Amino acid dipepetide frequency for Chlamydia phage 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.129AlaAla: 2.129 ± 1.894
0.0AlaCys: 0.0 ± 0.0
2.839AlaAsp: 2.839 ± 0.852
4.258AlaGlu: 4.258 ± 1.354
5.678AlaPhe: 5.678 ± 1.959
4.258AlaGly: 4.258 ± 2.016
0.71AlaHis: 0.71 ± 0.975
2.839AlaIle: 2.839 ± 1.786
4.968AlaLys: 4.968 ± 2.836
4.258AlaLeu: 4.258 ± 1.848
2.129AlaMet: 2.129 ± 1.727
1.419AlaAsn: 1.419 ± 1.418
2.129AlaPro: 2.129 ± 0.972
4.968AlaGln: 4.968 ± 1.883
6.388AlaArg: 6.388 ± 1.697
4.968AlaSer: 4.968 ± 2.482
5.678AlaThr: 5.678 ± 1.836
4.258AlaVal: 4.258 ± 1.951
0.0AlaTrp: 0.0 ± 0.0
4.258AlaTyr: 4.258 ± 1.562
0.0AlaXaa: 0.0 ± 0.0
Cys
1.419CysAla: 1.419 ± 1.089
0.0CysCys: 0.0 ± 0.0
1.419CysAsp: 1.419 ± 0.753
0.71CysGlu: 0.71 ± 1.164
1.419CysPhe: 1.419 ± 1.348
2.129CysGly: 2.129 ± 0.828
0.71CysHis: 0.71 ± 1.164
0.71CysIle: 0.71 ± 0.674
0.71CysLys: 0.71 ± 0.674
0.71CysLeu: 0.71 ± 0.441
2.129CysMet: 2.129 ± 1.337
0.71CysAsn: 0.71 ± 0.674
0.0CysPro: 0.0 ± 0.0
0.71CysGln: 0.71 ± 0.441
1.419CysArg: 1.419 ± 1.348
0.71CysSer: 0.71 ± 0.674
0.71CysThr: 0.71 ± 1.164
0.71CysVal: 0.71 ± 0.441
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.839AspAla: 2.839 ± 1.764
0.71AspCys: 0.71 ± 0.76
2.129AspAsp: 2.129 ± 1.171
4.258AspGlu: 4.258 ± 1.45
4.258AspPhe: 4.258 ± 1.143
1.419AspGly: 1.419 ± 0.753
1.419AspHis: 1.419 ± 0.613
2.839AspIle: 2.839 ± 1.659
4.968AspLys: 4.968 ± 3.212
2.129AspLeu: 2.129 ± 1.056
1.419AspMet: 1.419 ± 1.239
0.71AspAsn: 0.71 ± 0.441
5.678AspPro: 5.678 ± 2.192
2.129AspGln: 2.129 ± 1.213
2.839AspArg: 2.839 ± 1.176
4.968AspSer: 4.968 ± 2.097
2.129AspThr: 2.129 ± 1.323
1.419AspVal: 1.419 ± 1.047
1.419AspTrp: 1.419 ± 0.613
3.549AspTyr: 3.549 ± 1.194
0.0AspXaa: 0.0 ± 0.0
Glu
6.388GluAla: 6.388 ± 3.64
0.71GluCys: 0.71 ± 0.76
3.549GluAsp: 3.549 ± 2.057
4.968GluGlu: 4.968 ± 2.693
2.129GluPhe: 2.129 ± 0.828
1.419GluGly: 1.419 ± 0.782
2.839GluHis: 2.839 ± 1.217
2.839GluIle: 2.839 ± 1.94
3.549GluLys: 3.549 ± 2.708
2.129GluLeu: 2.129 ± 1.32
1.419GluMet: 1.419 ± 0.864
4.258GluAsn: 4.258 ± 0.818
2.129GluPro: 2.129 ± 0.972
5.678GluGln: 5.678 ± 1.877
4.968GluArg: 4.968 ± 2.459
1.419GluSer: 1.419 ± 1.263
0.0GluThr: 0.0 ± 0.0
3.549GluVal: 3.549 ± 1.388
0.0GluTrp: 0.0 ± 0.0
3.549GluTyr: 3.549 ± 1.19
0.0GluXaa: 0.0 ± 0.0
Phe
2.839PheAla: 2.839 ± 1.444
2.129PheCys: 2.129 ± 0.828
3.549PheAsp: 3.549 ± 1.009
2.129PheGlu: 2.129 ± 0.788
2.129PhePhe: 2.129 ± 1.171
2.129PheGly: 2.129 ± 0.788
0.0PheHis: 0.0 ± 0.0
2.129PheIle: 2.129 ± 0.901
2.129PheLys: 2.129 ± 1.433
5.678PheLeu: 5.678 ± 1.294
1.419PheMet: 1.419 ± 1.348
1.419PheAsn: 1.419 ± 0.613
2.129PhePro: 2.129 ± 1.21
2.129PheGln: 2.129 ± 0.976
2.839PheArg: 2.839 ± 2.155
5.678PheSer: 5.678 ± 2.036
4.258PheThr: 4.258 ± 1.143
2.839PheVal: 2.839 ± 1.258
1.419PheTrp: 1.419 ± 1.089
0.71PheTyr: 0.71 ± 0.441
0.0PheXaa: 0.0 ± 0.0
Gly
4.258GlyAla: 4.258 ± 2.421
0.71GlyCys: 0.71 ± 0.674
2.129GlyAsp: 2.129 ± 1.323
3.549GlyGlu: 3.549 ± 1.388
2.129GlyPhe: 2.129 ± 0.788
4.968GlyGly: 4.968 ± 2.062
0.0GlyHis: 0.0 ± 0.0
3.549GlyIle: 3.549 ± 0.952
2.129GlyLys: 2.129 ± 0.828
8.517GlyLeu: 8.517 ± 3.176
0.0GlyMet: 0.0 ± 0.0
2.839GlyAsn: 2.839 ± 0.852
2.129GlyPro: 2.129 ± 1.323
1.419GlyGln: 1.419 ± 0.613
0.71GlyArg: 0.71 ± 0.812
7.097GlySer: 7.097 ± 1.456
4.258GlyThr: 4.258 ± 2.099
4.968GlyVal: 4.968 ± 2.261
0.71GlyTrp: 0.71 ± 0.441
3.549GlyTyr: 3.549 ± 1.272
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.71HisCys: 0.71 ± 1.164
0.71HisAsp: 0.71 ± 0.441
0.71HisGlu: 0.71 ± 0.674
1.419HisPhe: 1.419 ± 0.882
0.71HisGly: 0.71 ± 0.441
0.0HisHis: 0.0 ± 0.0
0.71HisIle: 0.71 ± 0.674
1.419HisLys: 1.419 ± 1.047
2.839HisLeu: 2.839 ± 1.225
0.0HisMet: 0.0 ± 0.0
0.71HisAsn: 0.71 ± 0.76
1.419HisPro: 1.419 ± 1.047
0.0HisGln: 0.0 ± 0.0
1.419HisArg: 1.419 ± 0.916
2.129HisSer: 2.129 ± 1.075
0.0HisThr: 0.0 ± 0.0
0.71HisVal: 0.71 ± 0.76
0.0HisTrp: 0.0 ± 0.0
1.419HisTyr: 1.419 ± 1.348
0.0HisXaa: 0.0 ± 0.0
Ile
2.129IleAla: 2.129 ± 2.225
0.0IleCys: 0.0 ± 0.0
1.419IleAsp: 1.419 ± 0.613
2.129IleGlu: 2.129 ± 0.972
2.129IlePhe: 2.129 ± 0.828
2.839IleGly: 2.839 ± 0.958
0.71IleHis: 0.71 ± 0.441
1.419IleIle: 1.419 ± 1.089
1.419IleLys: 1.419 ± 0.97
4.258IleLeu: 4.258 ± 1.438
0.71IleMet: 0.71 ± 0.914
1.419IleAsn: 1.419 ± 0.753
2.129IlePro: 2.129 ± 1.149
2.129IleGln: 2.129 ± 1.323
6.388IleArg: 6.388 ± 3.129
4.258IleSer: 4.258 ± 1.796
1.419IleThr: 1.419 ± 0.882
1.419IleVal: 1.419 ± 0.753
1.419IleTrp: 1.419 ± 0.613
2.839IleTyr: 2.839 ± 1.481
0.0IleXaa: 0.0 ± 0.0
Lys
4.258LysAla: 4.258 ± 2.266
0.71LysCys: 0.71 ± 1.164
2.129LysAsp: 2.129 ± 1.447
1.419LysGlu: 1.419 ± 0.882
2.839LysPhe: 2.839 ± 0.852
3.549LysGly: 3.549 ± 1.466
0.71LysHis: 0.71 ± 0.975
3.549LysIle: 3.549 ± 1.19
4.968LysLys: 4.968 ± 1.781
5.678LysLeu: 5.678 ± 2.188
2.129LysMet: 2.129 ± 1.601
1.419LysAsn: 1.419 ± 1.239
2.129LysPro: 2.129 ± 1.21
3.549LysGln: 3.549 ± 1.78
5.678LysArg: 5.678 ± 3.0
4.968LysSer: 4.968 ± 2.203
2.839LysThr: 2.839 ± 1.191
3.549LysVal: 3.549 ± 1.811
0.0LysTrp: 0.0 ± 0.0
1.419LysTyr: 1.419 ± 0.864
0.0LysXaa: 0.0 ± 0.0
Leu
7.097LeuAla: 7.097 ± 2.728
0.0LeuCys: 0.0 ± 0.0
6.388LeuAsp: 6.388 ± 2.416
0.71LeuGlu: 0.71 ± 0.76
3.549LeuPhe: 3.549 ± 2.056
7.807LeuGly: 7.807 ± 2.668
0.71LeuHis: 0.71 ± 0.674
4.258LeuIle: 4.258 ± 1.354
3.549LeuLys: 3.549 ± 1.388
4.258LeuLeu: 4.258 ± 1.229
3.549LeuMet: 3.549 ± 1.889
4.258LeuAsn: 4.258 ± 1.223
7.097LeuPro: 7.097 ± 1.501
3.549LeuGln: 3.549 ± 1.129
7.807LeuArg: 7.807 ± 2.448
6.388LeuSer: 6.388 ± 1.225
4.968LeuThr: 4.968 ± 1.176
1.419LeuVal: 1.419 ± 1.348
2.129LeuTrp: 2.129 ± 1.21
2.129LeuTyr: 2.129 ± 0.901
0.0LeuXaa: 0.0 ± 0.0
Met
2.839MetAla: 2.839 ± 1.014
0.71MetCys: 0.71 ± 0.674
3.549MetAsp: 3.549 ± 1.386
1.419MetGlu: 1.419 ± 1.058
0.71MetPhe: 0.71 ± 0.76
0.71MetGly: 0.71 ± 0.441
1.419MetHis: 1.419 ± 1.088
0.0MetIle: 0.0 ± 0.0
2.129MetLys: 2.129 ± 1.433
2.839MetLeu: 2.839 ± 2.252
0.0MetMet: 0.0 ± 0.0
1.419MetAsn: 1.419 ± 1.624
1.419MetPro: 1.419 ± 0.613
2.129MetGln: 2.129 ± 1.146
1.419MetArg: 1.419 ± 1.248
2.129MetSer: 2.129 ± 1.392
0.71MetThr: 0.71 ± 0.674
1.419MetVal: 1.419 ± 0.97
1.419MetTrp: 1.419 ± 1.089
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.258AsnAla: 4.258 ± 1.427
1.419AsnCys: 1.419 ± 1.263
1.419AsnAsp: 1.419 ± 0.951
0.71AsnGlu: 0.71 ± 0.975
0.71AsnPhe: 0.71 ± 0.441
2.129AsnGly: 2.129 ± 0.828
0.71AsnHis: 0.71 ± 0.674
2.129AsnIle: 2.129 ± 0.972
2.129AsnLys: 2.129 ± 0.972
4.258AsnLeu: 4.258 ± 1.951
0.0AsnMet: 0.0 ± 0.0
2.129AsnAsn: 2.129 ± 0.931
4.968AsnPro: 4.968 ± 2.009
3.549AsnGln: 3.549 ± 0.987
2.129AsnArg: 2.129 ± 1.149
2.839AsnSer: 2.839 ± 1.294
2.129AsnThr: 2.129 ± 1.532
2.839AsnVal: 2.839 ± 1.506
0.0AsnTrp: 0.0 ± 0.0
2.839AsnTyr: 2.839 ± 0.852
0.0AsnXaa: 0.0 ± 0.0
Pro
4.968ProAla: 4.968 ± 1.935
1.419ProCys: 1.419 ± 1.348
2.129ProAsp: 2.129 ± 0.828
6.388ProGlu: 6.388 ± 2.751
1.419ProPhe: 1.419 ± 1.047
4.968ProGly: 4.968 ± 1.144
1.419ProHis: 1.419 ± 1.348
3.549ProIle: 3.549 ± 2.204
2.129ProLys: 2.129 ± 1.267
2.839ProLeu: 2.839 ± 0.958
2.839ProMet: 2.839 ± 1.001
1.419ProAsn: 1.419 ± 0.782
1.419ProPro: 1.419 ± 0.613
4.258ProGln: 4.258 ± 1.45
2.129ProArg: 2.129 ± 0.788
1.419ProSer: 1.419 ± 0.882
4.258ProThr: 4.258 ± 1.515
4.258ProVal: 4.258 ± 1.951
2.129ProTrp: 2.129 ± 1.075
0.71ProTyr: 0.71 ± 0.674
0.0ProXaa: 0.0 ± 0.0
Gln
3.549GlnAla: 3.549 ± 1.684
0.71GlnCys: 0.71 ± 0.441
4.258GlnAsp: 4.258 ± 2.42
3.549GlnGlu: 3.549 ± 1.486
1.419GlnPhe: 1.419 ± 1.26
3.549GlnGly: 3.549 ± 1.673
1.419GlnHis: 1.419 ± 0.951
0.71GlnIle: 0.71 ± 0.812
4.968GlnLys: 4.968 ± 1.242
2.839GlnLeu: 2.839 ± 1.071
2.839GlnMet: 2.839 ± 1.742
5.678GlnAsn: 5.678 ± 1.829
1.419GlnPro: 1.419 ± 1.047
2.129GlnGln: 2.129 ± 1.171
4.258GlnArg: 4.258 ± 1.304
1.419GlnSer: 1.419 ± 0.613
2.839GlnThr: 2.839 ± 0.852
2.129GlnVal: 2.129 ± 1.056
0.71GlnTrp: 0.71 ± 0.441
2.129GlnTyr: 2.129 ± 0.828
0.0GlnXaa: 0.0 ± 0.0
Arg
4.258ArgAla: 4.258 ± 1.69
2.129ArgCys: 2.129 ± 1.21
5.678ArgAsp: 5.678 ± 1.496
5.678ArgGlu: 5.678 ± 2.272
3.549ArgPhe: 3.549 ± 1.634
2.839ArgGly: 2.839 ± 1.017
0.0ArgHis: 0.0 ± 0.0
3.549ArgIle: 3.549 ± 3.702
2.839ArgLys: 2.839 ± 2.112
9.226ArgLeu: 9.226 ± 2.855
3.549ArgMet: 3.549 ± 1.681
2.839ArgAsn: 2.839 ± 1.014
2.129ArgPro: 2.129 ± 1.21
0.71ArgGln: 0.71 ± 0.674
8.517ArgArg: 8.517 ± 5.428
5.678ArgSer: 5.678 ± 2.009
2.839ArgThr: 2.839 ± 1.511
3.549ArgVal: 3.549 ± 0.97
1.419ArgTrp: 1.419 ± 0.613
5.678ArgTyr: 5.678 ± 1.724
0.0ArgXaa: 0.0 ± 0.0
Ser
4.258SerAla: 4.258 ± 1.195
2.129SerCys: 2.129 ± 1.186
2.129SerAsp: 2.129 ± 1.48
2.129SerGlu: 2.129 ± 1.584
5.678SerPhe: 5.678 ± 3.086
3.549SerGly: 3.549 ± 3.265
2.129SerHis: 2.129 ± 1.323
1.419SerIle: 1.419 ± 0.929
4.968SerLys: 4.968 ± 1.631
7.807SerLeu: 7.807 ± 2.009
0.0SerMet: 0.0 ± 0.0
2.129SerAsn: 2.129 ± 0.976
7.807SerPro: 7.807 ± 1.069
2.129SerGln: 2.129 ± 2.021
7.097SerArg: 7.097 ± 3.945
7.097SerSer: 7.097 ± 2.564
5.678SerThr: 5.678 ± 2.286
4.968SerVal: 4.968 ± 1.837
2.129SerTrp: 2.129 ± 1.303
2.839SerTyr: 2.839 ± 1.262
0.0SerXaa: 0.0 ± 0.0
Thr
4.968ThrAla: 4.968 ± 2.002
0.71ThrCys: 0.71 ± 0.674
2.129ThrAsp: 2.129 ± 1.323
2.839ThrGlu: 2.839 ± 1.191
2.839ThrPhe: 2.839 ± 1.243
4.968ThrGly: 4.968 ± 2.933
0.0ThrHis: 0.0 ± 0.0
1.419ThrIle: 1.419 ± 0.882
3.549ThrLys: 3.549 ± 1.391
2.839ThrLeu: 2.839 ± 1.071
0.0ThrMet: 0.0 ± 0.0
1.419ThrAsn: 1.419 ± 0.782
2.839ThrPro: 2.839 ± 1.764
3.549ThrGln: 3.549 ± 1.386
2.839ThrArg: 2.839 ± 1.225
5.678ThrSer: 5.678 ± 2.331
2.839ThrThr: 2.839 ± 1.05
1.419ThrVal: 1.419 ± 1.047
0.0ThrTrp: 0.0 ± 0.0
2.839ThrTyr: 2.839 ± 1.14
0.0ThrXaa: 0.0 ± 0.0
Val
5.678ValAla: 5.678 ± 2.145
0.71ValCys: 0.71 ± 0.674
1.419ValAsp: 1.419 ± 0.882
2.839ValGlu: 2.839 ± 0.745
2.839ValPhe: 2.839 ± 1.94
1.419ValGly: 1.419 ± 0.613
0.0ValHis: 0.0 ± 0.0
1.419ValIle: 1.419 ± 0.753
2.839ValLys: 2.839 ± 1.258
4.258ValLeu: 4.258 ± 1.401
1.419ValMet: 1.419 ± 0.613
4.258ValAsn: 4.258 ± 2.188
4.258ValPro: 4.258 ± 1.69
4.968ValGln: 4.968 ± 1.303
2.839ValArg: 2.839 ± 1.225
2.129ValSer: 2.129 ± 1.32
2.129ValThr: 2.129 ± 0.828
2.839ValVal: 2.839 ± 0.852
0.0ValTrp: 0.0 ± 0.0
2.129ValTyr: 2.129 ± 0.788
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.71TrpCys: 0.71 ± 1.164
1.419TrpAsp: 1.419 ± 0.613
0.0TrpGlu: 0.0 ± 0.0
1.419TrpPhe: 1.419 ± 0.613
0.71TrpGly: 0.71 ± 0.441
1.419TrpHis: 1.419 ± 0.882
0.71TrpIle: 0.71 ± 0.674
0.0TrpLys: 0.0 ± 0.0
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
1.419TrpAsn: 1.419 ± 1.089
2.129TrpPro: 2.129 ± 0.828
0.0TrpGln: 0.0 ± 0.0
1.419TrpArg: 1.419 ± 1.089
3.549TrpSer: 3.549 ± 1.002
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.71TrpTyr: 0.71 ± 0.674
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.0TyrAla: 0.0 ± 0.0
0.71TyrCys: 0.71 ± 0.441
2.839TyrAsp: 2.839 ± 1.262
7.097TyrGlu: 7.097 ± 2.944
2.129TyrPhe: 2.129 ± 0.828
3.549TyrGly: 3.549 ± 1.796
0.71TyrHis: 0.71 ± 0.674
2.839TyrIle: 2.839 ± 0.958
2.129TyrLys: 2.129 ± 0.828
4.258TyrLeu: 4.258 ± 1.354
2.129TyrMet: 2.129 ± 1.101
1.419TyrAsn: 1.419 ± 0.613
0.71TyrPro: 0.71 ± 0.674
2.839TyrGln: 2.839 ± 1.191
3.549TyrArg: 3.549 ± 1.321
3.549TyrSer: 3.549 ± 1.69
0.0TyrThr: 0.0 ± 0.0
2.129TyrVal: 2.129 ± 0.828
0.71TyrTrp: 0.71 ± 0.441
2.129TyrTyr: 2.129 ± 0.828
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (1410 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski