Amino acid dipepetide frequency for Achromobacter phage vB_AxyP_19-32_Axy13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.777AlaAla: 11.777 ± 1.315
0.556AlaCys: 0.556 ± 0.187
6.167AlaAsp: 6.167 ± 0.577
6.538AlaGlu: 6.538 ± 0.685
2.411AlaPhe: 2.411 ± 0.38
7.001AlaGly: 7.001 ± 0.752
1.53AlaHis: 1.53 ± 0.294
3.756AlaIle: 3.756 ± 0.453
6.445AlaLys: 6.445 ± 0.677
9.32AlaLeu: 9.32 ± 1.293
2.55AlaMet: 2.55 ± 0.351
4.359AlaAsn: 4.359 ± 0.486
4.451AlaPro: 4.451 ± 0.663
4.498AlaGln: 4.498 ± 0.571
4.729AlaArg: 4.729 ± 0.546
4.544AlaSer: 4.544 ± 0.378
5.425AlaThr: 5.425 ± 0.64
6.584AlaVal: 6.584 ± 0.88
1.252AlaTrp: 1.252 ± 0.223
3.292AlaTyr: 3.292 ± 0.378
0.0AlaXaa: 0.0 ± 0.0
Cys
0.464CysAla: 0.464 ± 0.214
0.093CysCys: 0.093 ± 0.076
0.232CysAsp: 0.232 ± 0.103
0.371CysGlu: 0.371 ± 0.151
0.278CysPhe: 0.278 ± 0.099
0.603CysGly: 0.603 ± 0.183
0.278CysHis: 0.278 ± 0.119
0.371CysIle: 0.371 ± 0.135
0.325CysLys: 0.325 ± 0.117
0.649CysLeu: 0.649 ± 0.214
0.185CysMet: 0.185 ± 0.106
0.371CysAsn: 0.371 ± 0.149
0.325CysPro: 0.325 ± 0.161
0.185CysGln: 0.185 ± 0.08
0.325CysArg: 0.325 ± 0.135
0.464CysSer: 0.464 ± 0.16
0.556CysThr: 0.556 ± 0.187
0.371CysVal: 0.371 ± 0.143
0.185CysTrp: 0.185 ± 0.092
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.677AspAla: 6.677 ± 0.599
0.417AspCys: 0.417 ± 0.139
3.385AspAsp: 3.385 ± 0.424
4.359AspGlu: 4.359 ± 0.451
2.55AspPhe: 2.55 ± 0.279
5.1AspGly: 5.1 ± 0.412
1.159AspHis: 1.159 ± 0.306
3.617AspIle: 3.617 ± 0.526
3.385AspLys: 3.385 ± 0.408
4.683AspLeu: 4.683 ± 0.372
1.901AspMet: 1.901 ± 0.277
1.716AspAsn: 1.716 ± 0.22
3.153AspPro: 3.153 ± 0.317
3.199AspGln: 3.199 ± 0.4
3.431AspArg: 3.431 ± 0.488
3.338AspSer: 3.338 ± 0.411
3.199AspThr: 3.199 ± 0.359
3.663AspVal: 3.663 ± 0.457
1.298AspTrp: 1.298 ± 0.221
2.504AspTyr: 2.504 ± 0.296
0.0AspXaa: 0.0 ± 0.0
Glu
7.28GluAla: 7.28 ± 0.824
0.325GluCys: 0.325 ± 0.135
3.431GluAsp: 3.431 ± 0.562
4.822GluGlu: 4.822 ± 0.501
2.643GluPhe: 2.643 ± 0.392
4.961GluGly: 4.961 ± 0.435
1.345GluHis: 1.345 ± 0.2
3.153GluIle: 3.153 ± 0.374
3.802GluLys: 3.802 ± 0.551
5.564GluLeu: 5.564 ± 0.557
2.318GluMet: 2.318 ± 0.256
1.994GluAsn: 1.994 ± 0.322
2.365GluPro: 2.365 ± 0.311
3.802GluGln: 3.802 ± 0.49
2.365GluArg: 2.365 ± 0.407
3.06GluSer: 3.06 ± 0.326
2.875GluThr: 2.875 ± 0.321
4.219GluVal: 4.219 ± 0.402
0.788GluTrp: 0.788 ± 0.218
1.947GluTyr: 1.947 ± 0.27
0.0GluXaa: 0.0 ± 0.0
Phe
2.55PheAla: 2.55 ± 0.349
0.417PheCys: 0.417 ± 0.157
2.55PheAsp: 2.55 ± 0.297
1.298PheGlu: 1.298 ± 0.253
1.159PhePhe: 1.159 ± 0.241
2.597PheGly: 2.597 ± 0.319
0.51PheHis: 0.51 ± 0.171
1.808PheIle: 1.808 ± 0.198
2.133PheLys: 2.133 ± 0.31
1.994PheLeu: 1.994 ± 0.297
1.623PheMet: 1.623 ± 0.295
1.716PheAsn: 1.716 ± 0.367
1.159PhePro: 1.159 ± 0.197
1.345PheGln: 1.345 ± 0.227
1.947PheArg: 1.947 ± 0.318
2.087PheSer: 2.087 ± 0.346
2.643PheThr: 2.643 ± 0.38
2.318PheVal: 2.318 ± 0.419
0.417PheTrp: 0.417 ± 0.124
1.159PheTyr: 1.159 ± 0.197
0.0PheXaa: 0.0 ± 0.0
Gly
5.518GlyAla: 5.518 ± 0.597
0.371GlyCys: 0.371 ± 0.134
4.915GlyAsp: 4.915 ± 0.587
4.637GlyGlu: 4.637 ± 0.428
2.643GlyPhe: 2.643 ± 0.421
5.286GlyGly: 5.286 ± 0.684
1.159GlyHis: 1.159 ± 0.231
4.544GlyIle: 4.544 ± 0.384
4.729GlyLys: 4.729 ± 0.427
5.008GlyLeu: 5.008 ± 0.591
3.524GlyMet: 3.524 ± 0.334
4.173GlyAsn: 4.173 ± 0.401
1.947GlyPro: 1.947 ± 0.319
3.292GlyGln: 3.292 ± 0.318
3.756GlyArg: 3.756 ± 0.517
4.312GlySer: 4.312 ± 0.47
4.915GlyThr: 4.915 ± 0.392
3.988GlyVal: 3.988 ± 0.578
1.716GlyTrp: 1.716 ± 0.318
3.014GlyTyr: 3.014 ± 0.38
0.0GlyXaa: 0.0 ± 0.0
His
1.391HisAla: 1.391 ± 0.276
0.232HisCys: 0.232 ± 0.099
1.252HisAsp: 1.252 ± 0.172
1.159HisGlu: 1.159 ± 0.214
0.788HisPhe: 0.788 ± 0.257
1.252HisGly: 1.252 ± 0.314
0.51HisHis: 0.51 ± 0.193
1.02HisIle: 1.02 ± 0.261
1.159HisLys: 1.159 ± 0.242
1.808HisLeu: 1.808 ± 0.3
0.696HisMet: 0.696 ± 0.169
0.696HisAsn: 0.696 ± 0.159
0.927HisPro: 0.927 ± 0.237
0.974HisGln: 0.974 ± 0.236
1.066HisArg: 1.066 ± 0.205
1.02HisSer: 1.02 ± 0.189
0.603HisThr: 0.603 ± 0.136
0.835HisVal: 0.835 ± 0.247
0.371HisTrp: 0.371 ± 0.12
1.113HisTyr: 1.113 ± 0.231
0.0HisXaa: 0.0 ± 0.0
Ile
4.961IleAla: 4.961 ± 0.457
0.185IleCys: 0.185 ± 0.102
3.941IleAsp: 3.941 ± 0.427
3.802IleGlu: 3.802 ± 0.347
1.298IlePhe: 1.298 ± 0.205
3.338IleGly: 3.338 ± 0.424
1.252IleHis: 1.252 ± 0.253
3.014IleIle: 3.014 ± 0.544
3.292IleLys: 3.292 ± 0.333
2.828IleLeu: 2.828 ± 0.409
0.974IleMet: 0.974 ± 0.164
2.782IleAsn: 2.782 ± 0.372
2.365IlePro: 2.365 ± 0.326
1.947IleGln: 1.947 ± 0.269
2.318IleArg: 2.318 ± 0.307
2.272IleSer: 2.272 ± 0.272
4.127IleThr: 4.127 ± 0.54
3.338IleVal: 3.338 ± 0.508
0.51IleTrp: 0.51 ± 0.184
2.226IleTyr: 2.226 ± 0.305
0.0IleXaa: 0.0 ± 0.0
Lys
6.909LysAla: 6.909 ± 0.791
0.278LysCys: 0.278 ± 0.121
3.895LysAsp: 3.895 ± 0.463
4.312LysGlu: 4.312 ± 0.547
1.901LysPhe: 1.901 ± 0.302
3.617LysGly: 3.617 ± 0.562
1.345LysHis: 1.345 ± 0.306
2.875LysIle: 2.875 ± 0.377
3.663LysLys: 3.663 ± 0.488
6.074LysLeu: 6.074 ± 0.63
1.669LysMet: 1.669 ± 0.236
2.318LysAsn: 2.318 ± 0.228
2.55LysPro: 2.55 ± 0.416
3.199LysGln: 3.199 ± 0.451
2.457LysArg: 2.457 ± 0.417
3.524LysSer: 3.524 ± 0.356
3.848LysThr: 3.848 ± 0.443
5.239LysVal: 5.239 ± 0.412
0.788LysTrp: 0.788 ± 0.174
1.669LysTyr: 1.669 ± 0.276
0.0LysXaa: 0.0 ± 0.0
Leu
7.975LeuAla: 7.975 ± 0.755
0.464LeuCys: 0.464 ± 0.164
5.75LeuAsp: 5.75 ± 0.461
4.59LeuGlu: 4.59 ± 0.47
2.643LeuPhe: 2.643 ± 0.364
6.491LeuGly: 6.491 ± 0.518
1.623LeuHis: 1.623 ± 0.334
3.941LeuIle: 3.941 ± 0.37
4.729LeuLys: 4.729 ± 0.456
6.167LeuLeu: 6.167 ± 0.697
2.55LeuMet: 2.55 ± 0.31
4.451LeuAsn: 4.451 ± 0.4
4.312LeuPro: 4.312 ± 0.362
3.431LeuGln: 3.431 ± 0.439
4.08LeuArg: 4.08 ± 0.42
4.312LeuSer: 4.312 ± 0.645
5.008LeuThr: 5.008 ± 0.478
5.842LeuVal: 5.842 ± 0.53
0.974LeuTrp: 0.974 ± 0.214
2.226LeuTyr: 2.226 ± 0.334
0.046LeuXaa: 0.046 ± 0.047
Met
3.292MetAla: 3.292 ± 0.462
0.093MetCys: 0.093 ± 0.061
1.994MetAsp: 1.994 ± 0.253
1.623MetGlu: 1.623 ± 0.268
0.788MetPhe: 0.788 ± 0.207
1.669MetGly: 1.669 ± 0.206
0.696MetHis: 0.696 ± 0.195
1.855MetIle: 1.855 ± 0.321
1.576MetLys: 1.576 ± 0.284
2.828MetLeu: 2.828 ± 0.367
0.927MetMet: 0.927 ± 0.256
1.901MetAsn: 1.901 ± 0.282
1.252MetPro: 1.252 ± 0.208
1.669MetGln: 1.669 ± 0.288
1.623MetArg: 1.623 ± 0.198
2.689MetSer: 2.689 ± 0.384
2.457MetThr: 2.457 ± 0.306
1.808MetVal: 1.808 ± 0.321
0.464MetTrp: 0.464 ± 0.132
1.02MetTyr: 1.02 ± 0.219
0.0MetXaa: 0.0 ± 0.0
Asn
3.478AsnAla: 3.478 ± 0.312
0.185AsnCys: 0.185 ± 0.103
2.457AsnAsp: 2.457 ± 0.285
2.55AsnGlu: 2.55 ± 0.287
1.391AsnPhe: 1.391 ± 0.223
3.292AsnGly: 3.292 ± 0.402
0.974AsnHis: 0.974 ± 0.176
2.272AsnIle: 2.272 ± 0.388
2.226AsnLys: 2.226 ± 0.288
4.08AsnLeu: 4.08 ± 0.469
1.53AsnMet: 1.53 ± 0.309
2.133AsnAsn: 2.133 ± 0.379
3.524AsnPro: 3.524 ± 0.545
2.736AsnGln: 2.736 ± 0.36
2.736AsnArg: 2.736 ± 0.387
2.875AsnSer: 2.875 ± 0.312
2.736AsnThr: 2.736 ± 0.398
2.828AsnVal: 2.828 ± 0.396
0.927AsnTrp: 0.927 ± 0.232
1.901AsnTyr: 1.901 ± 0.266
0.0AsnXaa: 0.0 ± 0.0
Pro
4.034ProAla: 4.034 ± 0.485
0.371ProCys: 0.371 ± 0.132
2.597ProAsp: 2.597 ± 0.408
3.617ProGlu: 3.617 ± 0.451
1.947ProPhe: 1.947 ± 0.262
2.782ProGly: 2.782 ± 0.367
0.417ProHis: 0.417 ± 0.177
1.762ProIle: 1.762 ± 0.276
3.153ProLys: 3.153 ± 0.38
3.848ProLeu: 3.848 ± 0.372
1.437ProMet: 1.437 ± 0.212
1.716ProAsn: 1.716 ± 0.346
1.808ProPro: 1.808 ± 0.447
1.808ProGln: 1.808 ± 0.291
1.947ProArg: 1.947 ± 0.327
2.504ProSer: 2.504 ± 0.278
2.736ProThr: 2.736 ± 0.358
4.312ProVal: 4.312 ± 0.492
0.603ProTrp: 0.603 ± 0.192
1.298ProTyr: 1.298 ± 0.245
0.0ProXaa: 0.0 ± 0.0
Gln
5.471GlnAla: 5.471 ± 0.626
0.093GlnCys: 0.093 ± 0.073
2.179GlnAsp: 2.179 ± 0.308
2.782GlnGlu: 2.782 ± 0.328
1.391GlnPhe: 1.391 ± 0.222
3.617GlnGly: 3.617 ± 0.471
1.113GlnHis: 1.113 ± 0.238
2.087GlnIle: 2.087 ± 0.356
3.478GlnLys: 3.478 ± 0.357
3.802GlnLeu: 3.802 ± 0.424
1.994GlnMet: 1.994 ± 0.272
2.411GlnAsn: 2.411 ± 0.405
1.855GlnPro: 1.855 ± 0.262
2.597GlnGln: 2.597 ± 0.372
2.318GlnArg: 2.318 ± 0.42
3.014GlnSer: 3.014 ± 0.386
1.808GlnThr: 1.808 ± 0.262
3.478GlnVal: 3.478 ± 0.411
0.927GlnTrp: 0.927 ± 0.209
1.762GlnTyr: 1.762 ± 0.222
0.0GlnXaa: 0.0 ± 0.0
Arg
4.451ArgAla: 4.451 ± 0.661
0.278ArgCys: 0.278 ± 0.128
3.107ArgAsp: 3.107 ± 0.426
3.153ArgGlu: 3.153 ± 0.412
1.901ArgPhe: 1.901 ± 0.304
3.431ArgGly: 3.431 ± 0.406
0.603ArgHis: 0.603 ± 0.19
2.55ArgIle: 2.55 ± 0.375
2.736ArgLys: 2.736 ± 0.305
3.988ArgLeu: 3.988 ± 0.505
1.855ArgMet: 1.855 ± 0.314
2.04ArgAsn: 2.04 ± 0.295
1.669ArgPro: 1.669 ± 0.282
2.643ArgGln: 2.643 ± 0.347
2.272ArgArg: 2.272 ± 0.523
2.967ArgSer: 2.967 ± 0.353
2.457ArgThr: 2.457 ± 0.254
3.524ArgVal: 3.524 ± 0.416
0.696ArgTrp: 0.696 ± 0.191
1.252ArgTyr: 1.252 ± 0.272
0.0ArgXaa: 0.0 ± 0.0
Ser
5.1SerAla: 5.1 ± 0.471
0.51SerCys: 0.51 ± 0.18
3.663SerAsp: 3.663 ± 0.425
2.643SerGlu: 2.643 ± 0.375
1.716SerPhe: 1.716 ± 0.285
4.219SerGly: 4.219 ± 0.398
0.835SerHis: 0.835 ± 0.207
2.782SerIle: 2.782 ± 0.494
3.107SerLys: 3.107 ± 0.407
5.61SerLeu: 5.61 ± 0.569
1.345SerMet: 1.345 ± 0.215
2.736SerAsn: 2.736 ± 0.303
2.643SerPro: 2.643 ± 0.331
2.179SerGln: 2.179 ± 0.391
2.597SerArg: 2.597 ± 0.358
2.828SerSer: 2.828 ± 0.373
3.57SerThr: 3.57 ± 0.396
3.524SerVal: 3.524 ± 0.472
0.835SerTrp: 0.835 ± 0.18
1.947SerTyr: 1.947 ± 0.293
0.0SerXaa: 0.0 ± 0.0
Thr
5.425ThrAla: 5.425 ± 0.565
0.649ThrCys: 0.649 ± 0.211
3.941ThrAsp: 3.941 ± 0.466
3.431ThrGlu: 3.431 ± 0.339
2.133ThrPhe: 2.133 ± 0.226
4.683ThrGly: 4.683 ± 0.456
0.881ThrHis: 0.881 ± 0.241
2.921ThrIle: 2.921 ± 0.333
4.219ThrLys: 4.219 ± 0.32
4.683ThrLeu: 4.683 ± 0.404
1.762ThrMet: 1.762 ± 0.252
3.199ThrAsn: 3.199 ± 0.513
2.967ThrPro: 2.967 ± 0.295
2.365ThrGln: 2.365 ± 0.388
2.411ThrArg: 2.411 ± 0.268
2.736ThrSer: 2.736 ± 0.415
3.617ThrThr: 3.617 ± 0.376
4.127ThrVal: 4.127 ± 0.386
0.603ThrTrp: 0.603 ± 0.192
2.133ThrTyr: 2.133 ± 0.477
0.0ThrXaa: 0.0 ± 0.0
Val
6.723ValAla: 6.723 ± 1.04
0.742ValCys: 0.742 ± 0.196
3.895ValAsp: 3.895 ± 0.387
4.683ValGlu: 4.683 ± 0.416
2.133ValPhe: 2.133 ± 0.391
5.1ValGly: 5.1 ± 0.852
1.345ValHis: 1.345 ± 0.286
3.246ValIle: 3.246 ± 0.49
4.729ValLys: 4.729 ± 0.425
4.637ValLeu: 4.637 ± 0.435
2.457ValMet: 2.457 ± 0.33
3.431ValAsn: 3.431 ± 0.318
3.524ValPro: 3.524 ± 0.44
3.478ValGln: 3.478 ± 0.421
3.06ValArg: 3.06 ± 0.371
3.617ValSer: 3.617 ± 0.299
4.034ValThr: 4.034 ± 0.417
4.869ValVal: 4.869 ± 0.546
0.835ValTrp: 0.835 ± 0.203
1.855ValTyr: 1.855 ± 0.395
0.0ValXaa: 0.0 ± 0.0
Trp
1.206TrpAla: 1.206 ± 0.194
0.185TrpCys: 0.185 ± 0.112
1.159TrpAsp: 1.159 ± 0.271
0.788TrpGlu: 0.788 ± 0.212
0.696TrpPhe: 0.696 ± 0.175
1.484TrpGly: 1.484 ± 0.415
0.371TrpHis: 0.371 ± 0.118
0.835TrpIle: 0.835 ± 0.226
1.02TrpLys: 1.02 ± 0.207
1.53TrpLeu: 1.53 ± 0.309
0.232TrpMet: 0.232 ± 0.114
0.788TrpAsn: 0.788 ± 0.183
0.325TrpPro: 0.325 ± 0.126
0.51TrpGln: 0.51 ± 0.123
0.649TrpArg: 0.649 ± 0.191
0.649TrpSer: 0.649 ± 0.228
0.788TrpThr: 0.788 ± 0.326
1.113TrpVal: 1.113 ± 0.202
0.51TrpTrp: 0.51 ± 0.243
0.464TrpTyr: 0.464 ± 0.152
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.504TyrAla: 2.504 ± 0.288
0.185TyrCys: 0.185 ± 0.097
2.226TyrAsp: 2.226 ± 0.252
1.901TyrGlu: 1.901 ± 0.287
1.02TyrPhe: 1.02 ± 0.224
2.967TyrGly: 2.967 ± 0.387
0.927TyrHis: 0.927 ± 0.301
2.365TyrIle: 2.365 ± 0.302
2.226TyrLys: 2.226 ± 0.394
2.504TyrLeu: 2.504 ± 0.392
0.649TyrMet: 0.649 ± 0.182
1.901TyrAsn: 1.901 ± 0.275
1.576TyrPro: 1.576 ± 0.356
2.318TyrGln: 2.318 ± 0.346
1.484TyrArg: 1.484 ± 0.309
1.576TyrSer: 1.576 ± 0.244
1.484TyrThr: 1.484 ± 0.333
2.365TyrVal: 2.365 ± 0.329
0.603TyrTrp: 0.603 ± 0.209
0.835TyrTyr: 0.835 ± 0.166
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.046XaaVal: 0.046 ± 0.047
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (21568 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski