Amino acid dipepetide frequency for Saccharomyces arboricola (strain H-6 / AS 2.3317 / CBS 10644) (Yeast)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.204AlaAla: 4.204 ± 0.083	0.682AlaCys: 0.682 ± 0.022	2.662AlaAsp: 2.662 ± 0.044	3.05AlaGlu: 3.05 ± 0.05	2.272AlaPhe: 2.272 ± 0.039	2.946AlaGly: 2.946 ± 0.054	1.113AlaHis: 1.113 ± 0.025	3.596AlaIle: 3.596 ± 0.054	4.097AlaLys: 4.097 ± 0.054	5.434AlaLeu: 5.434 ± 0.064	1.295AlaMet: 1.295 ± 0.029	3.216AlaAsn: 3.216 ± 0.046	2.316AlaPro: 2.316 ± 0.045	2.246AlaGln: 2.246 ± 0.042	2.482AlaArg: 2.482 ± 0.043	4.955AlaSer: 4.955 ± 0.066	3.717AlaThr: 3.717 ± 0.059	3.272AlaVal: 3.272 ± 0.049	0.488AlaTrp: 0.488 ± 0.017	1.686AlaTyr: 1.686 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	0.639CysAla: 0.639 ± 0.018	0.281CysCys: 0.281 ± 0.013	0.671CysAsp: 0.671 ± 0.021	0.606CysGlu: 0.606 ± 0.018	0.65CysPhe: 0.65 ± 0.018	0.846CysGly: 0.846 ± 0.024	0.336CysHis: 0.336 ± 0.015	0.92CysIle: 0.92 ± 0.024	0.734CysLys: 0.734 ± 0.022	1.279CysLeu: 1.279 ± 0.027	0.259CysMet: 0.259 ± 0.012	0.595CysAsn: 0.595 ± 0.019	0.514CysPro: 0.514 ± 0.019	0.466CysGln: 0.466 ± 0.016	0.469CysArg: 0.469 ± 0.016	1.028CysSer: 1.028 ± 0.024	0.598CysThr: 0.598 ± 0.018	0.761CysVal: 0.761 ± 0.022	0.142CysTrp: 0.142 ± 0.01	0.46CysTyr: 0.46 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.264AspAla: 3.264 ± 0.045	0.648AspCys: 0.648 ± 0.019	4.856AspAsp: 4.856 ± 0.087	5.066AspGlu: 5.066 ± 0.067	2.797AspPhe: 2.797 ± 0.041	3.041AspGly: 3.041 ± 0.046	1.14AspHis: 1.14 ± 0.025	4.28AspIle: 4.28 ± 0.055	3.631AspLys: 3.631 ± 0.054	5.811AspLeu: 5.811 ± 0.055	1.268AspMet: 1.268 ± 0.029	3.406AspAsn: 3.406 ± 0.049	2.472AspPro: 2.472 ± 0.032	1.837AspGln: 1.837 ± 0.035	2.145AspArg: 2.145 ± 0.034	4.862AspSer: 4.862 ± 0.052	3.087AspThr: 3.087 ± 0.046	3.565AspVal: 3.565 ± 0.048	0.659AspTrp: 0.659 ± 0.018	2.144AspTyr: 2.144 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	3.464GluAla: 3.464 ± 0.052	0.644GluCys: 0.644 ± 0.02	4.481GluAsp: 4.481 ± 0.063	5.972GluGlu: 5.972 ± 0.103	2.765GluPhe: 2.765 ± 0.045	2.767GluGly: 2.767 ± 0.042	1.292GluHis: 1.292 ± 0.03	4.327GluIle: 4.327 ± 0.059	5.148GluLys: 5.148 ± 0.065	6.361GluLeu: 6.361 ± 0.067	1.387GluMet: 1.387 ± 0.025	4.422GluAsn: 4.422 ± 0.055	2.091GluPro: 2.091 ± 0.036	2.663GluGln: 2.663 ± 0.044	2.971GluArg: 2.971 ± 0.046	4.649GluSer: 4.649 ± 0.06	3.712GluThr: 3.712 ± 0.048	3.396GluVal: 3.396 ± 0.055	0.66GluTrp: 0.66 ± 0.018	2.227GluTyr: 2.227 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	2.461PheAla: 2.461 ± 0.046	0.532PheCys: 0.532 ± 0.018	2.783PheAsp: 2.783 ± 0.034	2.8PheGlu: 2.8 ± 0.045	2.059PhePhe: 2.059 ± 0.04	2.567PheGly: 2.567 ± 0.043	1.02PheHis: 1.02 ± 0.025	3.019PheIle: 3.019 ± 0.049	3.077PheLys: 3.077 ± 0.047	4.207PheLeu: 4.207 ± 0.056	0.935PheMet: 0.935 ± 0.023	2.635PheAsn: 2.635 ± 0.042	1.898PhePro: 1.898 ± 0.038	2.02PheGln: 2.02 ± 0.035	1.623PheArg: 1.623 ± 0.031	3.536PheSer: 3.536 ± 0.057	2.511PheThr: 2.511 ± 0.043	2.556PheVal: 2.556 ± 0.043	0.516PheTrp: 0.516 ± 0.015	1.574PheTyr: 1.574 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	2.95GlyAla: 2.95 ± 0.056	0.706GlyCys: 0.706 ± 0.022	2.858GlyAsp: 2.858 ± 0.042	2.982GlyGlu: 2.982 ± 0.043	2.435GlyPhe: 2.435 ± 0.039	3.299GlyGly: 3.299 ± 0.064	1.165GlyHis: 1.165 ± 0.029	3.511GlyIle: 3.511 ± 0.051	3.777GlyLys: 3.777 ± 0.046	4.596GlyLeu: 4.596 ± 0.061	1.015GlyMet: 1.015 ± 0.025	2.951GlyAsn: 2.951 ± 0.046	1.718GlyPro: 1.718 ± 0.035	1.718GlyGln: 1.718 ± 0.038	2.124GlyArg: 2.124 ± 0.04	4.697GlySer: 4.697 ± 0.052	3.071GlyThr: 3.071 ± 0.05	3.118GlyVal: 3.118 ± 0.053	0.581GlyTrp: 0.581 ± 0.021	1.851GlyTyr: 1.851 ± 0.033	0.0GlyXaa: 0.0 ± 0.0
His	1.064HisAla: 1.064 ± 0.023	0.323HisCys: 0.323 ± 0.012	1.27HisAsp: 1.27 ± 0.029	1.296HisGlu: 1.296 ± 0.028	0.956HisPhe: 0.956 ± 0.022	1.187HisGly: 1.187 ± 0.027	0.72HisHis: 0.72 ± 0.025	1.389HisIle: 1.389 ± 0.03	1.264HisLys: 1.264 ± 0.025	2.131HisLeu: 2.131 ± 0.039	0.432HisMet: 0.432 ± 0.016	1.155HisAsn: 1.155 ± 0.028	1.105HisPro: 1.105 ± 0.025	0.859HisGln: 0.859 ± 0.024	1.023HisArg: 1.023 ± 0.025	1.9HisSer: 1.9 ± 0.034	1.105HisThr: 1.105 ± 0.028	1.218HisVal: 1.218 ± 0.025	0.25HisTrp: 0.25 ± 0.012	0.79HisTyr: 0.79 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	3.559IleAla: 3.559 ± 0.051	0.902IleCys: 0.902 ± 0.025	4.098IleAsp: 4.098 ± 0.048	4.021IleGlu: 4.021 ± 0.052	3.0IlePhe: 3.0 ± 0.048	3.118IleGly: 3.118 ± 0.047	1.333IleHis: 1.333 ± 0.027	4.255IleIle: 4.255 ± 0.055	4.527IleLys: 4.527 ± 0.053	6.382IleLeu: 6.382 ± 0.07	1.376IleMet: 1.376 ± 0.03	3.835IleAsn: 3.835 ± 0.059	3.276IlePro: 3.276 ± 0.049	2.395IleGln: 2.395 ± 0.038	2.789IleArg: 2.789 ± 0.043	5.839IleSer: 5.839 ± 0.061	3.752IleThr: 3.752 ± 0.045	3.714IleVal: 3.714 ± 0.051	0.745IleTrp: 0.745 ± 0.02	2.03IleTyr: 2.03 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.561LysAla: 3.561 ± 0.055	0.824LysCys: 0.824 ± 0.026	4.238LysAsp: 4.238 ± 0.058	5.231LysGlu: 5.231 ± 0.081	3.281LysPhe: 3.281 ± 0.047	3.032LysGly: 3.032 ± 0.04	1.499LysHis: 1.499 ± 0.029	4.805LysIle: 4.805 ± 0.062	6.517LysLys: 6.517 ± 0.09	7.154LysLeu: 7.154 ± 0.071	1.446LysMet: 1.446 ± 0.029	4.479LysAsn: 4.479 ± 0.058	2.944LysPro: 2.944 ± 0.042	2.866LysGln: 2.866 ± 0.044	3.914LysArg: 3.914 ± 0.054	5.47LysSer: 5.47 ± 0.064	3.982LysThr: 3.982 ± 0.05	3.885LysVal: 3.885 ± 0.046	0.754LysTrp: 0.754 ± 0.019	2.682LysTyr: 2.682 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	5.331LeuAla: 5.331 ± 0.059	1.271LeuCys: 1.271 ± 0.029	5.539LeuAsp: 5.539 ± 0.055	6.138LeuGlu: 6.138 ± 0.072	4.129LeuPhe: 4.129 ± 0.061	4.538LeuGly: 4.538 ± 0.055	2.076LeuHis: 2.076 ± 0.033	5.764LeuIle: 5.764 ± 0.064	7.471LeuLys: 7.471 ± 0.078	9.458LeuLeu: 9.458 ± 0.089	1.968LeuMet: 1.968 ± 0.032	5.809LeuAsn: 5.809 ± 0.063	4.656LeuPro: 4.656 ± 0.057	4.525LeuGln: 4.525 ± 0.055	4.439LeuArg: 4.439 ± 0.052	8.327LeuSer: 8.327 ± 0.073	5.314LeuThr: 5.314 ± 0.054	5.179LeuVal: 5.179 ± 0.063	0.893LeuTrp: 0.893 ± 0.023	3.104LeuTyr: 3.104 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.411MetAla: 1.411 ± 0.027	0.253MetCys: 0.253 ± 0.012	1.38MetAsp: 1.38 ± 0.027	1.369MetGlu: 1.369 ± 0.027	0.883MetPhe: 0.883 ± 0.022	1.228MetGly: 1.228 ± 0.028	0.38MetHis: 0.38 ± 0.016	1.258MetIle: 1.258 ± 0.03	1.57MetLys: 1.57 ± 0.029	1.766MetLeu: 1.766 ± 0.036	0.501MetMet: 0.501 ± 0.019	1.365MetAsn: 1.365 ± 0.025	0.816MetPro: 0.816 ± 0.022	0.7MetGln: 0.7 ± 0.02	0.806MetArg: 0.806 ± 0.02	1.97MetSer: 1.97 ± 0.035	1.236MetThr: 1.236 ± 0.025	1.233MetVal: 1.233 ± 0.026	0.18MetTrp: 0.18 ± 0.011	0.578MetTyr: 0.578 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.263AsnAla: 3.263 ± 0.041	0.687AsnCys: 0.687 ± 0.021	4.217AsnAsp: 4.217 ± 0.058	4.329AsnGlu: 4.329 ± 0.049	2.554AsnPhe: 2.554 ± 0.037	3.604AsnGly: 3.604 ± 0.047	1.228AsnHis: 1.228 ± 0.028	3.933AsnIle: 3.933 ± 0.057	4.156AsnLys: 4.156 ± 0.056	5.228AsnLeu: 5.228 ± 0.062	1.255AsnMet: 1.255 ± 0.027	4.847AsnAsn: 4.847 ± 0.127	2.471AsnPro: 2.471 ± 0.045	1.993AsnGln: 1.993 ± 0.037	2.184AsnArg: 2.184 ± 0.035	5.678AsnSer: 5.678 ± 0.08	3.457AsnThr: 3.457 ± 0.055	3.466AsnVal: 3.466 ± 0.045	0.657AsnTrp: 0.657 ± 0.019	1.933AsnTyr: 1.933 ± 0.036	0.0AsnXaa: 0.0 ± 0.0
Pro	2.265ProAla: 2.265 ± 0.038	0.374ProCys: 0.374 ± 0.015	2.214ProAsp: 2.214 ± 0.039	2.94ProGlu: 2.94 ± 0.043	1.893ProPhe: 1.893 ± 0.038	2.0ProGly: 2.0 ± 0.039	0.966ProHis: 0.966 ± 0.023	2.868ProIle: 2.868 ± 0.044	2.856ProLys: 2.856 ± 0.04	4.153ProLeu: 4.153 ± 0.049	0.826ProMet: 0.826 ± 0.023	2.505ProAsn: 2.505 ± 0.042	2.401ProPro: 2.401 ± 0.066	2.004ProGln: 2.004 ± 0.048	1.837ProArg: 1.837 ± 0.033	4.1ProSer: 4.1 ± 0.066	2.796ProThr: 2.796 ± 0.044	2.576ProVal: 2.576 ± 0.039	0.42ProTrp: 0.42 ± 0.016	1.372ProTyr: 1.372 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	2.008GlnAla: 2.008 ± 0.044	0.427GlnCys: 0.427 ± 0.015	2.277GlnAsp: 2.277 ± 0.038	2.834GlnGlu: 2.834 ± 0.043	1.771GlnPhe: 1.771 ± 0.029	1.833GlnGly: 1.833 ± 0.029	0.86GlnHis: 0.86 ± 0.022	2.487GlnIle: 2.487 ± 0.038	2.696GlnLys: 2.696 ± 0.043	4.13GlnLeu: 4.13 ± 0.057	0.854GlnMet: 0.854 ± 0.018	2.439GlnAsn: 2.439 ± 0.043	1.702GlnPro: 1.702 ± 0.04	3.179GlnGln: 3.179 ± 0.142	2.077GlnArg: 2.077 ± 0.04	2.942GlnSer: 2.942 ± 0.041	2.067GlnThr: 2.067 ± 0.04	2.144GlnVal: 2.144 ± 0.039	0.427GlnTrp: 0.427 ± 0.014	1.404GlnTyr: 1.404 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	2.302ArgAla: 2.302 ± 0.037	0.573ArgCys: 0.573 ± 0.018	2.519ArgAsp: 2.519 ± 0.041	2.807ArgGlu: 2.807 ± 0.044	1.953ArgPhe: 1.953 ± 0.037	2.159ArgGly: 2.159 ± 0.052	1.022ArgHis: 1.022 ± 0.024	2.916ArgIle: 2.916 ± 0.038	3.61ArgLys: 3.61 ± 0.056	4.198ArgLeu: 4.198 ± 0.051	0.927ArgMet: 0.927 ± 0.023	2.684ArgAsn: 2.684 ± 0.045	1.675ArgPro: 1.675 ± 0.033	1.781ArgGln: 1.781 ± 0.034	2.736ArgArg: 2.736 ± 0.045	3.629ArgSer: 3.629 ± 0.05	2.345ArgThr: 2.345 ± 0.038	2.289ArgVal: 2.289 ± 0.036	0.479ArgTrp: 0.479 ± 0.017	1.549ArgTyr: 1.549 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	4.639SerAla: 4.639 ± 0.061	0.938SerCys: 0.938 ± 0.023	4.524SerAsp: 4.524 ± 0.054	4.555SerGlu: 4.555 ± 0.05	3.718SerPhe: 3.718 ± 0.046	4.366SerGly: 4.366 ± 0.061	1.931SerHis: 1.931 ± 0.036	5.596SerIle: 5.596 ± 0.063	6.45SerLys: 6.45 ± 0.069	8.451SerLeu: 8.451 ± 0.079	1.855SerMet: 1.855 ± 0.035	5.66SerAsn: 5.66 ± 0.079	3.812SerPro: 3.812 ± 0.066	3.501SerGln: 3.501 ± 0.049	3.762SerArg: 3.762 ± 0.052	10.306SerSer: 10.306 ± 0.184	5.764SerThr: 5.764 ± 0.085	4.693SerVal: 4.693 ± 0.05	0.828SerTrp: 0.828 ± 0.021	2.477SerTyr: 2.477 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	3.578ThrAla: 3.578 ± 0.052	0.645ThrCys: 0.645 ± 0.023	3.052ThrAsp: 3.052 ± 0.048	3.199ThrGlu: 3.199 ± 0.049	2.47ThrPhe: 2.47 ± 0.033	3.173ThrGly: 3.173 ± 0.046	1.2ThrHis: 1.2 ± 0.025	3.746ThrIle: 3.746 ± 0.046	4.014ThrLys: 4.014 ± 0.05	5.561ThrLeu: 5.561 ± 0.064	1.138ThrMet: 1.138 ± 0.026	3.466ThrAsn: 3.466 ± 0.054	3.022ThrPro: 3.022 ± 0.046	1.949ThrGln: 1.949 ± 0.03	2.435ThrArg: 2.435 ± 0.04	5.567ThrSer: 5.567 ± 0.073	4.154ThrThr: 4.154 ± 0.068	3.578ThrVal: 3.578 ± 0.047	0.565ThrTrp: 0.565 ± 0.021	1.668ThrTyr: 1.668 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	3.514ValAla: 3.514 ± 0.053	0.76ValCys: 0.76 ± 0.022	3.531ValAsp: 3.531 ± 0.045	3.552ValGlu: 3.552 ± 0.049	2.561ValPhe: 2.561 ± 0.042	3.005ValGly: 3.005 ± 0.047	1.177ValHis: 1.177 ± 0.027	3.613ValIle: 3.613 ± 0.045	3.877ValLys: 3.877 ± 0.045	5.404ValLeu: 5.404 ± 0.054	1.184ValMet: 1.184 ± 0.027	3.124ValAsn: 3.124 ± 0.041	2.795ValPro: 2.795 ± 0.04	2.097ValGln: 2.097 ± 0.034	2.393ValArg: 2.393 ± 0.041	4.852ValSer: 4.852 ± 0.053	3.202ValThr: 3.202 ± 0.046	3.694ValVal: 3.694 ± 0.052	0.564ValTrp: 0.564 ± 0.018	1.847ValTyr: 1.847 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	0.54TrpAla: 0.54 ± 0.017	0.238TrpCys: 0.238 ± 0.012	0.681TrpAsp: 0.681 ± 0.023	0.631TrpGlu: 0.631 ± 0.02	0.51TrpPhe: 0.51 ± 0.017	0.516TrpGly: 0.516 ± 0.02	0.205TrpHis: 0.205 ± 0.01	0.634TrpIle: 0.634 ± 0.021	0.877TrpLys: 0.877 ± 0.023	0.962TrpLeu: 0.962 ± 0.022	0.229TrpMet: 0.229 ± 0.011	0.659TrpAsn: 0.659 ± 0.02	0.299TrpPro: 0.299 ± 0.014	0.413TrpGln: 0.413 ± 0.015	0.51TrpArg: 0.51 ± 0.018	0.849TrpSer: 0.849 ± 0.019	0.533TrpThr: 0.533 ± 0.017	0.542TrpVal: 0.542 ± 0.019	0.14TrpTrp: 0.14 ± 0.01	0.373TrpTyr: 0.373 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.713TyrAla: 1.713 ± 0.035	0.546TyrCys: 0.546 ± 0.019	2.13TyrAsp: 2.13 ± 0.038	2.022TyrGlu: 2.022 ± 0.032	1.671TyrPhe: 1.671 ± 0.032	1.898TyrGly: 1.898 ± 0.038	0.776TyrHis: 0.776 ± 0.02	2.026TyrIle: 2.026 ± 0.032	2.216TyrLys: 2.216 ± 0.033	3.26TyrLeu: 3.26 ± 0.047	0.732TyrMet: 0.732 ± 0.018	1.888TyrAsn: 1.888 ± 0.037	1.385TyrPro: 1.385 ± 0.029	1.348TyrGln: 1.348 ± 0.031	1.432TyrArg: 1.432 ± 0.031	2.668TyrSer: 2.668 ± 0.05	1.779TyrThr: 1.779 ± 0.032	1.868TyrVal: 1.868 ± 0.033	0.393TyrTrp: 0.393 ± 0.017	1.356TyrTyr: 1.356 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3653 proteins (1820601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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