Amino acid dipepetide frequency for Lake Baikal phage Baikal-20-5m-C28

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.317AlaAla: 5.317 ± 0.461
0.754AlaCys: 0.754 ± 0.142
3.884AlaAsp: 3.884 ± 0.288
4.016AlaGlu: 4.016 ± 0.321
2.734AlaPhe: 2.734 ± 0.219
4.544AlaGly: 4.544 ± 0.391
1.301AlaHis: 1.301 ± 0.195
4.902AlaIle: 4.902 ± 0.325
4.544AlaLys: 4.544 ± 0.354
5.6AlaLeu: 5.6 ± 0.435
1.659AlaMet: 1.659 ± 0.167
3.639AlaAsn: 3.639 ± 0.241
2.677AlaPro: 2.677 ± 0.224
2.489AlaGln: 2.489 ± 0.225
2.413AlaArg: 2.413 ± 0.228
4.978AlaSer: 4.978 ± 0.385
4.827AlaThr: 4.827 ± 0.407
4.167AlaVal: 4.167 ± 0.359
0.943AlaTrp: 0.943 ± 0.148
2.564AlaTyr: 2.564 ± 0.258
0.0AlaXaa: 0.0 ± 0.0
Cys
0.848CysAla: 0.848 ± 0.16
0.434CysCys: 0.434 ± 0.172
0.735CysAsp: 0.735 ± 0.12
0.679CysGlu: 0.679 ± 0.138
0.339CysPhe: 0.339 ± 0.073
0.886CysGly: 0.886 ± 0.174
0.226CysHis: 0.226 ± 0.074
0.566CysIle: 0.566 ± 0.109
0.566CysLys: 0.566 ± 0.106
0.754CysLeu: 0.754 ± 0.13
0.207CysMet: 0.207 ± 0.065
0.754CysAsn: 0.754 ± 0.132
0.566CysPro: 0.566 ± 0.113
0.207CysGln: 0.207 ± 0.07
0.321CysArg: 0.321 ± 0.083
0.999CysSer: 0.999 ± 0.176
0.566CysThr: 0.566 ± 0.129
0.698CysVal: 0.698 ± 0.118
0.151CysTrp: 0.151 ± 0.054
0.358CysTyr: 0.358 ± 0.079
0.0CysXaa: 0.0 ± 0.0
Asp
4.28AspAla: 4.28 ± 0.321
0.66AspCys: 0.66 ± 0.122
3.752AspAsp: 3.752 ± 0.301
3.978AspGlu: 3.978 ± 0.307
3.092AspPhe: 3.092 ± 0.261
4.525AspGly: 4.525 ± 0.28
1.282AspHis: 1.282 ± 0.18
4.638AspIle: 4.638 ± 0.332
4.035AspLys: 4.035 ± 0.361
5.091AspLeu: 5.091 ± 0.28
1.32AspMet: 1.32 ± 0.136
2.998AspAsn: 2.998 ± 0.238
2.244AspPro: 2.244 ± 0.215
1.81AspGln: 1.81 ± 0.184
2.376AspArg: 2.376 ± 0.188
3.752AspSer: 3.752 ± 0.268
4.242AspThr: 4.242 ± 0.261
4.299AspVal: 4.299 ± 0.289
1.169AspTrp: 1.169 ± 0.143
2.922AspTyr: 2.922 ± 0.26
0.0AspXaa: 0.0 ± 0.0
Glu
3.394GluAla: 3.394 ± 0.305
0.773GluCys: 0.773 ± 0.137
3.318GluAsp: 3.318 ± 0.35
4.412GluGlu: 4.412 ± 0.461
3.281GluPhe: 3.281 ± 0.323
3.149GluGly: 3.149 ± 0.271
1.622GluHis: 1.622 ± 0.184
4.921GluIle: 4.921 ± 0.326
4.714GluLys: 4.714 ± 0.381
5.298GluLeu: 5.298 ± 0.352
1.584GluMet: 1.584 ± 0.17
3.149GluAsn: 3.149 ± 0.265
1.716GluPro: 1.716 ± 0.195
2.263GluGln: 2.263 ± 0.285
2.545GluArg: 2.545 ± 0.192
3.658GluSer: 3.658 ± 0.276
3.79GluThr: 3.79 ± 0.246
3.526GluVal: 3.526 ± 0.282
0.811GluTrp: 0.811 ± 0.117
2.828GluTyr: 2.828 ± 0.251
0.0GluXaa: 0.0 ± 0.0
Phe
2.64PheAla: 2.64 ± 0.209
0.528PheCys: 0.528 ± 0.101
2.941PheAsp: 2.941 ± 0.229
2.357PheGlu: 2.357 ± 0.253
1.829PhePhe: 1.829 ± 0.22
2.866PheGly: 2.866 ± 0.28
0.528PheHis: 0.528 ± 0.113
3.281PheIle: 3.281 ± 0.285
3.526PheLys: 3.526 ± 0.297
2.96PheLeu: 2.96 ± 0.284
1.112PheMet: 1.112 ± 0.136
2.677PheAsn: 2.677 ± 0.233
1.64PhePro: 1.64 ± 0.16
1.433PheGln: 1.433 ± 0.167
1.678PheArg: 1.678 ± 0.148
2.715PheSer: 2.715 ± 0.228
2.866PheThr: 2.866 ± 0.248
2.602PheVal: 2.602 ± 0.246
0.566PheTrp: 0.566 ± 0.109
1.584PheTyr: 1.584 ± 0.185
0.0PheXaa: 0.0 ± 0.0
Gly
4.638GlyAla: 4.638 ± 0.362
0.754GlyCys: 0.754 ± 0.139
4.45GlyAsp: 4.45 ± 0.372
3.281GlyGlu: 3.281 ± 0.287
2.432GlyPhe: 2.432 ± 0.216
5.845GlyGly: 5.845 ± 0.675
1.49GlyHis: 1.49 ± 0.198
5.147GlyIle: 5.147 ± 0.372
4.167GlyLys: 4.167 ± 0.312
5.034GlyLeu: 5.034 ± 0.413
1.64GlyMet: 1.64 ± 0.178
4.242GlyAsn: 4.242 ± 0.379
1.49GlyPro: 1.49 ± 0.168
1.81GlyGln: 1.81 ± 0.246
2.017GlyArg: 2.017 ± 0.199
5.128GlySer: 5.128 ± 0.461
5.713GlyThr: 5.713 ± 0.617
3.752GlyVal: 3.752 ± 0.316
0.867GlyTrp: 0.867 ± 0.134
2.338GlyTyr: 2.338 ± 0.214
0.0GlyXaa: 0.0 ± 0.0
His
1.32HisAla: 1.32 ± 0.18
0.358HisCys: 0.358 ± 0.106
1.395HisAsp: 1.395 ± 0.178
1.226HisGlu: 1.226 ± 0.174
0.848HisPhe: 0.848 ± 0.126
1.301HisGly: 1.301 ± 0.185
0.83HisHis: 0.83 ± 0.191
1.282HisIle: 1.282 ± 0.163
1.622HisLys: 1.622 ± 0.22
1.508HisLeu: 1.508 ± 0.184
0.679HisMet: 0.679 ± 0.128
0.905HisAsn: 0.905 ± 0.159
0.924HisPro: 0.924 ± 0.135
0.773HisGln: 0.773 ± 0.106
0.792HisArg: 0.792 ± 0.102
1.226HisSer: 1.226 ± 0.169
1.094HisThr: 1.094 ± 0.146
1.169HisVal: 1.169 ± 0.163
0.49HisTrp: 0.49 ± 0.101
0.962HisTyr: 0.962 ± 0.144
0.0HisXaa: 0.0 ± 0.0
Ile
5.6IleAla: 5.6 ± 0.35
0.641IleCys: 0.641 ± 0.104
5.656IleAsp: 5.656 ± 0.361
4.827IleGlu: 4.827 ± 0.312
2.432IlePhe: 2.432 ± 0.24
4.148IleGly: 4.148 ± 0.273
1.565IleHis: 1.565 ± 0.202
5.317IleIle: 5.317 ± 0.437
5.77IleLys: 5.77 ± 0.36
5.242IleLeu: 5.242 ± 0.357
1.395IleMet: 1.395 ± 0.205
5.034IleAsn: 5.034 ± 0.268
2.866IlePro: 2.866 ± 0.223
2.545IleGln: 2.545 ± 0.245
2.659IleArg: 2.659 ± 0.236
5.581IleSer: 5.581 ± 0.357
5.864IleThr: 5.864 ± 0.458
4.205IleVal: 4.205 ± 0.349
0.754IleTrp: 0.754 ± 0.127
2.338IleTyr: 2.338 ± 0.203
0.0IleXaa: 0.0 ± 0.0
Lys
5.053LysAla: 5.053 ± 0.413
0.622LysCys: 0.622 ± 0.117
4.883LysAsp: 4.883 ± 0.356
4.751LysGlu: 4.751 ± 0.409
3.205LysPhe: 3.205 ± 0.305
3.601LysGly: 3.601 ± 0.312
1.49LysHis: 1.49 ± 0.213
5.619LysIle: 5.619 ± 0.367
5.147LysLys: 5.147 ± 0.521
5.826LysLeu: 5.826 ± 0.386
1.999LysMet: 1.999 ± 0.207
3.884LysAsn: 3.884 ± 0.322
2.545LysPro: 2.545 ± 0.247
2.564LysGln: 2.564 ± 0.214
2.545LysArg: 2.545 ± 0.252
3.809LysSer: 3.809 ± 0.289
5.091LysThr: 5.091 ± 0.338
3.809LysVal: 3.809 ± 0.322
0.792LysTrp: 0.792 ± 0.114
3.601LysTyr: 3.601 ± 0.283
0.0LysXaa: 0.0 ± 0.0
Leu
5.223LeuAla: 5.223 ± 0.332
0.886LeuCys: 0.886 ± 0.139
5.638LeuAsp: 5.638 ± 0.317
4.751LeuGlu: 4.751 ± 0.288
2.847LeuPhe: 2.847 ± 0.244
4.073LeuGly: 4.073 ± 0.269
1.772LeuHis: 1.772 ± 0.191
5.506LeuIle: 5.506 ± 0.34
6.203LeuLys: 6.203 ± 0.429
5.336LeuLeu: 5.336 ± 0.311
1.829LeuMet: 1.829 ± 0.188
5.091LeuAsn: 5.091 ± 0.344
2.677LeuPro: 2.677 ± 0.207
3.205LeuGln: 3.205 ± 0.264
3.017LeuArg: 3.017 ± 0.223
5.223LeuSer: 5.223 ± 0.345
5.166LeuThr: 5.166 ± 0.389
4.789LeuVal: 4.789 ± 0.317
0.641LeuTrp: 0.641 ± 0.127
2.847LeuTyr: 2.847 ± 0.242
0.0LeuXaa: 0.0 ± 0.0
Met
2.338MetAla: 2.338 ± 0.208
0.207MetCys: 0.207 ± 0.068
1.376MetAsp: 1.376 ± 0.176
1.301MetGlu: 1.301 ± 0.168
1.131MetPhe: 1.131 ± 0.149
1.376MetGly: 1.376 ± 0.148
0.509MetHis: 0.509 ± 0.104
1.829MetIle: 1.829 ± 0.187
2.093MetLys: 2.093 ± 0.174
1.885MetLeu: 1.885 ± 0.194
0.867MetMet: 0.867 ± 0.142
1.829MetAsn: 1.829 ± 0.174
0.98MetPro: 0.98 ± 0.161
1.112MetGln: 1.112 ± 0.153
0.98MetArg: 0.98 ± 0.115
1.81MetSer: 1.81 ± 0.165
1.678MetThr: 1.678 ± 0.177
1.226MetVal: 1.226 ± 0.143
0.245MetTrp: 0.245 ± 0.08
0.98MetTyr: 0.98 ± 0.166
0.0MetXaa: 0.0 ± 0.0
Asn
3.149AsnAla: 3.149 ± 0.259
0.528AsnCys: 0.528 ± 0.123
3.62AsnAsp: 3.62 ± 0.279
3.846AsnGlu: 3.846 ± 0.298
2.319AsnPhe: 2.319 ± 0.215
4.073AsnGly: 4.073 ± 0.326
1.037AsnHis: 1.037 ± 0.139
4.186AsnIle: 4.186 ± 0.325
3.997AsnLys: 3.997 ± 0.277
5.298AsnLeu: 5.298 ± 0.319
1.358AsnMet: 1.358 ± 0.155
3.564AsnAsn: 3.564 ± 0.306
2.772AsnPro: 2.772 ± 0.247
1.848AsnGln: 1.848 ± 0.187
2.036AsnArg: 2.036 ± 0.174
4.261AsnSer: 4.261 ± 0.343
4.223AsnThr: 4.223 ± 0.318
4.11AsnVal: 4.11 ± 0.283
0.716AsnTrp: 0.716 ± 0.12
2.281AsnTyr: 2.281 ± 0.199
0.0AsnXaa: 0.0 ± 0.0
Pro
2.621ProAla: 2.621 ± 0.228
0.207ProCys: 0.207 ± 0.057
1.848ProAsp: 1.848 ± 0.177
2.791ProGlu: 2.791 ± 0.248
1.829ProPhe: 1.829 ± 0.201
2.244ProGly: 2.244 ± 0.235
0.754ProHis: 0.754 ± 0.126
2.677ProIle: 2.677 ± 0.229
2.281ProLys: 2.281 ± 0.23
2.64ProLeu: 2.64 ± 0.227
0.792ProMet: 0.792 ± 0.12
2.338ProAsn: 2.338 ± 0.199
1.075ProPro: 1.075 ± 0.152
1.226ProGln: 1.226 ± 0.154
1.244ProArg: 1.244 ± 0.178
2.847ProSer: 2.847 ± 0.233
2.866ProThr: 2.866 ± 0.288
1.923ProVal: 1.923 ± 0.225
0.509ProTrp: 0.509 ± 0.091
1.301ProTyr: 1.301 ± 0.151
0.0ProXaa: 0.0 ± 0.0
Gln
2.168GlnAla: 2.168 ± 0.185
0.321GlnCys: 0.321 ± 0.074
2.017GlnAsp: 2.017 ± 0.196
2.281GlnGlu: 2.281 ± 0.227
1.546GlnPhe: 1.546 ± 0.142
2.263GlnGly: 2.263 ± 0.219
0.716GlnHis: 0.716 ± 0.125
2.376GlnIle: 2.376 ± 0.211
2.3GlnLys: 2.3 ± 0.258
2.677GlnLeu: 2.677 ± 0.264
0.98GlnMet: 0.98 ± 0.121
1.716GlnAsn: 1.716 ± 0.201
1.112GlnPro: 1.112 ± 0.148
1.678GlnGln: 1.678 ± 0.185
1.716GlnArg: 1.716 ± 0.196
2.149GlnSer: 2.149 ± 0.237
2.432GlnThr: 2.432 ± 0.25
2.338GlnVal: 2.338 ± 0.217
0.471GlnTrp: 0.471 ± 0.104
1.678GlnTyr: 1.678 ± 0.225
0.0GlnXaa: 0.0 ± 0.0
Arg
2.432ArgAla: 2.432 ± 0.218
0.339ArgCys: 0.339 ± 0.079
2.244ArgAsp: 2.244 ± 0.209
2.413ArgGlu: 2.413 ± 0.222
1.471ArgPhe: 1.471 ± 0.179
2.357ArgGly: 2.357 ± 0.199
0.698ArgHis: 0.698 ± 0.116
3.073ArgIle: 3.073 ± 0.248
2.395ArgLys: 2.395 ± 0.283
2.828ArgLeu: 2.828 ± 0.31
1.508ArgMet: 1.508 ± 0.179
1.98ArgAsn: 1.98 ± 0.176
1.075ArgPro: 1.075 ± 0.139
1.64ArgGln: 1.64 ± 0.187
1.64ArgArg: 1.64 ± 0.197
2.206ArgSer: 2.206 ± 0.231
1.603ArgThr: 1.603 ± 0.171
2.715ArgVal: 2.715 ± 0.245
0.509ArgTrp: 0.509 ± 0.102
1.848ArgTyr: 1.848 ± 0.192
0.0ArgXaa: 0.0 ± 0.0
Ser
4.393SerAla: 4.393 ± 0.335
0.811SerCys: 0.811 ± 0.126
3.658SerAsp: 3.658 ± 0.246
3.318SerGlu: 3.318 ± 0.279
3.281SerPhe: 3.281 ± 0.26
6.147SerGly: 6.147 ± 0.57
1.282SerHis: 1.282 ± 0.155
5.034SerIle: 5.034 ± 0.316
4.167SerLys: 4.167 ± 0.289
4.676SerLeu: 4.676 ± 0.364
1.697SerMet: 1.697 ± 0.198
3.564SerAsn: 3.564 ± 0.328
2.847SerPro: 2.847 ± 0.245
2.093SerGln: 2.093 ± 0.18
2.338SerArg: 2.338 ± 0.218
4.582SerSer: 4.582 ± 0.323
5.26SerThr: 5.26 ± 0.386
4.544SerVal: 4.544 ± 0.316
0.999SerTrp: 0.999 ± 0.148
2.847SerTyr: 2.847 ± 0.255
0.0SerXaa: 0.0 ± 0.0
Thr
5.166ThrAla: 5.166 ± 0.488
0.811ThrCys: 0.811 ± 0.126
3.733ThrAsp: 3.733 ± 0.325
3.526ThrGlu: 3.526 ± 0.266
2.772ThrPhe: 2.772 ± 0.247
6.222ThrGly: 6.222 ± 0.647
1.376ThrHis: 1.376 ± 0.167
5.204ThrIle: 5.204 ± 0.399
4.525ThrLys: 4.525 ± 0.329
5.656ThrLeu: 5.656 ± 0.382
1.942ThrMet: 1.942 ± 0.239
4.261ThrAsn: 4.261 ± 0.331
2.659ThrPro: 2.659 ± 0.223
2.3ThrGln: 2.3 ± 0.231
2.225ThrArg: 2.225 ± 0.191
4.808ThrSer: 4.808 ± 0.505
4.997ThrThr: 4.997 ± 0.602
4.374ThrVal: 4.374 ± 0.345
0.83ThrTrp: 0.83 ± 0.12
3.036ThrTyr: 3.036 ± 0.259
0.0ThrXaa: 0.0 ± 0.0
Val
4.129ValAla: 4.129 ± 0.293
0.566ValCys: 0.566 ± 0.108
3.526ValAsp: 3.526 ± 0.245
4.035ValGlu: 4.035 ± 0.282
2.281ValPhe: 2.281 ± 0.215
3.601ValGly: 3.601 ± 0.304
0.962ValHis: 0.962 ± 0.167
4.487ValIle: 4.487 ± 0.31
4.695ValLys: 4.695 ± 0.285
4.695ValLeu: 4.695 ± 0.252
1.659ValMet: 1.659 ± 0.202
3.752ValAsn: 3.752 ± 0.321
2.206ValPro: 2.206 ± 0.223
2.225ValGln: 2.225 ± 0.187
2.319ValArg: 2.319 ± 0.231
4.318ValSer: 4.318 ± 0.307
4.619ValThr: 4.619 ± 0.4
3.677ValVal: 3.677 ± 0.292
0.641ValTrp: 0.641 ± 0.109
2.885ValTyr: 2.885 ± 0.223
0.0ValXaa: 0.0 ± 0.0
Trp
0.773TrpAla: 0.773 ± 0.124
0.189TrpCys: 0.189 ± 0.06
0.735TrpAsp: 0.735 ± 0.123
0.471TrpGlu: 0.471 ± 0.1
0.641TrpPhe: 0.641 ± 0.116
0.886TrpGly: 0.886 ± 0.121
0.434TrpHis: 0.434 ± 0.098
1.056TrpIle: 1.056 ± 0.135
1.226TrpLys: 1.226 ± 0.151
0.716TrpLeu: 0.716 ± 0.133
0.396TrpMet: 0.396 ± 0.089
0.924TrpAsn: 0.924 ± 0.144
0.396TrpPro: 0.396 ± 0.088
0.339TrpGln: 0.339 ± 0.093
0.415TrpArg: 0.415 ± 0.096
0.735TrpSer: 0.735 ± 0.11
0.792TrpThr: 0.792 ± 0.137
0.792TrpVal: 0.792 ± 0.14
0.132TrpTrp: 0.132 ± 0.044
0.716TrpTyr: 0.716 ± 0.13
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.47TyrAla: 2.47 ± 0.261
0.471TyrCys: 0.471 ± 0.099
3.054TyrAsp: 3.054 ± 0.232
2.489TyrGlu: 2.489 ± 0.234
2.017TyrPhe: 2.017 ± 0.214
2.131TyrGly: 2.131 ± 0.227
0.83TyrHis: 0.83 ± 0.127
3.337TyrIle: 3.337 ± 0.248
2.866TyrLys: 2.866 ± 0.274
2.998TyrLeu: 2.998 ± 0.243
1.112TyrMet: 1.112 ± 0.142
2.922TyrAsn: 2.922 ± 0.253
1.546TyrPro: 1.546 ± 0.188
1.376TyrGln: 1.376 ± 0.183
1.697TyrArg: 1.697 ± 0.175
2.772TyrSer: 2.772 ± 0.201
2.734TyrThr: 2.734 ± 0.24
2.564TyrVal: 2.564 ± 0.224
0.528TyrTrp: 0.528 ± 0.097
1.885TyrTyr: 1.885 ± 0.216
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 234 proteins (53038 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski