Amino acid dipepetide frequency for Firmicutes bacterium CAG:822

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.561AlaAla: 2.561 ± 0.095
0.515AlaCys: 0.515 ± 0.039
2.539AlaAsp: 2.539 ± 0.082
2.878AlaGlu: 2.878 ± 0.083
2.152AlaPhe: 2.152 ± 0.08
2.843AlaGly: 2.843 ± 0.096
0.792AlaHis: 0.792 ± 0.047
4.67AlaIle: 4.67 ± 0.127
4.344AlaLys: 4.344 ± 0.108
4.995AlaLeu: 4.995 ± 0.121
1.257AlaMet: 1.257 ± 0.056
2.805AlaAsn: 2.805 ± 0.097
1.053AlaPro: 1.053 ± 0.052
1.093AlaGln: 1.093 ± 0.058
1.837AlaArg: 1.837 ± 0.075
3.195AlaSer: 3.195 ± 0.115
2.85AlaThr: 2.85 ± 0.156
2.921AlaVal: 2.921 ± 0.08
0.261AlaTrp: 0.261 ± 0.026
2.247AlaTyr: 2.247 ± 0.084
0.0AlaXaa: 0.0 ± 0.0
Cys
0.503CysAla: 0.503 ± 0.039
0.106CysCys: 0.106 ± 0.017
0.686CysAsp: 0.686 ± 0.046
0.659CysGlu: 0.659 ± 0.034
0.455CysPhe: 0.455 ± 0.04
0.867CysGly: 0.867 ± 0.048
0.211CysHis: 0.211 ± 0.029
0.719CysIle: 0.719 ± 0.036
0.797CysLys: 0.797 ± 0.051
0.955CysLeu: 0.955 ± 0.05
0.274CysMet: 0.274 ± 0.025
0.553CysAsn: 0.553 ± 0.042
0.447CysPro: 0.447 ± 0.039
0.239CysGln: 0.239 ± 0.026
0.282CysArg: 0.282 ± 0.028
0.553CysSer: 0.553 ± 0.033
0.576CysThr: 0.576 ± 0.05
0.533CysVal: 0.533 ± 0.037
0.053CysTrp: 0.053 ± 0.012
0.473CysTyr: 0.473 ± 0.036
0.0CysXaa: 0.0 ± 0.0
Asp
2.669AspAla: 2.669 ± 0.084
0.498AspCys: 0.498 ± 0.035
4.163AspAsp: 4.163 ± 0.135
5.822AspGlu: 5.822 ± 0.134
2.923AspPhe: 2.923 ± 0.088
3.823AspGly: 3.823 ± 0.111
0.684AspHis: 0.684 ± 0.042
6.314AspIle: 6.314 ± 0.121
6.425AspLys: 6.425 ± 0.135
5.756AspLeu: 5.756 ± 0.127
1.631AspMet: 1.631 ± 0.062
4.248AspAsn: 4.248 ± 0.115
1.297AspPro: 1.297 ± 0.06
0.923AspGln: 0.923 ± 0.051
1.772AspArg: 1.772 ± 0.067
3.479AspSer: 3.479 ± 0.101
2.951AspThr: 2.951 ± 0.09
3.813AspVal: 3.813 ± 0.11
0.342AspTrp: 0.342 ± 0.028
3.861AspTyr: 3.861 ± 0.109
0.0AspXaa: 0.0 ± 0.0
Glu
3.851GluAla: 3.851 ± 0.108
0.593GluCys: 0.593 ± 0.042
4.356GluAsp: 4.356 ± 0.117
6.447GluGlu: 6.447 ± 0.173
2.896GluPhe: 2.896 ± 0.094
3.119GluGly: 3.119 ± 0.091
0.832GluHis: 0.832 ± 0.052
6.704GluIle: 6.704 ± 0.152
7.297GluLys: 7.297 ± 0.153
6.664GluLeu: 6.664 ± 0.151
1.885GluMet: 1.885 ± 0.069
5.658GluAsn: 5.658 ± 0.116
1.41GluPro: 1.41 ± 0.068
1.621GluGln: 1.621 ± 0.07
2.255GluArg: 2.255 ± 0.085
3.253GluSer: 3.253 ± 0.091
3.6GluThr: 3.6 ± 0.105
4.859GluVal: 4.859 ± 0.129
0.442GluTrp: 0.442 ± 0.034
3.662GluTyr: 3.662 ± 0.1
0.0GluXaa: 0.0 ± 0.0
Phe
1.953PheAla: 1.953 ± 0.064
0.475PheCys: 0.475 ± 0.037
3.24PheAsp: 3.24 ± 0.09
2.82PheGlu: 2.82 ± 0.099
1.807PhePhe: 1.807 ± 0.077
2.529PheGly: 2.529 ± 0.089
0.54PheHis: 0.54 ± 0.036
4.374PheIle: 4.374 ± 0.143
4.037PheLys: 4.037 ± 0.117
4.034PheLeu: 4.034 ± 0.134
1.081PheMet: 1.081 ± 0.054
2.981PheAsn: 2.981 ± 0.104
1.259PhePro: 1.259 ± 0.056
0.817PheGln: 0.817 ± 0.046
1.179PheArg: 1.179 ± 0.063
2.81PheSer: 2.81 ± 0.091
2.481PheThr: 2.481 ± 0.078
2.571PheVal: 2.571 ± 0.079
0.264PheTrp: 0.264 ± 0.026
1.956PheTyr: 1.956 ± 0.073
0.0PheXaa: 0.0 ± 0.0
Gly
2.969GlyAla: 2.969 ± 0.129
0.611GlyCys: 0.611 ± 0.049
3.202GlyAsp: 3.202 ± 0.086
3.703GlyGlu: 3.703 ± 0.108
2.576GlyPhe: 2.576 ± 0.073
3.31GlyGly: 3.31 ± 0.107
1.058GlyHis: 1.058 ± 0.058
4.909GlyIle: 4.909 ± 0.132
5.314GlyLys: 5.314 ± 0.126
4.969GlyLeu: 4.969 ± 0.121
1.506GlyMet: 1.506 ± 0.07
3.469GlyAsn: 3.469 ± 0.106
1.098GlyPro: 1.098 ± 0.109
1.237GlyGln: 1.237 ± 0.064
1.765GlyArg: 1.765 ± 0.078
3.346GlySer: 3.346 ± 0.103
3.587GlyThr: 3.587 ± 0.118
3.846GlyVal: 3.846 ± 0.101
0.435GlyTrp: 0.435 ± 0.058
3.376GlyTyr: 3.376 ± 0.105
0.0GlyXaa: 0.0 ± 0.0
His
0.674HisAla: 0.674 ± 0.046
0.146HisCys: 0.146 ± 0.021
0.814HisAsp: 0.814 ± 0.051
0.89HisGlu: 0.89 ± 0.054
0.654HisPhe: 0.654 ± 0.044
0.892HisGly: 0.892 ± 0.058
0.354HisHis: 0.354 ± 0.03
1.264HisIle: 1.264 ± 0.063
1.227HisLys: 1.227 ± 0.058
1.4HisLeu: 1.4 ± 0.065
0.337HisMet: 0.337 ± 0.03
0.92HisAsn: 0.92 ± 0.045
0.628HisPro: 0.628 ± 0.038
0.432HisGln: 0.432 ± 0.033
0.503HisArg: 0.503 ± 0.035
0.882HisSer: 0.882 ± 0.048
0.736HisThr: 0.736 ± 0.043
0.749HisVal: 0.749 ± 0.04
0.065HisTrp: 0.065 ± 0.013
0.802HisTyr: 0.802 ± 0.044
0.0HisXaa: 0.0 ± 0.0
Ile
4.472IleAla: 4.472 ± 0.118
1.078IleCys: 1.078 ± 0.053
6.465IleAsp: 6.465 ± 0.132
5.749IleGlu: 5.749 ± 0.117
4.205IlePhe: 4.205 ± 0.152
4.929IleGly: 4.929 ± 0.109
1.219IleHis: 1.219 ± 0.055
9.944IleIle: 9.944 ± 0.282
8.715IleLys: 8.715 ± 0.17
8.74IleLeu: 8.74 ± 0.198
2.061IleMet: 2.061 ± 0.075
6.892IleAsn: 6.892 ± 0.15
2.732IlePro: 2.732 ± 0.086
1.905IleGln: 1.905 ± 0.076
2.68IleArg: 2.68 ± 0.083
6.166IleSer: 6.166 ± 0.142
5.814IleThr: 5.814 ± 0.157
5.671IleVal: 5.671 ± 0.143
0.513IleTrp: 0.513 ± 0.038
4.318IleTyr: 4.318 ± 0.111
0.0IleXaa: 0.0 ± 0.0
Lys
4.391LysAla: 4.391 ± 0.107
0.885LysCys: 0.885 ± 0.053
6.54LysAsp: 6.54 ± 0.146
8.83LysGlu: 8.83 ± 0.164
3.192LysPhe: 3.192 ± 0.094
4.582LysGly: 4.582 ± 0.108
1.433LysHis: 1.433 ± 0.065
8.974LysIle: 8.974 ± 0.162
9.798LysLys: 9.798 ± 0.208
7.953LysLeu: 7.953 ± 0.18
2.707LysMet: 2.707 ± 0.088
6.732LysAsn: 6.732 ± 0.158
2.313LysPro: 2.313 ± 0.078
2.667LysGln: 2.667 ± 0.096
3.333LysArg: 3.333 ± 0.109
4.492LysSer: 4.492 ± 0.109
5.095LysThr: 5.095 ± 0.137
6.239LysVal: 6.239 ± 0.14
0.616LysTrp: 0.616 ± 0.043
5.447LysTyr: 5.447 ± 0.134
0.0LysXaa: 0.0 ± 0.0
Leu
4.261LeuAla: 4.261 ± 0.109
0.96LeuCys: 0.96 ± 0.046
6.068LeuAsp: 6.068 ± 0.147
6.601LeuGlu: 6.601 ± 0.16
4.087LeuPhe: 4.087 ± 0.141
5.12LeuGly: 5.12 ± 0.129
1.083LeuHis: 1.083 ± 0.053
8.509LeuIle: 8.509 ± 0.19
9.625LeuLys: 9.625 ± 0.19
8.031LeuLeu: 8.031 ± 0.186
2.056LeuMet: 2.056 ± 0.067
6.639LeuAsn: 6.639 ± 0.142
2.614LeuPro: 2.614 ± 0.084
1.825LeuGln: 1.825 ± 0.073
2.584LeuArg: 2.584 ± 0.087
6.174LeuSer: 6.174 ± 0.128
5.44LeuThr: 5.44 ± 0.151
5.442LeuVal: 5.442 ± 0.122
0.5LeuTrp: 0.5 ± 0.036
3.826LeuTyr: 3.826 ± 0.095
0.0LeuXaa: 0.0 ± 0.0
Met
1.486MetAla: 1.486 ± 0.059
0.236MetCys: 0.236 ± 0.022
1.503MetAsp: 1.503 ± 0.06
1.624MetGlu: 1.624 ± 0.066
1.196MetPhe: 1.196 ± 0.059
1.36MetGly: 1.36 ± 0.068
0.395MetHis: 0.395 ± 0.035
2.018MetIle: 2.018 ± 0.073
2.471MetLys: 2.471 ± 0.08
2.059MetLeu: 2.059 ± 0.083
0.633MetMet: 0.633 ± 0.042
1.822MetAsn: 1.822 ± 0.072
0.792MetPro: 0.792 ± 0.051
0.709MetGln: 0.709 ± 0.046
0.885MetArg: 0.885 ± 0.039
1.558MetSer: 1.558 ± 0.065
1.39MetThr: 1.39 ± 0.064
1.42MetVal: 1.42 ± 0.064
0.128MetTrp: 0.128 ± 0.019
1.028MetTyr: 1.028 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
2.773AsnAla: 2.773 ± 0.083
0.608AsnCys: 0.608 ± 0.036
4.263AsnAsp: 4.263 ± 0.109
5.025AsnGlu: 5.025 ± 0.124
2.858AsnPhe: 2.858 ± 0.092
4.193AsnGly: 4.193 ± 0.111
1.043AsnHis: 1.043 ± 0.058
7.051AsnIle: 7.051 ± 0.149
6.749AsnLys: 6.749 ± 0.136
6.412AsnLeu: 6.412 ± 0.13
1.772AsnMet: 1.772 ± 0.071
5.407AsnAsn: 5.407 ± 0.168
2.167AsnPro: 2.167 ± 0.071
1.825AsnGln: 1.825 ± 0.069
1.89AsnArg: 1.89 ± 0.075
4.15AsnSer: 4.15 ± 0.111
3.655AsnThr: 3.655 ± 0.121
4.08AsnVal: 4.08 ± 0.109
0.44AsnTrp: 0.44 ± 0.03
3.896AsnTyr: 3.896 ± 0.111
0.0AsnXaa: 0.0 ± 0.0
Pro
1.136ProAla: 1.136 ± 0.061
0.229ProCys: 0.229 ± 0.026
