Amino acid dipepetide frequency for Calycomorphotria hydatis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.554AlaAla: 9.554 ± 0.117	1.053AlaCys: 1.053 ± 0.031	5.391AlaAsp: 5.391 ± 0.065	7.039AlaGlu: 7.039 ± 0.092	3.143AlaPhe: 3.143 ± 0.051	7.118AlaGly: 7.118 ± 0.09	1.599AlaHis: 1.599 ± 0.034	5.379AlaIle: 5.379 ± 0.066	3.779AlaLys: 3.779 ± 0.055	7.649AlaLeu: 7.649 ± 0.088	2.298AlaMet: 2.298 ± 0.047	3.046AlaAsn: 3.046 ± 0.05	3.481AlaPro: 3.481 ± 0.061	2.725AlaGln: 2.725 ± 0.047	4.92AlaArg: 4.92 ± 0.06	5.126AlaSer: 5.126 ± 0.07	5.112AlaThr: 5.112 ± 0.061	6.702AlaVal: 6.702 ± 0.07	1.108AlaTrp: 1.108 ± 0.029	2.142AlaTyr: 2.142 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.797CysAla: 0.797 ± 0.023	0.266CysCys: 0.266 ± 0.018	0.716CysAsp: 0.716 ± 0.028	0.714CysGlu: 0.714 ± 0.022	0.479CysPhe: 0.479 ± 0.019	1.186CysGly: 1.186 ± 0.036	0.428CysHis: 0.428 ± 0.019	0.525CysIle: 0.525 ± 0.021	0.409CysLys: 0.409 ± 0.019	1.155CysLeu: 1.155 ± 0.031	0.215CysMet: 0.215 ± 0.012	0.347CysAsn: 0.347 ± 0.017	0.659CysPro: 0.659 ± 0.024	0.367CysGln: 0.367 ± 0.016	0.816CysArg: 0.816 ± 0.024	0.753CysSer: 0.753 ± 0.021	0.563CysThr: 0.563 ± 0.022	0.812CysVal: 0.812 ± 0.025	0.178CysTrp: 0.178 ± 0.012	0.369CysTyr: 0.369 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	5.289AspAla: 5.289 ± 0.059	0.629AspCys: 0.629 ± 0.021	3.807AspAsp: 3.807 ± 0.062	4.591AspGlu: 4.591 ± 0.06	2.433AspPhe: 2.433 ± 0.042	5.104AspGly: 5.104 ± 0.079	1.422AspHis: 1.422 ± 0.033	2.899AspIle: 2.899 ± 0.039	1.838AspLys: 1.838 ± 0.036	5.671AspLeu: 5.671 ± 0.062	1.08AspMet: 1.08 ± 0.029	1.658AspAsn: 1.658 ± 0.033	3.201AspPro: 3.201 ± 0.048	2.443AspGln: 2.443 ± 0.043	3.961AspArg: 3.961 ± 0.051	3.657AspSer: 3.657 ± 0.06	2.642AspThr: 2.642 ± 0.045	4.153AspVal: 4.153 ± 0.053	1.042AspTrp: 1.042 ± 0.03	1.724AspTyr: 1.724 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.992GluAla: 5.992 ± 0.087	0.618GluCys: 0.618 ± 0.023	3.38GluAsp: 3.38 ± 0.051	5.406GluGlu: 5.406 ± 0.081	2.909GluPhe: 2.909 ± 0.044	4.249GluGly: 4.249 ± 0.054	1.615GluHis: 1.615 ± 0.036	3.799GluIle: 3.799 ± 0.046	3.211GluLys: 3.211 ± 0.057	7.737GluLeu: 7.737 ± 0.085	1.728GluMet: 1.728 ± 0.035	2.402GluAsn: 2.402 ± 0.042	3.095GluPro: 3.095 ± 0.053	3.604GluGln: 3.604 ± 0.065	4.508GluArg: 4.508 ± 0.072	4.268GluSer: 4.268 ± 0.057	3.908GluThr: 3.908 ± 0.056	4.832GluVal: 4.832 ± 0.07	0.954GluTrp: 0.954 ± 0.026	1.821GluTyr: 1.821 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.554PheAla: 3.554 ± 0.054	0.542PheCys: 0.542 ± 0.021	2.784PheAsp: 2.784 ± 0.043	2.654PheGlu: 2.654 ± 0.042	1.467PhePhe: 1.467 ± 0.034	3.349PheGly: 3.349 ± 0.047	0.927PheHis: 0.927 ± 0.026	1.804PheIle: 1.804 ± 0.034	1.085PheLys: 1.085 ± 0.026	3.783PheLeu: 3.783 ± 0.061	0.758PheMet: 0.758 ± 0.023	1.299PheAsn: 1.299 ± 0.029	1.851PhePro: 1.851 ± 0.041	1.422PheGln: 1.422 ± 0.033	2.495PheArg: 2.495 ± 0.044	2.552PheSer: 2.552 ± 0.041	2.227PheThr: 2.227 ± 0.042	2.867PheVal: 2.867 ± 0.043	0.582PheTrp: 0.582 ± 0.018	0.945PheTyr: 0.945 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	5.278GlyAla: 5.278 ± 0.068	1.084GlyCys: 1.084 ± 0.03	4.353GlyAsp: 4.353 ± 0.06	5.146GlyGlu: 5.146 ± 0.059	3.146GlyPhe: 3.146 ± 0.049	6.197GlyGly: 6.197 ± 0.115	1.743GlyHis: 1.743 ± 0.034	4.296GlyIle: 4.296 ± 0.056	3.701GlyLys: 3.701 ± 0.052	6.99GlyLeu: 6.99 ± 0.074	1.924GlyMet: 1.924 ± 0.037	2.742GlyAsn: 2.742 ± 0.065	3.082GlyPro: 3.082 ± 0.056	2.791GlyGln: 2.791 ± 0.047	4.619GlyArg: 4.619 ± 0.067	4.662GlySer: 4.662 ± 0.064	4.623GlyThr: 4.623 ± 0.095	5.396GlyVal: 5.396 ± 0.065	1.259GlyTrp: 1.259 ± 0.031	2.288GlyTyr: 2.288 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.905HisAla: 1.905 ± 0.04	0.351HisCys: 0.351 ± 0.017	1.46HisAsp: 1.46 ± 0.031	1.477HisGlu: 1.477 ± 0.033	1.029HisPhe: 1.029 ± 0.024	1.813HisGly: 1.813 ± 0.04	0.764HisHis: 0.764 ± 0.027	1.045HisIle: 1.045 ± 0.027	0.657HisLys: 0.657 ± 0.02	2.221HisLeu: 2.221 ± 0.042	0.418HisMet: 0.418 ± 0.017	0.786HisAsn: 0.786 ± 0.024	1.399HisPro: 1.399 ± 0.033	0.913HisGln: 0.913 ± 0.024	1.533HisArg: 1.533 ± 0.036	1.343HisSer: 1.343 ± 0.032	1.034HisThr: 1.034 ± 0.028	1.604HisVal: 1.604 ± 0.033	0.394HisTrp: 0.394 ± 0.018	0.657HisTyr: 0.657 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.703IleAla: 5.703 ± 0.064	0.706IleCys: 0.706 ± 0.022	3.986IleAsp: 3.986 ± 0.054	4.017IleGlu: 4.017 ± 0.05	1.78IlePhe: 1.78 ± 0.037	4.359IleGly: 4.359 ± 0.066	1.166IleHis: 1.166 ± 0.028	2.47IleIle: 2.47 ± 0.043	1.722IleLys: 1.722 ± 0.034	4.624IleLeu: 4.624 ± 0.06	0.813IleMet: 0.813 ± 0.025	1.926IleAsn: 1.926 ± 0.039	2.851IlePro: 2.851 ± 0.047	1.782IleGln: 1.782 ± 0.036	3.359IleArg: 3.359 ± 0.051	3.619IleSer: 3.619 ± 0.05	3.125IleThr: 3.125 ± 0.053	3.914IleVal: 3.914 ± 0.055	0.633IleTrp: 0.633 ± 0.022	1.378IleTyr: 1.378 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.25LysAla: 3.25 ± 0.062	0.311LysCys: 0.311 ± 0.017	1.978LysAsp: 1.978 ± 0.039	2.658LysGlu: 2.658 ± 0.048	1.492LysPhe: 1.492 ± 0.029	2.294LysGly: 2.294 ± 0.042	0.937LysHis: 0.937 ± 0.026	2.065LysIle: 2.065 ± 0.039	2.199LysLys: 2.199 ± 0.058	4.323LysLeu: 4.323 ± 0.054	0.985LysMet: 0.985 ± 0.027	1.461LysAsn: 1.461 ± 0.038	2.354LysPro: 2.354 ± 0.051	1.903LysGln: 1.903 ± 0.04	2.451LysArg: 2.451 ± 0.038	2.75LysSer: 2.75 ± 0.045	2.339LysThr: 2.339 ± 0.043	2.6LysVal: 2.6 ± 0.048	0.559LysTrp: 0.559 ± 0.021	1.164LysTyr: 1.164 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	9.427LeuAla: 9.427 ± 0.098	1.275LeuCys: 1.275 ± 0.028	5.626LeuAsp: 5.626 ± 0.062	5.974LeuGlu: 5.974 ± 0.069	3.739LeuPhe: 3.739 ± 0.052	6.849LeuGly: 6.849 ± 0.079	2.09LeuHis: 2.09 ± 0.038	5.575LeuIle: 5.575 ± 0.072	4.33LeuLys: 4.33 ± 0.063	10.216LeuLeu: 10.216 ± 0.13	2.185LeuMet: 2.185 ± 0.041	3.485LeuAsn: 3.485 ± 0.052	5.426LeuPro: 5.426 ± 0.062	3.48LeuGln: 3.48 ± 0.049	5.963LeuArg: 5.963 ± 0.079	6.774LeuSer: 6.774 ± 0.072	5.831LeuThr: 5.831 ± 0.068	6.559LeuVal: 6.559 ± 0.072	1.271LeuTrp: 1.271 ± 0.034	2.239LeuTyr: 2.239 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.954MetAla: 1.954 ± 0.042	0.21MetCys: 0.21 ± 0.011	0.947MetAsp: 0.947 ± 0.021	1.255MetGlu: 1.255 ± 0.033	0.781MetPhe: 0.781 ± 0.025	1.446MetGly: 1.446 ± 0.031	0.512MetHis: 0.512 ± 0.02	1.298MetIle: 1.298 ± 0.032	1.087MetLys: 1.087 ± 0.027	2.42MetLeu: 2.42 ± 0.038	0.552MetMet: 0.552 ± 0.022	0.85MetAsn: 0.85 ± 0.022	1.307MetPro: 1.307 ± 0.032	0.901MetGln: 0.901 ± 0.027	1.39MetArg: 1.39 ± 0.03	1.695MetSer: 1.695 ± 0.033	1.519MetThr: 1.519 ± 0.029	1.391MetVal: 1.391 ± 0.035	0.247MetTrp: 0.247 ± 0.013	0.447MetTyr: 0.447 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.891AsnAla: 2.891 ± 0.048	0.42AsnCys: 0.42 ± 0.017	2.127AsnAsp: 2.127 ± 0.04	2.112AsnGlu: 2.112 ± 0.035	1.291AsnPhe: 1.291 ± 0.031	2.932AsnGly: 2.932 ± 0.057	0.812AsnHis: 0.812 ± 0.027	1.705AsnIle: 1.705 ± 0.042	1.116AsnLys: 1.116 ± 0.031	3.199AsnLeu: 3.199 ± 0.048	0.687AsnMet: 0.687 ± 0.021	1.359AsnAsn: 1.359 ± 0.036	2.119AsnPro: 2.119 ± 0.04	1.265AsnGln: 1.265 ± 0.03	2.209AsnArg: 2.209 ± 0.042	2.499AsnSer: 2.499 ± 0.048	1.879AsnThr: 1.879 ± 0.042	2.374AsnVal: 2.374 ± 0.043	0.613AsnTrp: 0.613 ± 0.021	1.122AsnTyr: 1.122 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.625ProAla: 4.625 ± 0.065	0.388ProCys: 0.388 ± 0.017	3.264ProAsp: 3.264 ± 0.051	4.421ProGlu: 4.421 ± 0.055	1.971ProPhe: 1.971 ± 0.038	3.781ProGly: 3.781 ± 0.057	1.255ProHis: 1.255 ± 0.03	2.601ProIle: 2.601 ± 0.044	2.094ProLys: 2.094 ± 0.04	4.462ProLeu: 4.462 ± 0.064	1.028ProMet: 1.028 ± 0.03	1.873ProAsn: 1.873 ± 0.037	2.65ProPro: 2.65 ± 0.059	2.035ProGln: 2.035 ± 0.04	2.513ProArg: 2.513 ± 0.04	3.148ProSer: 3.148 ± 0.049	2.867ProThr: 2.867 ± 0.047	3.887ProVal: 3.887 ± 0.059	0.626ProTrp: 0.626 ± 0.02	1.258ProTyr: 1.258 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.453GlnAla: 3.453 ± 0.055	0.43GlnCys: 0.43 ± 0.02	1.542GlnAsp: 1.542 ± 0.034	2.311GlnGlu: 2.311 ± 0.048	1.707GlnPhe: 1.707 ± 0.033	2.23GlnGly: 2.23 ± 0.04	0.962GlnHis: 0.962 ± 0.024	2.17GlnIle: 2.17 ± 0.035	1.633GlnLys: 1.633 ± 0.038	4.566GlnLeu: 4.566 ± 0.068	0.919GlnMet: 0.919 ± 0.026	1.253GlnAsn: 1.253 ± 0.031	2.181GlnPro: 2.181 ± 0.049	2.374GlnGln: 2.374 ± 0.061	2.584GlnArg: 2.584 ± 0.052	2.579GlnSer: 2.579 ± 0.045	2.112GlnThr: 2.112 ± 0.037	2.559GlnVal: 2.559 ± 0.048	0.577GlnTrp: 0.577 ± 0.02	0.935GlnTyr: 0.935 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	4.373ArgAla: 4.373 ± 0.071	0.728ArgCys: 0.728 ± 0.027	3.779ArgAsp: 3.779 ± 0.055	4.693ArgGlu: 4.693 ± 0.075	2.722ArgPhe: 2.722 ± 0.042	4.024ArgGly: 4.024 ± 0.058	1.404ArgHis: 1.404 ± 0.03	3.54ArgIle: 3.54 ± 0.046	2.833ArgLys: 2.833 ± 0.041	6.422ArgLeu: 6.422 ± 0.075	1.608ArgMet: 1.608 ± 0.038	2.251ArgAsn: 2.251 ± 0.037	2.778ArgPro: 2.778 ± 0.05	2.654ArgGln: 2.654 ± 0.052	4.481ArgArg: 4.481 ± 0.069	3.738ArgSer: 3.738 ± 0.051	3.175ArgThr: 3.175 ± 0.046	4.202ArgVal: 4.202 ± 0.052	1.017ArgTrp: 1.017 ± 0.025	1.821ArgTyr: 1.821 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	5.452SerAla: 5.452 ± 0.066	0.708SerCys: 0.708 ± 0.027	3.918SerAsp: 3.918 ± 0.053	4.409SerGlu: 4.409 ± 0.06	2.394SerPhe: 2.394 ± 0.041	5.414SerGly: 5.414 ± 0.079	1.446SerHis: 1.446 ± 0.035	3.452SerIle: 3.452 ± 0.046	2.368SerLys: 2.368 ± 0.047	6.23SerLeu: 6.23 ± 0.062	1.448SerMet: 1.448 ± 0.026	2.3SerAsn: 2.3 ± 0.043	3.552SerPro: 3.552 ± 0.052	2.447SerGln: 2.447 ± 0.042	4.067SerArg: 4.067 ± 0.054	4.565SerSer: 4.565 ± 0.064	3.576SerThr: 3.576 ± 0.058	4.479SerVal: 4.479 ± 0.049	0.849SerTrp: 0.849 ± 0.022	1.603SerTyr: 1.603 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.233ThrAla: 5.233 ± 0.068	0.579ThrCys: 0.579 ± 0.02	3.417ThrAsp: 3.417 ± 0.047	3.588ThrGlu: 3.588 ± 0.05	2.201ThrPhe: 2.201 ± 0.038	4.802ThrGly: 4.802 ± 0.089	1.164ThrHis: 1.164 ± 0.028	3.305ThrIle: 3.305 ± 0.054	1.95ThrLys: 1.95 ± 0.042	5.513ThrLeu: 5.513 ± 0.062	1.084ThrMet: 1.084 ± 0.026	1.949ThrAsn: 1.949 ± 0.041	3.258ThrPro: 3.258 ± 0.05	1.815ThrGln: 1.815 ± 0.033	2.996ThrArg: 2.996 ± 0.049	3.717ThrSer: 3.717 ± 0.056	3.34ThrThr: 3.34 ± 0.079	4.339ThrVal: 4.339 ± 0.068	0.728ThrTrp: 0.728 ± 0.022	1.401ThrTyr: 1.401 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	6.539ValAla: 6.539 ± 0.072	0.885ValCys: 0.885 ± 0.034	4.199ValAsp: 4.199 ± 0.061	4.965ValGlu: 4.965 ± 0.056	2.547ValPhe: 2.547 ± 0.046	5.109ValGly: 5.109 ± 0.059	1.459ValHis: 1.459 ± 0.031	4.2ValIle: 4.2 ± 0.055	2.595ValLys: 2.595 ± 0.047	6.894ValLeu: 6.894 ± 0.073	1.652ValMet: 1.652 ± 0.035	2.299ValAsn: 2.299 ± 0.039	3.596ValPro: 3.596 ± 0.051	2.327ValGln: 2.327 ± 0.041	4.325ValArg: 4.325 ± 0.06	4.556ValSer: 4.556 ± 0.053	4.531ValThr: 4.531 ± 0.065	5.33ValVal: 5.33 ± 0.073	0.927ValTrp: 0.927 ± 0.029	1.654ValTyr: 1.654 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.064TrpAla: 1.064 ± 0.028	0.204TrpCys: 0.204 ± 0.011	0.814TrpAsp: 0.814 ± 0.024	0.829TrpGlu: 0.829 ± 0.024	0.532TrpPhe: 0.532 ± 0.02	0.936TrpGly: 0.936 ± 0.028	0.349TrpHis: 0.349 ± 0.014	0.745TrpIle: 0.745 ± 0.022	0.691TrpLys: 0.691 ± 0.022	1.539TrpLeu: 1.539 ± 0.034	0.386TrpMet: 0.386 ± 0.018	0.6TrpAsn: 0.6 ± 0.021	0.656TrpPro: 0.656 ± 0.025	0.669TrpGln: 0.669 ± 0.02	0.961TrpArg: 0.961 ± 0.024	1.018TrpSer: 1.018 ± 0.028	0.793TrpThr: 0.793 ± 0.025	0.82TrpVal: 0.82 ± 0.025	0.278TrpTrp: 0.278 ± 0.016	0.412TrpTyr: 0.412 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.032TyrAla: 2.032 ± 0.038	0.365TyrCys: 0.365 ± 0.014	1.758TyrAsp: 1.758 ± 0.046	1.778TyrGlu: 1.778 ± 0.041	1.185TyrPhe: 1.185 ± 0.03	2.124TyrGly: 2.124 ± 0.048	0.75TyrHis: 0.75 ± 0.025	1.06TyrIle: 1.06 ± 0.028	0.776TyrLys: 0.776 ± 0.028	2.701TyrLeu: 2.701 ± 0.047	0.441TyrMet: 0.441 ± 0.016	0.842TyrAsn: 0.842 ± 0.027	1.251TyrPro: 1.251 ± 0.033	1.16TyrGln: 1.16 ± 0.03	2.088TyrArg: 2.088 ± 0.039	1.66TyrSer: 1.66 ± 0.043	1.183TyrThr: 1.183 ± 0.029	1.768TyrVal: 1.768 ± 0.033	0.454TyrTrp: 0.454 ± 0.018	0.888TyrTyr: 0.888 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4286 proteins (1496807 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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