Amino acid dipepetide frequency for Sulfitobacter brevis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.093AlaAla: 16.093 ± 0.183	1.156AlaCys: 1.156 ± 0.028	6.861AlaAsp: 6.861 ± 0.085	7.702AlaGlu: 7.702 ± 0.092	4.183AlaPhe: 4.183 ± 0.057	10.246AlaGly: 10.246 ± 0.103	2.313AlaHis: 2.313 ± 0.044	5.942AlaIle: 5.942 ± 0.073	4.167AlaLys: 4.167 ± 0.067	13.266AlaLeu: 13.266 ± 0.141	3.888AlaMet: 3.888 ± 0.057	2.862AlaAsn: 2.862 ± 0.05	5.593AlaPro: 5.593 ± 0.092	4.979AlaGln: 4.979 ± 0.064	7.927AlaArg: 7.927 ± 0.09	5.798AlaSer: 5.798 ± 0.068	6.216AlaThr: 6.216 ± 0.077	8.332AlaVal: 8.332 ± 0.096	1.365AlaTrp: 1.365 ± 0.035	2.495AlaTyr: 2.495 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.145CysAla: 1.145 ± 0.032	0.131CysCys: 0.131 ± 0.011	0.613CysAsp: 0.613 ± 0.021	0.461CysGlu: 0.461 ± 0.017	0.353CysPhe: 0.353 ± 0.019	0.946CysGly: 0.946 ± 0.03	0.283CysHis: 0.283 ± 0.015	0.429CysIle: 0.429 ± 0.017	0.256CysLys: 0.256 ± 0.014	0.83CysLeu: 0.83 ± 0.029	0.2CysMet: 0.2 ± 0.012	0.253CysAsn: 0.253 ± 0.015	0.501CysPro: 0.501 ± 0.019	0.211CysGln: 0.211 ± 0.012	0.522CysArg: 0.522 ± 0.023	0.464CysSer: 0.464 ± 0.021	0.49CysThr: 0.49 ± 0.02	0.633CysVal: 0.633 ± 0.023	0.136CysTrp: 0.136 ± 0.01	0.214CysTyr: 0.214 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.373AspAla: 7.373 ± 0.088	0.545AspCys: 0.545 ± 0.023	3.452AspAsp: 3.452 ± 0.066	3.341AspGlu: 3.341 ± 0.056	2.245AspPhe: 2.245 ± 0.041	5.396AspGly: 5.396 ± 0.082	1.383AspHis: 1.383 ± 0.032	3.255AspIle: 3.255 ± 0.055	1.887AspLys: 1.887 ± 0.042	6.273AspLeu: 6.273 ± 0.078	1.729AspMet: 1.729 ± 0.035	1.439AspAsn: 1.439 ± 0.037	3.398AspPro: 3.398 ± 0.054	1.961AspGln: 1.961 ± 0.04	3.843AspArg: 3.843 ± 0.059	2.281AspSer: 2.281 ± 0.045	3.188AspThr: 3.188 ± 0.052	4.497AspVal: 4.497 ± 0.064	1.139AspTrp: 1.139 ± 0.03	1.492AspTyr: 1.492 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.445GluAla: 7.445 ± 0.095	0.369GluCys: 0.369 ± 0.017	3.141GluAsp: 3.141 ± 0.05	3.11GluGlu: 3.11 ± 0.057	1.856GluPhe: 1.856 ± 0.035	4.492GluGly: 4.492 ± 0.075	1.136GluHis: 1.136 ± 0.03	3.671GluIle: 3.671 ± 0.052	2.277GluLys: 2.277 ± 0.046	5.008GluLeu: 5.008 ± 0.062	1.945GluMet: 1.945 ± 0.044	1.912GluAsn: 1.912 ± 0.039	2.281GluPro: 2.281 ± 0.044	2.001GluGln: 2.001 ± 0.039	3.902GluArg: 3.902 ± 0.061	2.16GluSer: 2.16 ± 0.042	3.745GluThr: 3.745 ± 0.062	4.363GluVal: 4.363 ± 0.066	0.739GluTrp: 0.739 ± 0.025	1.11GluTyr: 1.11 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	4.546PheAla: 4.546 ± 0.067	0.434PheCys: 0.434 ± 0.019	2.911PheAsp: 2.911 ± 0.052	2.255PheGlu: 2.255 ± 0.05	1.386PhePhe: 1.386 ± 0.04	3.705PheGly: 3.705 ± 0.055	0.729PheHis: 0.729 ± 0.031	1.736PheIle: 1.736 ± 0.037	1.14PheLys: 1.14 ± 0.035	3.244PheLeu: 3.244 ± 0.058	0.908PheMet: 0.908 ± 0.027	1.144PheAsn: 1.144 ± 0.033	1.452PhePro: 1.452 ± 0.036	1.076PheGln: 1.076 ± 0.031	1.968PheArg: 1.968 ± 0.046	2.253PheSer: 2.253 ± 0.04	2.111PheThr: 2.111 ± 0.043	2.706PheVal: 2.706 ± 0.05	0.563PheTrp: 0.563 ± 0.021	0.909PheTyr: 0.909 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.502GlyAla: 9.502 ± 0.096	0.862GlyCys: 0.862 ± 0.028	4.661GlyAsp: 4.661 ± 0.082	4.288GlyGlu: 4.288 ± 0.064	3.691GlyPhe: 3.691 ± 0.055	7.204GlyGly: 7.204 ± 0.131	1.906GlyHis: 1.906 ± 0.039	4.568GlyIle: 4.568 ± 0.063	3.445GlyLys: 3.445 ± 0.065	8.755GlyLeu: 8.755 ± 0.085	2.629GlyMet: 2.629 ± 0.052	2.333GlyAsn: 2.333 ± 0.059	3.497GlyPro: 3.497 ± 0.058	3.1GlyGln: 3.1 ± 0.047	5.172GlyArg: 5.172 ± 0.072	4.418GlySer: 4.418 ± 0.083	4.74GlyThr: 4.74 ± 0.081	6.356GlyVal: 6.356 ± 0.073	1.414GlyTrp: 1.414 ± 0.033	2.234GlyTyr: 2.234 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.289HisAla: 2.289 ± 0.041	0.241HisCys: 0.241 ± 0.015	1.275HisAsp: 1.275 ± 0.033	1.014HisGlu: 1.014 ± 0.029	0.823HisPhe: 0.823 ± 0.026	1.883HisGly: 1.883 ± 0.037	0.579HisHis: 0.579 ± 0.021	1.078HisIle: 1.078 ± 0.031	0.627HisLys: 0.627 ± 0.021	2.222HisLeu: 2.222 ± 0.046	0.583HisMet: 0.583 ± 0.022	0.525HisAsn: 0.525 ± 0.022	1.35HisPro: 1.35 ± 0.034	0.654HisGln: 0.654 ± 0.022	1.341HisArg: 1.341 ± 0.034	1.031HisSer: 1.031 ± 0.029	0.933HisThr: 0.933 ± 0.028	1.493HisVal: 1.493 ± 0.034	0.314HisTrp: 0.314 ± 0.014	0.556HisTyr: 0.556 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.15IleAla: 7.15 ± 0.076	0.651IleCys: 0.651 ± 0.023	3.654IleAsp: 3.654 ± 0.062	3.657IleGlu: 3.657 ± 0.052	1.894IlePhe: 1.894 ± 0.044	4.917IleGly: 4.917 ± 0.065	0.958IleHis: 0.958 ± 0.029	2.598IleIle: 2.598 ± 0.049	1.74IleLys: 1.74 ± 0.042	4.744IleLeu: 4.744 ± 0.064	1.196IleMet: 1.196 ± 0.029	1.57IleAsn: 1.57 ± 0.034	2.364IlePro: 2.364 ± 0.048	1.273IleGln: 1.273 ± 0.033	3.019IleArg: 3.019 ± 0.044	3.298IleSer: 3.298 ± 0.052	3.29IleThr: 3.29 ± 0.046	3.91IleVal: 3.91 ± 0.064	0.764IleTrp: 0.764 ± 0.024	1.266IleTyr: 1.266 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.12LysAla: 4.12 ± 0.069	0.199LysCys: 0.199 ± 0.013	1.942LysAsp: 1.942 ± 0.042	1.666LysGlu: 1.666 ± 0.041	1.083LysPhe: 1.083 ± 0.032	2.926LysGly: 2.926 ± 0.061	0.743LysHis: 0.743 ± 0.026	1.945LysIle: 1.945 ± 0.044	1.373LysLys: 1.373 ± 0.04	3.375LysLeu: 3.375 ± 0.052	1.042LysMet: 1.042 ± 0.029	1.02LysAsn: 1.02 ± 0.028	1.929LysPro: 1.929 ± 0.046	1.081LysGln: 1.081 ± 0.031	2.41LysArg: 2.41 ± 0.046	2.052LysSer: 2.052 ± 0.043	2.129LysThr: 2.129 ± 0.045	2.525LysVal: 2.525 ± 0.055	0.423LysTrp: 0.423 ± 0.018	0.721LysTyr: 0.721 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	12.471LeuAla: 12.471 ± 0.125	0.921LeuCys: 0.921 ± 0.028	5.646LeuAsp: 5.646 ± 0.068	5.336LeuGlu: 5.336 ± 0.07	3.385LeuPhe: 3.385 ± 0.062	8.2LeuGly: 8.2 ± 0.111	1.953LeuHis: 1.953 ± 0.042	5.546LeuIle: 5.546 ± 0.081	3.472LeuLys: 3.472 ± 0.057	8.937LeuLeu: 8.937 ± 0.118	2.775LeuMet: 2.775 ± 0.049	2.892LeuAsn: 2.892 ± 0.055	5.342LeuPro: 5.342 ± 0.065	2.959LeuGln: 2.959 ± 0.045	6.874LeuArg: 6.874 ± 0.075	6.63LeuSer: 6.63 ± 0.077	6.043LeuThr: 6.043 ± 0.07	6.644LeuVal: 6.644 ± 0.077	1.26LeuTrp: 1.26 ± 0.034	1.896LeuTyr: 1.896 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.618MetAla: 3.618 ± 0.052	0.194MetCys: 0.194 ± 0.011	1.437MetAsp: 1.437 ± 0.032	1.329MetGlu: 1.329 ± 0.036	0.893MetPhe: 0.893 ± 0.029	2.363MetGly: 2.363 ± 0.046	0.501MetHis: 0.501 ± 0.02	1.691MetIle: 1.691 ± 0.044	1.11MetLys: 1.11 ± 0.032	2.809MetLeu: 2.809 ± 0.053	0.917MetMet: 0.917 ± 0.031	0.936MetAsn: 0.936 ± 0.029	1.652MetPro: 1.652 ± 0.034	1.104MetGln: 1.104 ± 0.033	1.967MetArg: 1.967 ± 0.047	1.805MetSer: 1.805 ± 0.037	2.17MetThr: 2.17 ± 0.046	2.011MetVal: 2.011 ± 0.041	0.249MetTrp: 0.249 ± 0.014	0.395MetTyr: 0.395 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.389AsnAla: 3.389 ± 0.058	0.29AsnCys: 0.29 ± 0.016	1.703AsnAsp: 1.703 ± 0.05	1.329AsnGlu: 1.329 ± 0.033	1.094AsnPhe: 1.094 ± 0.03	2.592AsnGly: 2.592 ± 0.056	0.576AsnHis: 0.576 ± 0.018	1.567AsnIle: 1.567 ± 0.036	0.793AsnLys: 0.793 ± 0.021	2.738AsnLeu: 2.738 ± 0.046	0.743AsnMet: 0.743 ± 0.027	0.829AsnAsn: 0.829 ± 0.031	1.855AsnPro: 1.855 ± 0.035	0.798AsnGln: 0.798 ± 0.024	1.816AsnArg: 1.816 ± 0.041	1.334AsnSer: 1.334 ± 0.04	1.5AsnThr: 1.5 ± 0.034	1.925AsnVal: 1.925 ± 0.043	0.463AsnTrp: 0.463 ± 0.018	0.696AsnTyr: 0.696 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	5.573ProAla: 5.573 ± 0.085	0.351ProCys: 0.351 ± 0.016	3.844ProAsp: 3.844 ± 0.059	3.73ProGlu: 3.73 ± 0.06	1.93ProPhe: 1.93 ± 0.041	3.448ProGly: 3.448 ± 0.052	1.08ProHis: 1.08 ± 0.031	2.32ProIle: 2.32 ± 0.051	1.804ProLys: 1.804 ± 0.042	4.627ProLeu: 4.627 ± 0.068	1.339ProMet: 1.339 ± 0.036	1.39ProAsn: 1.39 ± 0.035	2.115ProPro: 2.115 ± 0.046	1.897ProGln: 1.897 ± 0.042	2.648ProArg: 2.648 ± 0.048	2.553ProSer: 2.553 ± 0.041	2.546ProThr: 2.546 ± 0.043	4.082ProVal: 4.082 ± 0.055	0.615ProTrp: 0.615 ± 0.022	1.142ProTyr: 1.142 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.163GlnAla: 4.163 ± 0.053	0.211GlnCys: 0.211 ± 0.014	1.784GlnAsp: 1.784 ± 0.04	1.626GlnGlu: 1.626 ± 0.041	1.163GlnPhe: 1.163 ± 0.031	2.761GlnGly: 2.761 ± 0.055	0.686GlnHis: 0.686 ± 0.023	2.232GlnIle: 2.232 ± 0.042	1.227GlnLys: 1.227 ± 0.038	2.905GlnLeu: 2.905 ± 0.055	1.223GlnMet: 1.223 ± 0.031	1.009GlnAsn: 1.009 ± 0.029	1.623GlnPro: 1.623 ± 0.038	1.26GlnGln: 1.26 ± 0.03	2.242GlnArg: 2.242 ± 0.042	2.107GlnSer: 2.107 ± 0.04	2.094GlnThr: 2.094 ± 0.043	2.423GlnVal: 2.423 ± 0.046	0.414GlnTrp: 0.414 ± 0.018	0.637GlnTyr: 0.637 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	7.557ArgAla: 7.557 ± 0.086	0.491ArgCys: 0.491 ± 0.021	4.154ArgAsp: 4.154 ± 0.058	3.586ArgGlu: 3.586 ± 0.058	2.543ArgPhe: 2.543 ± 0.049	4.332ArgGly: 4.332 ± 0.058	1.45ArgHis: 1.45 ± 0.034	3.633ArgIle: 3.633 ± 0.055	2.484ArgLys: 2.484 ± 0.049	6.606ArgLeu: 6.606 ± 0.094	1.964ArgMet: 1.964 ± 0.045	1.827ArgAsn: 1.827 ± 0.039	2.868ArgPro: 2.868 ± 0.053	2.273ArgGln: 2.273 ± 0.044	4.41ArgArg: 4.41 ± 0.078	3.322ArgSer: 3.322 ± 0.053	3.035ArgThr: 3.035 ± 0.05	4.434ArgVal: 4.434 ± 0.068	0.915ArgTrp: 0.915 ± 0.029	1.457ArgTyr: 1.457 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.096SerAla: 6.096 ± 0.071	0.45SerCys: 0.45 ± 0.023	3.502SerAsp: 3.502 ± 0.057	3.035SerGlu: 3.035 ± 0.048	2.353SerPhe: 2.353 ± 0.04	5.56SerGly: 5.56 ± 0.075	1.144SerHis: 1.144 ± 0.029	2.664SerIle: 2.664 ± 0.043	1.771SerLys: 1.771 ± 0.038	5.163SerLeu: 5.163 ± 0.065	1.528SerMet: 1.528 ± 0.032	1.525SerAsn: 1.525 ± 0.031	2.47SerPro: 2.47 ± 0.046	1.723SerGln: 1.723 ± 0.039	3.171SerArg: 3.171 ± 0.052	2.719SerSer: 2.719 ± 0.052	2.74SerThr: 2.74 ± 0.045	3.968SerVal: 3.968 ± 0.059	0.649SerTrp: 0.649 ± 0.024	1.394SerTyr: 1.394 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.464ThrAla: 6.464 ± 0.075	0.55ThrCys: 0.55 ± 0.023	3.261ThrAsp: 3.261 ± 0.054	2.938ThrGlu: 2.938 ± 0.044	1.985ThrPhe: 1.985 ± 0.045	5.293ThrGly: 5.293 ± 0.081	1.172ThrHis: 1.172 ± 0.032	2.879ThrIle: 2.879 ± 0.045	1.742ThrLys: 1.742 ± 0.039	6.284ThrLeu: 6.284 ± 0.083	1.402ThrMet: 1.402 ± 0.034	1.466ThrAsn: 1.466 ± 0.036	3.536ThrPro: 3.536 ± 0.059	1.817ThrGln: 1.817 ± 0.044	3.389ThrArg: 3.389 ± 0.06	3.082ThrSer: 3.082 ± 0.055	3.116ThrThr: 3.116 ± 0.062	4.256ThrVal: 4.256 ± 0.058	0.725ThrTrp: 0.725 ± 0.024	1.299ThrTyr: 1.299 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.573ValAla: 8.573 ± 0.092	0.648ValCys: 0.648 ± 0.024	3.988ValAsp: 3.988 ± 0.058	4.394ValGlu: 4.394 ± 0.069	2.802ValPhe: 2.802 ± 0.05	5.418ValGly: 5.418 ± 0.072	1.338ValHis: 1.338 ± 0.034	4.359ValIle: 4.359 ± 0.068	2.318ValLys: 2.318 ± 0.048	7.504ValLeu: 7.504 ± 0.087	2.249ValMet: 2.249 ± 0.042	2.002ValAsn: 2.002 ± 0.043	3.491ValPro: 3.491 ± 0.05	2.293ValGln: 2.293 ± 0.04	4.156ValArg: 4.156 ± 0.058	4.305ValSer: 4.305 ± 0.059	4.697ValThr: 4.697 ± 0.062	5.657ValVal: 5.657 ± 0.073	0.964ValTrp: 0.964 ± 0.028	1.488ValTyr: 1.488 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.348TrpAla: 1.348 ± 0.032	0.153TrpCys: 0.153 ± 0.012	0.718TrpAsp: 0.718 ± 0.026	0.633TrpGlu: 0.633 ± 0.024	0.591TrpPhe: 0.591 ± 0.02	1.007TrpGly: 1.007 ± 0.03	0.355TrpHis: 0.355 ± 0.019	0.736TrpIle: 0.736 ± 0.02	0.448TrpLys: 0.448 ± 0.02	1.627TrpLeu: 1.627 ± 0.042	0.407TrpMet: 0.407 ± 0.02	0.438TrpAsn: 0.438 ± 0.019	0.669TrpPro: 0.669 ± 0.026	0.634TrpGln: 0.634 ± 0.023	1.041TrpArg: 1.041 ± 0.031	0.8TrpSer: 0.8 ± 0.024	0.728TrpThr: 0.728 ± 0.022	0.88TrpVal: 0.88 ± 0.027	0.222TrpTrp: 0.222 ± 0.012	0.25TrpTyr: 0.25 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.471TyrAla: 2.471 ± 0.047	0.225TyrCys: 0.225 ± 0.014	1.574TyrAsp: 1.574 ± 0.034	1.233TyrGlu: 1.233 ± 0.035	0.922TyrPhe: 0.922 ± 0.028	2.084TyrGly: 2.084 ± 0.04	0.528TyrHis: 0.528 ± 0.019	1.063TyrIle: 1.063 ± 0.03	0.622TyrLys: 0.622 ± 0.025	2.266TyrLeu: 2.266 ± 0.044	0.484TyrMet: 0.484 ± 0.019	0.659TyrAsn: 0.659 ± 0.023	1.047TyrPro: 1.047 ± 0.031	0.693TyrGln: 0.693 ± 0.025	1.525TyrArg: 1.525 ± 0.033	1.209TyrSer: 1.209 ± 0.033	1.144TyrThr: 1.144 ± 0.037	1.551TyrVal: 1.551 ± 0.036	0.351TyrTrp: 0.351 ± 0.02	0.591TyrTyr: 0.591 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4154 proteins (1253621 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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