1.541ProAsp: 1.541 ± 0.076
1.971ProGlu: 1.971 ± 0.078
1.38ProPhe: 1.38 ± 0.068
1.433ProGly: 1.433 ± 0.065
0.455ProHis: 0.455 ± 0.039
2.451ProIle: 2.451 ± 0.073
2.403ProLys: 2.403 ± 0.08
2.184ProLeu: 2.184 ± 0.09
0.566ProMet: 0.566 ± 0.037
1.885ProAsn: 1.885 ± 0.069
0.43ProPro: 0.43 ± 0.036
0.55ProGln: 0.55 ± 0.034
0.759ProArg: 0.759 ± 0.041
1.893ProSer: 1.893 ± 0.067
1.707ProThr: 1.707 ± 0.111
1.86ProVal: 1.86 ± 0.087
0.173ProTrp: 0.173 ± 0.023
1.408ProTyr: 1.408 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
1.202GlnAla: 1.202 ± 0.058
0.171GlnCys: 0.171 ± 0.019
1.279GlnAsp: 1.279 ± 0.059
1.506GlnGlu: 1.506 ± 0.071
0.764GlnPhe: 0.764 ± 0.042
1.129GlnGly: 1.129 ± 0.054
0.199GlnHis: 0.199 ± 0.024
2.441GlnIle: 2.441 ± 0.085
2.506GlnLys: 2.506 ± 0.085
1.732GlnLeu: 1.732 ± 0.068
0.721GlnMet: 0.721 ± 0.047
2.157GlnAsn: 2.157 ± 0.078
0.463GlnPro: 0.463 ± 0.045
0.528GlnGln: 0.528 ± 0.052
0.877GlnArg: 0.877 ± 0.054
1.367GlnSer: 1.367 ± 0.066
1.556GlnThr: 1.556 ± 0.078
1.33GlnVal: 1.33 ± 0.061
0.136GlnTrp: 0.136 ± 0.018
0.94GlnTyr: 0.94 ± 0.051
0.0GlnXaa: 0.0 ± 0.0
Arg
1.39ArgAla: 1.39 ± 0.063
0.367ArgCys: 0.367 ± 0.031
1.775ArgAsp: 1.775 ± 0.077
2.257ArgGlu: 2.257 ± 0.076
1.352ArgPhe: 1.352 ± 0.056
1.649ArgGly: 1.649 ± 0.064
0.533ArgHis: 0.533 ± 0.04
2.592ArgIle: 2.592 ± 0.087
3.222ArgLys: 3.222 ± 0.09
3.014ArgLeu: 3.014 ± 0.093
0.887ArgMet: 0.887 ± 0.049
2.096ArgAsn: 2.096 ± 0.078
0.867ArgPro: 0.867 ± 0.049
0.885ArgGln: 0.885 ± 0.047
1.325ArgArg: 1.325 ± 0.069
1.606ArgSer: 1.606 ± 0.072
1.413ArgThr: 1.413 ± 0.056
1.938ArgVal: 1.938 ± 0.085
0.199ArgTrp: 0.199 ± 0.025
1.581ArgTyr: 1.581 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
2.78SerAla: 2.78 ± 0.117
0.561SerCys: 0.561 ± 0.057
3.876SerAsp: 3.876 ± 0.118
3.992SerGlu: 3.992 ± 0.084
2.823SerPhe: 2.823 ± 0.09
4.039SerGly: 4.039 ± 0.123
0.978SerHis: 0.978 ± 0.05
4.977SerIle: 4.977 ± 0.122
6.138SerLys: 6.138 ± 0.135
5.917SerLeu: 5.917 ± 0.127
1.521SerMet: 1.521 ± 0.061
4.137SerAsn: 4.137 ± 0.117
1.47SerPro: 1.47 ± 0.059
1.563SerGln: 1.563 ± 0.069
1.85SerArg: 1.85 ± 0.067
4.532SerSer: 4.532 ± 0.167
3.089SerThr: 3.089 ± 0.121
3.557SerVal: 3.557 ± 0.096
0.377SerTrp: 0.377 ± 0.035
3.042SerTyr: 3.042 ± 0.101
0.0SerXaa: 0.0 ± 0.0
Thr
2.855ThrAla: 2.855 ± 0.127
0.593ThrCys: 0.593 ± 0.042
3.424ThrAsp: 3.424 ± 0.106
3.459ThrGlu: 3.459 ± 0.114
2.607ThrPhe: 2.607 ± 0.095
3.65ThrGly: 3.65 ± 0.205
0.799ThrHis: 0.799 ± 0.048
5.399ThrIle: 5.399 ± 0.133
4.567ThrLys: 4.567 ± 0.114
5.437ThrLeu: 5.437 ± 0.139
1.171ThrMet: 1.171 ± 0.06
3.632ThrAsn: 3.632 ± 0.119
1.958ThrPro: 1.958 ± 0.075
1.081ThrGln: 1.081 ± 0.057
1.521ThrArg: 1.521 ± 0.065
3.999ThrSer: 3.999 ± 0.184
3.225ThrThr: 3.225 ± 0.127
3.808ThrVal: 3.808 ± 0.134
0.362ThrTrp: 0.362 ± 0.031
2.878ThrTyr: 2.878 ± 0.13
0.0ThrXaa: 0.0 ± 0.0
Val
3.225ValAla: 3.225 ± 0.105
0.716ValCys: 0.716 ± 0.043
3.662ValAsp: 3.662 ± 0.092
3.341ValGlu: 3.341 ± 0.104
2.707ValPhe: 2.707 ± 0.097
3.479ValGly: 3.479 ± 0.097
0.817ValHis: 0.817 ± 0.048
6.088ValIle: 6.088 ± 0.144
5.688ValLys: 5.688 ± 0.136
5.724ValLeu: 5.724 ± 0.135
1.445ValMet: 1.445 ± 0.07
3.921ValAsn: 3.921 ± 0.105
1.936ValPro: 1.936 ± 0.078
1.41ValGln: 1.41 ± 0.067
1.843ValArg: 1.843 ± 0.076
4.409ValSer: 4.409 ± 0.122
4.2ValThr: 4.2 ± 0.137
4.107ValVal: 4.107 ± 0.121
0.44ValTrp: 0.44 ± 0.033
2.737ValTyr: 2.737 ± 0.089
0.0ValXaa: 0.0 ± 0.0
Trp
0.312TrpAla: 0.312 ± 0.03
0.078TrpCys: 0.078 ± 0.015
0.397TrpAsp: 0.397 ± 0.036
0.327TrpGlu: 0.327 ± 0.032
0.297TrpPhe: 0.297 ± 0.027
0.349TrpGly: 0.349 ± 0.032
0.126TrpHis: 0.126 ± 0.019
0.583TrpIle: 0.583 ± 0.043
0.364TrpLys: 0.364 ± 0.027
0.603TrpLeu: 0.603 ± 0.041
0.168TrpMet: 0.168 ± 0.023
0.435TrpAsn: 0.435 ± 0.035
0.133TrpPro: 0.133 ± 0.019
0.254TrpGln: 0.254 ± 0.026
0.191TrpArg: 0.191 ± 0.022
0.377TrpSer: 0.377 ± 0.036
0.342TrpThr: 0.342 ± 0.029
0.319TrpVal: 0.319 ± 0.031
0.088TrpTrp: 0.088 ± 0.015
0.37TrpTyr: 0.37 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.348TyrAla: 2.348 ± 0.092
0.513TyrCys: 0.513 ± 0.035
3.6TyrAsp: 3.6 ± 0.104
3.507TyrGlu: 3.507 ± 0.093
2.277TyrPhe: 2.277 ± 0.077
2.989TyrGly: 2.989 ± 0.085
0.819TyrHis: 0.819 ± 0.043
4.288TyrIle: 4.288 ± 0.111
4.535TyrLys: 4.535 ± 0.115
4.864TyrLeu: 4.864 ± 0.125
1.031TyrMet: 1.031 ± 0.048
3.866TyrAsn: 3.866 ± 0.116
1.345TyrPro: 1.345 ± 0.058
1.438TyrGln: 1.438 ± 0.064
1.619TyrArg: 1.619 ± 0.063
2.979TyrSer: 2.979 ± 0.1
2.72TyrThr: 2.72 ± 0.091
2.833TyrVal: 2.833 ± 0.084
0.279TyrTrp: 0.279 ± 0.028
2.818TyrTyr: 2.818 ± 0.117
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1377 proteins (397830 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski