Amino acid dipepetide frequency for Amycolatopsis keratiniphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.106AlaAla: 19.106 ± 0.134	0.967AlaCys: 0.967 ± 0.021	7.838AlaAsp: 7.838 ± 0.061	9.31AlaGlu: 9.31 ± 0.079	3.627AlaPhe: 3.627 ± 0.037	12.816AlaGly: 12.816 ± 0.089	2.389AlaHis: 2.389 ± 0.031	4.609AlaIle: 4.609 ± 0.056	3.841AlaLys: 3.841 ± 0.056	13.762AlaLeu: 13.762 ± 0.105	2.499AlaMet: 2.499 ± 0.035	2.357AlaAsn: 2.357 ± 0.033	5.951AlaPro: 5.951 ± 0.063	3.335AlaGln: 3.335 ± 0.04	8.823AlaArg: 8.823 ± 0.07	6.034AlaSer: 6.034 ± 0.053	6.818AlaThr: 6.818 ± 0.059	11.338AlaVal: 11.338 ± 0.078	1.818AlaTrp: 1.818 ± 0.03	2.412AlaTyr: 2.412 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.966CysAla: 0.966 ± 0.02	0.087CysCys: 0.087 ± 0.005	0.416CysAsp: 0.416 ± 0.012	0.397CysGlu: 0.397 ± 0.013	0.219CysPhe: 0.219 ± 0.01	0.905CysGly: 0.905 ± 0.019	0.177CysHis: 0.177 ± 0.009	0.137CysIle: 0.137 ± 0.007	0.125CysLys: 0.125 ± 0.007	0.719CysLeu: 0.719 ± 0.018	0.101CysMet: 0.101 ± 0.007	0.126CysAsn: 0.126 ± 0.008	0.446CysPro: 0.446 ± 0.014	0.17CysGln: 0.17 ± 0.008	0.535CysArg: 0.535 ± 0.014	0.464CysSer: 0.464 ± 0.014	0.446CysThr: 0.446 ± 0.014	0.628CysVal: 0.628 ± 0.017	0.121CysTrp: 0.121 ± 0.007	0.159CysTyr: 0.159 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.072AspAla: 7.072 ± 0.061	0.383AspCys: 0.383 ± 0.013	3.533AspAsp: 3.533 ± 0.041	4.154AspGlu: 4.154 ± 0.05	1.741AspPhe: 1.741 ± 0.027	6.312AspGly: 6.312 ± 0.066	1.295AspHis: 1.295 ± 0.022	1.972AspIle: 1.972 ± 0.029	1.391AspLys: 1.391 ± 0.025	6.428AspLeu: 6.428 ± 0.061	0.732AspMet: 0.732 ± 0.017	1.018AspAsn: 1.018 ± 0.024	4.252AspPro: 4.252 ± 0.049	1.593AspGln: 1.593 ± 0.026	4.683AspArg: 4.683 ± 0.051	2.476AspSer: 2.476 ± 0.032	2.934AspThr: 2.934 ± 0.037	5.261AspVal: 5.261 ± 0.048	0.917AspTrp: 0.917 ± 0.019	1.152AspTyr: 1.152 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.193GluAla: 7.193 ± 0.073	0.351GluCys: 0.351 ± 0.01	2.982GluAsp: 2.982 ± 0.04	3.285GluGlu: 3.285 ± 0.04	1.879GluPhe: 1.879 ± 0.03	4.052GluGly: 4.052 ± 0.049	1.611GluHis: 1.611 ± 0.027	2.808GluIle: 2.808 ± 0.031	1.73GluLys: 1.73 ± 0.029	7.47GluLeu: 7.47 ± 0.069	0.936GluMet: 0.936 ± 0.017	1.277GluAsn: 1.277 ± 0.021	3.579GluPro: 3.579 ± 0.044	2.18GluGln: 2.18 ± 0.031	5.372GluArg: 5.372 ± 0.042	2.743GluSer: 2.743 ± 0.036	3.299GluThr: 3.299 ± 0.036	4.863GluVal: 4.863 ± 0.055	0.794GluTrp: 0.794 ± 0.017	1.152GluTyr: 1.152 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.185PheAla: 4.185 ± 0.052	0.278PheCys: 0.278 ± 0.009	2.225PheAsp: 2.225 ± 0.036	1.631PheGlu: 1.631 ± 0.026	0.971PhePhe: 0.971 ± 0.022	3.516PheGly: 3.516 ± 0.039	0.61PheHis: 0.61 ± 0.015	0.759PheIle: 0.759 ± 0.017	0.554PheLys: 0.554 ± 0.014	2.859PheLeu: 2.859 ± 0.034	0.365PheMet: 0.365 ± 0.013	0.571PheAsn: 0.571 ± 0.017	1.46PhePro: 1.46 ± 0.023	0.703PheGln: 0.703 ± 0.016	1.955PheArg: 1.955 ± 0.027	1.762PheSer: 1.762 ± 0.029	2.103PheThr: 2.103 ± 0.032	2.674PheVal: 2.674 ± 0.034	0.453PheTrp: 0.453 ± 0.014	0.633PheTyr: 0.633 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.03GlyAla: 10.03 ± 0.067	0.782GlyCys: 0.782 ± 0.018	5.251GlyAsp: 5.251 ± 0.053	5.632GlyGlu: 5.632 ± 0.049	3.281GlyPhe: 3.281 ± 0.039	8.567GlyGly: 8.567 ± 0.096	2.1GlyHis: 2.1 ± 0.029	3.815GlyIle: 3.815 ± 0.046	3.169GlyLys: 3.169 ± 0.039	9.664GlyLeu: 9.664 ± 0.066	2.019GlyMet: 2.019 ± 0.025	1.983GlyAsn: 1.983 ± 0.032	4.617GlyPro: 4.617 ± 0.053	2.697GlyGln: 2.697 ± 0.039	6.787GlyArg: 6.787 ± 0.049	5.121GlySer: 5.121 ± 0.057	5.816GlyThr: 5.816 ± 0.057	7.915GlyVal: 7.915 ± 0.062	1.785GlyTrp: 1.785 ± 0.027	2.353GlyTyr: 2.353 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	2.414HisAla: 2.414 ± 0.034	0.206HisCys: 0.206 ± 0.009	1.292HisAsp: 1.292 ± 0.024	1.207HisGlu: 1.207 ± 0.023	0.621HisPhe: 0.621 ± 0.016	2.207HisGly: 2.207 ± 0.031	0.648HisHis: 0.648 ± 0.02	0.603HisIle: 0.603 ± 0.013	0.364HisLys: 0.364 ± 0.01	2.183HisLeu: 2.183 ± 0.028	0.255HisMet: 0.255 ± 0.01	0.398HisAsn: 0.398 ± 0.013	1.508HisPro: 1.508 ± 0.028	0.583HisGln: 0.583 ± 0.016	1.867HisArg: 1.867 ± 0.029	0.954HisSer: 0.954 ± 0.021	1.081HisThr: 1.081 ± 0.02	1.646HisVal: 1.646 ± 0.026	0.364HisTrp: 0.364 ± 0.012	0.488HisTyr: 0.488 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.585IleAla: 5.585 ± 0.053	0.281IleCys: 0.281 ± 0.011	2.594IleAsp: 2.594 ± 0.033	2.391IleGlu: 2.391 ± 0.031	0.848IlePhe: 0.848 ± 0.02	4.166IleGly: 4.166 ± 0.051	0.627IleHis: 0.627 ± 0.015	1.037IleIle: 1.037 ± 0.025	0.857IleLys: 0.857 ± 0.018	2.843IleLeu: 2.843 ± 0.043	0.466IleMet: 0.466 ± 0.014	0.759IleAsn: 0.759 ± 0.018	2.059IlePro: 2.059 ± 0.031	0.814IleGln: 0.814 ± 0.02	2.456IleArg: 2.456 ± 0.035	1.998IleSer: 1.998 ± 0.03	2.518IleThr: 2.518 ± 0.03	3.239IleVal: 3.239 ± 0.041	0.415IleTrp: 0.415 ± 0.011	0.592IleTyr: 0.592 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.328LysAla: 3.328 ± 0.045	0.12LysCys: 0.12 ± 0.007	1.371LysAsp: 1.371 ± 0.025	1.281LysGlu: 1.281 ± 0.025	0.703LysPhe: 0.703 ± 0.017	1.818LysGly: 1.818 ± 0.032	0.546LysHis: 0.546 ± 0.014	1.255LysIle: 1.255 ± 0.022	0.872LysLys: 0.872 ± 0.023	2.793LysLeu: 2.793 ± 0.037	0.471LysMet: 0.471 ± 0.013	0.629LysAsn: 0.629 ± 0.018	1.825LysPro: 1.825 ± 0.029	0.805LysGln: 0.805 ± 0.02	1.798LysArg: 1.798 ± 0.031	1.352LysSer: 1.352 ± 0.026	1.711LysThr: 1.711 ± 0.027	2.316LysVal: 2.316 ± 0.034	0.343LysTrp: 0.343 ± 0.011	0.541LysTyr: 0.541 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	15.368LeuAla: 15.368 ± 0.101	0.786LeuCys: 0.786 ± 0.019	6.878LeuAsp: 6.878 ± 0.054	5.077LeuGlu: 5.077 ± 0.061	2.903LeuPhe: 2.903 ± 0.032	9.699LeuGly: 9.699 ± 0.07	2.041LeuHis: 2.041 ± 0.03	3.767LeuIle: 3.767 ± 0.049	2.282LeuLys: 2.282 ± 0.034	11.048LeuLeu: 11.048 ± 0.096	1.549LeuMet: 1.549 ± 0.026	1.922LeuAsn: 1.922 ± 0.026	6.372LeuPro: 6.372 ± 0.056	2.041LeuGln: 2.041 ± 0.028	8.516LeuArg: 8.516 ± 0.076	5.916LeuSer: 5.916 ± 0.041	6.654LeuThr: 6.654 ± 0.06	9.287LeuVal: 9.287 ± 0.062	1.298LeuTrp: 1.298 ± 0.025	1.719LeuTyr: 1.719 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.144MetAla: 2.144 ± 0.034	0.109MetCys: 0.109 ± 0.006	0.832MetAsp: 0.832 ± 0.016	0.653MetGlu: 0.653 ± 0.018	0.511MetPhe: 0.511 ± 0.014	1.213MetGly: 1.213 ± 0.024	0.297MetHis: 0.297 ± 0.011	0.777MetIle: 0.777 ± 0.021	0.475MetLys: 0.475 ± 0.014	1.795MetLeu: 1.795 ± 0.026	0.318MetMet: 0.318 ± 0.012	0.431MetAsn: 0.431 ± 0.011	1.116MetPro: 1.116 ± 0.021	0.378MetGln: 0.378 ± 0.013	1.388MetArg: 1.388 ± 0.024	1.261MetSer: 1.261 ± 0.021	1.577MetThr: 1.577 ± 0.024	1.328MetVal: 1.328 ± 0.023	0.188MetTrp: 0.188 ± 0.008	0.291MetTyr: 0.291 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.461AsnAla: 2.461 ± 0.037	0.179AsnCys: 0.179 ± 0.009	1.07AsnAsp: 1.07 ± 0.025	0.971AsnGlu: 0.971 ± 0.02	0.561AsnPhe: 0.561 ± 0.015	2.157AsnGly: 2.157 ± 0.032	0.405AsnHis: 0.405 ± 0.012	0.661AsnIle: 0.661 ± 0.018	0.464AsnLys: 0.464 ± 0.015	1.947AsnLeu: 1.947 ± 0.032	0.291AsnMet: 0.291 ± 0.012	0.465AsnAsn: 0.465 ± 0.016	1.561AsnPro: 1.561 ± 0.028	0.572AsnGln: 0.572 ± 0.016	1.368AsnArg: 1.368 ± 0.021	0.992AsnSer: 0.992 ± 0.02	1.205AsnThr: 1.205 ± 0.027	1.603AsnVal: 1.603 ± 0.024	0.32AsnTrp: 0.32 ± 0.012	0.445AsnTyr: 0.445 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	7.753ProAla: 7.753 ± 0.069	0.332ProCys: 0.332 ± 0.011	4.167ProAsp: 4.167 ± 0.047	4.426ProGlu: 4.426 ± 0.043	1.598ProPhe: 1.598 ± 0.027	6.364ProGly: 6.364 ± 0.058	1.094ProHis: 1.094 ± 0.02	1.751ProIle: 1.751 ± 0.024	1.562ProLys: 1.562 ± 0.026	5.088ProLeu: 5.088 ± 0.051	1.025ProMet: 1.025 ± 0.019	1.086ProAsn: 1.086 ± 0.025	3.408ProPro: 3.408 ± 0.06	1.493ProGln: 1.493 ± 0.029	3.509ProArg: 3.509 ± 0.04	3.43ProSer: 3.43 ± 0.041	2.832ProThr: 2.832 ± 0.034	5.34ProVal: 5.34 ± 0.05	0.834ProTrp: 0.834 ± 0.017	1.115ProTyr: 1.115 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.667GlnAla: 3.667 ± 0.041	0.164GlnCys: 0.164 ± 0.009	1.221GlnAsp: 1.221 ± 0.024	1.269GlnGlu: 1.269 ± 0.023	0.749GlnPhe: 0.749 ± 0.016	2.088GlnGly: 2.088 ± 0.034	0.56GlnHis: 0.56 ± 0.015	1.067GlnIle: 1.067 ± 0.021	0.608GlnLys: 0.608 ± 0.016	2.926GlnLeu: 2.926 ± 0.038	0.422GlnMet: 0.422 ± 0.012	0.556GlnAsn: 0.556 ± 0.015	1.632GlnPro: 1.632 ± 0.035	1.149GlnGln: 1.149 ± 0.033	2.376GlnArg: 2.376 ± 0.033	1.177GlnSer: 1.177 ± 0.022	1.256GlnThr: 1.256 ± 0.02	2.456GlnVal: 2.456 ± 0.031	0.436GlnTrp: 0.436 ± 0.014	0.565GlnTyr: 0.565 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	8.723ArgAla: 8.723 ± 0.073	0.512ArgCys: 0.512 ± 0.014	4.118ArgAsp: 4.118 ± 0.039	4.858ArgGlu: 4.858 ± 0.052	2.58ArgPhe: 2.58 ± 0.034	5.466ArgGly: 5.466 ± 0.048	1.805ArgHis: 1.805 ± 0.029	3.23ArgIle: 3.23 ± 0.036	2.091ArgLys: 2.091 ± 0.032	8.449ArgLeu: 8.449 ± 0.073	1.717ArgMet: 1.717 ± 0.024	1.482ArgAsn: 1.482 ± 0.026	4.332ArgPro: 4.332 ± 0.047	2.106ArgGln: 2.106 ± 0.032	7.013ArgArg: 7.013 ± 0.073	3.882ArgSer: 3.882 ± 0.043	4.535ArgThr: 4.535 ± 0.043	5.818ArgVal: 5.818 ± 0.05	1.336ArgTrp: 1.336 ± 0.024	1.786ArgTyr: 1.786 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.745SerAla: 6.745 ± 0.053	0.416SerCys: 0.416 ± 0.013	2.702SerAsp: 2.702 ± 0.031	2.721SerGlu: 2.721 ± 0.043	1.685SerPhe: 1.685 ± 0.027	6.047SerGly: 6.047 ± 0.054	0.945SerHis: 0.945 ± 0.02	1.792SerIle: 1.792 ± 0.027	1.189SerLys: 1.189 ± 0.023	5.116SerLeu: 5.116 ± 0.049	1.139SerMet: 1.139 ± 0.024	0.946SerAsn: 0.946 ± 0.021	3.171SerPro: 3.171 ± 0.038	1.256SerGln: 1.256 ± 0.023	3.793SerArg: 3.793 ± 0.04	3.065SerSer: 3.065 ± 0.045	3.245SerThr: 3.245 ± 0.034	4.568SerVal: 4.568 ± 0.044	0.973SerTrp: 0.973 ± 0.021	1.156SerTyr: 1.156 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	7.929ThrAla: 7.929 ± 0.061	0.425ThrCys: 0.425 ± 0.013	3.289ThrAsp: 3.289 ± 0.035	3.51ThrGlu: 3.51 ± 0.037	1.798ThrPhe: 1.798 ± 0.027	6.426ThrGly: 6.426 ± 0.057	1.037ThrHis: 1.037 ± 0.02	2.161ThrIle: 2.161 ± 0.029	1.528ThrLys: 1.528 ± 0.026	5.638ThrLeu: 5.638 ± 0.042	0.998ThrMet: 0.998 ± 0.019	1.055ThrAsn: 1.055 ± 0.022	3.828ThrPro: 3.828 ± 0.048	1.306ThrGln: 1.306 ± 0.023	3.62ThrArg: 3.62 ± 0.037	3.273ThrSer: 3.273 ± 0.037	3.777ThrThr: 3.777 ± 0.045	5.921ThrVal: 5.921 ± 0.049	0.937ThrTrp: 0.937 ± 0.019	1.229ThrTyr: 1.229 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	11.057ValAla: 11.057 ± 0.074	0.649ValCys: 0.649 ± 0.015	5.413ValAsp: 5.413 ± 0.048	4.993ValGlu: 4.993 ± 0.046	2.734ValPhe: 2.734 ± 0.034	6.597ValGly: 6.597 ± 0.06	1.909ValHis: 1.909 ± 0.026	3.257ValIle: 3.257 ± 0.042	2.017ValLys: 2.017 ± 0.029	10.254ValLeu: 10.254 ± 0.081	1.283ValMet: 1.283 ± 0.023	1.802ValAsn: 1.802 ± 0.026	5.146ValPro: 5.146 ± 0.055	2.008ValGln: 2.008 ± 0.031	6.745ValArg: 6.745 ± 0.059	4.755ValSer: 4.755 ± 0.049	5.644ValThr: 5.644 ± 0.051	8.562ValVal: 8.562 ± 0.071	1.065ValTrp: 1.065 ± 0.023	1.508ValTyr: 1.508 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.569TrpAla: 1.569 ± 0.026	0.147TrpCys: 0.147 ± 0.007	0.774TrpAsp: 0.774 ± 0.019	0.712TrpGlu: 0.712 ± 0.016	0.542TrpPhe: 0.542 ± 0.014	0.995TrpGly: 0.995 ± 0.019	0.357TrpHis: 0.357 ± 0.011	0.605TrpIle: 0.605 ± 0.015	0.393TrpLys: 0.393 ± 0.011	1.905TrpLeu: 1.905 ± 0.028	0.279TrpMet: 0.279 ± 0.01	0.404TrpAsn: 0.404 ± 0.013	0.819TrpPro: 0.819 ± 0.02	0.568TrpGln: 0.568 ± 0.016	1.376TrpArg: 1.376 ± 0.023	0.941TrpSer: 0.941 ± 0.02	1.04TrpThr: 1.04 ± 0.019	1.029TrpVal: 1.029 ± 0.025	0.331TrpTrp: 0.331 ± 0.011	0.302TrpTyr: 0.302 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.354TyrAla: 2.354 ± 0.03	0.168TyrCys: 0.168 ± 0.008	1.332TyrAsp: 1.332 ± 0.026	1.08TyrGlu: 1.08 ± 0.022	0.717TyrPhe: 0.717 ± 0.016	1.97TyrGly: 1.97 ± 0.03	0.438TyrHis: 0.438 ± 0.013	0.483TyrIle: 0.483 ± 0.014	0.369TyrLys: 0.369 ± 0.012	2.233TyrLeu: 2.233 ± 0.033	0.22TyrMet: 0.22 ± 0.009	0.432TyrAsn: 0.432 ± 0.015	1.124TyrPro: 1.124 ± 0.02	0.585TyrGln: 0.585 ± 0.016	1.859TyrArg: 1.859 ± 0.026	1.074TyrSer: 1.074 ± 0.023	1.196TyrThr: 1.196 ± 0.024	1.605TyrVal: 1.605 ± 0.026	0.36TyrTrp: 0.36 ± 0.011	0.452TyrTyr: 0.452 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8161 proteins (2694571 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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