Amino acid dipepetide frequency for [Clostridium] symbiosum WAL-14163

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.461AlaAla: 9.461 ± 0.12	1.279AlaCys: 1.279 ± 0.031	4.562AlaAsp: 4.562 ± 0.056	5.863AlaGlu: 5.863 ± 0.073	3.251AlaPhe: 3.251 ± 0.049	7.843AlaGly: 7.843 ± 0.09	1.045AlaHis: 1.045 ± 0.027	4.801AlaIle: 4.801 ± 0.071	4.383AlaLys: 4.383 ± 0.061	7.309AlaLeu: 7.309 ± 0.074	2.552AlaMet: 2.552 ± 0.045	2.289AlaAsn: 2.289 ± 0.042	2.44AlaPro: 2.44 ± 0.051	2.253AlaGln: 2.253 ± 0.037	3.324AlaArg: 3.324 ± 0.049	4.255AlaSer: 4.255 ± 0.057	3.101AlaThr: 3.101 ± 0.059	7.394AlaVal: 7.394 ± 0.082	0.671AlaTrp: 0.671 ± 0.022	2.623AlaTyr: 2.623 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.051CysAla: 1.051 ± 0.027	0.332CysCys: 0.332 ± 0.018	0.764CysAsp: 0.764 ± 0.025	0.882CysGlu: 0.882 ± 0.025	0.671CysPhe: 0.671 ± 0.02	1.594CysGly: 1.594 ± 0.033	0.327CysHis: 0.327 ± 0.015	1.053CysIle: 1.053 ± 0.029	0.665CysLys: 0.665 ± 0.021	1.342CysLeu: 1.342 ± 0.033	0.431CysMet: 0.431 ± 0.016	0.535CysAsn: 0.535 ± 0.021	0.666CysPro: 0.666 ± 0.024	0.381CysGln: 0.381 ± 0.016	1.031CysArg: 1.031 ± 0.026	0.983CysSer: 0.983 ± 0.028	0.765CysThr: 0.765 ± 0.024	0.946CysVal: 0.946 ± 0.024	0.124CysTrp: 0.124 ± 0.01	0.569CysTyr: 0.569 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.907AspAla: 3.907 ± 0.06	0.815AspCys: 0.815 ± 0.026	2.667AspAsp: 2.667 ± 0.061	4.277AspGlu: 4.277 ± 0.061	2.5AspPhe: 2.5 ± 0.041	4.837AspGly: 4.837 ± 0.074	0.754AspHis: 0.754 ± 0.025	4.164AspIle: 4.164 ± 0.062	3.239AspLys: 3.239 ± 0.055	4.179AspLeu: 4.179 ± 0.06	1.85AspMet: 1.85 ± 0.039	2.091AspAsn: 2.091 ± 0.045	1.753AspPro: 1.753 ± 0.035	1.134AspGln: 1.134 ± 0.028	2.704AspArg: 2.704 ± 0.051	3.071AspSer: 3.071 ± 0.05	2.932AspThr: 2.932 ± 0.052	3.369AspVal: 3.369 ± 0.051	0.592AspTrp: 0.592 ± 0.02	2.544AspTyr: 2.544 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.981GluAla: 5.981 ± 0.074	0.8GluCys: 0.8 ± 0.025	4.074GluAsp: 4.074 ± 0.054	7.247GluGlu: 7.247 ± 0.102	2.595GluPhe: 2.595 ± 0.043	4.639GluGly: 4.639 ± 0.061	1.278GluHis: 1.278 ± 0.029	5.361GluIle: 5.361 ± 0.064	6.118GluLys: 6.118 ± 0.077	7.21GluLeu: 7.21 ± 0.083	2.406GluMet: 2.406 ± 0.042	3.636GluAsn: 3.636 ± 0.056	2.298GluPro: 2.298 ± 0.05	2.976GluGln: 2.976 ± 0.059	3.795GluArg: 3.795 ± 0.063	3.441GluSer: 3.441 ± 0.054	3.889GluThr: 3.889 ± 0.064	4.093GluVal: 4.093 ± 0.044	0.721GluTrp: 0.721 ± 0.025	2.995GluTyr: 2.995 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	3.076PheAla: 3.076 ± 0.041	0.804PheCys: 0.804 ± 0.021	2.369PheAsp: 2.369 ± 0.04	2.661PheGlu: 2.661 ± 0.051	1.825PhePhe: 1.825 ± 0.038	3.294PheGly: 3.294 ± 0.055	0.796PheHis: 0.796 ± 0.024	2.95PheIle: 2.95 ± 0.055	1.949PheLys: 1.949 ± 0.04	4.073PheLeu: 4.073 ± 0.059	1.188PheMet: 1.188 ± 0.031	1.574PheAsn: 1.574 ± 0.036	1.469PhePro: 1.469 ± 0.032	1.159PheGln: 1.159 ± 0.03	1.867PheArg: 1.867 ± 0.037	2.91PheSer: 2.91 ± 0.047	2.53PheThr: 2.53 ± 0.042	2.631PheVal: 2.631 ± 0.05	0.407PheTrp: 0.407 ± 0.016	1.765PheTyr: 1.765 ± 0.041	0.001PheXaa: 0.001 ± 0.001
Gly	5.724GlyAla: 5.724 ± 0.085	1.368GlyCys: 1.368 ± 0.037	3.681GlyAsp: 3.681 ± 0.055	5.295GlyGlu: 5.295 ± 0.065	3.304GlyPhe: 3.304 ± 0.047	5.894GlyGly: 5.894 ± 0.097	1.322GlyHis: 1.322 ± 0.034	6.515GlyIle: 6.515 ± 0.079	5.443GlyLys: 5.443 ± 0.061	6.558GlyLeu: 6.558 ± 0.072	2.604GlyMet: 2.604 ± 0.047	3.222GlyAsn: 3.222 ± 0.067	1.741GlyPro: 1.741 ± 0.041	2.235GlyGln: 2.235 ± 0.042	4.045GlyArg: 4.045 ± 0.057	4.67GlySer: 4.67 ± 0.071	4.714GlyThr: 4.714 ± 0.07	5.095GlyVal: 5.095 ± 0.072	0.887GlyTrp: 0.887 ± 0.033	3.242GlyTyr: 3.242 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.057HisAla: 1.057 ± 0.03	0.293HisCys: 0.293 ± 0.014	0.811HisAsp: 0.811 ± 0.028	0.976HisGlu: 0.976 ± 0.026	0.826HisPhe: 0.826 ± 0.022	1.255HisGly: 1.255 ± 0.031	0.385HisHis: 0.385 ± 0.019	1.314HisIle: 1.314 ± 0.034	0.831HisLys: 0.831 ± 0.025	1.453HisLeu: 1.453 ± 0.036	0.502HisMet: 0.502 ± 0.017	0.693HisAsn: 0.693 ± 0.023	0.871HisPro: 0.871 ± 0.026	0.478HisGln: 0.478 ± 0.019	0.796HisArg: 0.796 ± 0.024	0.956HisSer: 0.956 ± 0.023	0.855HisThr: 0.855 ± 0.024	1.012HisVal: 1.012 ± 0.029	0.153HisTrp: 0.153 ± 0.01	0.727HisTyr: 0.727 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.705IleAla: 5.705 ± 0.077	1.325IleCys: 1.325 ± 0.03	3.715IleAsp: 3.715 ± 0.056	4.526IleGlu: 4.526 ± 0.054	2.933IlePhe: 2.933 ± 0.054	5.233IleGly: 5.233 ± 0.069	1.205IleHis: 1.205 ± 0.027	5.053IleIle: 5.053 ± 0.07	3.73IleLys: 3.73 ± 0.06	7.03IleLeu: 7.03 ± 0.082	1.995IleMet: 1.995 ± 0.042	2.677IleAsn: 2.677 ± 0.046	3.284IlePro: 3.284 ± 0.051	2.119IleGln: 2.119 ± 0.041	3.946IleArg: 3.946 ± 0.066	4.686IleSer: 4.686 ± 0.054	4.095IleThr: 4.095 ± 0.052	4.507IleVal: 4.507 ± 0.063	0.648IleTrp: 0.648 ± 0.022	2.572IleTyr: 2.572 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	5.048LysAla: 5.048 ± 0.067	0.615LysCys: 0.615 ± 0.025	3.458LysAsp: 3.458 ± 0.053	6.061LysGlu: 6.061 ± 0.082	1.72LysPhe: 1.72 ± 0.035	4.054LysGly: 4.054 ± 0.056	0.874LysHis: 0.874 ± 0.029	4.269LysIle: 4.269 ± 0.056	5.455LysLys: 5.455 ± 0.076	5.176LysLeu: 5.176 ± 0.055	2.091LysMet: 2.091 ± 0.037	3.11LysAsn: 3.11 ± 0.053	2.025LysPro: 2.025 ± 0.041	2.148LysGln: 2.148 ± 0.04	3.153LysArg: 3.153 ± 0.045	3.161LysSer: 3.161 ± 0.045	3.681LysThr: 3.681 ± 0.057	3.618LysVal: 3.618 ± 0.058	0.608LysTrp: 0.608 ± 0.021	2.498LysTyr: 2.498 ± 0.041	0.001LysXaa: 0.001 ± 0.001
Leu	7.506LeuAla: 7.506 ± 0.076	1.549LeuCys: 1.549 ± 0.033	4.842LeuAsp: 4.842 ± 0.062	6.367LeuGlu: 6.367 ± 0.076	4.055LeuPhe: 4.055 ± 0.06	6.219LeuGly: 6.219 ± 0.07	1.475LeuHis: 1.475 ± 0.036	6.04LeuIle: 6.04 ± 0.081	6.105LeuLys: 6.105 ± 0.067	8.968LeuLeu: 8.968 ± 0.101	2.803LeuMet: 2.803 ± 0.05	3.755LeuAsn: 3.755 ± 0.046	3.697LeuPro: 3.697 ± 0.05	2.666LeuGln: 2.666 ± 0.045	4.101LeuArg: 4.101 ± 0.068	6.459LeuSer: 6.459 ± 0.071	5.268LeuThr: 5.268 ± 0.06	5.364LeuVal: 5.364 ± 0.066	0.767LeuTrp: 0.767 ± 0.024	3.416LeuTyr: 3.416 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.862MetAla: 2.862 ± 0.051	0.367MetCys: 0.367 ± 0.017	1.819MetAsp: 1.819 ± 0.034	2.75MetGlu: 2.75 ± 0.047	1.027MetPhe: 1.027 ± 0.029	2.301MetGly: 2.301 ± 0.048	0.42MetHis: 0.42 ± 0.017	2.135MetIle: 2.135 ± 0.045	2.473MetLys: 2.473 ± 0.044	2.683MetLeu: 2.683 ± 0.041	1.045MetMet: 1.045 ± 0.029	1.554MetAsn: 1.554 ± 0.031	1.196MetPro: 1.196 ± 0.029	0.963MetGln: 0.963 ± 0.027	1.37MetArg: 1.37 ± 0.034	1.733MetSer: 1.733 ± 0.032	1.889MetThr: 1.889 ± 0.037	2.02MetVal: 2.02 ± 0.037	0.232MetTrp: 0.232 ± 0.013	0.837MetTyr: 0.837 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.997AsnAla: 2.997 ± 0.049	0.597AsnCys: 0.597 ± 0.022	1.777AsnAsp: 1.777 ± 0.042	2.521AsnGlu: 2.521 ± 0.046	1.478AsnPhe: 1.478 ± 0.032	3.387AsnGly: 3.387 ± 0.066	0.696AsnHis: 0.696 ± 0.022	3.042AsnIle: 3.042 ± 0.049	2.197AsnLys: 2.197 ± 0.046	3.655AsnLeu: 3.655 ± 0.051	1.366AsnMet: 1.366 ± 0.032	1.642AsnAsn: 1.642 ± 0.038	2.005AsnPro: 2.005 ± 0.041	1.324AsnGln: 1.324 ± 0.029	2.349AsnArg: 2.349 ± 0.043	2.247AsnSer: 2.247 ± 0.041	2.16AsnThr: 2.16 ± 0.053	2.53AsnVal: 2.53 ± 0.047	0.392AsnTrp: 0.392 ± 0.016	1.635AsnTyr: 1.635 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.126ProAla: 3.126 ± 0.046	0.481ProCys: 0.481 ± 0.019	2.482ProAsp: 2.482 ± 0.046	3.645ProGlu: 3.645 ± 0.056	1.647ProPhe: 1.647 ± 0.038	2.987ProGly: 2.987 ± 0.052	0.617ProHis: 0.617 ± 0.02	2.0ProIle: 2.0 ± 0.043	1.678ProLys: 1.678 ± 0.032	3.094ProLeu: 3.094 ± 0.049	0.976ProMet: 0.976 ± 0.027	1.116ProAsn: 1.116 ± 0.028	1.035ProPro: 1.035 ± 0.038	1.101ProGln: 1.101 ± 0.027	1.081ProArg: 1.081 ± 0.029	2.04ProSer: 2.04 ± 0.044	1.451ProThr: 1.451 ± 0.032	3.452ProVal: 3.452 ± 0.045	0.351ProTrp: 0.351 ± 0.016	1.486ProTyr: 1.486 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	2.581GlnAla: 2.581 ± 0.049	0.341GlnCys: 0.341 ± 0.016	1.458GlnAsp: 1.458 ± 0.03	2.554GlnGlu: 2.554 ± 0.045	1.172GlnPhe: 1.172 ± 0.03	1.992GlnGly: 1.992 ± 0.035	0.404GlnHis: 0.404 ± 0.016	2.445GlnIle: 2.445 ± 0.047	2.301GlnLys: 2.301 ± 0.049	2.582GlnLeu: 2.582 ± 0.045	1.2GlnMet: 1.2 ± 0.03	1.398GlnAsn: 1.398 ± 0.034	1.012GlnPro: 1.012 ± 0.028	1.041GlnGln: 1.041 ± 0.031	1.363GlnArg: 1.363 ± 0.026	1.632GlnSer: 1.632 ± 0.038	1.708GlnThr: 1.708 ± 0.035	1.944GlnVal: 1.944 ± 0.036	0.315GlnTrp: 0.315 ± 0.018	1.296GlnTyr: 1.296 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	3.133ArgAla: 3.133 ± 0.05	0.667ArgCys: 0.667 ± 0.021	2.436ArgAsp: 2.436 ± 0.045	4.617ArgGlu: 4.617 ± 0.066	2.042ArgPhe: 2.042 ± 0.041	2.889ArgGly: 2.889 ± 0.044	0.843ArgHis: 0.843 ± 0.023	3.802ArgIle: 3.802 ± 0.049	3.594ArgLys: 3.594 ± 0.052	4.645ArgLeu: 4.645 ± 0.071	1.735ArgMet: 1.735 ± 0.036	2.078ArgAsn: 2.078 ± 0.041	1.597ArgPro: 1.597 ± 0.039	1.951ArgGln: 1.951 ± 0.043	2.819ArgArg: 2.819 ± 0.057	2.353ArgSer: 2.353 ± 0.045	2.5ArgThr: 2.5 ± 0.042	2.788ArgVal: 2.788 ± 0.047	0.413ArgTrp: 0.413 ± 0.017	2.022ArgTyr: 2.022 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.539SerAla: 4.539 ± 0.061	0.84SerCys: 0.84 ± 0.024	3.148SerAsp: 3.148 ± 0.054	3.811SerGlu: 3.811 ± 0.049	2.779SerPhe: 2.779 ± 0.049	5.829SerGly: 5.829 ± 0.065	1.012SerHis: 1.012 ± 0.023	3.968SerIle: 3.968 ± 0.057	2.852SerLys: 2.852 ± 0.048	5.467SerLeu: 5.467 ± 0.06	1.85SerMet: 1.85 ± 0.035	1.945SerAsn: 1.945 ± 0.04	1.949SerPro: 1.949 ± 0.04	1.731SerGln: 1.731 ± 0.037	3.144SerArg: 3.144 ± 0.052	3.78SerSer: 3.78 ± 0.06	2.694SerThr: 2.694 ± 0.052	4.345SerVal: 4.345 ± 0.054	0.57SerTrp: 0.57 ± 0.022	2.298SerTyr: 2.298 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	5.178ThrAla: 5.178 ± 0.069	0.66ThrCys: 0.66 ± 0.024	2.977ThrAsp: 2.977 ± 0.053	3.784ThrGlu: 3.784 ± 0.06	2.121ThrPhe: 2.121 ± 0.043	5.398ThrGly: 5.398 ± 0.087	0.764ThrHis: 0.764 ± 0.023	3.615ThrIle: 3.615 ± 0.057	2.729ThrLys: 2.729 ± 0.049	4.698ThrLeu: 4.698 ± 0.054	1.541ThrMet: 1.541 ± 0.034	1.769ThrAsn: 1.769 ± 0.036	2.304ThrPro: 2.304 ± 0.043	1.482ThrGln: 1.482 ± 0.031	2.058ThrArg: 2.058 ± 0.038	2.801ThrSer: 2.801 ± 0.048	2.524ThrThr: 2.524 ± 0.05	4.704ThrVal: 4.704 ± 0.074	0.468ThrTrp: 0.468 ± 0.017	1.898ThrTyr: 1.898 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.56ValAla: 4.56 ± 0.075	1.188ValCys: 1.188 ± 0.027	3.414ValAsp: 3.414 ± 0.055	4.318ValGlu: 4.318 ± 0.061	3.135ValPhe: 3.135 ± 0.054	4.162ValGly: 4.162 ± 0.058	1.039ValHis: 1.039 ± 0.026	5.183ValIle: 5.183 ± 0.065	4.3ValLys: 4.3 ± 0.055	6.579ValLeu: 6.579 ± 0.08	2.125ValMet: 2.125 ± 0.039	2.734ValAsn: 2.734 ± 0.046	2.75ValPro: 2.75 ± 0.037	1.83ValGln: 1.83 ± 0.037	3.274ValArg: 3.274 ± 0.048	4.589ValSer: 4.589 ± 0.054	4.207ValThr: 4.207 ± 0.072	4.394ValVal: 4.394 ± 0.061	0.636ValTrp: 0.636 ± 0.022	2.582ValTyr: 2.582 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.537TrpAla: 0.537 ± 0.021	0.152TrpCys: 0.152 ± 0.009	0.554TrpAsp: 0.554 ± 0.022	0.693TrpGlu: 0.693 ± 0.018	0.466TrpPhe: 0.466 ± 0.023	0.693TrpGly: 0.693 ± 0.022	0.177TrpHis: 0.177 ± 0.012	0.65TrpIle: 0.65 ± 0.021	0.707TrpLys: 0.707 ± 0.021	0.958TrpLeu: 0.958 ± 0.026	0.323TrpMet: 0.323 ± 0.015	0.493TrpAsn: 0.493 ± 0.017	0.249TrpPro: 0.249 ± 0.014	0.402TrpGln: 0.402 ± 0.016	0.4TrpArg: 0.4 ± 0.016	0.469TrpSer: 0.469 ± 0.02	0.428TrpThr: 0.428 ± 0.017	0.513TrpVal: 0.513 ± 0.018	0.11TrpTrp: 0.11 ± 0.01	0.438TrpTyr: 0.438 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.666TyrAla: 2.666 ± 0.042	0.635TyrCys: 0.635 ± 0.021	2.37TyrAsp: 2.37 ± 0.053	2.705TyrGlu: 2.705 ± 0.048	1.752TyrPhe: 1.752 ± 0.038	3.06TyrGly: 3.06 ± 0.046	0.814TyrHis: 0.814 ± 0.023	2.623TyrIle: 2.623 ± 0.042	2.074TyrLys: 2.074 ± 0.044	3.76TyrLeu: 3.76 ± 0.055	1.094TyrMet: 1.094 ± 0.029	1.685TyrAsn: 1.685 ± 0.035	1.507TyrPro: 1.507 ± 0.031	1.366TyrGln: 1.366 ± 0.033	2.306TyrArg: 2.306 ± 0.042	2.32TyrSer: 2.32 ± 0.041	2.081TyrThr: 2.081 ± 0.046	2.279TyrVal: 2.279 ± 0.039	0.348TyrTrp: 0.348 ± 0.015	1.862TyrTyr: 1.862 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4668 proteins (1494359 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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