Amino acid dipepetide frequency for Apis mellifera associated microvirus 13

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.015AlaAla: 14.015 ± 2.757
0.701AlaCys: 0.701 ± 0.621
7.008AlaAsp: 7.008 ± 1.336
6.307AlaGlu: 6.307 ± 0.834
2.102AlaPhe: 2.102 ± 0.961
5.606AlaGly: 5.606 ± 2.882
0.701AlaHis: 0.701 ± 0.459
2.803AlaIle: 2.803 ± 1.14
6.307AlaLys: 6.307 ± 2.639
4.205AlaLeu: 4.205 ± 2.024
2.803AlaMet: 2.803 ± 0.841
6.307AlaAsn: 6.307 ± 1.328
3.504AlaPro: 3.504 ± 1.627
7.708AlaGln: 7.708 ± 2.001
7.008AlaArg: 7.008 ± 1.039
7.708AlaSer: 7.708 ± 1.967
8.409AlaThr: 8.409 ± 2.479
5.606AlaVal: 5.606 ± 2.738
0.701AlaTrp: 0.701 ± 0.66
3.504AlaTyr: 3.504 ± 1.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.701CysAsp: 0.701 ± 0.714
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.701CysGly: 0.701 ± 0.621
0.0CysHis: 0.0 ± 0.0
1.402CysIle: 1.402 ± 1.242
0.0CysLys: 0.0 ± 0.0
0.701CysLeu: 0.701 ± 0.459
0.701CysMet: 0.701 ± 0.621
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.701CysArg: 0.701 ± 0.621
0.0CysSer: 0.0 ± 0.0
1.402CysThr: 1.402 ± 0.711
0.701CysVal: 0.701 ± 0.621
0.0CysTrp: 0.0 ± 0.0
0.701CysTyr: 0.701 ± 0.621
0.0CysXaa: 0.0 ± 0.0
Asp
3.504AspAla: 3.504 ± 1.145
0.0AspCys: 0.0 ± 0.0
1.402AspAsp: 1.402 ± 1.227
2.102AspGlu: 2.102 ± 1.285
4.905AspPhe: 4.905 ± 0.888
1.402AspGly: 1.402 ± 0.919
2.102AspHis: 2.102 ± 1.112
6.307AspIle: 6.307 ± 1.748
1.402AspLys: 1.402 ± 1.242
4.905AspLeu: 4.905 ± 1.757
0.701AspMet: 0.701 ± 1.093
3.504AspAsn: 3.504 ± 1.248
2.102AspPro: 2.102 ± 1.349
2.803AspGln: 2.803 ± 1.025
0.701AspArg: 0.701 ± 0.714
2.803AspSer: 2.803 ± 1.357
2.803AspThr: 2.803 ± 0.628
1.402AspVal: 1.402 ± 0.811
0.0AspTrp: 0.0 ± 0.0
2.102AspTyr: 2.102 ± 0.961
0.0AspXaa: 0.0 ± 0.0
Glu
9.11GluAla: 9.11 ± 4.025
0.701GluCys: 0.701 ± 0.714
1.402GluAsp: 1.402 ± 1.24
4.905GluGlu: 4.905 ± 2.541
0.701GluPhe: 0.701 ± 0.714
0.701GluGly: 0.701 ± 1.093
1.402GluHis: 1.402 ± 0.584
4.905GluIle: 4.905 ± 0.941
4.205GluLys: 4.205 ± 2.576
4.205GluLeu: 4.205 ± 2.416
0.701GluMet: 0.701 ± 1.157
1.402GluAsn: 1.402 ± 0.909
0.701GluPro: 0.701 ± 0.714
6.307GluGln: 6.307 ± 2.085
4.905GluArg: 4.905 ± 1.541
2.803GluSer: 2.803 ± 2.413
4.905GluThr: 4.905 ± 2.086
0.0GluVal: 0.0 ± 0.0
0.701GluTrp: 0.701 ± 0.459
4.205GluTyr: 4.205 ± 1.621
0.0GluXaa: 0.0 ± 0.0
Phe
3.504PheAla: 3.504 ± 1.4
0.0PheCys: 0.0 ± 0.0
0.701PheAsp: 0.701 ± 1.237
0.701PheGlu: 0.701 ± 0.714
1.402PhePhe: 1.402 ± 0.711
4.205PheGly: 4.205 ± 0.796
1.402PheHis: 1.402 ± 0.584
3.504PheIle: 3.504 ± 2.035
1.402PheLys: 1.402 ± 0.909
0.0PheLeu: 0.0 ± 0.0
3.504PheMet: 3.504 ± 1.13
3.504PheAsn: 3.504 ± 1.117
0.701PhePro: 0.701 ± 0.459
4.205PheGln: 4.205 ± 1.848
2.102PheArg: 2.102 ± 1.378
0.701PheSer: 0.701 ± 0.621
4.205PheThr: 4.205 ± 2.338
2.102PheVal: 2.102 ± 0.847
0.0PheTrp: 0.0 ± 0.0
2.102PheTyr: 2.102 ± 1.378
0.0PheXaa: 0.0 ± 0.0
Gly
4.905GlyAla: 4.905 ± 1.553
0.701GlyCys: 0.701 ± 0.621
4.905GlyAsp: 4.905 ± 1.33
8.409GlyGlu: 8.409 ± 2.766
1.402GlyPhe: 1.402 ± 0.584
4.905GlyGly: 4.905 ± 1.779
0.0GlyHis: 0.0 ± 0.0
1.402GlyIle: 1.402 ± 0.711
3.504GlyLys: 3.504 ± 1.695
5.606GlyLeu: 5.606 ± 2.325
1.402GlyMet: 1.402 ± 0.59
2.102GlyAsn: 2.102 ± 1.628
2.803GlyPro: 2.803 ± 0.628
4.205GlyGln: 4.205 ± 0.871
2.102GlyArg: 2.102 ± 1.259
2.102GlySer: 2.102 ± 1.259
4.905GlyThr: 4.905 ± 1.553
2.803GlyVal: 2.803 ± 1.167
0.0GlyTrp: 0.0 ± 0.0
3.504GlyTyr: 3.504 ± 0.946
0.0GlyXaa: 0.0 ± 0.0
His
3.504HisAla: 3.504 ± 2.681
0.0HisCys: 0.0 ± 0.0
1.402HisAsp: 1.402 ± 0.584
0.701HisGlu: 0.701 ± 0.621
2.803HisPhe: 2.803 ± 1.178
0.701HisGly: 0.701 ± 0.459
0.0HisHis: 0.0 ± 0.0
1.402HisIle: 1.402 ± 1.24
2.803HisLys: 2.803 ± 1.462
0.701HisLeu: 0.701 ± 0.66
0.0HisMet: 0.0 ± 0.0
0.701HisAsn: 0.701 ± 0.459
2.803HisPro: 2.803 ± 1.14
0.701HisGln: 0.701 ± 0.459
0.701HisArg: 0.701 ± 0.459
0.701HisSer: 0.701 ± 0.459
0.0HisThr: 0.0 ± 0.0
0.701HisVal: 0.701 ± 0.621
0.0HisTrp: 0.0 ± 0.0
1.402HisTyr: 1.402 ± 0.584
0.0HisXaa: 0.0 ± 0.0
Ile
2.803IleAla: 2.803 ± 0.628
0.0IleCys: 0.0 ± 0.0
4.205IleAsp: 4.205 ± 1.266
4.205IleGlu: 4.205 ± 2.627
3.504IlePhe: 3.504 ± 2.262
4.905IleGly: 4.905 ± 1.56
0.701IleHis: 0.701 ± 1.093
3.504IleIle: 3.504 ± 1.326
2.803IleLys: 2.803 ± 1.462
1.402IleLeu: 1.402 ± 0.711
0.0IleMet: 0.0 ± 0.566
6.307IleAsn: 6.307 ± 1.328
2.803IlePro: 2.803 ± 1.837
2.803IleGln: 2.803 ± 1.422
6.307IleArg: 6.307 ± 1.229
1.402IleSer: 1.402 ± 0.59
4.905IleThr: 4.905 ± 1.672
0.701IleVal: 0.701 ± 0.621
1.402IleTrp: 1.402 ± 0.919
3.504IleTyr: 3.504 ± 0.887
0.0IleXaa: 0.0 ± 0.0
Lys
3.504LysAla: 3.504 ± 1.695
0.0LysCys: 0.0 ± 0.0
0.701LysAsp: 0.701 ± 0.714
4.205LysGlu: 4.205 ± 1.754
1.402LysPhe: 1.402 ± 0.584
2.102LysGly: 2.102 ± 1.164
1.402LysHis: 1.402 ± 1.227
4.205LysIle: 4.205 ± 1.98
0.701LysLys: 0.701 ± 0.459
5.606LysLeu: 5.606 ± 3.086
1.402LysMet: 1.402 ± 0.59
4.205LysAsn: 4.205 ± 1.961
1.402LysPro: 1.402 ± 0.584
3.504LysGln: 3.504 ± 2.273
4.205LysArg: 4.205 ± 1.848
1.402LysSer: 1.402 ± 1.242
7.008LysThr: 7.008 ± 2.629
0.701LysVal: 0.701 ± 0.621
0.0LysTrp: 0.0 ± 0.0
1.402LysTyr: 1.402 ± 1.242
0.0LysXaa: 0.0 ± 0.0
Leu
3.504LeuAla: 3.504 ± 1.388
0.0LeuCys: 0.0 ± 0.0
0.0LeuAsp: 0.0 ± 0.0
7.008LeuGlu: 7.008 ± 2.96
0.701LeuPhe: 0.701 ± 0.459
5.606LeuGly: 5.606 ± 1.613
0.0LeuHis: 0.0 ± 0.0
3.504LeuIle: 3.504 ± 1.739
4.905LeuLys: 4.905 ± 1.807
3.504LeuLeu: 3.504 ± 0.935
1.402LeuMet: 1.402 ± 1.142
7.008LeuAsn: 7.008 ± 1.906
7.708LeuPro: 7.708 ± 3.209
5.606LeuGln: 5.606 ± 3.051
4.205LeuArg: 4.205 ± 1.277
3.504LeuSer: 3.504 ± 1.166
6.307LeuThr: 6.307 ± 2.868
2.803LeuVal: 2.803 ± 1.2
1.402LeuTrp: 1.402 ± 0.584
2.803LeuTyr: 2.803 ± 1.178
0.0LeuXaa: 0.0 ± 0.0
Met
2.803MetAla: 2.803 ± 1.144
0.0MetCys: 0.0 ± 0.0
2.102MetAsp: 2.102 ± 1.285
1.402MetGlu: 1.402 ± 0.909
1.402MetPhe: 1.402 ± 1.139
2.102MetGly: 2.102 ± 0.847
2.102MetHis: 2.102 ± 1.114
2.102MetIle: 2.102 ± 1.387
1.402MetLys: 1.402 ± 1.227
4.205MetLeu: 4.205 ± 1.266
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.102MetPro: 2.102 ± 1.341
2.102MetGln: 2.102 ± 0.827
0.701MetArg: 0.701 ± 0.66
0.701MetSer: 0.701 ± 0.621
0.0MetThr: 0.0 ± 0.0
0.0MetVal: 0.0 ± 0.0
0.701MetTrp: 0.701 ± 0.459
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.205AsnAla: 4.205 ± 2.026
0.0AsnCys: 0.0 ± 0.0
0.701AsnAsp: 0.701 ± 0.714
2.102AsnGlu: 2.102 ± 0.827
0.701AsnPhe: 0.701 ± 0.459
2.102AsnGly: 2.102 ± 0.847
2.102AsnHis: 2.102 ± 1.383
2.803AsnIle: 2.803 ± 1.589
4.905AsnLys: 4.905 ± 1.47
7.008AsnLeu: 7.008 ± 1.592
0.701AsnMet: 0.701 ± 0.609
1.402AsnAsn: 1.402 ± 1.428
3.504AsnPro: 3.504 ± 1.224
2.803AsnGln: 2.803 ± 1.328
4.905AsnArg: 4.905 ± 1.808
3.504AsnSer: 3.504 ± 0.969
6.307AsnThr: 6.307 ± 2.373
3.504AsnVal: 3.504 ± 0.969
0.701AsnTrp: 0.701 ± 0.459
2.102AsnTyr: 2.102 ± 0.766
0.0AsnXaa: 0.0 ± 0.0
Pro
8.409ProAla: 8.409 ± 2.077
1.402ProCys: 1.402 ± 1.242
2.803ProAsp: 2.803 ± 1.822
2.102ProGlu: 2.102 ± 1.131
2.102ProPhe: 2.102 ± 0.961
2.803ProGly: 2.803 ± 1.328
0.701ProHis: 0.701 ± 0.621
2.102ProIle: 2.102 ± 0.847
1.402ProLys: 1.402 ± 0.584
4.905ProLeu: 4.905 ± 2.61
1.402ProMet: 1.402 ± 0.59
2.102ProAsn: 2.102 ± 1.378
2.102ProPro: 2.102 ± 0.752
2.803ProGln: 2.803 ± 0.695
1.402ProArg: 1.402 ± 0.711
1.402ProSer: 1.402 ± 0.919
4.905ProThr: 4.905 ± 1.708
2.803ProVal: 2.803 ± 1.837
0.701ProTrp: 0.701 ± 0.459
2.803ProTyr: 2.803 ± 1.39
0.0ProXaa: 0.0 ± 0.0
Gln
7.008GlnAla: 7.008 ± 1.226
0.701GlnCys: 0.701 ± 0.621
3.504GlnAsp: 3.504 ± 1.224
2.803GlnGlu: 2.803 ± 1.289
2.803GlnPhe: 2.803 ± 2.183
2.803GlnGly: 2.803 ± 1.068
2.803GlnHis: 2.803 ± 2.48
4.905GlnIle: 4.905 ± 2.299
3.504GlnLys: 3.504 ± 0.935
2.102GlnLeu: 2.102 ± 0.561
2.102GlnMet: 2.102 ± 1.02
5.606GlnAsn: 5.606 ± 1.236
2.102GlnPro: 2.102 ± 2.332
6.307GlnGln: 6.307 ± 1.628
4.905GlnArg: 4.905 ± 1.807
2.803GlnSer: 2.803 ± 1.232
7.008GlnThr: 7.008 ± 2.585
2.803GlnVal: 2.803 ± 1.18
1.402GlnTrp: 1.402 ± 0.584
0.0GlnTyr: 0.0 ± 0.0
0.0GlnXaa: 0.0 ± 0.0
Arg
7.708ArgAla: 7.708 ± 2.339
0.701ArgCys: 0.701 ± 0.621
4.205ArgAsp: 4.205 ± 1.369
2.102ArgGlu: 2.102 ± 1.512
1.402ArgPhe: 1.402 ± 0.711
2.102ArgGly: 2.102 ± 0.847
0.701ArgHis: 0.701 ± 0.459
2.803ArgIle: 2.803 ± 1.776
2.803ArgLys: 2.803 ± 1.201
7.008ArgLeu: 7.008 ± 2.066
1.402ArgMet: 1.402 ± 0.584
2.803ArgAsn: 2.803 ± 1.076
3.504ArgPro: 3.504 ± 0.997
3.504ArgGln: 3.504 ± 1.127
0.0ArgArg: 0.0 ± 0.0
5.606ArgSer: 5.606 ± 1.236
0.701ArgThr: 0.701 ± 0.714
1.402ArgVal: 1.402 ± 1.227
1.402ArgTrp: 1.402 ± 0.584
4.205ArgTyr: 4.205 ± 1.751
0.0ArgXaa: 0.0 ± 0.0
Ser
8.409SerAla: 8.409 ± 1.852
0.701SerCys: 0.701 ± 0.459
1.402SerAsp: 1.402 ± 0.584
1.402SerGlu: 1.402 ± 1.319
2.102SerPhe: 2.102 ± 0.847
2.803SerGly: 2.803 ± 1.167
1.402SerHis: 1.402 ± 0.919
2.803SerIle: 2.803 ± 1.289
1.402SerLys: 1.402 ± 0.584
4.205SerLeu: 4.205 ± 1.332
2.102SerMet: 2.102 ± 1.771
1.402SerAsn: 1.402 ± 0.59
2.102SerPro: 2.102 ± 1.378
2.102SerGln: 2.102 ± 1.259
2.102SerArg: 2.102 ± 0.561
1.402SerSer: 1.402 ± 1.319
7.008SerThr: 7.008 ± 1.651
3.504SerVal: 3.504 ± 1.619
0.0SerTrp: 0.0 ± 0.0
1.402SerTyr: 1.402 ± 1.231
0.0SerXaa: 0.0 ± 0.0
Thr
9.11ThrAla: 9.11 ± 2.486
0.0ThrCys: 0.0 ± 0.0
3.504ThrAsp: 3.504 ± 0.997
5.606ThrGlu: 5.606 ± 1.403
4.205ThrPhe: 4.205 ± 2.093
9.811ThrGly: 9.811 ± 1.169
1.402ThrHis: 1.402 ± 0.584
4.205ThrIle: 4.205 ± 1.522
1.402ThrLys: 1.402 ± 1.319
5.606ThrLeu: 5.606 ± 1.646
2.102ThrMet: 2.102 ± 1.006
2.803ThrAsn: 2.803 ± 1.18
6.307ThrPro: 6.307 ± 1.642
2.803ThrGln: 2.803 ± 1.776
3.504ThrArg: 3.504 ± 1.528
6.307ThrSer: 6.307 ± 2.069
6.307ThrThr: 6.307 ± 2.006
4.905ThrVal: 4.905 ± 2.403
2.803ThrTrp: 2.803 ± 1.848
0.701ThrTyr: 0.701 ± 0.621
0.0ThrXaa: 0.0 ± 0.0
Val
3.504ValAla: 3.504 ± 1.528
0.701ValCys: 0.701 ± 0.714
1.402ValAsp: 1.402 ± 0.584
2.102ValGlu: 2.102 ± 1.259
2.102ValPhe: 2.102 ± 0.847
2.102ValGly: 2.102 ± 1.164
0.701ValHis: 0.701 ± 0.66
2.803ValIle: 2.803 ± 0.628
0.701ValLys: 0.701 ± 0.621
2.803ValLeu: 2.803 ± 1.058
1.402ValMet: 1.402 ± 0.919
0.701ValAsn: 0.701 ± 0.459
3.504ValPro: 3.504 ± 2.297
2.102ValGln: 2.102 ± 1.341
3.504ValArg: 3.504 ± 1.385
2.102ValSer: 2.102 ± 0.827
4.205ValThr: 4.205 ± 1.458
0.701ValVal: 0.701 ± 0.459
0.701ValTrp: 0.701 ± 0.459
0.701ValTyr: 0.701 ± 0.621
0.0ValXaa: 0.0 ± 0.0
Trp
1.402TrpAla: 1.402 ± 0.919
0.0TrpCys: 0.0 ± 0.0
0.701TrpAsp: 0.701 ± 0.621
0.0TrpGlu: 0.0 ± 0.0
0.701TrpPhe: 0.701 ± 0.459
1.402TrpGly: 1.402 ± 0.811
0.701TrpHis: 0.701 ± 0.459
0.0TrpIle: 0.0 ± 0.0
0.701TrpLys: 0.701 ± 0.459
0.701TrpLeu: 0.701 ± 0.621
0.0TrpMet: 0.0 ± 0.0
0.701TrpAsn: 0.701 ± 0.459
1.402TrpPro: 1.402 ± 0.584
2.102TrpGln: 2.102 ± 0.561
0.701TrpArg: 0.701 ± 0.621
1.402TrpSer: 1.402 ± 0.919
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.701TrpTrp: 0.701 ± 0.66
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.102TyrAla: 2.102 ± 1.378
1.402TyrCys: 1.402 ± 0.584
4.205TyrAsp: 4.205 ± 1.653
0.701TyrGlu: 0.701 ± 1.093
3.504TyrPhe: 3.504 ± 1.4
2.803TyrGly: 2.803 ± 1.941
1.402TyrHis: 1.402 ± 0.584
1.402TyrIle: 1.402 ± 0.584
2.803TyrLys: 2.803 ± 1.401
2.102TyrLeu: 2.102 ± 1.259
1.402TyrMet: 1.402 ± 0.584
3.504TyrAsn: 3.504 ± 1.731
0.0TyrPro: 0.0 ± 0.0
3.504TyrGln: 3.504 ± 0.969
1.402TyrArg: 1.402 ± 0.584
1.402TyrSer: 1.402 ± 0.59
2.102TyrThr: 2.102 ± 0.847
1.402TyrVal: 1.402 ± 0.919
0.0TyrTrp: 0.0 ± 0.0
2.102TyrTyr: 2.102 ± 1.501
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (1428 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski