Amino acid dipepetide frequency for Grapevine leafroll-associated virus 5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.286AlaAla: 5.286 ± 0.736
1.149AlaCys: 1.149 ± 0.338
4.367AlaAsp: 4.367 ± 1.22
4.826AlaGlu: 4.826 ± 0.775
1.609AlaPhe: 1.609 ± 0.506
3.447AlaGly: 3.447 ± 0.592
0.919AlaHis: 0.919 ± 0.725
3.907AlaIle: 3.907 ± 0.903
3.907AlaLys: 3.907 ± 0.736
7.355AlaLeu: 7.355 ± 1.378
1.149AlaMet: 1.149 ± 0.294
2.298AlaAsn: 2.298 ± 0.693
2.758AlaPro: 2.758 ± 0.548
0.919AlaGln: 0.919 ± 0.349
2.988AlaArg: 2.988 ± 0.964
4.137AlaSer: 4.137 ± 0.787
4.597AlaThr: 4.597 ± 0.839
6.435AlaVal: 6.435 ± 1.269
0.919AlaTrp: 0.919 ± 0.565
1.609AlaTyr: 1.609 ± 0.729
0.0AlaXaa: 0.0 ± 0.0
Cys
2.068CysAla: 2.068 ± 0.548
0.689CysCys: 0.689 ± 0.42
0.919CysAsp: 0.919 ± 0.46
1.609CysGlu: 1.609 ± 0.553
1.609CysPhe: 1.609 ± 0.512
1.379CysGly: 1.379 ± 0.583
0.46CysHis: 0.46 ± 0.255
1.149CysIle: 1.149 ± 0.416
0.689CysLys: 0.689 ± 0.383
2.298CysLeu: 2.298 ± 0.957
0.23CysMet: 0.23 ± 0.266
0.919CysAsn: 0.919 ± 0.277
0.23CysPro: 0.23 ± 0.128
0.23CysGln: 0.23 ± 0.338
0.46CysArg: 0.46 ± 0.255
1.839CysSer: 1.839 ± 0.803
0.0CysThr: 0.0 ± 0.0
1.149CysVal: 1.149 ± 1.009
0.46CysTrp: 0.46 ± 0.255
0.919CysTyr: 0.919 ± 0.395
0.0CysXaa: 0.0 ± 0.0
Asp
2.758AspAla: 2.758 ± 0.777
1.839AspCys: 1.839 ± 0.665
1.839AspAsp: 1.839 ± 0.609
3.907AspGlu: 3.907 ± 1.035
3.677AspPhe: 3.677 ± 0.76
3.218AspGly: 3.218 ± 0.738
0.23AspHis: 0.23 ± 0.338
4.597AspIle: 4.597 ± 1.031
4.137AspLys: 4.137 ± 0.654
4.137AspLeu: 4.137 ± 0.631
0.689AspMet: 0.689 ± 0.456
2.988AspAsn: 2.988 ± 0.824
2.528AspPro: 2.528 ± 0.42
0.689AspGln: 0.689 ± 0.546
2.988AspArg: 2.988 ± 0.706
4.367AspSer: 4.367 ± 1.032
2.528AspThr: 2.528 ± 0.963
6.665AspVal: 6.665 ± 1.675
0.689AspTrp: 0.689 ± 0.314
1.149AspTyr: 1.149 ± 0.684
0.0AspXaa: 0.0 ± 0.0
Glu
3.907GluAla: 3.907 ± 0.875
0.689GluCys: 0.689 ± 0.314
3.677GluAsp: 3.677 ± 0.511
3.907GluGlu: 3.907 ± 1.336
1.379GluPhe: 1.379 ± 0.463
1.839GluGly: 1.839 ± 0.911
0.689GluHis: 0.689 ± 0.383
4.597GluIle: 4.597 ± 0.724
4.826GluLys: 4.826 ± 0.504
4.826GluLeu: 4.826 ± 0.907
0.46GluMet: 0.46 ± 0.273
2.528GluAsn: 2.528 ± 0.64
2.758GluPro: 2.758 ± 1.129
0.689GluGln: 0.689 ± 0.314
2.758GluArg: 2.758 ± 1.054
5.286GluSer: 5.286 ± 1.575
3.447GluThr: 3.447 ± 0.609
7.125GluVal: 7.125 ± 1.378
0.0GluTrp: 0.0 ± 0.0
1.609GluTyr: 1.609 ± 1.12
0.0GluXaa: 0.0 ± 0.0
Phe
2.298PheAla: 2.298 ± 1.373
1.609PheCys: 1.609 ± 1.04
2.758PheAsp: 2.758 ± 1.089
3.218PheGlu: 3.218 ± 1.002
2.298PhePhe: 2.298 ± 0.842
3.907PheGly: 3.907 ± 0.961
0.23PheHis: 0.23 ± 0.288
3.677PheIle: 3.677 ± 0.466
2.988PheLys: 2.988 ± 1.519
3.677PheLeu: 3.677 ± 1.008
0.689PheMet: 0.689 ± 0.383
2.528PheAsn: 2.528 ± 0.605
2.298PhePro: 2.298 ± 0.614
2.298PheGln: 2.298 ± 0.512
2.528PheArg: 2.528 ± 0.569
6.665PheSer: 6.665 ± 1.437
2.298PheThr: 2.298 ± 0.403
3.447PheVal: 3.447 ± 0.698
0.0PheTrp: 0.0 ± 0.0
2.298PheTyr: 2.298 ± 1.249
0.0PheXaa: 0.0 ± 0.0
Gly
3.907GlyAla: 3.907 ± 0.756
0.919GlyCys: 0.919 ± 0.609
3.677GlyAsp: 3.677 ± 0.541
2.988GlyGlu: 2.988 ± 0.612
2.528GlyPhe: 2.528 ± 0.743
5.286GlyGly: 5.286 ± 0.689
0.23GlyHis: 0.23 ± 0.266
3.447GlyIle: 3.447 ± 0.775
5.746GlyLys: 5.746 ± 1.257
5.056GlyLeu: 5.056 ± 0.88
1.609GlyMet: 1.609 ± 0.409
3.677GlyAsn: 3.677 ± 1.489
1.149GlyPro: 1.149 ± 0.362
1.149GlyGln: 1.149 ± 0.575
3.907GlyArg: 3.907 ± 0.919
5.746GlySer: 5.746 ± 0.48
2.528GlyThr: 2.528 ± 0.67
5.286GlyVal: 5.286 ± 1.902
0.689GlyTrp: 0.689 ± 0.279
0.919GlyTyr: 0.919 ± 0.526
0.0GlyXaa: 0.0 ± 0.0
His
0.46HisAla: 0.46 ± 0.255
0.23HisCys: 0.23 ± 0.128
0.689HisAsp: 0.689 ± 0.338
1.379HisGlu: 1.379 ± 0.326
0.689HisPhe: 0.689 ± 0.314
0.46HisGly: 0.46 ± 0.263
0.46HisHis: 0.46 ± 0.255
0.689HisIle: 0.689 ± 0.314
0.919HisLys: 0.919 ± 0.399
1.379HisLeu: 1.379 ± 0.496
0.23HisMet: 0.23 ± 0.338
1.379HisAsn: 1.379 ± 0.616
0.689HisPro: 0.689 ± 0.311
0.46HisGln: 0.46 ± 0.263
0.23HisArg: 0.23 ± 0.128
1.839HisSer: 1.839 ± 0.854
0.46HisThr: 0.46 ± 0.283
1.839HisVal: 1.839 ± 0.663
0.0HisTrp: 0.0 ± 0.0
0.689HisTyr: 0.689 ± 0.279
0.0HisXaa: 0.0 ± 0.0
Ile
1.839IleAla: 1.839 ± 0.803
1.149IleCys: 1.149 ± 0.443
2.758IleAsp: 2.758 ± 0.522
3.677IleGlu: 3.677 ± 0.531
3.447IlePhe: 3.447 ± 0.276
4.137IleGly: 4.137 ± 1.08
0.689IleHis: 0.689 ± 0.279
2.068IleIle: 2.068 ± 0.536
3.447IleLys: 3.447 ± 0.776
4.367IleLeu: 4.367 ± 0.888
0.46IleMet: 0.46 ± 0.339
3.677IleAsn: 3.677 ± 0.898
3.218IlePro: 3.218 ± 0.296
1.149IleGln: 1.149 ± 0.609
1.839IleArg: 1.839 ± 0.62
4.367IleSer: 4.367 ± 0.595
3.218IleThr: 3.218 ± 0.838
4.367IleVal: 4.367 ± 0.707
0.23IleTrp: 0.23 ± 0.128
0.23IleTyr: 0.23 ± 0.266
0.0IleXaa: 0.0 ± 0.0
Lys
5.746LysAla: 5.746 ± 1.511
1.149LysCys: 1.149 ± 0.294
3.218LysAsp: 3.218 ± 0.963
4.597LysGlu: 4.597 ± 0.356
3.677LysPhe: 3.677 ± 1.073
4.826LysGly: 4.826 ± 0.667
2.298LysHis: 2.298 ± 0.744
2.298LysIle: 2.298 ± 0.919
4.597LysLys: 4.597 ± 1.297
7.814LysLeu: 7.814 ± 1.096
2.068LysMet: 2.068 ± 0.566
4.367LysAsn: 4.367 ± 0.674
3.447LysPro: 3.447 ± 0.469
1.379LysGln: 1.379 ± 0.558
3.677LysArg: 3.677 ± 1.081
5.056LysSer: 5.056 ± 1.126
4.137LysThr: 4.137 ± 0.705
4.826LysVal: 4.826 ± 0.897
0.23LysTrp: 0.23 ± 0.338
2.068LysTyr: 2.068 ± 0.658
0.0LysXaa: 0.0 ± 0.0
Leu
5.976LeuAla: 5.976 ± 1.384
1.379LeuCys: 1.379 ± 0.537
6.895LeuAsp: 6.895 ± 1.954
3.218LeuGlu: 3.218 ± 1.408
4.137LeuPhe: 4.137 ± 0.927
4.597LeuGly: 4.597 ± 1.385
0.919LeuHis: 0.919 ± 0.359
5.286LeuIle: 5.286 ± 0.827
8.504LeuLys: 8.504 ± 1.686
9.193LeuLeu: 9.193 ± 2.673
2.068LeuMet: 2.068 ± 0.362
5.746LeuAsn: 5.746 ± 1.298
4.826LeuPro: 4.826 ± 0.871
1.839LeuGln: 1.839 ± 0.516
3.677LeuArg: 3.677 ± 0.824
11.492LeuSer: 11.492 ± 1.471
3.218LeuThr: 3.218 ± 1.056
5.286LeuVal: 5.286 ± 1.262
0.689LeuTrp: 0.689 ± 0.546
2.068LeuTyr: 2.068 ± 0.482
0.0LeuXaa: 0.0 ± 0.0
Met
0.919MetAla: 0.919 ± 0.532
0.46MetCys: 0.46 ± 0.273
1.149MetAsp: 1.149 ± 0.416
1.379MetGlu: 1.379 ± 0.843
1.379MetPhe: 1.379 ± 0.193
0.46MetGly: 0.46 ± 0.283
0.23MetHis: 0.23 ± 0.128
0.919MetIle: 0.919 ± 0.329
1.609MetLys: 1.609 ± 0.722
2.298MetLeu: 2.298 ± 0.878
1.149MetMet: 1.149 ± 0.638
0.689MetAsn: 0.689 ± 0.618
0.919MetPro: 0.919 ± 0.39
0.46MetGln: 0.46 ± 0.263
0.919MetArg: 0.919 ± 0.277
2.298MetSer: 2.298 ± 0.59
1.379MetThr: 1.379 ± 0.479
1.379MetVal: 1.379 ± 0.599
0.0MetTrp: 0.0 ± 0.0
0.919MetTyr: 0.919 ± 0.546
0.0MetXaa: 0.0 ± 0.0
Asn
3.907AsnAla: 3.907 ± 0.516
0.689AsnCys: 0.689 ± 0.314
2.298AsnAsp: 2.298 ± 0.312
2.528AsnGlu: 2.528 ± 0.887
2.758AsnPhe: 2.758 ± 0.37
3.218AsnGly: 3.218 ± 0.504
0.689AsnHis: 0.689 ± 0.383
3.447AsnIle: 3.447 ± 1.84
4.137AsnLys: 4.137 ± 0.546
4.597AsnLeu: 4.597 ± 0.916
1.149AsnMet: 1.149 ± 0.495
2.298AsnAsn: 2.298 ± 1.012
2.988AsnPro: 2.988 ± 0.755
1.379AsnGln: 1.379 ± 0.537
2.298AsnArg: 2.298 ± 0.749
5.286AsnSer: 5.286 ± 1.248
4.597AsnThr: 4.597 ± 0.756
3.447AsnVal: 3.447 ± 1.348
1.149AsnTrp: 1.149 ± 0.37
1.609AsnTyr: 1.609 ± 1.306
0.0AsnXaa: 0.0 ± 0.0
Pro
3.677ProAla: 3.677 ± 0.513
0.23ProCys: 0.23 ± 0.128
1.839ProAsp: 1.839 ± 0.983
2.298ProGlu: 2.298 ± 0.6
1.839ProPhe: 1.839 ± 0.555
2.528ProGly: 2.528 ± 0.661
0.46ProHis: 0.46 ± 0.255
1.839ProIle: 1.839 ± 0.803
3.218ProLys: 3.218 ± 0.882
5.056ProLeu: 5.056 ± 0.953
0.23ProMet: 0.23 ± 0.338
1.839ProAsn: 1.839 ± 0.663
1.609ProPro: 1.609 ± 0.566
1.609ProGln: 1.609 ± 0.722
1.839ProArg: 1.839 ± 0.58
2.528ProSer: 2.528 ± 0.7
4.367ProThr: 4.367 ± 0.855
4.597ProVal: 4.597 ± 1.445
0.0ProTrp: 0.0 ± 0.0
0.919ProTyr: 0.919 ± 0.399
0.0ProXaa: 0.0 ± 0.0
Gln
2.068GlnAla: 2.068 ± 0.537
0.0GlnCys: 0.0 ± 0.0
0.919GlnAsp: 0.919 ± 0.725
0.46GlnGlu: 0.46 ± 0.255
2.068GlnPhe: 2.068 ± 1.046
2.068GlnGly: 2.068 ± 0.598
0.919GlnHis: 0.919 ± 0.395
0.46GlnIle: 0.46 ± 0.331
1.609GlnLys: 1.609 ± 0.563
0.689GlnLeu: 0.689 ± 0.383
0.23GlnMet: 0.23 ± 0.128
1.609GlnAsn: 1.609 ± 0.803
1.149GlnPro: 1.149 ± 0.488
0.23GlnGln: 0.23 ± 0.266
1.379GlnArg: 1.379 ± 0.496
1.149GlnSer: 1.149 ± 0.533
2.528GlnThr: 2.528 ± 0.455
2.068GlnVal: 2.068 ± 0.486
0.23GlnTrp: 0.23 ± 0.338
0.46GlnTyr: 0.46 ± 0.255
0.0GlnXaa: 0.0 ± 0.0
Arg
3.218ArgAla: 3.218 ± 0.895
1.149ArgCys: 1.149 ± 0.638
1.609ArgAsp: 1.609 ± 0.609
2.758ArgGlu: 2.758 ± 0.692
2.528ArgPhe: 2.528 ± 1.571
2.758ArgGly: 2.758 ± 0.75
0.46ArgHis: 0.46 ± 0.283
1.609ArgIle: 1.609 ± 0.489
3.677ArgLys: 3.677 ± 1.261
5.056ArgLeu: 5.056 ± 0.783
0.689ArgMet: 0.689 ± 0.294
4.137ArgAsn: 4.137 ± 0.556
1.839ArgPro: 1.839 ± 0.609
1.609ArgGln: 1.609 ± 0.234
3.677ArgArg: 3.677 ± 0.808
4.367ArgSer: 4.367 ± 1.41
3.907ArgThr: 3.907 ± 0.513
3.447ArgVal: 3.447 ± 0.516
0.0ArgTrp: 0.0 ± 0.0
1.379ArgTyr: 1.379 ± 0.882
0.0ArgXaa: 0.0 ± 0.0
Ser
5.516SerAla: 5.516 ± 1.074
1.609SerCys: 1.609 ± 0.489
6.435SerAsp: 6.435 ± 0.934
6.205SerGlu: 6.205 ± 1.215
5.976SerPhe: 5.976 ± 0.895
5.516SerGly: 5.516 ± 0.958
1.839SerHis: 1.839 ± 0.663
3.907SerIle: 3.907 ± 1.185
5.976SerLys: 5.976 ± 0.823
9.883SerLeu: 9.883 ± 0.687
2.068SerMet: 2.068 ± 0.262
6.205SerAsn: 6.205 ± 1.062
2.528SerPro: 2.528 ± 1.103
2.528SerGln: 2.528 ± 0.583
4.597SerArg: 4.597 ± 0.504
11.032SerSer: 11.032 ± 1.873
4.367SerThr: 4.367 ± 0.865
6.435SerVal: 6.435 ± 1.056
0.23SerTrp: 0.23 ± 0.288
2.298SerTyr: 2.298 ± 0.903
0.0SerXaa: 0.0 ± 0.0
Thr
3.447ThrAla: 3.447 ± 1.166
1.379ThrCys: 1.379 ± 0.468
2.298ThrAsp: 2.298 ± 0.912
2.528ThrGlu: 2.528 ± 0.765
3.677ThrPhe: 3.677 ± 1.064
4.367ThrGly: 4.367 ± 0.84
1.839ThrHis: 1.839 ± 0.788
1.839ThrIle: 1.839 ± 0.689
3.447ThrLys: 3.447 ± 0.77
2.988ThrLeu: 2.988 ± 0.633
0.919ThrMet: 0.919 ± 0.333
2.068ThrAsn: 2.068 ± 0.478
2.068ThrPro: 2.068 ± 0.875
0.689ThrGln: 0.689 ± 0.61
3.907ThrArg: 3.907 ± 0.449
6.435ThrSer: 6.435 ± 0.957
3.218ThrThr: 3.218 ± 0.721
7.125ThrVal: 7.125 ± 1.204
0.919ThrTrp: 0.919 ± 0.547
2.528ThrTyr: 2.528 ± 1.167
0.0ThrXaa: 0.0 ± 0.0
Val
5.746ValAla: 5.746 ± 1.265
2.528ValCys: 2.528 ± 0.718
6.205ValAsp: 6.205 ± 0.988
3.907ValGlu: 3.907 ± 1.1
4.597ValPhe: 4.597 ± 1.73
4.826ValGly: 4.826 ± 1.17
0.46ValHis: 0.46 ± 0.255
2.988ValIle: 2.988 ± 0.87
6.895ValLys: 6.895 ± 1.057
7.355ValLeu: 7.355 ± 0.555
2.758ValMet: 2.758 ± 0.74
3.907ValAsn: 3.907 ± 1.238
3.677ValPro: 3.677 ± 0.705
2.758ValGln: 2.758 ± 0.954
3.907ValArg: 3.907 ± 0.984
6.895ValSer: 6.895 ± 0.982
4.826ValThr: 4.826 ± 1.027
6.665ValVal: 6.665 ± 1.868
0.46ValTrp: 0.46 ± 0.255
3.218ValTyr: 3.218 ± 0.908
0.0ValXaa: 0.0 ± 0.0
Trp
0.46TrpAla: 0.46 ± 0.273
0.23TrpCys: 0.23 ± 0.338
0.0TrpAsp: 0.0 ± 0.0
0.46TrpGlu: 0.46 ± 0.255
0.919TrpPhe: 0.919 ± 0.395
0.46TrpGly: 0.46 ± 0.283
0.23TrpHis: 0.23 ± 0.288
0.23TrpIle: 0.23 ± 0.288
0.46TrpLys: 0.46 ± 0.283
0.689TrpLeu: 0.689 ± 0.383
0.23TrpMet: 0.23 ± 0.128
0.23TrpAsn: 0.23 ± 0.27
0.46TrpPro: 0.46 ± 0.283
0.0TrpGln: 0.0 ± 0.0
0.46TrpArg: 0.46 ± 0.273
0.46TrpSer: 0.46 ± 0.486
0.23TrpThr: 0.23 ± 0.338
0.46TrpVal: 0.46 ± 0.331
0.0TrpTrp: 0.0 ± 0.0
0.689TrpTyr: 0.689 ± 0.327
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.379TyrAla: 1.379 ± 0.581
0.23TyrCys: 0.23 ± 0.39
2.068TyrAsp: 2.068 ± 0.578
1.149TyrGlu: 1.149 ± 0.705
0.919TyrPhe: 0.919 ± 0.46
1.149TyrGly: 1.149 ± 0.415
0.919TyrHis: 0.919 ± 0.51
1.609TyrIle: 1.609 ± 0.847
0.689TyrLys: 0.689 ± 0.311
2.298TyrLeu: 2.298 ± 0.798
1.609TyrMet: 1.609 ± 0.6
1.379TyrAsn: 1.379 ± 0.45
1.379TyrPro: 1.379 ± 0.706
0.23TyrGln: 0.23 ± 0.338
1.839TyrArg: 1.839 ± 0.945
3.907TyrSer: 3.907 ± 0.622
1.839TyrThr: 1.839 ± 0.288
2.528TyrVal: 2.528 ± 0.652
0.46TyrTrp: 0.46 ± 0.255
0.919TyrTyr: 0.919 ± 0.323
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (4352 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski