Amino acid dipepetide frequency for Firmicutes bacterium CAG:321

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.948AlaAla: 1.948 ± 0.108
0.428AlaCys: 0.428 ± 0.04
1.911AlaAsp: 1.911 ± 0.086
2.019AlaGlu: 2.019 ± 0.102
1.772AlaPhe: 1.772 ± 0.079
2.452AlaGly: 2.452 ± 0.106
0.484AlaHis: 0.484 ± 0.039
4.315AlaIle: 4.315 ± 0.126
3.87AlaLys: 3.87 ± 0.118
3.777AlaLeu: 3.777 ± 0.1
1.113AlaMet: 1.113 ± 0.062
2.511AlaAsn: 2.511 ± 0.103
0.917AlaPro: 0.917 ± 0.059
0.617AlaGln: 0.617 ± 0.042
1.648AlaArg: 1.648 ± 0.072
3.001AlaSer: 3.001 ± 0.091
2.296AlaThr: 2.296 ± 0.091
2.537AlaVal: 2.537 ± 0.094
0.221AlaTrp: 0.221 ± 0.026
1.979AlaTyr: 1.979 ± 0.072
0.0AlaXaa: 0.0 ± 0.0
Cys
0.345CysAla: 0.345 ± 0.038
0.122CysCys: 0.122 ± 0.023
0.623CysAsp: 0.623 ± 0.042
0.609CysGlu: 0.609 ± 0.044
0.416CysPhe: 0.416 ± 0.033
0.793CysGly: 0.793 ± 0.049
0.21CysHis: 0.21 ± 0.028
0.858CysIle: 0.858 ± 0.048
0.852CysLys: 0.852 ± 0.057
0.931CysLeu: 0.931 ± 0.055
0.232CysMet: 0.232 ± 0.025
0.713CysAsn: 0.713 ± 0.043
0.351CysPro: 0.351 ± 0.035
0.221CysGln: 0.221 ± 0.027
0.249CysArg: 0.249 ± 0.025
0.705CysSer: 0.705 ± 0.059
0.589CysThr: 0.589 ± 0.044
0.464CysVal: 0.464 ± 0.035
0.057CysTrp: 0.057 ± 0.014
0.566CysTyr: 0.566 ± 0.037
0.0CysXaa: 0.0 ± 0.0
Asp
2.2AspAla: 2.2 ± 0.081
0.532AspCys: 0.532 ± 0.04
3.8AspAsp: 3.8 ± 0.135
4.1AspGlu: 4.1 ± 0.128
2.735AspPhe: 2.735 ± 0.104
3.497AspGly: 3.497 ± 0.117
0.544AspHis: 0.544 ± 0.04
7.848AspIle: 7.848 ± 0.196
7.469AspLys: 7.469 ± 0.147
5.113AspLeu: 5.113 ± 0.126
1.693AspMet: 1.693 ± 0.079
6.096AspAsn: 6.096 ± 0.152
1.161AspPro: 1.161 ± 0.066
0.629AspGln: 0.629 ± 0.047
1.934AspArg: 1.934 ± 0.079
3.785AspSer: 3.785 ± 0.112
3.522AspThr: 3.522 ± 0.111
3.429AspVal: 3.429 ± 0.107
0.277AspTrp: 0.277 ± 0.032
3.76AspTyr: 3.76 ± 0.12
0.0AspXaa: 0.0 ± 0.0
Glu
3.095GluAla: 3.095 ± 0.107
0.569GluCys: 0.569 ± 0.044
4.652GluAsp: 4.652 ± 0.118
7.293GluGlu: 7.293 ± 0.195
2.455GluPhe: 2.455 ± 0.097
3.1GluGly: 3.1 ± 0.103
0.776GluHis: 0.776 ± 0.049
6.803GluIle: 6.803 ± 0.152
7.228GluLys: 7.228 ± 0.149
6.939GluLeu: 6.939 ± 0.162
1.778GluMet: 1.778 ± 0.08
4.901GluAsn: 4.901 ± 0.124
1.249GluPro: 1.249 ± 0.068
1.254GluGln: 1.254 ± 0.066
2.452GluArg: 2.452 ± 0.093
3.035GluSer: 3.035 ± 0.101
3.032GluThr: 3.032 ± 0.103
5.3GluVal: 5.3 ± 0.131
0.365GluTrp: 0.365 ± 0.037
4.19GluTyr: 4.19 ± 0.112
0.0GluXaa: 0.0 ± 0.0
Phe
1.815PheAla: 1.815 ± 0.076
0.399PheCys: 0.399 ± 0.035
3.117PheAsp: 3.117 ± 0.102
2.361PheGlu: 2.361 ± 0.084
1.574PhePhe: 1.574 ± 0.073
2.163PheGly: 2.163 ± 0.09
0.47PheHis: 0.47 ± 0.041
4.468PheIle: 4.468 ± 0.127
3.358PheLys: 3.358 ± 0.111
3.508PheLeu: 3.508 ± 0.109
0.898PheMet: 0.898 ± 0.053
3.389PheAsn: 3.389 ± 0.116
1.002PhePro: 1.002 ± 0.058
0.612PheGln: 0.612 ± 0.042
1.152PheArg: 1.152 ± 0.059
2.797PheSer: 2.797 ± 0.085
2.404PheThr: 2.404 ± 0.084
2.254PheVal: 2.254 ± 0.086
0.153PheTrp: 0.153 ± 0.024
2.07PheTyr: 2.07 ± 0.08
0.0PheXaa: 0.0 ± 0.0
Gly
2.378GlyAla: 2.378 ± 0.094
0.722GlyCys: 0.722 ± 0.049
2.885GlyAsp: 2.885 ± 0.092
3.202GlyGlu: 3.202 ± 0.119
2.203GlyPhe: 2.203 ± 0.092
3.284GlyGly: 3.284 ± 0.144
0.898GlyHis: 0.898 ± 0.056
5.711GlyIle: 5.711 ± 0.138
5.351GlyLys: 5.351 ± 0.125
4.221GlyLeu: 4.221 ± 0.138
1.305GlyMet: 1.305 ± 0.065
3.658GlyAsn: 3.658 ± 0.122
0.909GlyPro: 0.909 ± 0.07
0.9GlyGln: 0.9 ± 0.054
1.662GlyArg: 1.662 ± 0.069
3.366GlySer: 3.366 ± 0.108
3.757GlyThr: 3.757 ± 0.152
3.548GlyVal: 3.548 ± 0.118
0.297GlyTrp: 0.297 ± 0.031
3.381GlyTyr: 3.381 ± 0.114
0.0GlyXaa: 0.0 ± 0.0
His
0.501HisAla: 0.501 ± 0.04
0.116HisCys: 0.116 ± 0.019
0.663HisAsp: 0.663 ± 0.042
0.694HisGlu: 0.694 ± 0.041
0.561HisPhe: 0.561 ± 0.041
0.796HisGly: 0.796 ± 0.055
0.243HisHis: 0.243 ± 0.031
1.172HisIle: 1.172 ± 0.053
0.943HisLys: 0.943 ± 0.056
1.093HisLeu: 1.093 ± 0.064
0.263HisMet: 0.263 ± 0.028
1.008HisAsn: 1.008 ± 0.054
0.578HisPro: 0.578 ± 0.045
0.294HisGln: 0.294 ± 0.03
0.436HisArg: 0.436 ± 0.038
0.725HisSer: 0.725 ± 0.049
0.66HisThr: 0.66 ± 0.044
0.529HisVal: 0.529 ± 0.043
0.048HisTrp: 0.048 ± 0.011
0.623HisTyr: 0.623 ± 0.037
0.0HisXaa: 0.0 ± 0.0
Ile
4.236IleAla: 4.236 ± 0.107
1.048IleCys: 1.048 ± 0.056
7.568IleAsp: 7.568 ± 0.156
6.679IleGlu: 6.679 ± 0.147
4.261IlePhe: 4.261 ± 0.122
5.178IleGly: 5.178 ± 0.124
1.121IleHis: 1.121 ± 0.062
11.942IleIle: 11.942 ± 0.287
10.645IleLys: 10.645 ± 0.223
9.465IleLeu: 9.465 ± 0.22
2.155IleMet: 2.155 ± 0.083
8.635IleAsn: 8.635 ± 0.174
3.23IlePro: 3.23 ± 0.115
1.28IleGln: 1.28 ± 0.053
3.083IleArg: 3.083 ± 0.094
7.5IleSer: 7.5 ± 0.163
6.254IleThr: 6.254 ± 0.143
6.39IleVal: 6.39 ± 0.145
0.493IleTrp: 0.493 ± 0.038
5.173IleTyr: 5.173 ± 0.131
0.0IleXaa: 0.0 ± 0.0
Lys
3.355LysAla: 3.355 ± 0.1
0.892LysCys: 0.892 ± 0.06
7.602LysAsp: 7.602 ± 0.149
10.742LysGlu: 10.742 ± 0.171
2.831LysPhe: 2.831 ± 0.087
4.394LysGly: 4.394 ± 0.123
0.977LysHis: 0.977 ± 0.057
9.87LysIle: 9.87 ± 0.213
10.801LysLys: 10.801 ± 0.214
8.032LysLeu: 8.032 ± 0.171
2.814LysMet: 2.814 ± 0.098
7.619LysAsn: 7.619 ± 0.16
1.716LysPro: 1.716 ± 0.082
1.888LysGln: 1.888 ± 0.074
3.579LysArg: 3.579 ± 0.108
4.683LysSer: 4.683 ± 0.102
4.567LysThr: 4.567 ± 0.122
6.427LysVal: 6.427 ± 0.121
0.575LysTrp: 0.575 ± 0.043
6.232LysTyr: 6.232 ± 0.152
0.0LysXaa: 0.0 ± 0.0
Leu
3.825LeuAla: 3.825 ± 0.105
0.866LeuCys: 0.866 ± 0.049
5.696LeuAsp: 5.696 ± 0.128
6.421LeuGlu: 6.421 ± 0.158
4.003LeuPhe: 4.003 ± 0.117
5.093LeuGly: 5.093 ± 0.14
0.98LeuHis: 0.98 ± 0.059
8.615LeuIle: 8.615 ± 0.187
8.035LeuLys: 8.035 ± 0.151
8.335LeuLeu: 8.335 ± 0.189
1.905LeuMet: 1.905 ± 0.082
6.509LeuAsn: 6.509 ± 0.156
2.486LeuPro: 2.486 ± 0.091
1.314LeuGln: 1.314 ± 0.064
2.613LeuArg: 2.613 ± 0.089
6.501LeuSer: 6.501 ± 0.145
4.963LeuThr: 4.963 ± 0.142
5.572LeuVal: 5.572 ± 0.147
0.467LeuTrp: 0.467 ± 0.035
4.1LeuTyr: 4.1 ± 0.112
0.0LeuXaa: 0.0 ± 0.0
Met
1.24MetAla: 1.24 ± 0.061
0.252MetCys: 0.252 ± 0.028
1.353MetAsp: 1.353 ± 0.064
1.673MetGlu: 1.673 ± 0.07
1.13MetPhe: 1.13 ± 0.074
1.311MetGly: 1.311 ± 0.069
0.3MetHis: 0.3 ± 0.035
2.463MetIle: 2.463 ± 0.085
2.63MetLys: 2.63 ± 0.082
1.985MetLeu: 1.985 ± 0.08
0.668MetMet: 0.668 ± 0.045
2.092MetAsn: 2.092 ± 0.078
0.725MetPro: 0.725 ± 0.045
0.501MetGln: 0.501 ± 0.039
0.708MetArg: 0.708 ± 0.043
1.339MetSer: 1.339 ± 0.061
1.3MetThr: 1.3 ± 0.054
1.345MetVal: 1.345 ± 0.064
0.13MetTrp: 0.13 ± 0.02
1.096MetTyr: 1.096 ± 0.062
0.0MetXaa: 0.0 ± 0.0
Asn
2.489AsnAla: 2.489 ± 0.102
0.764AsnCys: 0.764 ± 0.05
4.963AsnAsp: 4.963 ± 0.135
5.0AsnGlu: 5.0 ± 0.141
2.758AsnPhe: 2.758 ± 0.097
3.986AsnGly: 3.986 ± 0.125
0.929AsnHis: 0.929 ± 0.054
9.839AsnIle: 9.839 ± 0.207
9.1AsnLys: 9.1 ± 0.194
5.937AsnLeu: 5.937 ± 0.14
1.982AsnMet: 1.982 ± 0.079
8.392AsnAsn: 8.392 ± 0.207
2.047AsnPro: 2.047 ± 0.08
1.294AsnGln: 1.294 ± 0.065
2.208AsnArg: 2.208 ± 0.071
4.649AsnSer: 4.649 ± 0.133
4.312AsnThr: 4.312 ± 0.124
3.95AsnVal: 3.95 ± 0.097
0.371AsnTrp: 0.371 ± 0.04
4.816AsnTyr: 4.816 ± 0.131
0.0AsnXaa: 0.0 ± 0.0
Pro
0.818ProAla: 0.818 ± 0.056
0.243ProCys: 0.243 ± 0.024
1.365ProAsp: 1.365 ± 0.068
1.696ProGlu: 1.696 ± 0.086
1.215ProPhe: 1.215 ± 0.061
1.249ProGly: 1.249 ± 0.061
0.345ProHis: 0.345 ± 0.032
2.458ProIle: 2.458 ± 0.087
2.112ProLys: 2.112 ± 0.086
1.979ProLeu: 1.979 ± 0.082
0.606ProMet: 0.606 ± 0.043
1.914ProAsn: 1.914 ± 0.077
0.396ProPro: 0.396 ± 0.036
0.402ProGln: 0.402 ± 0.039
0.776ProArg: 0.776 ± 0.046
1.903ProSer: 1.903 ± 0.078
1.6ProThr: 1.6 ± 0.082
1.569ProVal: 1.569 ± 0.064
0.19ProTrp: 0.19 ± 0.022
1.393ProTyr: 1.393 ± 0.072
0.0ProXaa: 0.0 ± 0.0
Gln
0.827GlnAla: 0.827 ± 0.058
0.133GlnCys: 0.133 ± 0.022
1.039GlnAsp: 1.039 ± 0.059
1.13GlnGlu: 1.13 ± 0.055
0.473GlnPhe: 0.473 ± 0.039
0.943GlnGly: 0.943 ± 0.064
0.139GlnHis: 0.139 ± 0.02
1.792GlnIle: 1.792 ± 0.077
1.787GlnLys: 1.787 ± 0.069
1.319GlnLeu: 1.319 ± 0.065
0.47GlnMet: 0.47 ± 0.037
1.351GlnAsn: 1.351 ± 0.062
0.343GlnPro: 0.343 ± 0.035
0.328GlnGln: 0.328 ± 0.04
0.699GlnArg: 0.699 ± 0.045
0.912GlnSer: 0.912 ± 0.051
0.886GlnThr: 0.886 ± 0.054
0.968GlnVal: 0.968 ± 0.055
0.088GlnTrp: 0.088 ± 0.017
0.705GlnTyr: 0.705 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
1.183ArgAla: 1.183 ± 0.059
0.388ArgCys: 0.388 ± 0.037
1.985ArgAsp: 1.985 ± 0.08
2.854ArgGlu: 2.854 ± 0.102
1.149ArgPhe: 1.149 ± 0.073
1.682ArgGly: 1.682 ± 0.08
0.419ArgHis: 0.419 ± 0.035
3.112ArgIle: 3.112 ± 0.103
3.168ArgLys: 3.168 ± 0.1
2.879ArgLeu: 2.879 ± 0.096
0.954ArgMet: 0.954 ± 0.057
2.217ArgAsn: 2.217 ± 0.087
0.694ArgPro: 0.694 ± 0.048
0.682ArgGln: 0.682 ± 0.046
1.367ArgArg: 1.367 ± 0.071
1.512ArgSer: 1.512 ± 0.063
1.441ArgThr: 1.441 ± 0.07
2.109ArgVal: 2.109 ± 0.08
0.19ArgTrp: 0.19 ± 0.022
1.716ArgTyr: 1.716 ± 0.081
0.0ArgXaa: 0.0 ± 0.0
Ser
2.288SerAla: 2.288 ± 0.094
0.614SerCys: 0.614 ± 0.046
3.853SerAsp: 3.853 ± 0.112
3.613SerGlu: 3.613 ± 0.1
2.964SerPhe: 2.964 ± 0.091
3.72SerGly: 3.72 ± 0.138
0.855SerHis: 0.855 ± 0.049
6.549SerIle: 6.549 ± 0.152
6.169SerLys: 6.169 ± 0.112
5.881SerLeu: 5.881 ± 0.137
1.486SerMet: 1.486 ± 0.063
5.11SerAsn: 5.11 ± 0.135
1.382SerPro: 1.382 ± 0.06
1.101SerGln: 1.101 ± 0.059
1.922SerArg: 1.922 ± 0.07
5.031SerSer: 5.031 ± 0.141
3.641SerThr: 3.641 ± 0.124
3.338SerVal: 3.338 ± 0.101
0.351SerTrp: 0.351 ± 0.027
3.477SerTyr: 3.477 ± 0.119
0.0SerXaa: 0.0 ± 0.0
Thr
2.426ThrAla: 2.426 ± 0.099
0.612ThrCys: 0.612 ± 0.041
3.352ThrAsp: 3.352 ± 0.106
3.069ThrGlu: 3.069 ± 0.098
2.373ThrPhe: 2.373 ± 0.083
3.417ThrGly: 3.417 ± 0.126
0.677ThrHis: 0.677 ± 0.038
6.079ThrIle: 6.079 ± 0.155
5.289ThrLys: 5.289 ± 0.125
5.235ThrLeu: 5.235 ± 0.125
1.2ThrMet: 1.2 ± 0.052
4.148ThrAsn: 4.148 ± 0.128
1.721ThrPro: 1.721 ± 0.067
0.665ThrGln: 0.665 ± 0.044
1.653ThrArg: 1.653 ± 0.07
4.097ThrSer: 4.097 ± 0.123
3.635ThrThr: 3.635 ± 0.131
3.194ThrVal: 3.194 ± 0.137
0.354ThrTrp: 0.354 ± 0.034
2.823ThrTyr: 2.823 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
2.63ValAla: 2.63 ± 0.095
0.617ValCys: 0.617 ± 0.047
3.57ValAsp: 3.57 ± 0.114
3.709ValGlu: 3.709 ± 0.121
2.424ValPhe: 2.424 ± 0.077
3.403ValGly: 3.403 ± 0.095
0.705ValHis: 0.705 ± 0.042
6.602ValIle: 6.602 ± 0.148
5.351ValLys: 5.351 ± 0.128
5.685ValLeu: 5.685 ± 0.123
1.438ValMet: 1.438 ± 0.072
4.264ValAsn: 4.264 ± 0.112
1.829ValPro: 1.829 ± 0.076
0.892ValGln: 0.892 ± 0.051
1.809ValArg: 1.809 ± 0.079
4.221ValSer: 4.221 ± 0.107
3.664ValThr: 3.664 ± 0.103
4.465ValVal: 4.465 ± 0.124
0.328ValTrp: 0.328 ± 0.033
2.868ValTyr: 2.868 ± 0.101
0.0ValXaa: 0.0 ± 0.0
Trp
0.187TrpAla: 0.187 ± 0.024
0.096TrpCys: 0.096 ± 0.018
0.357TrpAsp: 0.357 ± 0.033
0.286TrpGlu: 0.286 ± 0.024
0.246TrpPhe: 0.246 ± 0.029
0.289TrpGly: 0.289 ± 0.029
0.091TrpHis: 0.091 ± 0.015
0.478TrpIle: 0.478 ± 0.038
0.442TrpLys: 0.442 ± 0.041
0.507TrpLeu: 0.507 ± 0.042
0.125TrpMet: 0.125 ± 0.019
0.422TrpAsn: 0.422 ± 0.033
0.13TrpPro: 0.13 ± 0.02
0.161TrpGln: 0.161 ± 0.023
0.173TrpArg: 0.173 ± 0.024
0.32TrpSer: 0.32 ± 0.033
0.3TrpThr: 0.3 ± 0.029
0.21TrpVal: 0.21 ± 0.021
0.051TrpTrp: 0.051 ± 0.011
0.36TrpTyr: 0.36 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.03TyrAla: 2.03 ± 0.093
0.495TyrCys: 0.495 ± 0.037
3.768TyrAsp: 3.768 ± 0.113
3.318TyrGlu: 3.318 ± 0.101
2.421TyrPhe: 2.421 ± 0.104
2.888TyrGly: 2.888 ± 0.098
0.784TyrHis: 0.784 ± 0.048
5.362TyrIle: 5.362 ± 0.137
4.994TyrLys: 4.994 ± 0.121
5.478TyrLeu: 5.478 ± 0.139
1.152TyrMet: 1.152 ± 0.056
4.836TyrAsn: 4.836 ± 0.134
1.362TyrPro: 1.362 ± 0.072
1.294TyrGln: 1.294 ± 0.072
1.577TyrArg: 1.577 ± 0.07
3.264TyrSer: 3.264 ± 0.096
3.196TyrThr: 3.196 ± 0.115
2.879TyrVal: 2.879 ± 0.094
0.224TyrTrp: 0.224 ± 0.028
3.23TyrTyr: 3.23 ± 0.112
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1220 proteins (353202 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski