Amino acid dipepetide frequency for Dinoroseobacter phage vB_DshS-R4C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
23.722AlaAla: 23.722 ± 2.09
0.774AlaCys: 0.774 ± 0.296
9.368AlaAsp: 9.368 ± 1.124
8.681AlaGlu: 8.681 ± 1.092
2.836AlaPhe: 2.836 ± 0.565
12.978AlaGly: 12.978 ± 1.464
2.664AlaHis: 2.664 ± 0.58
5.415AlaIle: 5.415 ± 0.676
3.352AlaLys: 3.352 ± 0.633
15.299AlaLeu: 15.299 ± 1.27
2.836AlaMet: 2.836 ± 0.512
2.149AlaAsn: 2.149 ± 0.423
11.087AlaPro: 11.087 ± 1.286
5.157AlaGln: 5.157 ± 0.617
12.634AlaArg: 12.634 ± 1.345
6.188AlaSer: 6.188 ± 0.804
8.165AlaThr: 8.165 ± 0.886
7.048AlaVal: 7.048 ± 0.899
2.407AlaTrp: 2.407 ± 0.362
2.492AlaTyr: 2.492 ± 0.435
0.0AlaXaa: 0.0 ± 0.0
Cys
1.719CysAla: 1.719 ± 0.562
0.0CysCys: 0.0 ± 0.0
0.43CysAsp: 0.43 ± 0.258
0.774CysGlu: 0.774 ± 0.267
0.344CysPhe: 0.344 ± 0.188
0.859CysGly: 0.859 ± 0.26
0.258CysHis: 0.258 ± 0.153
0.0CysIle: 0.0 ± 0.0
0.258CysLys: 0.258 ± 0.168
0.688CysLeu: 0.688 ± 0.246
0.258CysMet: 0.258 ± 0.145
0.344CysAsn: 0.344 ± 0.138
1.375CysPro: 1.375 ± 0.355
0.43CysGln: 0.43 ± 0.149
0.516CysArg: 0.516 ± 0.176
0.258CysSer: 0.258 ± 0.167
0.258CysThr: 0.258 ± 0.179
0.688CysVal: 0.688 ± 0.222
0.086CysTrp: 0.086 ± 0.076
0.172CysTyr: 0.172 ± 0.131
0.0CysXaa: 0.0 ± 0.0
Asp
7.993AspAla: 7.993 ± 0.602
0.774AspCys: 0.774 ± 0.322
3.438AspAsp: 3.438 ± 0.846
1.805AspGlu: 1.805 ± 0.447
1.977AspPhe: 1.977 ± 0.45
5.844AspGly: 5.844 ± 0.834
1.977AspHis: 1.977 ± 0.409
4.04AspIle: 4.04 ± 0.734
0.945AspLys: 0.945 ± 0.322
9.024AspLeu: 9.024 ± 0.7
1.117AspMet: 1.117 ± 0.312
1.117AspAsn: 1.117 ± 0.279
4.469AspPro: 4.469 ± 0.612
1.461AspGln: 1.461 ± 0.314
5.329AspArg: 5.329 ± 0.724
2.149AspSer: 2.149 ± 0.416
4.641AspThr: 4.641 ± 1.031
4.641AspVal: 4.641 ± 0.575
1.805AspTrp: 1.805 ± 0.512
1.633AspTyr: 1.633 ± 0.376
0.0AspXaa: 0.0 ± 0.0
Glu
9.11GluAla: 9.11 ± 0.999
0.516GluCys: 0.516 ± 0.187
2.578GluAsp: 2.578 ± 0.44
1.461GluGlu: 1.461 ± 0.443
1.633GluPhe: 1.633 ± 0.526
5.415GluGly: 5.415 ± 0.712
0.344GluHis: 0.344 ± 0.233
3.008GluIle: 3.008 ± 0.529
1.203GluLys: 1.203 ± 0.292
3.008GluLeu: 3.008 ± 0.684
0.774GluMet: 0.774 ± 0.327
1.203GluAsn: 1.203 ± 0.376
1.977GluPro: 1.977 ± 0.469
0.258GluGln: 0.258 ± 0.144
4.297GluArg: 4.297 ± 0.727
2.407GluSer: 2.407 ± 0.547
3.266GluThr: 3.266 ± 0.521
4.641GluVal: 4.641 ± 0.541
1.461GluTrp: 1.461 ± 0.265
0.688GluTyr: 0.688 ± 0.234
0.0GluXaa: 0.0 ± 0.0
Phe
3.008PheAla: 3.008 ± 0.426
0.258PheCys: 0.258 ± 0.156
2.407PheAsp: 2.407 ± 0.569
1.719PheGlu: 1.719 ± 0.311
1.117PhePhe: 1.117 ± 0.417
3.008PheGly: 3.008 ± 0.464
0.43PheHis: 0.43 ± 0.189
1.117PheIle: 1.117 ± 0.264
0.945PheLys: 0.945 ± 0.226
2.407PheLeu: 2.407 ± 0.462
1.203PheMet: 1.203 ± 0.318
0.344PheAsn: 0.344 ± 0.161
1.461PhePro: 1.461 ± 0.35
0.859PheGln: 0.859 ± 0.307
2.578PheArg: 2.578 ± 0.65
2.407PheSer: 2.407 ± 0.532
2.149PheThr: 2.149 ± 0.412
1.891PheVal: 1.891 ± 0.439
0.43PheTrp: 0.43 ± 0.196
0.945PheTyr: 0.945 ± 0.21
0.0PheXaa: 0.0 ± 0.0
Gly
12.892GlyAla: 12.892 ± 1.171
1.117GlyCys: 1.117 ± 0.341
6.36GlyAsp: 6.36 ± 1.125
4.469GlyGlu: 4.469 ± 0.636
3.61GlyPhe: 3.61 ± 0.674
11.345GlyGly: 11.345 ± 1.85
2.149GlyHis: 2.149 ± 0.479
2.578GlyIle: 2.578 ± 0.389
3.18GlyLys: 3.18 ± 0.616
8.423GlyLeu: 8.423 ± 0.754
1.289GlyMet: 1.289 ± 0.358
1.805GlyAsn: 1.805 ± 0.434
3.868GlyPro: 3.868 ± 0.685
3.438GlyGln: 3.438 ± 0.58
6.446GlyArg: 6.446 ± 0.646
5.587GlySer: 5.587 ± 0.864
5.501GlyThr: 5.501 ± 0.838
8.509GlyVal: 8.509 ± 1.058
1.547GlyTrp: 1.547 ± 0.286
1.719GlyTyr: 1.719 ± 0.439
0.0GlyXaa: 0.0 ± 0.0
His
2.492HisAla: 2.492 ± 0.524
0.43HisCys: 0.43 ± 0.198
0.774HisAsp: 0.774 ± 0.237
0.602HisGlu: 0.602 ± 0.224
0.344HisPhe: 0.344 ± 0.16
1.547HisGly: 1.547 ± 0.42
0.43HisHis: 0.43 ± 0.181
0.602HisIle: 0.602 ± 0.266
0.258HisLys: 0.258 ± 0.199
2.407HisLeu: 2.407 ± 0.581
0.516HisMet: 0.516 ± 0.268
0.43HisAsn: 0.43 ± 0.145
1.117HisPro: 1.117 ± 0.351
0.43HisGln: 0.43 ± 0.182
1.805HisArg: 1.805 ± 0.478
0.602HisSer: 0.602 ± 0.194
1.289HisThr: 1.289 ± 0.346
1.203HisVal: 1.203 ± 0.346
0.172HisTrp: 0.172 ± 0.096
0.258HisTyr: 0.258 ± 0.19
0.0HisXaa: 0.0 ± 0.0
Ile
5.501IleAla: 5.501 ± 0.697
0.344IleCys: 0.344 ± 0.163
2.75IleAsp: 2.75 ± 0.475
4.383IleGlu: 4.383 ± 0.55
1.203IlePhe: 1.203 ± 0.365
3.61IleGly: 3.61 ± 0.827
1.117IleHis: 1.117 ± 0.397
1.117IleIle: 1.117 ± 0.439
1.633IleLys: 1.633 ± 0.452
3.954IleLeu: 3.954 ± 0.687
0.516IleMet: 0.516 ± 0.18
0.602IleAsn: 0.602 ± 0.225
3.18IlePro: 3.18 ± 0.509
0.602IleGln: 0.602 ± 0.208
1.719IleArg: 1.719 ± 0.374
2.407IleSer: 2.407 ± 0.684
2.836IleThr: 2.836 ± 0.579
1.719IleVal: 1.719 ± 0.333
0.43IleTrp: 0.43 ± 0.159
0.602IleTyr: 0.602 ± 0.175
0.0IleXaa: 0.0 ± 0.0
Lys
3.438LysAla: 3.438 ± 0.488
0.172LysCys: 0.172 ± 0.126
1.891LysAsp: 1.891 ± 0.49
1.203LysGlu: 1.203 ± 0.307
0.43LysPhe: 0.43 ± 0.199
2.578LysGly: 2.578 ± 0.521
0.344LysHis: 0.344 ± 0.164
0.859LysIle: 0.859 ± 0.288
0.774LysLys: 0.774 ± 0.278
1.891LysLeu: 1.891 ± 0.377
0.516LysMet: 0.516 ± 0.212
0.688LysAsn: 0.688 ± 0.262
1.117LysPro: 1.117 ± 0.36
0.602LysGln: 0.602 ± 0.23
2.407LysArg: 2.407 ± 0.666
2.235LysSer: 2.235 ± 0.332
2.063LysThr: 2.063 ± 0.493
2.235LysVal: 2.235 ± 0.558
0.172LysTrp: 0.172 ± 0.108
0.602LysTyr: 0.602 ± 0.318
0.0LysXaa: 0.0 ± 0.0
Leu
12.376LeuAla: 12.376 ± 1.522
0.774LeuCys: 0.774 ± 0.283
7.649LeuAsp: 7.649 ± 0.824
3.954LeuGlu: 3.954 ± 0.534
2.063LeuPhe: 2.063 ± 0.47
8.423LeuGly: 8.423 ± 1.085
1.117LeuHis: 1.117 ± 0.314
3.008LeuIle: 3.008 ± 0.477
2.664LeuLys: 2.664 ± 0.492
5.501LeuLeu: 5.501 ± 0.762
1.203LeuMet: 1.203 ± 0.274
1.805LeuAsn: 1.805 ± 0.342
6.532LeuPro: 6.532 ± 0.677
1.547LeuGln: 1.547 ± 0.384
8.595LeuArg: 8.595 ± 0.676
6.962LeuSer: 6.962 ± 0.571
6.704LeuThr: 6.704 ± 0.781
6.016LeuVal: 6.016 ± 0.724
0.688LeuTrp: 0.688 ± 0.296
1.547LeuTyr: 1.547 ± 0.397
0.0LeuXaa: 0.0 ± 0.0
Met
1.805MetAla: 1.805 ± 0.293
0.086MetCys: 0.086 ± 0.076
1.805MetAsp: 1.805 ± 0.313
0.688MetGlu: 0.688 ± 0.2
0.43MetPhe: 0.43 ± 0.201
1.633MetGly: 1.633 ± 0.353
0.258MetHis: 0.258 ± 0.128
1.289MetIle: 1.289 ± 0.3
0.602MetLys: 0.602 ± 0.212
1.461MetLeu: 1.461 ± 0.377
0.688MetMet: 0.688 ± 0.215
0.172MetAsn: 0.172 ± 0.124
1.375MetPro: 1.375 ± 0.317
0.344MetGln: 0.344 ± 0.164
1.117MetArg: 1.117 ± 0.309
0.859MetSer: 0.859 ± 0.289
1.805MetThr: 1.805 ± 0.372
1.375MetVal: 1.375 ± 0.476
0.172MetTrp: 0.172 ± 0.124
0.172MetTyr: 0.172 ± 0.118
0.0MetXaa: 0.0 ± 0.0
Asn
2.063AsnAla: 2.063 ± 0.36
0.172AsnCys: 0.172 ± 0.151
0.602AsnAsp: 0.602 ± 0.178
0.43AsnGlu: 0.43 ± 0.24
0.688AsnPhe: 0.688 ± 0.222
1.633AsnGly: 1.633 ± 0.446
0.172AsnHis: 0.172 ± 0.121
0.688AsnIle: 0.688 ± 0.197
0.688AsnLys: 0.688 ± 0.275
1.547AsnLeu: 1.547 ± 0.372
0.344AsnMet: 0.344 ± 0.234
0.258AsnAsn: 0.258 ± 0.142
1.805AsnPro: 1.805 ± 0.484
0.344AsnGln: 0.344 ± 0.183
2.235AsnArg: 2.235 ± 0.421
0.945AsnSer: 0.945 ± 0.243
1.375AsnThr: 1.375 ± 0.351
1.289AsnVal: 1.289 ± 0.333
0.688AsnTrp: 0.688 ± 0.296
0.172AsnTyr: 0.172 ± 0.104
0.0AsnXaa: 0.0 ± 0.0
Pro
11.001ProAla: 11.001 ± 1.327
