Amino acid dipepetide frequency for Mycolicibacterium tokaiense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.273AlaAla: 21.273 ± 0.158	1.002AlaCys: 1.002 ± 0.021	8.664AlaAsp: 8.664 ± 0.069	7.779AlaGlu: 7.779 ± 0.074	3.549AlaPhe: 3.549 ± 0.043	12.222AlaGly: 12.222 ± 0.088	2.651AlaHis: 2.651 ± 0.038	5.013AlaIle: 5.013 ± 0.05	2.575AlaLys: 2.575 ± 0.05	13.882AlaLeu: 13.882 ± 0.108	2.912AlaMet: 2.912 ± 0.043	2.357AlaAsn: 2.357 ± 0.041	6.556AlaPro: 6.556 ± 0.081	4.336AlaGln: 4.336 ± 0.051	8.553AlaArg: 8.553 ± 0.088	5.745AlaSer: 5.745 ± 0.056	7.47AlaThr: 7.47 ± 0.068	12.627AlaVal: 12.627 ± 0.104	1.597AlaTrp: 1.597 ± 0.026	2.353AlaTyr: 2.353 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.105CysAla: 1.105 ± 0.025	0.091CysCys: 0.091 ± 0.007	0.498CysAsp: 0.498 ± 0.016	0.368CysGlu: 0.368 ± 0.014	0.215CysPhe: 0.215 ± 0.012	0.932CysGly: 0.932 ± 0.024	0.186CysHis: 0.186 ± 0.009	0.276CysIle: 0.276 ± 0.011	0.106CysLys: 0.106 ± 0.007	0.643CysLeu: 0.643 ± 0.018	0.122CysMet: 0.122 ± 0.007	0.156CysAsn: 0.156 ± 0.009	0.443CysPro: 0.443 ± 0.016	0.188CysGln: 0.188 ± 0.009	0.573CysArg: 0.573 ± 0.017	0.48CysSer: 0.48 ± 0.016	0.52CysThr: 0.52 ± 0.018	0.644CysVal: 0.644 ± 0.018	0.139CysTrp: 0.139 ± 0.008	0.174CysTyr: 0.174 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.905AspAla: 7.905 ± 0.064	0.44AspCys: 0.44 ± 0.016	4.212AspAsp: 4.212 ± 0.053	3.806AspGlu: 3.806 ± 0.045	1.807AspPhe: 1.807 ± 0.029	6.08AspGly: 6.08 ± 0.067	1.435AspHis: 1.435 ± 0.029	2.659AspIle: 2.659 ± 0.038	1.143AspLys: 1.143 ± 0.028	6.25AspLeu: 6.25 ± 0.057	0.977AspMet: 0.977 ± 0.021	1.291AspAsn: 1.291 ± 0.03	4.381AspPro: 4.381 ± 0.054	1.827AspGln: 1.827 ± 0.029	4.397AspArg: 4.397 ± 0.043	2.838AspSer: 2.838 ± 0.045	3.559AspThr: 3.559 ± 0.042	5.481AspVal: 5.481 ± 0.068	0.945AspTrp: 0.945 ± 0.021	1.33AspTyr: 1.33 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.111GluAla: 6.111 ± 0.063	0.338GluCys: 0.338 ± 0.014	2.449GluAsp: 2.449 ± 0.038	2.313GluGlu: 2.313 ± 0.034	1.789GluPhe: 1.789 ± 0.031	3.125GluGly: 3.125 ± 0.043	1.468GluHis: 1.468 ± 0.029	2.535GluIle: 2.535 ± 0.035	1.204GluLys: 1.204 ± 0.026	6.445GluLeu: 6.445 ± 0.059	1.048GluMet: 1.048 ± 0.022	1.13GluAsn: 1.13 ± 0.023	3.074GluPro: 3.074 ± 0.049	2.281GluGln: 2.281 ± 0.039	3.964GluArg: 3.964 ± 0.051	2.7GluSer: 2.7 ± 0.044	2.741GluThr: 2.741 ± 0.039	4.441GluVal: 4.441 ± 0.05	0.689GluTrp: 0.689 ± 0.02	1.107GluTyr: 1.107 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.132PheAla: 4.132 ± 0.047	0.31PheCys: 0.31 ± 0.011	2.42PheAsp: 2.42 ± 0.037	1.539PheGlu: 1.539 ± 0.029	1.061PhePhe: 1.061 ± 0.03	3.534PheGly: 3.534 ± 0.045	0.624PheHis: 0.624 ± 0.018	1.123PheIle: 1.123 ± 0.025	0.447PheLys: 0.447 ± 0.016	2.677PheLeu: 2.677 ± 0.043	0.492PheMet: 0.492 ± 0.017	0.701PheAsn: 0.701 ± 0.017	1.469PhePro: 1.469 ± 0.032	0.73PheGln: 0.73 ± 0.022	1.647PheArg: 1.647 ± 0.031	1.718PheSer: 1.718 ± 0.028	2.212PheThr: 2.212 ± 0.035	2.633PheVal: 2.633 ± 0.038	0.481PheTrp: 0.481 ± 0.017	0.71PheTyr: 0.71 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.625GlyAla: 10.625 ± 0.098	0.791GlyCys: 0.791 ± 0.02	5.098GlyAsp: 5.098 ± 0.052	4.341GlyGlu: 4.341 ± 0.046	3.208GlyPhe: 3.208 ± 0.036	7.921GlyGly: 7.921 ± 0.129	2.031GlyHis: 2.031 ± 0.037	4.192GlyIle: 4.192 ± 0.05	2.028GlyLys: 2.028 ± 0.036	8.874GlyLeu: 8.874 ± 0.072	2.111GlyMet: 2.111 ± 0.035	1.953GlyAsn: 1.953 ± 0.046	4.414GlyPro: 4.414 ± 0.05	2.832GlyGln: 2.832 ± 0.041	6.215GlyArg: 6.215 ± 0.062	5.209GlySer: 5.209 ± 0.06	5.554GlyThr: 5.554 ± 0.059	7.96GlyVal: 7.96 ± 0.079	1.606GlyTrp: 1.606 ± 0.031	2.301GlyTyr: 2.301 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	2.401HisAla: 2.401 ± 0.04	0.222HisCys: 0.222 ± 0.012	1.315HisAsp: 1.315 ± 0.027	1.004HisGlu: 1.004 ± 0.024	0.677HisPhe: 0.677 ± 0.018	2.083HisGly: 2.083 ± 0.035	0.736HisHis: 0.736 ± 0.021	0.816HisIle: 0.816 ± 0.023	0.327HisLys: 0.327 ± 0.013	2.33HisLeu: 2.33 ± 0.035	0.326HisMet: 0.326 ± 0.013	0.462HisAsn: 0.462 ± 0.015	1.64HisPro: 1.64 ± 0.028	0.691HisGln: 0.691 ± 0.02	1.907HisArg: 1.907 ± 0.032	1.101HisSer: 1.101 ± 0.025	1.283HisThr: 1.283 ± 0.024	1.655HisVal: 1.655 ± 0.028	0.364HisTrp: 0.364 ± 0.014	0.5HisTyr: 0.5 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.237IleAla: 6.237 ± 0.054	0.377IleCys: 0.377 ± 0.013	3.281IleAsp: 3.281 ± 0.044	2.454IleGlu: 2.454 ± 0.035	1.036IlePhe: 1.036 ± 0.027	4.446IleGly: 4.446 ± 0.052	0.739IleHis: 0.739 ± 0.017	1.523IleIle: 1.523 ± 0.033	0.786IleLys: 0.786 ± 0.024	3.158IleLeu: 3.158 ± 0.042	0.608IleMet: 0.608 ± 0.019	1.103IleAsn: 1.103 ± 0.029	2.321IlePro: 2.321 ± 0.033	0.913IleGln: 0.913 ± 0.021	2.589IleArg: 2.589 ± 0.038	2.353IleSer: 2.353 ± 0.039	2.968IleThr: 2.968 ± 0.042	3.663IleVal: 3.663 ± 0.049	0.467IleTrp: 0.467 ± 0.016	0.784IleTyr: 0.784 ± 0.02	0.0IleXaa: 0.0 ± 0.0
Lys	2.381LysAla: 2.381 ± 0.047	0.09LysCys: 0.09 ± 0.007	0.996LysAsp: 0.996 ± 0.027	0.838LysGlu: 0.838 ± 0.024	0.542LysPhe: 0.542 ± 0.017	1.372LysGly: 1.372 ± 0.029	0.406LysHis: 0.406 ± 0.014	0.891LysIle: 0.891 ± 0.025	0.577LysLys: 0.577 ± 0.025	1.97LysLeu: 1.97 ± 0.033	0.396LysMet: 0.396 ± 0.013	0.463LysAsn: 0.463 ± 0.016	1.229LysPro: 1.229 ± 0.028	0.652LysGln: 0.652 ± 0.019	1.362LysArg: 1.362 ± 0.03	1.098LysSer: 1.098 ± 0.026	1.217LysThr: 1.217 ± 0.03	1.777LysVal: 1.777 ± 0.036	0.264LysTrp: 0.264 ± 0.012	0.419LysTyr: 0.419 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	14.358LeuAla: 14.358 ± 0.1	0.802LeuCys: 0.802 ± 0.02	6.644LeuAsp: 6.644 ± 0.06	4.51LeuGlu: 4.51 ± 0.056	2.801LeuPhe: 2.801 ± 0.042	9.129LeuGly: 9.129 ± 0.082	2.089LeuHis: 2.089 ± 0.031	4.28LeuIle: 4.28 ± 0.054	1.594LeuLys: 1.594 ± 0.03	10.076LeuLeu: 10.076 ± 0.109	1.864LeuMet: 1.864 ± 0.03	2.021LeuAsn: 2.021 ± 0.028	5.815LeuPro: 5.815 ± 0.06	2.802LeuGln: 2.802 ± 0.036	7.496LeuArg: 7.496 ± 0.064	5.844LeuSer: 5.844 ± 0.058	6.717LeuThr: 6.717 ± 0.062	8.761LeuVal: 8.761 ± 0.071	1.205LeuTrp: 1.205 ± 0.027	1.663LeuTyr: 1.663 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.66MetAla: 2.66 ± 0.033	0.176MetCys: 0.176 ± 0.01	0.869MetAsp: 0.869 ± 0.02	0.71MetGlu: 0.71 ± 0.022	0.634MetPhe: 0.634 ± 0.02	1.509MetGly: 1.509 ± 0.027	0.397MetHis: 0.397 ± 0.015	0.897MetIle: 0.897 ± 0.023	0.433MetLys: 0.433 ± 0.014	2.01MetLeu: 2.01 ± 0.029	0.41MetMet: 0.41 ± 0.016	0.511MetAsn: 0.511 ± 0.014	1.194MetPro: 1.194 ± 0.023	0.562MetGln: 0.562 ± 0.016	1.449MetArg: 1.449 ± 0.027	1.626MetSer: 1.626 ± 0.028	1.899MetThr: 1.899 ± 0.029	1.691MetVal: 1.691 ± 0.026	0.26MetTrp: 0.26 ± 0.012	0.367MetTyr: 0.367 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.558AsnAla: 2.558 ± 0.044	0.167AsnCys: 0.167 ± 0.01	1.137AsnAsp: 1.137 ± 0.026	0.922AsnGlu: 0.922 ± 0.023	0.667AsnPhe: 0.667 ± 0.017	1.989AsnGly: 1.989 ± 0.053	0.445AsnHis: 0.445 ± 0.013	0.93AsnIle: 0.93 ± 0.023	0.395AsnLys: 0.395 ± 0.016	2.055AsnLeu: 2.055 ± 0.03	0.4AsnMet: 0.4 ± 0.016	0.596AsnAsn: 0.596 ± 0.023	1.709AsnPro: 1.709 ± 0.029	0.664AsnGln: 0.664 ± 0.02	1.492AsnArg: 1.492 ± 0.029	1.122AsnSer: 1.122 ± 0.025	1.329AsnThr: 1.329 ± 0.029	1.698AsnVal: 1.698 ± 0.028	0.364AsnTrp: 0.364 ± 0.013	0.539AsnTyr: 0.539 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	7.668ProAla: 7.668 ± 0.07	0.278ProCys: 0.278 ± 0.013	4.329ProAsp: 4.329 ± 0.044	3.713ProGlu: 3.713 ± 0.051	1.638ProPhe: 1.638 ± 0.03	5.721ProGly: 5.721 ± 0.078	1.173ProHis: 1.173 ± 0.026	1.934ProIle: 1.934 ± 0.034	1.067ProLys: 1.067 ± 0.03	4.99ProLeu: 4.99 ± 0.055	1.222ProMet: 1.222 ± 0.026	1.142ProAsn: 1.142 ± 0.026	3.548ProPro: 3.548 ± 0.074	1.856ProGln: 1.856 ± 0.031	3.346ProArg: 3.346 ± 0.038	2.961ProSer: 2.961 ± 0.04	3.533ProThr: 3.533 ± 0.048	5.314ProVal: 5.314 ± 0.057	0.902ProTrp: 0.902 ± 0.024	1.131ProTyr: 1.131 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.704GlnAla: 3.704 ± 0.049	0.236GlnCys: 0.236 ± 0.011	1.34GlnAsp: 1.34 ± 0.026	1.223GlnGlu: 1.223 ± 0.029	0.984GlnPhe: 0.984 ± 0.026	2.053GlnGly: 2.053 ± 0.034	0.741GlnHis: 0.741 ± 0.02	1.509GlnIle: 1.509 ± 0.028	0.616GlnLys: 0.616 ± 0.02	3.563GlnLeu: 3.563 ± 0.041	0.74GlnMet: 0.74 ± 0.019	0.604GlnAsn: 0.604 ± 0.019	1.83GlnPro: 1.83 ± 0.03	1.42GlnGln: 1.42 ± 0.034	2.899GlnArg: 2.899 ± 0.048	1.541GlnSer: 1.541 ± 0.032	1.695GlnThr: 1.695 ± 0.027	2.712GlnVal: 2.712 ± 0.039	0.617GlnTrp: 0.617 ± 0.016	0.636GlnTyr: 0.636 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.195ArgAla: 8.195 ± 0.071	0.571ArgCys: 0.571 ± 0.017	4.226ArgAsp: 4.226 ± 0.045	3.603ArgGlu: 3.603 ± 0.044	2.408ArgPhe: 2.408 ± 0.036	5.161ArgGly: 5.161 ± 0.052	1.753ArgHis: 1.753 ± 0.031	3.278ArgIle: 3.278 ± 0.044	1.382ArgLys: 1.382 ± 0.031	7.182ArgLeu: 7.182 ± 0.066	1.741ArgMet: 1.741 ± 0.029	1.572ArgAsn: 1.572 ± 0.027	3.759ArgPro: 3.759 ± 0.044	2.248ArgGln: 2.248 ± 0.029	6.461ArgArg: 6.461 ± 0.079	4.123ArgSer: 4.123 ± 0.046	4.381ArgThr: 4.381 ± 0.046	5.554ArgVal: 5.554 ± 0.057	1.323ArgTrp: 1.323 ± 0.026	1.764ArgTyr: 1.764 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.168SerAla: 7.168 ± 0.066	0.407SerCys: 0.407 ± 0.016	3.239SerAsp: 3.239 ± 0.045	2.611SerGlu: 2.611 ± 0.041	1.682SerPhe: 1.682 ± 0.03	5.646SerGly: 5.646 ± 0.056	1.021SerHis: 1.021 ± 0.025	2.156SerIle: 2.156 ± 0.029	1.001SerLys: 1.001 ± 0.024	4.796SerLeu: 4.796 ± 0.056	1.36SerMet: 1.36 ± 0.025	1.063SerAsn: 1.063 ± 0.028	3.13SerPro: 3.13 ± 0.04	1.511SerGln: 1.511 ± 0.03	3.687SerArg: 3.687 ± 0.047	3.221SerSer: 3.221 ± 0.049	3.572SerThr: 3.572 ± 0.044	4.699SerVal: 4.699 ± 0.051	0.918SerTrp: 0.918 ± 0.022	1.216SerTyr: 1.216 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.511ThrAla: 8.511 ± 0.065	0.404ThrCys: 0.404 ± 0.014	3.992ThrAsp: 3.992 ± 0.049	3.259ThrGlu: 3.259 ± 0.037	1.915ThrPhe: 1.915 ± 0.028	6.051ThrGly: 6.051 ± 0.064	1.227ThrHis: 1.227 ± 0.027	2.384ThrIle: 2.384 ± 0.037	1.124ThrLys: 1.124 ± 0.023	5.927ThrLeu: 5.927 ± 0.056	1.255ThrMet: 1.255 ± 0.025	1.177ThrAsn: 1.177 ± 0.025	4.115ThrPro: 4.115 ± 0.052	1.551ThrGln: 1.551 ± 0.029	3.797ThrArg: 3.797 ± 0.043	3.375ThrSer: 3.375 ± 0.041	4.114ThrThr: 4.114 ± 0.066	6.459ThrVal: 6.459 ± 0.063	0.904ThrTrp: 0.904 ± 0.023	1.315ThrTyr: 1.315 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	12.12ValAla: 12.12 ± 0.094	0.794ValCys: 0.794 ± 0.022	5.923ValAsp: 5.923 ± 0.054	4.392ValGlu: 4.392 ± 0.047	2.766ValPhe: 2.766 ± 0.039	7.238ValGly: 7.238 ± 0.063	1.9ValHis: 1.9 ± 0.036	4.125ValIle: 4.125 ± 0.043	1.488ValLys: 1.488 ± 0.03	9.602ValLeu: 9.602 ± 0.084	1.658ValMet: 1.658 ± 0.027	2.014ValAsn: 2.014 ± 0.037	4.792ValPro: 4.792 ± 0.052	2.281ValGln: 2.281 ± 0.036	5.914ValArg: 5.914 ± 0.055	4.996ValSer: 4.996 ± 0.05	5.896ValThr: 5.896 ± 0.069	8.991ValVal: 8.991 ± 0.078	1.079ValTrp: 1.079 ± 0.022	1.619ValTyr: 1.619 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.591TrpAla: 1.591 ± 0.029	0.146TrpCys: 0.146 ± 0.009	0.769TrpAsp: 0.769 ± 0.019	0.602TrpGlu: 0.602 ± 0.017	0.561TrpPhe: 0.561 ± 0.019	1.046TrpGly: 1.046 ± 0.023	0.35TrpHis: 0.35 ± 0.014	0.626TrpIle: 0.626 ± 0.02	0.307TrpLys: 0.307 ± 0.012	1.697TrpLeu: 1.697 ± 0.031	0.338TrpMet: 0.338 ± 0.014	0.414TrpAsn: 0.414 ± 0.016	0.859TrpPro: 0.859 ± 0.02	0.62TrpGln: 0.62 ± 0.017	1.191TrpArg: 1.191 ± 0.029	0.927TrpSer: 0.927 ± 0.019	0.936TrpThr: 0.936 ± 0.025	1.171TrpVal: 1.171 ± 0.028	0.34TrpTrp: 0.34 ± 0.013	0.316TrpTyr: 0.316 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.413TyrAla: 2.413 ± 0.036	0.216TyrCys: 0.216 ± 0.01	1.359TyrAsp: 1.359 ± 0.032	0.964TyrGlu: 0.964 ± 0.022	0.72TyrPhe: 0.72 ± 0.018	2.006TyrGly: 2.006 ± 0.034	0.467TyrHis: 0.467 ± 0.018	0.662TyrIle: 0.662 ± 0.017	0.34TyrLys: 0.34 ± 0.012	2.343TyrLeu: 2.343 ± 0.039	0.284TyrMet: 0.284 ± 0.012	0.448TyrAsn: 0.448 ± 0.016	1.189TyrPro: 1.189 ± 0.027	0.699TyrGln: 0.699 ± 0.019	1.746TyrArg: 1.746 ± 0.024	1.129TyrSer: 1.129 ± 0.026	1.26TyrThr: 1.26 ± 0.03	1.659TyrVal: 1.659 ± 0.031	0.342TyrTrp: 0.342 ± 0.013	0.479TyrTyr: 0.479 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6211 proteins (1976286 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---