Amino acid dipepetide frequency for Dyella sp. M7H15-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.258AlaAla: 13.258 ± 0.169	1.181AlaCys: 1.181 ± 0.036	6.022AlaAsp: 6.022 ± 0.088	5.783AlaGlu: 5.783 ± 0.106	3.614AlaPhe: 3.614 ± 0.068	8.882AlaGly: 8.882 ± 0.125	2.748AlaHis: 2.748 ± 0.06	5.655AlaIle: 5.655 ± 0.095	3.883AlaLys: 3.883 ± 0.079	12.879AlaLeu: 12.879 ± 0.139	3.308AlaMet: 3.308 ± 0.07	3.526AlaAsn: 3.526 ± 0.084	4.869AlaPro: 4.869 ± 0.075	5.076AlaGln: 5.076 ± 0.09	7.097AlaArg: 7.097 ± 0.105	6.664AlaSer: 6.664 ± 0.121	6.081AlaThr: 6.081 ± 0.117	7.886AlaVal: 7.886 ± 0.12	1.745AlaTrp: 1.745 ± 0.053	2.66AlaTyr: 2.66 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.999CysAla: 0.999 ± 0.032	0.125CysCys: 0.125 ± 0.01	0.523CysAsp: 0.523 ± 0.023	0.485CysGlu: 0.485 ± 0.022	0.34CysPhe: 0.34 ± 0.023	0.894CysGly: 0.894 ± 0.032	0.273CysHis: 0.273 ± 0.017	0.457CysIle: 0.457 ± 0.022	0.302CysLys: 0.302 ± 0.018	0.923CysLeu: 0.923 ± 0.036	0.232CysMet: 0.232 ± 0.013	0.25CysAsn: 0.25 ± 0.018	0.434CysPro: 0.434 ± 0.021	0.281CysGln: 0.281 ± 0.018	0.578CysArg: 0.578 ± 0.023	0.579CysSer: 0.579 ± 0.027	0.516CysThr: 0.516 ± 0.024	0.715CysVal: 0.715 ± 0.033	0.128CysTrp: 0.128 ± 0.012	0.267CysTyr: 0.267 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	7.016AspAla: 7.016 ± 0.101	0.44AspCys: 0.44 ± 0.024	3.147AspAsp: 3.147 ± 0.066	3.113AspGlu: 3.113 ± 0.059	2.054AspPhe: 2.054 ± 0.055	4.856AspGly: 4.856 ± 0.078	1.313AspHis: 1.313 ± 0.036	2.828AspIle: 2.828 ± 0.069	1.83AspLys: 1.83 ± 0.048	5.368AspLeu: 5.368 ± 0.071	1.262AspMet: 1.262 ± 0.038	1.689AspAsn: 1.689 ± 0.047	3.174AspPro: 3.174 ± 0.062	1.972AspGln: 1.972 ± 0.045	3.282AspArg: 3.282 ± 0.061	2.69AspSer: 2.69 ± 0.053	3.054AspThr: 3.054 ± 0.062	4.266AspVal: 4.266 ± 0.071	0.975AspTrp: 0.975 ± 0.033	1.701AspTyr: 1.701 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	5.848GluAla: 5.848 ± 0.111	0.444GluCys: 0.444 ± 0.022	2.28GluAsp: 2.28 ± 0.059	2.48GluGlu: 2.48 ± 0.059	1.563GluPhe: 1.563 ± 0.045	3.531GluGly: 3.531 ± 0.06	1.602GluHis: 1.602 ± 0.042	2.397GluIle: 2.397 ± 0.056	1.925GluLys: 1.925 ± 0.054	5.845GluLeu: 5.845 ± 0.103	1.115GluMet: 1.115 ± 0.042	1.522GluAsn: 1.522 ± 0.042	2.21GluPro: 2.21 ± 0.05	2.844GluGln: 2.844 ± 0.059	4.271GluArg: 4.271 ± 0.08	2.741GluSer: 2.741 ± 0.053	2.618GluThr: 2.618 ± 0.058	3.63GluVal: 3.63 ± 0.06	0.705GluTrp: 0.705 ± 0.028	1.187GluTyr: 1.187 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.827PheAla: 3.827 ± 0.061	0.349PheCys: 0.349 ± 0.02	2.398PheAsp: 2.398 ± 0.051	1.84PheGlu: 1.84 ± 0.051	1.298PhePhe: 1.298 ± 0.046	3.169PheGly: 3.169 ± 0.077	0.858PheHis: 0.858 ± 0.028	1.464PheIle: 1.464 ± 0.048	1.1PheLys: 1.1 ± 0.034	3.048PheLeu: 3.048 ± 0.072	0.788PheMet: 0.788 ± 0.031	1.245PheAsn: 1.245 ± 0.043	1.43PhePro: 1.43 ± 0.046	1.09PheGln: 1.09 ± 0.031	1.938PheArg: 1.938 ± 0.048	2.134PheSer: 2.134 ± 0.056	1.903PheThr: 1.903 ± 0.05	2.543PheVal: 2.543 ± 0.062	0.434PheTrp: 0.434 ± 0.023	0.903PheTyr: 0.903 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.813GlyAla: 7.813 ± 0.141	0.853GlyCys: 0.853 ± 0.034	4.219GlyAsp: 4.219 ± 0.081	4.163GlyGlu: 4.163 ± 0.076	3.072GlyPhe: 3.072 ± 0.058	6.668GlyGly: 6.668 ± 0.127	2.314GlyHis: 2.314 ± 0.053	4.219GlyIle: 4.219 ± 0.074	3.401GlyLys: 3.401 ± 0.062	7.811GlyLeu: 7.811 ± 0.097	2.399GlyMet: 2.399 ± 0.053	3.199GlyAsn: 3.199 ± 0.121	2.702GlyPro: 2.702 ± 0.05	3.223GlyGln: 3.223 ± 0.066	4.695GlyArg: 4.695 ± 0.07	5.227GlySer: 5.227 ± 0.13	4.816GlyThr: 4.816 ± 0.129	6.198GlyVal: 6.198 ± 0.078	1.418GlyTrp: 1.418 ± 0.041	2.553GlyTyr: 2.553 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	3.306HisAla: 3.306 ± 0.071	0.306HisCys: 0.306 ± 0.022	1.576HisAsp: 1.576 ± 0.039	1.34HisGlu: 1.34 ± 0.04	0.953HisPhe: 0.953 ± 0.03	2.425HisGly: 2.425 ± 0.049	0.783HisHis: 0.783 ± 0.031	1.237HisIle: 1.237 ± 0.042	0.708HisLys: 0.708 ± 0.026	2.579HisLeu: 2.579 ± 0.049	0.625HisMet: 0.625 ± 0.027	0.692HisAsn: 0.692 ± 0.024	1.699HisPro: 1.699 ± 0.045	0.854HisGln: 0.854 ± 0.03	1.741HisArg: 1.741 ± 0.046	1.332HisSer: 1.332 ± 0.038	1.272HisThr: 1.272 ± 0.039	1.902HisVal: 1.902 ± 0.049	0.485HisTrp: 0.485 ± 0.026	0.83HisTyr: 0.83 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.212IleAla: 6.212 ± 0.09	0.444IleCys: 0.444 ± 0.021	3.617IleAsp: 3.617 ± 0.065	3.068IleGlu: 3.068 ± 0.066	1.485IlePhe: 1.485 ± 0.046	4.648IleGly: 4.648 ± 0.093	1.14IleHis: 1.14 ± 0.033	1.86IleIle: 1.86 ± 0.052	1.585IleLys: 1.585 ± 0.045	3.601IleLeu: 3.601 ± 0.083	0.795IleMet: 0.795 ± 0.028	1.765IleAsn: 1.765 ± 0.052	2.446IlePro: 2.446 ± 0.06	1.494IleGln: 1.494 ± 0.043	2.822IleArg: 2.822 ± 0.059	2.847IleSer: 2.847 ± 0.059	2.991IleThr: 2.991 ± 0.059	3.711IleVal: 3.711 ± 0.074	0.51IleTrp: 0.51 ± 0.026	1.141IleTyr: 1.141 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.741LysAla: 3.741 ± 0.076	0.187LysCys: 0.187 ± 0.014	1.772LysAsp: 1.772 ± 0.052	1.639LysGlu: 1.639 ± 0.047	0.864LysPhe: 0.864 ± 0.034	2.355LysGly: 2.355 ± 0.053	0.921LysHis: 0.921 ± 0.032	1.53LysIle: 1.53 ± 0.044	1.372LysLys: 1.372 ± 0.055	3.84LysLeu: 3.84 ± 0.072	0.774LysMet: 0.774 ± 0.03	1.082LysAsn: 1.082 ± 0.034	2.149LysPro: 2.149 ± 0.048	1.642LysGln: 1.642 ± 0.043	2.377LysArg: 2.377 ± 0.052	1.916LysSer: 1.916 ± 0.05	1.858LysThr: 1.858 ± 0.045	2.511LysVal: 2.511 ± 0.052	0.354LysTrp: 0.354 ± 0.02	0.819LysTyr: 0.819 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	12.484LeuAla: 12.484 ± 0.154	1.056LeuCys: 1.056 ± 0.03	6.327LeuAsp: 6.327 ± 0.089	5.077LeuGlu: 5.077 ± 0.093	3.401LeuPhe: 3.401 ± 0.071	8.218LeuGly: 8.218 ± 0.108	2.773LeuHis: 2.773 ± 0.066	4.947LeuIle: 4.947 ± 0.081	3.728LeuLys: 3.728 ± 0.069	11.029LeuLeu: 11.029 ± 0.16	2.369LeuMet: 2.369 ± 0.047	3.241LeuAsn: 3.241 ± 0.058	6.028LeuPro: 6.028 ± 0.095	3.99LeuGln: 3.99 ± 0.08	7.422LeuArg: 7.422 ± 0.114	6.693LeuSer: 6.693 ± 0.086	5.811LeuThr: 5.811 ± 0.092	6.843LeuVal: 6.843 ± 0.11	1.222LeuTrp: 1.222 ± 0.045	2.34LeuTyr: 2.34 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.778MetAla: 2.778 ± 0.056	0.184MetCys: 0.184 ± 0.014	1.214MetAsp: 1.214 ± 0.037	1.055MetGlu: 1.055 ± 0.036	0.683MetPhe: 0.683 ± 0.024	1.67MetGly: 1.67 ± 0.048	0.654MetHis: 0.654 ± 0.032	1.049MetIle: 1.049 ± 0.032	0.979MetLys: 0.979 ± 0.032	2.788MetLeu: 2.788 ± 0.055	0.64MetMet: 0.64 ± 0.026	0.881MetAsn: 0.881 ± 0.03	1.544MetPro: 1.544 ± 0.046	1.176MetGln: 1.176 ± 0.035	1.809MetArg: 1.809 ± 0.044	1.74MetSer: 1.74 ± 0.041	1.443MetThr: 1.443 ± 0.039	1.707MetVal: 1.707 ± 0.039	0.23MetTrp: 0.23 ± 0.016	0.456MetTyr: 0.456 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.942AsnAla: 3.942 ± 0.087	0.258AsnCys: 0.258 ± 0.018	1.924AsnAsp: 1.924 ± 0.049	1.499AsnGlu: 1.499 ± 0.044	1.098AsnPhe: 1.098 ± 0.036	3.169AsnGly: 3.169 ± 0.094	0.795AsnHis: 0.795 ± 0.032	1.522AsnIle: 1.522 ± 0.041	0.98AsnLys: 0.98 ± 0.039	3.125AsnLeu: 3.125 ± 0.085	0.691AsnMet: 0.691 ± 0.031	1.25AsnAsn: 1.25 ± 0.048	1.971AsnPro: 1.971 ± 0.047	1.267AsnGln: 1.267 ± 0.044	1.79AsnArg: 1.79 ± 0.045	1.757AsnSer: 1.757 ± 0.069	2.004AsnThr: 2.004 ± 0.062	2.415AsnVal: 2.415 ± 0.072	0.493AsnTrp: 0.493 ± 0.022	0.893AsnTyr: 0.893 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.567ProAla: 5.567 ± 0.089	0.4ProCys: 0.4 ± 0.021	3.141ProAsp: 3.141 ± 0.076	2.863ProGlu: 2.863 ± 0.05	1.719ProPhe: 1.719 ± 0.044	4.205ProGly: 4.205 ± 0.071	1.274ProHis: 1.274 ± 0.04	2.34ProIle: 2.34 ± 0.044	1.551ProLys: 1.551 ± 0.043	5.069ProLeu: 5.069 ± 0.08	1.309ProMet: 1.309 ± 0.037	1.656ProAsn: 1.656 ± 0.046	2.603ProPro: 2.603 ± 0.071	2.004ProGln: 2.004 ± 0.046	2.747ProArg: 2.747 ± 0.065	3.193ProSer: 3.193 ± 0.061	2.613ProThr: 2.613 ± 0.059	3.72ProVal: 3.72 ± 0.057	0.779ProTrp: 0.779 ± 0.032	1.379ProTyr: 1.379 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	5.09GlnAla: 5.09 ± 0.081	0.343GlnCys: 0.343 ± 0.023	1.753GlnAsp: 1.753 ± 0.047	1.709GlnGlu: 1.709 ± 0.041	1.267GlnPhe: 1.267 ± 0.038	3.086GlnGly: 3.086 ± 0.056	1.228GlnHis: 1.228 ± 0.038	2.057GlnIle: 2.057 ± 0.048	1.195GlnLys: 1.195 ± 0.031	4.45GlnLeu: 4.45 ± 0.085	1.002GlnMet: 1.002 ± 0.03	1.274GlnAsn: 1.274 ± 0.039	2.239GlnPro: 2.239 ± 0.053	2.417GlnGln: 2.417 ± 0.065	3.358GlnArg: 3.358 ± 0.063	2.337GlnSer: 2.337 ± 0.056	2.041GlnThr: 2.041 ± 0.05	3.007GlnVal: 3.007 ± 0.054	0.652GlnTrp: 0.652 ± 0.027	1.024GlnTyr: 1.024 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	6.412ArgAla: 6.412 ± 0.107	0.641ArgCys: 0.641 ± 0.025	3.681ArgAsp: 3.681 ± 0.063	4.0ArgGlu: 4.0 ± 0.085	2.508ArgPhe: 2.508 ± 0.049	4.416ArgGly: 4.416 ± 0.074	2.053ArgHis: 2.053 ± 0.05	3.561ArgIle: 3.561 ± 0.062	2.365ArgLys: 2.365 ± 0.053	7.235ArgLeu: 7.235 ± 0.121	1.85ArgMet: 1.85 ± 0.045	1.906ArgAsn: 1.906 ± 0.043	2.665ArgPro: 2.665 ± 0.064	2.785ArgGln: 2.785 ± 0.062	4.731ArgArg: 4.731 ± 0.086	3.413ArgSer: 3.413 ± 0.064	3.058ArgThr: 3.058 ± 0.054	4.619ArgVal: 4.619 ± 0.081	1.125ArgTrp: 1.125 ± 0.034	2.105ArgTyr: 2.105 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	6.341SerAla: 6.341 ± 0.096	0.509SerCys: 0.509 ± 0.026	3.067SerAsp: 3.067 ± 0.057	2.705SerGlu: 2.705 ± 0.06	2.12SerPhe: 2.12 ± 0.063	5.554SerGly: 5.554 ± 0.118	1.563SerHis: 1.563 ± 0.041	2.86SerIle: 2.86 ± 0.064	1.889SerLys: 1.889 ± 0.05	6.08SerLeu: 6.08 ± 0.092	1.59SerMet: 1.59 ± 0.042	2.067SerAsn: 2.067 ± 0.057	2.947SerPro: 2.947 ± 0.054	2.354SerGln: 2.354 ± 0.061	3.438SerArg: 3.438 ± 0.068	3.888SerSer: 3.888 ± 0.093	3.552SerThr: 3.552 ± 0.089	4.276SerVal: 4.276 ± 0.096	0.834SerTrp: 0.834 ± 0.035	1.575SerTyr: 1.575 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	5.851ThrAla: 5.851 ± 0.112	0.473ThrCys: 0.473 ± 0.022	2.924ThrAsp: 2.924 ± 0.058	2.369ThrGlu: 2.369 ± 0.052	1.739ThrPhe: 1.739 ± 0.047	4.632ThrGly: 4.632 ± 0.093	1.605ThrHis: 1.605 ± 0.041	2.607ThrIle: 2.607 ± 0.062	1.391ThrLys: 1.391 ± 0.041	6.645ThrLeu: 6.645 ± 0.102	1.197ThrMet: 1.197 ± 0.036	1.574ThrAsn: 1.574 ± 0.073	3.54ThrPro: 3.54 ± 0.074	2.414ThrGln: 2.414 ± 0.058	3.332ThrArg: 3.332 ± 0.066	3.306ThrSer: 3.306 ± 0.089	3.341ThrThr: 3.341 ± 0.113	4.502ThrVal: 4.502 ± 0.084	0.727ThrTrp: 0.727 ± 0.028	1.559ThrTyr: 1.559 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	8.202ValAla: 8.202 ± 0.13	0.698ValCys: 0.698 ± 0.029	4.249ValAsp: 4.249 ± 0.07	3.84ValGlu: 3.84 ± 0.069	2.471ValPhe: 2.471 ± 0.057	5.323ValGly: 5.323 ± 0.115	1.719ValHis: 1.719 ± 0.045	3.814ValIle: 3.814 ± 0.069	2.26ValLys: 2.26 ± 0.057	7.971ValLeu: 7.971 ± 0.108	1.849ValMet: 1.849 ± 0.049	2.565ValAsn: 2.565 ± 0.077	3.522ValPro: 3.522 ± 0.064	2.686ValGln: 2.686 ± 0.06	4.554ValArg: 4.554 ± 0.076	4.463ValSer: 4.463 ± 0.081	4.466ValThr: 4.466 ± 0.083	5.632ValVal: 5.632 ± 0.095	0.894ValTrp: 0.894 ± 0.034	1.74ValTyr: 1.74 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.131TrpAla: 1.131 ± 0.04	0.168TrpCys: 0.168 ± 0.014	0.621TrpAsp: 0.621 ± 0.028	0.533TrpGlu: 0.533 ± 0.027	0.515TrpPhe: 0.515 ± 0.023	0.89TrpGly: 0.89 ± 0.035	0.434TrpHis: 0.434 ± 0.019	0.759TrpIle: 0.759 ± 0.029	0.504TrpLys: 0.504 ± 0.024	2.07TrpLeu: 2.07 ± 0.056	0.429TrpMet: 0.429 ± 0.024	0.519TrpAsn: 0.519 ± 0.023	0.727TrpPro: 0.727 ± 0.033	0.797TrpGln: 0.797 ± 0.027	1.178TrpArg: 1.178 ± 0.041	0.837TrpSer: 0.837 ± 0.037	0.749TrpThr: 0.749 ± 0.028	0.89TrpVal: 0.89 ± 0.034	0.268TrpTrp: 0.268 ± 0.018	0.366TrpTyr: 0.366 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.998TyrAla: 2.998 ± 0.073	0.242TyrCys: 0.242 ± 0.016	1.575TyrAsp: 1.575 ± 0.048	1.195TyrGlu: 1.195 ± 0.029	0.996TyrPhe: 0.996 ± 0.034	2.369TyrGly: 2.369 ± 0.059	0.598TyrHis: 0.598 ± 0.024	1.017TyrIle: 1.017 ± 0.032	0.755TyrLys: 0.755 ± 0.031	2.644TyrLeu: 2.644 ± 0.05	0.457TyrMet: 0.457 ± 0.023	0.94TyrAsn: 0.94 ± 0.039	1.23TyrPro: 1.23 ± 0.035	1.164TyrGln: 1.164 ± 0.031	1.968TyrArg: 1.968 ± 0.048	1.452TyrSer: 1.452 ± 0.053	1.543TyrThr: 1.543 ± 0.049	1.944TyrVal: 1.944 ± 0.046	0.408TyrTrp: 0.408 ± 0.025	0.791TyrTyr: 0.791 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2958 proteins (982631 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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