0.516ProCys: 0.516 ± 0.23
6.102ProAsp: 6.102 ± 0.721
3.352ProGlu: 3.352 ± 0.514
3.266ProPhe: 3.266 ± 0.482
7.306ProGly: 7.306 ± 0.785
0.859ProHis: 0.859 ± 0.271
1.891ProIle: 1.891 ± 0.368
1.633ProLys: 1.633 ± 0.384
5.329ProLeu: 5.329 ± 0.727
1.203ProMet: 1.203 ± 0.344
0.859ProAsn: 0.859 ± 0.258
5.501ProPro: 5.501 ± 0.932
1.461ProGln: 1.461 ± 0.268
4.641ProArg: 4.641 ± 0.807
3.352ProSer: 3.352 ± 0.529
3.094ProThr: 3.094 ± 0.573
2.922ProVal: 2.922 ± 0.545
1.289ProTrp: 1.289 ± 0.347
0.945ProTyr: 0.945 ± 0.248
0.0ProXaa: 0.0 ± 0.0
Gln
3.18GlnAla: 3.18 ± 0.541
0.0GlnCys: 0.0 ± 0.0
1.031GlnAsp: 1.031 ± 0.298
1.117GlnGlu: 1.117 ± 0.278
0.602GlnPhe: 0.602 ± 0.19
2.235GlnGly: 2.235 ± 0.409
0.602GlnHis: 0.602 ± 0.278
1.461GlnIle: 1.461 ± 0.331
0.774GlnLys: 0.774 ± 0.268
1.289GlnLeu: 1.289 ± 0.416
0.602GlnMet: 0.602 ± 0.388
0.688GlnAsn: 0.688 ± 0.243
1.375GlnPro: 1.375 ± 0.389
0.258GlnGln: 0.258 ± 0.129
1.805GlnArg: 1.805 ± 0.32
1.633GlnSer: 1.633 ± 0.463
1.461GlnThr: 1.461 ± 0.63
2.149GlnVal: 2.149 ± 0.459
0.172GlnTrp: 0.172 ± 0.148
0.344GlnTyr: 0.344 ± 0.215
0.0GlnXaa: 0.0 ± 0.0
Arg
13.494ArgAla: 13.494 ± 1.097
0.945ArgCys: 0.945 ± 0.491
5.071ArgAsp: 5.071 ± 0.575
3.094ArgGlu: 3.094 ± 0.569
3.094ArgPhe: 3.094 ± 0.659
7.306ArgGly: 7.306 ± 0.715
1.891ArgHis: 1.891 ± 0.611
2.836ArgIle: 2.836 ± 0.391
2.75ArgLys: 2.75 ± 0.727
6.876ArgLeu: 6.876 ± 0.803
0.945ArgMet: 0.945 ± 0.323
1.977ArgAsn: 1.977 ± 0.507
5.157ArgPro: 5.157 ± 0.652
1.719ArgGln: 1.719 ± 0.364
6.704ArgArg: 6.704 ± 1.131
2.922ArgSer: 2.922 ± 0.568
4.899ArgThr: 4.899 ± 0.614
6.532ArgVal: 6.532 ± 0.681
1.547ArgTrp: 1.547 ± 0.321
2.063ArgTyr: 2.063 ± 0.509
0.0ArgXaa: 0.0 ± 0.0
Ser
7.22SerAla: 7.22 ± 0.838
0.602SerCys: 0.602 ± 0.323
3.954SerAsp: 3.954 ± 0.614
3.008SerGlu: 3.008 ± 0.579
1.719SerPhe: 1.719 ± 0.444
6.704SerGly: 6.704 ± 0.843
0.774SerHis: 0.774 ± 0.305
2.321SerIle: 2.321 ± 0.478
0.945SerLys: 0.945 ± 0.265
5.415SerLeu: 5.415 ± 0.633
0.774SerMet: 0.774 ± 0.214
0.859SerAsn: 0.859 ± 0.232
3.524SerPro: 3.524 ± 0.569
0.774SerGln: 0.774 ± 0.442
4.641SerArg: 4.641 ± 0.741
1.633SerSer: 1.633 ± 0.597
2.922SerThr: 2.922 ± 0.586
2.75SerVal: 2.75 ± 0.528
1.289SerTrp: 1.289 ± 0.395
0.945SerTyr: 0.945 ± 0.263
0.0SerXaa: 0.0 ± 0.0
Thr
10.4ThrAla: 10.4 ± 0.765
0.774ThrCys: 0.774 ± 0.246
3.266ThrAsp: 3.266 ± 0.639
3.438ThrGlu: 3.438 ± 0.587
1.289ThrPhe: 1.289 ± 0.434
6.102ThrGly: 6.102 ± 0.666
0.945ThrHis: 0.945 ± 0.302
3.094ThrIle: 3.094 ± 0.57
0.774ThrLys: 0.774 ± 0.19
5.157ThrLeu: 5.157 ± 0.652
0.859ThrMet: 0.859 ± 0.273
0.516ThrAsn: 0.516 ± 0.27
6.36ThrPro: 6.36 ± 0.725
1.031ThrGln: 1.031 ± 0.301
6.36ThrArg: 6.36 ± 0.66
2.922ThrSer: 2.922 ± 0.742
3.954ThrThr: 3.954 ± 0.562
5.587ThrVal: 5.587 ± 1.219
1.375ThrTrp: 1.375 ± 0.239
1.375ThrTyr: 1.375 ± 0.401
0.0ThrXaa: 0.0 ± 0.0
Val
8.595ValAla: 8.595 ± 0.836
0.859ValCys: 0.859 ± 0.325
4.383ValAsp: 4.383 ± 0.716
3.18ValGlu: 3.18 ± 0.567
2.922ValPhe: 2.922 ± 0.456
4.211ValGly: 4.211 ± 0.599
0.43ValHis: 0.43 ± 0.247
3.524ValIle: 3.524 ± 0.479
2.407ValLys: 2.407 ± 0.471
6.274ValLeu: 6.274 ± 0.809
1.805ValMet: 1.805 ± 0.336
1.375ValAsn: 1.375 ± 0.313
2.922ValPro: 2.922 ± 0.452
1.461ValGln: 1.461 ± 0.344
5.157ValArg: 5.157 ± 0.871
4.555ValSer: 4.555 ± 0.514
6.704ValThr: 6.704 ± 0.922
4.555ValVal: 4.555 ± 0.733
1.117ValTrp: 1.117 ± 0.346
1.289ValTyr: 1.289 ± 0.338
0.0ValXaa: 0.0 ± 0.0
Trp
2.321TrpAla: 2.321 ± 0.425
0.516TrpCys: 0.516 ± 0.191
1.031TrpAsp: 1.031 ± 0.259
1.117TrpGlu: 1.117 ± 0.387
0.602TrpPhe: 0.602 ± 0.297
0.945TrpGly: 0.945 ± 0.303
0.344TrpHis: 0.344 ± 0.155
0.859TrpIle: 0.859 ± 0.261
0.258TrpLys: 0.258 ± 0.131
1.461TrpLeu: 1.461 ± 0.401
0.172TrpMet: 0.172 ± 0.175
0.344TrpAsn: 0.344 ± 0.174
1.203TrpPro: 1.203 ± 0.265
0.258TrpGln: 0.258 ± 0.153
1.547TrpArg: 1.547 ± 0.443
1.891TrpSer: 1.891 ± 0.279
1.203TrpThr: 1.203 ± 0.309
1.117TrpVal: 1.117 ± 0.313
0.516TrpTrp: 0.516 ± 0.179
0.172TrpTyr: 0.172 ± 0.108
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.922TyrAla: 2.922 ± 0.46
0.086TyrCys: 0.086 ± 0.078
1.289TyrAsp: 1.289 ± 0.319
0.774TyrGlu: 0.774 ± 0.245
0.516TyrPhe: 0.516 ± 0.191
2.149TyrGly: 2.149 ± 0.443
0.602TyrHis: 0.602 ± 0.227
0.516TyrIle: 0.516 ± 0.214
0.172TyrLys: 0.172 ± 0.113
1.719TyrLeu: 1.719 ± 0.398
0.43TyrMet: 0.43 ± 0.17
0.602TyrAsn: 0.602 ± 0.24
1.117TyrPro: 1.117 ± 0.319
0.344TyrGln: 0.344 ± 0.137
1.375TyrArg: 1.375 ± 0.352
0.859TyrSer: 0.859 ± 0.237
1.289TyrThr: 1.289 ± 0.433
0.859TyrVal: 0.859 ± 0.291
0.516TyrTrp: 0.516 ± 0.277
0.344TyrTyr: 0.344 ± 0.149
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (11636 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski