Amino acid dipepetide frequency for Sphingobium baderi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.624AlaAla: 17.624 ± 0.19	1.072AlaCys: 1.072 ± 0.031	7.54AlaAsp: 7.54 ± 0.091	7.262AlaGlu: 7.262 ± 0.091	4.355AlaPhe: 4.355 ± 0.062	10.747AlaGly: 10.747 ± 0.113	2.372AlaHis: 2.372 ± 0.044	6.831AlaIle: 6.831 ± 0.075	4.028AlaLys: 4.028 ± 0.073	13.652AlaLeu: 13.652 ± 0.116	3.992AlaMet: 3.992 ± 0.065	3.106AlaAsn: 3.106 ± 0.05	5.904AlaPro: 5.904 ± 0.084	4.726AlaGln: 4.726 ± 0.063	9.589AlaArg: 9.589 ± 0.11	6.61AlaSer: 6.61 ± 0.089	6.065AlaThr: 6.065 ± 0.074	8.239AlaVal: 8.239 ± 0.098	1.57AlaTrp: 1.57 ± 0.038	2.555AlaTyr: 2.555 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.047CysAla: 1.047 ± 0.031	0.1CysCys: 0.1 ± 0.009	0.541CysAsp: 0.541 ± 0.023	0.443CysGlu: 0.443 ± 0.019	0.307CysPhe: 0.307 ± 0.016	0.865CysGly: 0.865 ± 0.024	0.199CysHis: 0.199 ± 0.011	0.383CysIle: 0.383 ± 0.02	0.192CysLys: 0.192 ± 0.012	0.747CysLeu: 0.747 ± 0.024	0.157CysMet: 0.157 ± 0.011	0.19CysAsn: 0.19 ± 0.012	0.462CysPro: 0.462 ± 0.019	0.224CysGln: 0.224 ± 0.013	0.609CysArg: 0.609 ± 0.022	0.471CysSer: 0.471 ± 0.019	0.373CysThr: 0.373 ± 0.018	0.555CysVal: 0.555 ± 0.021	0.121CysTrp: 0.121 ± 0.011	0.177CysTyr: 0.177 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.374AspAla: 7.374 ± 0.073	0.473AspCys: 0.473 ± 0.02	3.414AspAsp: 3.414 ± 0.06	3.439AspGlu: 3.439 ± 0.061	2.185AspPhe: 2.185 ± 0.045	5.486AspGly: 5.486 ± 0.097	1.408AspHis: 1.408 ± 0.036	3.261AspIle: 3.261 ± 0.048	1.751AspLys: 1.751 ± 0.04	5.883AspLeu: 5.883 ± 0.071	1.697AspMet: 1.697 ± 0.04	1.472AspAsn: 1.472 ± 0.035	3.732AspPro: 3.732 ± 0.051	1.919AspGln: 1.919 ± 0.044	5.109AspArg: 5.109 ± 0.067	2.481AspSer: 2.481 ± 0.049	2.489AspThr: 2.489 ± 0.045	3.995AspVal: 3.995 ± 0.059	1.085AspTrp: 1.085 ± 0.036	1.725AspTyr: 1.725 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.656GluAla: 7.656 ± 0.094	0.349GluCys: 0.349 ± 0.017	2.895GluAsp: 2.895 ± 0.056	3.246GluGlu: 3.246 ± 0.066	1.383GluPhe: 1.383 ± 0.036	4.614GluGly: 4.614 ± 0.061	1.154GluHis: 1.154 ± 0.031	3.165GluIle: 3.165 ± 0.056	2.162GluLys: 2.162 ± 0.045	4.903GluLeu: 4.903 ± 0.064	1.453GluMet: 1.453 ± 0.039	1.502GluAsn: 1.502 ± 0.033	2.448GluPro: 2.448 ± 0.048	2.281GluGln: 2.281 ± 0.047	5.143GluArg: 5.143 ± 0.076	2.488GluSer: 2.488 ± 0.043	3.091GluThr: 3.091 ± 0.051	3.396GluVal: 3.396 ± 0.057	0.748GluTrp: 0.748 ± 0.023	0.992GluTyr: 0.992 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.571PheAla: 4.571 ± 0.071	0.345PheCys: 0.345 ± 0.017	2.583PheAsp: 2.583 ± 0.054	1.954PheGlu: 1.954 ± 0.041	1.236PhePhe: 1.236 ± 0.038	3.488PheGly: 3.488 ± 0.058	0.806PheHis: 0.806 ± 0.028	1.541PheIle: 1.541 ± 0.04	0.867PheLys: 0.867 ± 0.027	3.184PheLeu: 3.184 ± 0.057	0.813PheMet: 0.813 ± 0.023	1.013PheAsn: 1.013 ± 0.037	1.554PhePro: 1.554 ± 0.034	0.933PheGln: 0.933 ± 0.028	2.306PheArg: 2.306 ± 0.047	2.121PheSer: 2.121 ± 0.048	1.965PheThr: 1.965 ± 0.045	2.43PheVal: 2.43 ± 0.044	0.501PheTrp: 0.501 ± 0.023	0.865PheTyr: 0.865 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.442GlyAla: 9.442 ± 0.114	0.794GlyCys: 0.794 ± 0.026	4.896GlyAsp: 4.896 ± 0.072	4.739GlyGlu: 4.739 ± 0.066	3.518GlyPhe: 3.518 ± 0.05	7.812GlyGly: 7.812 ± 0.118	1.923GlyHis: 1.923 ± 0.042	4.567GlyIle: 4.567 ± 0.066	3.446GlyLys: 3.446 ± 0.062	8.522GlyLeu: 8.522 ± 0.08	2.408GlyMet: 2.408 ± 0.052	2.29GlyAsn: 2.29 ± 0.041	3.505GlyPro: 3.505 ± 0.053	3.247GlyGln: 3.247 ± 0.056	6.415GlyArg: 6.415 ± 0.08	4.691GlySer: 4.691 ± 0.08	4.59GlyThr: 4.59 ± 0.096	6.056GlyVal: 6.056 ± 0.077	1.525GlyTrp: 1.525 ± 0.035	2.357GlyTyr: 2.357 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.5HisAla: 2.5 ± 0.049	0.219HisCys: 0.219 ± 0.013	1.269HisAsp: 1.269 ± 0.036	1.028HisGlu: 1.028 ± 0.027	0.854HisPhe: 0.854 ± 0.024	2.069HisGly: 2.069 ± 0.046	0.628HisHis: 0.628 ± 0.024	1.078HisIle: 1.078 ± 0.031	0.503HisLys: 0.503 ± 0.018	2.06HisLeu: 2.06 ± 0.04	0.564HisMet: 0.564 ± 0.022	0.48HisAsn: 0.48 ± 0.022	1.285HisPro: 1.285 ± 0.031	0.596HisGln: 0.596 ± 0.019	1.559HisArg: 1.559 ± 0.04	1.003HisSer: 1.003 ± 0.027	0.668HisThr: 0.668 ± 0.022	1.666HisVal: 1.666 ± 0.04	0.383HisTrp: 0.383 ± 0.018	0.621HisTyr: 0.621 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.889IleAla: 7.889 ± 0.087	0.486IleCys: 0.486 ± 0.019	3.952IleAsp: 3.952 ± 0.052	3.627IleGlu: 3.627 ± 0.057	1.791IlePhe: 1.791 ± 0.037	5.078IleGly: 5.078 ± 0.065	0.981IleHis: 0.981 ± 0.028	2.331IleIle: 2.331 ± 0.049	1.246IleLys: 1.246 ± 0.036	4.403IleLeu: 4.403 ± 0.065	1.044IleMet: 1.044 ± 0.03	1.423IleAsn: 1.423 ± 0.037	2.327IlePro: 2.327 ± 0.041	1.267IleGln: 1.267 ± 0.033	3.446IleArg: 3.446 ± 0.056	2.834IleSer: 2.834 ± 0.053	2.525IleThr: 2.525 ± 0.048	4.252IleVal: 4.252 ± 0.062	0.642IleTrp: 0.642 ± 0.025	1.105IleTyr: 1.105 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.366LysAla: 4.366 ± 0.071	0.172LysCys: 0.172 ± 0.013	1.787LysAsp: 1.787 ± 0.041	1.431LysGlu: 1.431 ± 0.037	0.76LysPhe: 0.76 ± 0.026	2.851LysGly: 2.851 ± 0.057	0.538LysHis: 0.538 ± 0.023	1.538LysIle: 1.538 ± 0.035	1.135LysLys: 1.135 ± 0.033	3.148LysLeu: 3.148 ± 0.057	0.786LysMet: 0.786 ± 0.029	0.755LysAsn: 0.755 ± 0.024	2.008LysPro: 2.008 ± 0.044	0.955LysGln: 0.955 ± 0.03	2.294LysArg: 2.294 ± 0.051	1.663LysSer: 1.663 ± 0.037	1.702LysThr: 1.702 ± 0.04	2.232LysVal: 2.232 ± 0.048	0.404LysTrp: 0.404 ± 0.017	0.582LysTyr: 0.582 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	13.246LeuAla: 13.246 ± 0.119	0.938LeuCys: 0.938 ± 0.031	6.215LeuAsp: 6.215 ± 0.072	4.958LeuGlu: 4.958 ± 0.062	3.761LeuPhe: 3.761 ± 0.061	8.073LeuGly: 8.073 ± 0.081	1.991LeuHis: 1.991 ± 0.044	5.129LeuIle: 5.129 ± 0.066	3.117LeuLys: 3.117 ± 0.053	9.588LeuLeu: 9.588 ± 0.105	2.24LeuMet: 2.24 ± 0.036	2.439LeuAsn: 2.439 ± 0.05	5.608LeuPro: 5.608 ± 0.068	2.62LeuGln: 2.62 ± 0.042	6.991LeuArg: 6.991 ± 0.09	6.44LeuSer: 6.44 ± 0.075	5.581LeuThr: 5.581 ± 0.082	6.699LeuVal: 6.699 ± 0.073	1.267LeuTrp: 1.267 ± 0.034	2.011LeuTyr: 2.011 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.546MetAla: 3.546 ± 0.049	0.159MetCys: 0.159 ± 0.01	1.242MetAsp: 1.242 ± 0.036	1.348MetGlu: 1.348 ± 0.037	0.691MetPhe: 0.691 ± 0.024	2.021MetGly: 2.021 ± 0.04	0.475MetHis: 0.475 ± 0.02	1.453MetIle: 1.453 ± 0.035	1.003MetLys: 1.003 ± 0.025	2.73MetLeu: 2.73 ± 0.041	0.777MetMet: 0.777 ± 0.026	0.751MetAsn: 0.751 ± 0.024	1.574MetPro: 1.574 ± 0.037	0.856MetGln: 0.856 ± 0.025	1.892MetArg: 1.892 ± 0.04	1.534MetSer: 1.534 ± 0.038	1.856MetThr: 1.856 ± 0.033	1.698MetVal: 1.698 ± 0.042	0.208MetTrp: 0.208 ± 0.013	0.233MetTyr: 0.233 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.309AsnAla: 3.309 ± 0.056	0.218AsnCys: 0.218 ± 0.013	1.443AsnAsp: 1.443 ± 0.04	1.22AsnGlu: 1.22 ± 0.035	0.909AsnPhe: 0.909 ± 0.028	2.494AsnGly: 2.494 ± 0.055	0.47AsnHis: 0.47 ± 0.019	1.443AsnIle: 1.443 ± 0.042	0.706AsnLys: 0.706 ± 0.026	2.523AsnLeu: 2.523 ± 0.048	0.626AsnMet: 0.626 ± 0.023	0.643AsnAsn: 0.643 ± 0.024	1.815AsnPro: 1.815 ± 0.039	0.808AsnGln: 0.808 ± 0.025	1.89AsnArg: 1.89 ± 0.044	1.28AsnSer: 1.28 ± 0.032	1.069AsnThr: 1.069 ± 0.032	1.914AsnVal: 1.914 ± 0.039	0.445AsnTrp: 0.445 ± 0.019	0.663AsnTyr: 0.663 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.67ProAla: 6.67 ± 0.089	0.36ProCys: 0.36 ± 0.016	3.87ProAsp: 3.87 ± 0.052	3.413ProGlu: 3.413 ± 0.051	1.874ProPhe: 1.874 ± 0.037	4.502ProGly: 4.502 ± 0.058	1.116ProHis: 1.116 ± 0.033	2.5ProIle: 2.5 ± 0.045	1.493ProLys: 1.493 ± 0.038	4.929ProLeu: 4.929 ± 0.057	1.342ProMet: 1.342 ± 0.028	1.22ProAsn: 1.22 ± 0.035	2.846ProPro: 2.846 ± 0.071	1.814ProGln: 1.814 ± 0.043	3.015ProArg: 3.015 ± 0.051	2.894ProSer: 2.894 ± 0.053	2.546ProThr: 2.546 ± 0.053	4.286ProVal: 4.286 ± 0.056	0.711ProTrp: 0.711 ± 0.024	1.11ProTyr: 1.11 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	4.502GlnAla: 4.502 ± 0.063	0.265GlnCys: 0.265 ± 0.014	1.594GlnAsp: 1.594 ± 0.037	1.521GlnGlu: 1.521 ± 0.035	1.116GlnPhe: 1.116 ± 0.026	2.641GlnGly: 2.641 ± 0.049	0.656GlnHis: 0.656 ± 0.025	1.967GlnIle: 1.967 ± 0.037	1.018GlnLys: 1.018 ± 0.029	3.089GlnLeu: 3.089 ± 0.059	0.913GlnMet: 0.913 ± 0.027	0.836GlnAsn: 0.836 ± 0.029	1.942GlnPro: 1.942 ± 0.044	1.307GlnGln: 1.307 ± 0.036	2.675GlnArg: 2.675 ± 0.049	1.904GlnSer: 1.904 ± 0.039	1.674GlnThr: 1.674 ± 0.04	2.305GlnVal: 2.305 ± 0.042	0.509GlnTrp: 0.509 ± 0.02	0.661GlnTyr: 0.661 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.551ArgAla: 8.551 ± 0.085	0.536ArgCys: 0.536 ± 0.02	4.465ArgAsp: 4.465 ± 0.061	4.12ArgGlu: 4.12 ± 0.062	3.07ArgPhe: 3.07 ± 0.052	5.011ArgGly: 5.011 ± 0.07	1.942ArgHis: 1.942 ± 0.042	4.349ArgIle: 4.349 ± 0.063	2.388ArgLys: 2.388 ± 0.047	8.338ArgLeu: 8.338 ± 0.1	2.053ArgMet: 2.053 ± 0.042	1.962ArgAsn: 1.962 ± 0.043	3.732ArgPro: 3.732 ± 0.062	2.802ArgGln: 2.802 ± 0.046	6.011ArgArg: 6.011 ± 0.081	3.785ArgSer: 3.785 ± 0.056	3.613ArgThr: 3.613 ± 0.052	4.556ArgVal: 4.556 ± 0.054	1.249ArgTrp: 1.249 ± 0.032	1.95ArgTyr: 1.95 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.554SerAla: 6.554 ± 0.084	0.429SerCys: 0.429 ± 0.019	3.183SerAsp: 3.183 ± 0.054	2.578SerGlu: 2.578 ± 0.047	2.234SerPhe: 2.234 ± 0.046	5.541SerGly: 5.541 ± 0.078	1.086SerHis: 1.086 ± 0.033	2.839SerIle: 2.839 ± 0.05	1.464SerLys: 1.464 ± 0.031	5.259SerLeu: 5.259 ± 0.058	1.394SerMet: 1.394 ± 0.032	1.472SerAsn: 1.472 ± 0.036	2.834SerPro: 2.834 ± 0.049	1.689SerGln: 1.689 ± 0.038	3.715SerArg: 3.715 ± 0.062	2.887SerSer: 2.887 ± 0.061	2.635SerThr: 2.635 ± 0.05	3.751SerVal: 3.751 ± 0.06	0.823SerTrp: 0.823 ± 0.022	1.394SerTyr: 1.394 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	6.041ThrAla: 6.041 ± 0.077	0.393ThrCys: 0.393 ± 0.018	2.881ThrAsp: 2.881 ± 0.062	2.393ThrGlu: 2.393 ± 0.048	1.684ThrPhe: 1.684 ± 0.034	5.169ThrGly: 5.169 ± 0.081	0.96ThrHis: 0.96 ± 0.031	2.924ThrIle: 2.924 ± 0.051	1.29ThrLys: 1.29 ± 0.033	5.71ThrLeu: 5.71 ± 0.08	1.184ThrMet: 1.184 ± 0.032	1.268ThrAsn: 1.268 ± 0.04	3.384ThrPro: 3.384 ± 0.054	1.583ThrGln: 1.583 ± 0.036	3.415ThrArg: 3.415 ± 0.054	2.61ThrSer: 2.61 ± 0.055	2.554ThrThr: 2.554 ± 0.06	4.073ThrVal: 4.073 ± 0.075	0.608ThrTrp: 0.608 ± 0.024	1.115ThrTyr: 1.115 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.912ValAla: 8.912 ± 0.096	0.503ValCys: 0.503 ± 0.019	4.281ValAsp: 4.281 ± 0.063	4.554ValGlu: 4.554 ± 0.066	1.973ValPhe: 1.973 ± 0.048	5.218ValGly: 5.218 ± 0.069	1.428ValHis: 1.428 ± 0.034	3.718ValIle: 3.718 ± 0.055	2.219ValLys: 2.219 ± 0.047	6.298ValLeu: 6.298 ± 0.066	1.745ValMet: 1.745 ± 0.04	1.976ValAsn: 1.976 ± 0.049	3.808ValPro: 3.808 ± 0.055	2.166ValGln: 2.166 ± 0.044	5.078ValArg: 5.078 ± 0.065	4.005ValSer: 4.005 ± 0.069	4.478ValThr: 4.478 ± 0.062	4.889ValVal: 4.889 ± 0.076	0.793ValTrp: 0.793 ± 0.029	1.368ValTyr: 1.368 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.358TrpAla: 1.358 ± 0.036	0.117TrpCys: 0.117 ± 0.008	0.75TrpAsp: 0.75 ± 0.025	0.623TrpGlu: 0.623 ± 0.021	0.511TrpPhe: 0.511 ± 0.023	0.922TrpGly: 0.922 ± 0.029	0.359TrpHis: 0.359 ± 0.016	0.726TrpIle: 0.726 ± 0.022	0.501TrpLys: 0.501 ± 0.019	1.762TrpLeu: 1.762 ± 0.042	0.383TrpMet: 0.383 ± 0.017	0.479TrpAsn: 0.479 ± 0.021	0.683TrpPro: 0.683 ± 0.021	0.586TrpGln: 0.586 ± 0.024	1.358TrpArg: 1.358 ± 0.033	0.918TrpSer: 0.918 ± 0.029	0.815TrpThr: 0.815 ± 0.024	0.841TrpVal: 0.841 ± 0.028	0.25TrpTrp: 0.25 ± 0.015	0.254TrpTyr: 0.254 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.681TyrAla: 2.681 ± 0.046	0.236TyrCys: 0.236 ± 0.014	1.577TyrAsp: 1.577 ± 0.035	1.173TyrGlu: 1.173 ± 0.028	0.86TyrPhe: 0.86 ± 0.027	2.141TyrGly: 2.141 ± 0.046	0.542TyrHis: 0.542 ± 0.022	0.906TyrIle: 0.906 ± 0.027	0.577TyrLys: 0.577 ± 0.022	2.185TyrLeu: 2.185 ± 0.043	0.474TyrMet: 0.474 ± 0.017	0.609TyrAsn: 0.609 ± 0.021	1.059TyrPro: 1.059 ± 0.029	0.717TyrGln: 0.717 ± 0.023	1.972TyrArg: 1.972 ± 0.041	1.145TyrSer: 1.145 ± 0.031	0.952TyrThr: 0.952 ± 0.035	1.577TyrVal: 1.577 ± 0.034	0.355TyrTrp: 0.355 ± 0.017	0.657TyrTyr: 0.657 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4283 proteins (1304597 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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