066GlyArg: 5.066 ± 0.051	4.868GlySer: 4.868 ± 0.063	4.7GlyThr: 4.7 ± 0.065	6.809GlyVal: 6.809 ± 0.06	1.314GlyTrp: 1.314 ± 0.026	2.449GlyTyr: 2.449 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.902HisAla: 2.902 ± 0.036	0.267HisCys: 0.267 ± 0.011	1.353HisAsp: 1.353 ± 0.022	1.178HisGlu: 1.178 ± 0.024	0.963HisPhe: 0.963 ± 0.025	2.066HisGly: 2.066 ± 0.034	0.609HisHis: 0.609 ± 0.018	0.949HisIle: 0.949 ± 0.018	0.569HisLys: 0.569 ± 0.015	2.188HisLeu: 2.188 ± 0.031	0.536HisMet: 0.536 ± 0.013	0.527HisAsn: 0.527 ± 0.015	1.377HisPro: 1.377 ± 0.027	0.673HisGln: 0.673 ± 0.014	1.513HisArg: 1.513 ± 0.026	1.11HisSer: 1.11 ± 0.023	1.053HisThr: 1.053 ± 0.02	1.775HisVal: 1.775 ± 0.023	0.372HisTrp: 0.372 ± 0.013	0.663HisTyr: 0.663 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	7.156IleAla: 7.156 ± 0.056	0.489IleCys: 0.489 ± 0.013	3.765IleAsp: 3.765 ± 0.046	3.395IleGlu: 3.395 ± 0.043	1.635IlePhe: 1.635 ± 0.028	5.032IleGly: 5.032 ± 0.055	0.962IleHis: 0.962 ± 0.017	1.802IleIle: 1.802 ± 0.028	1.555IleLys: 1.555 ± 0.024	3.755IleLeu: 3.755 ± 0.048	0.859IleMet: 0.859 ± 0.02	1.573IleAsn: 1.573 ± 0.026	2.233IlePro: 2.233 ± 0.031	1.369IleGln: 1.369 ± 0.022	2.919IleArg: 2.919 ± 0.034	2.884IleSer: 2.884 ± 0.035	2.591IleThr: 2.591 ± 0.04	4.655IleVal: 4.655 ± 0.047	0.529IleTrp: 0.529 ± 0.017	1.136IleTyr: 1.136 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.739LysAla: 3.739 ± 0.046	0.174LysCys: 0.174 ± 0.009	1.491LysAsp: 1.491 ± 0.028	1.507LysGlu: 1.507 ± 0.034	0.974LysPhe: 0.974 ± 0.018	2.266LysGly: 2.266 ± 0.033	0.746LysHis: 0.746 ± 0.018	1.74LysIle: 1.74 ± 0.035	1.366LysLys: 1.366 ± 0.034	3.563LysLeu: 3.563 ± 0.047	0.838LysMet: 0.838 ± 0.019	0.988LysAsn: 0.988 ± 0.018	2.021LysPro: 2.021 ± 0.032	1.351LysGln: 1.351 ± 0.024	2.492LysArg: 2.492 ± 0.033	1.942LysSer: 1.942 ± 0.028	2.057LysThr: 2.057 ± 0.03	2.461LysVal: 2.461 ± 0.034	0.418LysTrp: 0.418 ± 0.014	0.756LysTyr: 0.756 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	13.25LeuAla: 13.25 ± 0.085	0.999LeuCys: 0.999 ± 0.022	6.002LeuAsp: 6.002 ± 0.051	5.029LeuGlu: 5.029 ± 0.056	3.698LeuPhe: 3.698 ± 0.046	8.325LeuGly: 8.325 ± 0.062	2.231LeuHis: 2.231 ± 0.031	5.095LeuIle: 5.095 ± 0.051	3.577LeuLys: 3.577 ± 0.043	10.195LeuLeu: 10.195 ± 0.093	2.352LeuMet: 2.352 ± 0.03	2.932LeuAsn: 2.932 ± 0.036	5.598LeuPro: 5.598 ± 0.048	3.324LeuGln: 3.324 ± 0.038	6.787LeuArg: 6.787 ± 0.061	6.812LeuSer: 6.812 ± 0.061	5.849LeuThr: 5.849 ± 0.05	7.503LeuVal: 7.503 ± 0.06	1.089LeuTrp: 1.089 ± 0.026	2.2LeuTyr: 2.2 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.511MetAla: 2.511 ± 0.032	0.184MetCys: 0.184 ± 0.008	1.001MetAsp: 1.001 ± 0.021	0.96MetGlu: 0.96 ± 0.021	0.792MetPhe: 0.792 ± 0.017	1.588MetGly: 1.588 ± 0.028	0.569MetHis: 0.569 ± 0.014	1.268MetIle: 1.268 ± 0.023	1.099MetLys: 1.099 ± 0.02	2.723MetLeu: 2.723 ± 0.037	0.607MetMet: 0.607 ± 0.017	0.97MetAsn: 0.97 ± 0.021	1.421MetPro: 1.421 ± 0.024	1.024MetGln: 1.024 ± 0.019	1.723MetArg: 1.723 ± 0.028	1.821MetSer: 1.821 ± 0.028	1.759MetThr: 1.759 ± 0.025	1.586MetVal: 1.586 ± 0.025	0.218MetTrp: 0.218 ± 0.009	0.415MetTyr: 0.415 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.7AsnAla: 3.7 ± 0.045	0.274AsnCys: 0.274 ± 0.01	1.539AsnAsp: 1.539 ± 0.024	1.391AsnGlu: 1.391 ± 0.021	1.099AsnPhe: 1.099 ± 0.021	2.693AsnGly: 2.693 ± 0.037	0.602AsnHis: 0.602 ± 0.013	1.37AsnIle: 1.37 ± 0.026	0.781AsnLys: 0.781 ± 0.021	2.852AsnLeu: 2.852 ± 0.034	0.612AsnMet: 0.612 ± 0.015	0.944AsnAsn: 0.944 ± 0.022	1.876AsnPro: 1.876 ± 0.031	0.974AsnGln: 0.974 ± 0.024	1.829AsnArg: 1.829 ± 0.029	1.484AsnSer: 1.484 ± 0.03	1.647AsnThr: 1.647 ± 0.034	2.407AsnVal: 2.407 ± 0.031	0.443AsnTrp: 0.443 ± 0.013	0.76AsnTyr: 0.76 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	5.993ProAla: 5.993 ± 0.05	0.331ProCys: 0.331 ± 0.012	3.154ProAsp: 3.154 ± 0.038	2.933ProGlu: 2.933 ± 0.04	1.987ProPhe: 1.987 ± 0.03	4.058ProGly: 4.058 ± 0.044	1.173ProHis: 1.173 ± 0.023	2.15ProIle: 2.15 ± 0.03	1.541ProLys: 1.541 ± 0.028	5.03ProLeu: 5.03 ± 0.047	1.134ProMet: 1.134 ± 0.024	1.468ProAsn: 1.468 ± 0.028	2.327ProPro: 2.327 ± 0.041	1.725ProGln: 1.725 ± 0.025	2.605ProArg: 2.605 ± 0.033	2.993ProSer: 2.993 ± 0.036	2.583ProThr: 2.583 ± 0.033	4.287ProVal: 4.287 ± 0.044	0.643ProTrp: 0.643 ± 0.017	1.26ProTyr: 1.26 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	4.386GlnAla: 4.386 ± 0.049	0.266GlnCys: 0.266 ± 0.01	1.374GlnAsp: 1.374 ± 0.026	1.403GlnGlu: 1.403 ± 0.025	1.317GlnPhe: 1.317 ± 0.027	2.464GlnGly: 2.464 ± 0.033	0.894GlnHis: 0.894 ± 0.018	2.039GlnIle: 2.039 ± 0.027	1.174GlnLys: 1.174 ± 0.023	3.703GlnLeu: 3.703 ± 0.039	1.002GlnMet: 1.002 ± 0.022	0.986GlnAsn: 0.986 ± 0.022	1.846GlnPro: 1.846 ± 0.031	1.731GlnGln: 1.731 ± 0.032	2.769GlnArg: 2.769 ± 0.033	2.089GlnSer: 2.089 ± 0.031	2.011GlnThr: 2.011 ± 0.032	2.581GlnVal: 2.581 ± 0.036	0.541GlnTrp: 0.541 ± 0.015	0.912GlnTyr: 0.912 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.512ArgAla: 7.512 ± 0.059	0.553ArgCys: 0.553 ± 0.016	3.649ArgAsp: 3.649 ± 0.037	4.028ArgGlu: 4.028 ± 0.05	2.882ArgPhe: 2.882 ± 0.031	4.416ArgGly: 4.416 ± 0.043	1.755ArgHis: 1.755 ± 0.03	3.661ArgIle: 3.661 ± 0.037	2.08ArgLys: 2.08 ± 0.03	7.011ArgLeu: 7.011 ± 0.083	1.684ArgMet: 1.684 ± 0.024	1.86ArgAsn: 1.86 ± 0.03	2.822ArgPro: 2.822 ± 0.036	2.392ArgGln: 2.392 ± 0.03	4.862ArgArg: 4.862 ± 0.052	3.643ArgSer: 3.643 ± 0.042	3.441ArgThr: 3.441 ± 0.041	5.231ArgVal: 5.231 ± 0.055	0.998ArgTrp: 0.998 ± 0.02	1.829ArgTyr: 1.829 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.988SerAla: 6.988 ± 0.06	0.465SerCys: 0.465 ± 0.014	3.012SerAsp: 3.012 ± 0.031	2.709SerGlu: 2.709 ± 0.038	2.371SerPhe: 2.371 ± 0.033	5.596SerGly: 5.596 ± 0.059	1.275SerHis: 1.275 ± 0.024	3.144SerIle: 3.144 ± 0.037	1.936SerLys: 1.936 ± 0.029	6.154SerLeu: 6.154 ± 0.055	1.578SerMet: 1.578 ± 0.023	1.895SerAsn: 1.895 ± 0.027	2.959SerPro: 2.959 ± 0.035	1.954SerGln: 1.954 ± 0.032	3.689SerArg: 3.689 ± 0.043	3.851SerSer: 3.851 ± 0.052	3.528SerThr: 3.528 ± 0.045	4.707SerVal: 4.707 ± 0.046	0.766SerTrp: 0.766 ± 0.018	1.406SerTyr: 1.406 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	6.108ThrAla: 6.108 ± 0.064	0.417ThrCys: 0.417 ± 0.013	2.746ThrAsp: 2.746 ± 0.031	2.484ThrGlu: 2.484 ± 0.035	2.203ThrPhe: 2.203 ± 0.034	4.947ThrGly: 4.947 ± 0.065	1.325ThrHis: 1.325 ± 0.023	2.775ThrIle: 2.775 ± 0.034	1.473ThrLys: 1.473 ± 0.026	6.72ThrLeu: 6.72 ± 0.067	1.247ThrMet: 1.247 ± 0.021	1.529ThrAsn: 1.529 ± 0.026	3.47ThrPro: 3.47 ± 0.038	1.987ThrGln: 1.987 ± 0.028	3.491ThrArg: 3.491 ± 0.038	3.336ThrSer: 3.336 ± 0.046	3.2ThrThr: 3.2 ± 0.046	4.503ThrVal: 4.503 ± 0.048	0.705ThrTrp: 0.705 ± 0.019	1.335ThrTyr: 1.335 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	9.448ValAla: 9.448 ± 0.065	0.816ValCys: 0.816 ± 0.019	4.316ValAsp: 4.316 ± 0.043	4.142ValGlu: 4.142 ± 0.039	3.022ValPhe: 3.022 ± 0.038	5.638ValGly: 5.638 ± 0.056	1.541ValHis: 1.541 ± 0.023	4.174ValIle: 4.174 ± 0.045	2.601ValLys: 2.601 ± 0.036	8.178ValLeu: 8.178 ± 0.065	1.95ValMet: 1.95 ± 0.028	2.311ValAsn: 2.311 ± 0.035	3.947ValPro: 3.947 ± 0.047	2.514ValGln: 2.514 ± 0.032	5.037ValArg: 5.037 ± 0.049	5.014ValSer: 5.014 ± 0.046	4.723ValThr: 4.723 ± 0.046	6.529ValVal: 6.529 ± 0.063	0.914ValTrp: 0.914 ± 0.021	1.705ValTyr: 1.705 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.104TrpAla: 1.104 ± 0.025	0.141TrpCys: 0.141 ± 0.007	0.608TrpAsp: 0.608 ± 0.017	0.485TrpGlu: 0.485 ± 0.015	0.566TrpPhe: 0.566 ± 0.015	0.856TrpGly: 0.856 ± 0.018	0.368TrpHis: 0.368 ± 0.012	0.73TrpIle: 0.73 ± 0.016	0.429TrpLys: 0.429 ± 0.013	1.813TrpLeu: 1.813 ± 0.031	0.359TrpMet: 0.359 ± 0.013	0.473TrpAsn: 0.473 ± 0.015	0.608TrpPro: 0.608 ± 0.015	0.632TrpGln: 0.632 ± 0.016	1.109TrpArg: 1.109 ± 0.022	0.83TrpSer: 0.83 ± 0.018	0.739TrpThr: 0.739 ± 0.018	0.914TrpVal: 0.914 ± 0.022	0.22TrpTrp: 0.22 ± 0.01	0.299TrpTyr: 0.299 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.711TyrAla: 2.711 ± 0.035	0.254TyrCys: 0.254 ± 0.009	1.369TyrAsp: 1.369 ± 0.022	1.225TyrGlu: 1.225 ± 0.024	1.073TyrPhe: 1.073 ± 0.021	2.201TyrGly: 2.201 ± 0.032	0.509TyrHis: 0.509 ± 0.014	0.921TyrIle: 0.921 ± 0.019	0.699TyrLys: 0.699 ± 0.019	2.567TyrLeu: 2.567 ± 0.031	0.462TyrMet: 0.462 ± 0.014	0.657TyrAsn: 0.657 ± 0.017	1.269TyrPro: 1.269 ± 0.024	0.896TyrGln: 0.896 ± 0.019	1.842TyrArg: 1.842 ± 0.028	1.387TyrSer: 1.387 ± 0.028	1.322TyrThr: 1.322 ± 0.027	1.922TyrVal: 1.922 ± 0.027	0.393TyrTrp: 0.393 ± 0.013	0.655TyrTyr: 0.655 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8182 proteins (2499026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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