Amino acid dipepetide frequency for Staphylococcus virus 85

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.567AlaAla: 1.567 ± 0.496
0.356AlaCys: 0.356 ± 0.158
2.564AlaAsp: 2.564 ± 0.378
3.419AlaGlu: 3.419 ± 0.516
2.635AlaPhe: 2.635 ± 0.457
3.134AlaGly: 3.134 ± 0.34
1.211AlaHis: 1.211 ± 0.279
4.701AlaIle: 4.701 ± 0.719
5.057AlaLys: 5.057 ± 0.587
4.487AlaLeu: 4.487 ± 0.545
1.781AlaMet: 1.781 ± 0.413
4.06AlaAsn: 4.06 ± 0.476
1.852AlaPro: 1.852 ± 0.316
2.066AlaGln: 2.066 ± 0.395
2.564AlaArg: 2.564 ± 0.388
4.06AlaSer: 4.06 ± 0.601
3.632AlaThr: 3.632 ± 0.466
3.775AlaVal: 3.775 ± 0.517
0.997AlaTrp: 0.997 ± 0.283
2.493AlaTyr: 2.493 ± 0.332
0.0AlaXaa: 0.0 ± 0.0
Cys
0.214CysAla: 0.214 ± 0.131
0.0CysCys: 0.0 ± 0.0
0.285CysAsp: 0.285 ± 0.186
0.57CysGlu: 0.57 ± 0.214
0.427CysPhe: 0.427 ± 0.185
0.214CysGly: 0.214 ± 0.132
0.0CysHis: 0.0 ± 0.0
0.214CysIle: 0.214 ± 0.129
0.427CysLys: 0.427 ± 0.156
0.499CysLeu: 0.499 ± 0.193
0.071CysMet: 0.071 ± 0.075
0.356CysAsn: 0.356 ± 0.187
0.285CysPro: 0.285 ± 0.164
0.356CysGln: 0.356 ± 0.153
0.285CysArg: 0.285 ± 0.155
0.57CysSer: 0.57 ± 0.224
0.427CysThr: 0.427 ± 0.158
0.285CysVal: 0.285 ± 0.134
0.142CysTrp: 0.142 ± 0.091
0.427CysTyr: 0.427 ± 0.159
0.0CysXaa: 0.0 ± 0.0
Asp
3.49AspAla: 3.49 ± 0.5
0.285AspCys: 0.285 ± 0.164
4.06AspAsp: 4.06 ± 0.774
5.128AspGlu: 5.128 ± 0.72
3.49AspPhe: 3.49 ± 0.499
3.561AspGly: 3.561 ± 0.48
0.285AspHis: 0.285 ± 0.135
5.199AspIle: 5.199 ± 0.604
5.342AspLys: 5.342 ± 0.666
4.915AspLeu: 4.915 ± 0.621
1.781AspMet: 1.781 ± 0.386
3.917AspAsn: 3.917 ± 0.537
1.282AspPro: 1.282 ± 0.277
1.211AspGln: 1.211 ± 0.272
2.849AspArg: 2.849 ± 0.431
3.632AspSer: 3.632 ± 0.529
3.205AspThr: 3.205 ± 0.477
3.419AspVal: 3.419 ± 0.469
0.783AspTrp: 0.783 ± 0.245
3.063AspTyr: 3.063 ± 0.558
0.0AspXaa: 0.0 ± 0.0
Glu
5.698GluAla: 5.698 ± 0.724
0.641GluCys: 0.641 ± 0.22
3.49GluAsp: 3.49 ± 0.522
6.125GluGlu: 6.125 ± 0.8
3.348GluPhe: 3.348 ± 0.558
3.348GluGly: 3.348 ± 0.49
1.425GluHis: 1.425 ± 0.304
5.413GluIle: 5.413 ± 0.87
5.271GluLys: 5.271 ± 0.686
6.481GluLeu: 6.481 ± 0.766
2.137GluMet: 2.137 ± 0.396
4.843GluAsn: 4.843 ± 0.691
1.709GluPro: 1.709 ± 0.332
3.419GluGln: 3.419 ± 0.489
3.775GluArg: 3.775 ± 0.629
3.419GluSer: 3.419 ± 0.476
3.775GluThr: 3.775 ± 0.492
5.769GluVal: 5.769 ± 0.598
0.855GluTrp: 0.855 ± 0.226
4.558GluTyr: 4.558 ± 0.701
0.0GluXaa: 0.0 ± 0.0
Phe
1.994PheAla: 1.994 ± 0.327
0.285PheCys: 0.285 ± 0.137
3.276PheAsp: 3.276 ± 0.51
3.276PheGlu: 3.276 ± 0.453
1.425PhePhe: 1.425 ± 0.287
2.635PheGly: 2.635 ± 0.425
0.499PheHis: 0.499 ± 0.203
3.704PheIle: 3.704 ± 0.5
4.487PheLys: 4.487 ± 0.561
2.422PheLeu: 2.422 ± 0.336
1.211PheMet: 1.211 ± 0.261
3.063PheAsn: 3.063 ± 0.389
0.641PhePro: 0.641 ± 0.198
1.353PheGln: 1.353 ± 0.373
1.496PheArg: 1.496 ± 0.294
2.991PheSer: 2.991 ± 0.452
2.849PheThr: 2.849 ± 0.472
2.92PheVal: 2.92 ± 0.552
0.285PheTrp: 0.285 ± 0.131
1.781PheTyr: 1.781 ± 0.322
0.0PheXaa: 0.0 ± 0.0
Gly
2.635GlyAla: 2.635 ± 0.427
0.214GlyCys: 0.214 ± 0.12
3.419GlyAsp: 3.419 ± 0.444
3.276GlyGlu: 3.276 ± 0.546
2.778GlyPhe: 2.778 ± 0.457
2.92GlyGly: 2.92 ± 0.528
1.425GlyHis: 1.425 ± 0.362
4.345GlyIle: 4.345 ± 0.564
4.416GlyLys: 4.416 ± 0.48
5.413GlyLeu: 5.413 ± 0.691
1.638GlyMet: 1.638 ± 0.339
3.348GlyAsn: 3.348 ± 0.458
0.783GlyPro: 0.783 ± 0.296
1.496GlyGln: 1.496 ± 0.306
2.066GlyArg: 2.066 ± 0.393
2.849GlySer: 2.849 ± 0.482
3.205GlyThr: 3.205 ± 0.459
4.558GlyVal: 4.558 ± 0.54
1.282GlyTrp: 1.282 ± 0.437
2.991GlyTyr: 2.991 ± 0.478
0.0GlyXaa: 0.0 ± 0.0
His
1.567HisAla: 1.567 ± 0.388
0.071HisCys: 0.071 ± 0.06
1.14HisAsp: 1.14 ± 0.247
0.855HisGlu: 0.855 ± 0.244
0.712HisPhe: 0.712 ± 0.228
1.282HisGly: 1.282 ± 0.286
0.641HisHis: 0.641 ± 0.22
1.496HisIle: 1.496 ± 0.307
1.211HisLys: 1.211 ± 0.328
1.14HisLeu: 1.14 ± 0.264
0.285HisMet: 0.285 ± 0.164
1.282HisAsn: 1.282 ± 0.312
0.712HisPro: 0.712 ± 0.18
0.641HisGln: 0.641 ± 0.261
0.57HisArg: 0.57 ± 0.217
0.997HisSer: 0.997 ± 0.237
1.068HisThr: 1.068 ± 0.274
1.068HisVal: 1.068 ± 0.301
0.071HisTrp: 0.071 ± 0.058
0.641HisTyr: 0.641 ± 0.278
0.0HisXaa: 0.0 ± 0.0
Ile
4.345IleAla: 4.345 ± 0.679
0.142IleCys: 0.142 ± 0.099
6.481IleAsp: 6.481 ± 0.62
6.766IleGlu: 6.766 ± 0.776
2.137IlePhe: 2.137 ± 0.408
3.632IleGly: 3.632 ± 0.495
1.068IleHis: 1.068 ± 0.255
5.199IleIle: 5.199 ± 0.639
7.194IleLys: 7.194 ± 0.695
4.416IleLeu: 4.416 ± 0.543
2.066IleMet: 2.066 ± 0.336
4.915IleAsn: 4.915 ± 0.635
2.208IlePro: 2.208 ± 0.394
2.493IleGln: 2.493 ± 0.446
3.276IleArg: 3.276 ± 0.517
4.63IleSer: 4.63 ± 0.607
5.484IleThr: 5.484 ± 0.711
3.775IleVal: 3.775 ± 0.516
1.282IleTrp: 1.282 ± 0.599
3.348IleTyr: 3.348 ± 0.439
0.0IleXaa: 0.0 ± 0.0
Lys
6.268LysAla: 6.268 ± 0.663
0.427LysCys: 0.427 ± 0.208
5.627LysAsp: 5.627 ± 0.725
7.479LysGlu: 7.479 ± 0.799
3.348LysPhe: 3.348 ± 0.542
5.271LysGly: 5.271 ± 0.744
1.425LysHis: 1.425 ± 0.349
6.909LysIle: 6.909 ± 0.668
8.618LysLys: 8.618 ± 0.721
7.621LysLeu: 7.621 ± 0.728
2.066LysMet: 2.066 ± 0.388
5.912LysAsn: 5.912 ± 0.738
2.493LysPro: 2.493 ± 0.479
4.63LysGln: 4.63 ± 0.551
3.632LysArg: 3.632 ± 0.536
5.627LysSer: 5.627 ± 0.616
5.128LysThr: 5.128 ± 0.579
5.413LysVal: 5.413 ± 0.486
0.712LysTrp: 0.712 ± 0.225
3.989LysTyr: 3.989 ± 0.69
0.0LysXaa: 0.0 ± 0.0
Leu
3.205LeuAla: 3.205 ± 0.466
0.641LeuCys: 0.641 ± 0.255
4.202LeuAsp: 4.202 ± 0.466
6.197LeuGlu: 6.197 ± 0.577
3.419LeuPhe: 3.419 ± 0.608
3.846LeuGly: 3.846 ± 0.476
1.282LeuHis: 1.282 ± 0.358
4.131LeuIle: 4.131 ± 0.569
8.333LeuLys: 8.333 ± 0.622
5.413LeuLeu: 5.413 ± 0.512
1.353LeuMet: 1.353 ± 0.275
5.769LeuAsn: 5.769 ± 0.477
2.208LeuPro: 2.208 ± 0.389
3.205LeuGln: 3.205 ± 0.56
2.991LeuArg: 2.991 ± 0.565
5.627LeuSer: 5.627 ± 0.583
5.342LeuThr: 5.342 ± 0.658
4.63LeuVal: 4.63 ± 0.733
0.641LeuTrp: 0.641 ± 0.205
3.063LeuTyr: 3.063 ± 0.474
0.0LeuXaa: 0.0 ± 0.0
Met
1.14MetAla: 1.14 ± 0.251
0.0MetCys: 0.0 ± 0.0
1.496MetAsp: 1.496 ± 0.238
1.709MetGlu: 1.709 ± 0.344
0.855MetPhe: 0.855 ± 0.241
1.068MetGly: 1.068 ± 0.296
0.499MetHis: 0.499 ± 0.198
1.353MetIle: 1.353 ± 0.319
1.852MetLys: 1.852 ± 0.341
2.849MetLeu: 2.849 ± 0.36
0.57MetMet: 0.57 ± 0.166
2.137MetAsn: 2.137 ± 0.386
1.211MetPro: 1.211 ± 0.334
1.425MetGln: 1.425 ± 0.323
0.926MetArg: 0.926 ± 0.302
1.567MetSer: 1.567 ± 0.335
2.422MetThr: 2.422 ± 0.491
1.14MetVal: 1.14 ± 0.262
0.427MetTrp: 0.427 ± 0.174
1.14MetTyr: 1.14 ± 0.294
0.0MetXaa: 0.0 ± 0.0
Asn
5.342AsnAla: 5.342 ± 0.698
0.427AsnCys: 0.427 ± 0.2
3.775AsnAsp: 3.775 ± 0.497
4.274AsnGlu: 4.274 ± 0.557
2.92AsnPhe: 2.92 ± 0.593
4.487AsnGly: 4.487 ± 0.645
1.211AsnHis: 1.211 ± 0.321
4.274AsnIle: 4.274 ± 0.461
7.407AsnLys: 7.407 ± 0.539
4.63AsnLeu: 4.63 ± 0.6
1.638AsnMet: 1.638 ± 0.333
4.345AsnAsn: 4.345 ± 0.699
2.635AsnPro: 2.635 ± 0.459
2.635AsnGln: 2.635 ± 0.388
3.063AsnArg: 3.063 ± 0.434
3.632AsnSer: 3.632 ± 0.456
4.345AsnThr: 4.345 ± 0.572
3.989AsnVal: 3.989 ± 0.533
0.641AsnTrp: 0.641 ± 0.222
2.564AsnTyr: 2.564 ± 0.504
0.0AsnXaa: 0.0 ± 0.0
Pro
1.353ProAla: 1.353 ± 0.297
0.285ProCys: 0.285 ± 0.214
1.282ProAsp: 1.282 ± 0.276
2.279ProGlu: 2.279 ± 0.346
1.282ProPhe: 1.282 ± 0.261
1.638ProGly: 1.638 ± 0.428
0.499ProHis: 0.499 ± 0.196
2.635ProIle: 2.635 ± 0.426
2.707ProLys: 2.707 ± 0.602
1.852ProLeu: 1.852 ± 0.372
0.926ProMet: 0.926 ± 0.249
2.279ProAsn: 2.279 ± 0.399
0.712ProPro: 0.712 ± 0.239
1.425ProGln: 1.425 ± 0.343
1.068ProArg: 1.068 ± 0.32
1.496ProSer: 1.496 ± 0.331
1.923ProThr: 1.923 ± 0.366
1.709ProVal: 1.709 ± 0.467
0.214ProTrp: 0.214 ± 0.119
1.14ProTyr: 1.14 ± 0.374
0.0ProXaa: 0.0 ± 0.0
Gln
1.994GlnAla: 1.994 ± 0.395
0.427GlnCys: 0.427 ± 0.191
2.279GlnAsp: 2.279 ± 0.391
2.564GlnGlu: 2.564 ± 0.453
1.709GlnPhe: 1.709 ± 0.358
2.208GlnGly: 2.208 ± 0.318
0.783GlnHis: 0.783 ± 0.229
2.137GlnIle: 2.137 ± 0.359
2.635GlnLys: 2.635 ± 0.409
3.276GlnLeu: 3.276 ± 0.625
1.496GlnMet: 1.496 ± 0.297
1.994GlnAsn: 1.994 ± 0.299
1.709GlnPro: 1.709 ± 0.364
1.638GlnGln: 1.638 ± 0.351
1.852GlnArg: 1.852 ± 0.375
2.35GlnSer: 2.35 ± 0.387
1.994GlnThr: 1.994 ± 0.343
2.422GlnVal: 2.422 ± 0.425
0.285GlnTrp: 0.285 ± 0.147
1.353GlnTyr: 1.353 ± 0.393
0.0GlnXaa: 0.0 ± 0.0
Arg
1.567ArgAla: 1.567 ± 0.371
0.427ArgCys: 0.427 ± 0.158
1.923ArgAsp: 1.923 ± 0.459
2.422ArgGlu: 2.422 ± 0.36
2.35ArgPhe: 2.35 ± 0.447
2.493ArgGly: 2.493 ± 0.445
0.997ArgHis: 0.997 ± 0.263
3.561ArgIle: 3.561 ± 0.608
4.487ArgLys: 4.487 ± 0.71
3.561ArgLeu: 3.561 ± 0.474
1.068ArgMet: 1.068 ± 0.282
2.92ArgAsn: 2.92 ± 0.553
0.926ArgPro: 0.926 ± 0.213
1.282ArgGln: 1.282 ± 0.29
1.852ArgArg: 1.852 ± 0.383
2.422ArgSer: 2.422 ± 0.384
1.923ArgThr: 1.923 ± 0.383
2.849ArgVal: 2.849 ± 0.472
0.427ArgTrp: 0.427 ± 0.167
1.994ArgTyr: 1.994 ± 0.468
0.0ArgXaa: 0.0 ± 0.0
Ser
3.989SerAla: 3.989 ± 0.625
0.356SerCys: 0.356 ± 0.173
4.131SerAsp: 4.131 ± 0.584
3.846SerGlu: 3.846 ± 0.538
2.279SerPhe: 2.279 ± 0.537
3.134SerGly: 3.134 ± 0.576
1.14SerHis: 1.14 ± 0.369
5.627SerIle: 5.627 ± 0.558
5.912SerLys: 5.912 ± 0.697
4.416SerLeu: 4.416 ± 0.435
1.282SerMet: 1.282 ± 0.325
4.701SerAsn: 4.701 ± 0.458
1.638SerPro: 1.638 ± 0.419
1.923SerGln: 1.923 ± 0.412
2.778SerArg: 2.778 ± 0.309
3.134SerSer: 3.134 ± 0.491
3.917SerThr: 3.917 ± 0.42
3.205SerVal: 3.205 ± 0.411
0.356SerTrp: 0.356 ± 0.161
2.493SerTyr: 2.493 ± 0.348
0.0SerXaa: 0.0 ± 0.0
Thr
3.632ThrAla: 3.632 ± 0.559
0.142ThrCys: 0.142 ± 0.105
3.775ThrAsp: 3.775 ± 0.555
4.416ThrGlu: 4.416 ± 0.64
3.063ThrPhe: 3.063 ± 0.497
3.917ThrGly: 3.917 ± 0.545
0.855ThrHis: 0.855 ± 0.196
5.199ThrIle: 5.199 ± 1.074
5.84ThrLys: 5.84 ± 0.593
4.131ThrLeu: 4.131 ± 0.47
0.855ThrMet: 0.855 ± 0.258
3.632ThrAsn: 3.632 ± 0.543
2.137ThrPro: 2.137 ± 0.352
2.279ThrGln: 2.279 ± 0.457
2.35ThrArg: 2.35 ± 0.334
4.345ThrSer: 4.345 ± 0.607
4.345ThrThr: 4.345 ± 0.757
4.986ThrVal: 4.986 ± 0.714
0.641ThrTrp: 0.641 ± 0.234
2.137ThrTyr: 2.137 ± 0.408
0.0ThrXaa: 0.0 ± 0.0
Val
3.632ValAla: 3.632 ± 0.865
0.499ValCys: 0.499 ± 0.186
4.843ValAsp: 4.843 ± 0.682
5.556ValGlu: 5.556 ± 0.71
2.066ValPhe: 2.066 ± 0.462
2.564ValGly: 2.564 ± 0.395
0.926ValHis: 0.926 ± 0.239
5.057ValIle: 5.057 ± 0.599
6.054ValLys: 6.054 ± 0.538
4.274ValLeu: 4.274 ± 0.593
2.137ValMet: 2.137 ± 0.435
4.487ValAsn: 4.487 ± 0.482
2.208ValPro: 2.208 ± 0.454
1.496ValGln: 1.496 ± 0.276
2.208ValArg: 2.208 ± 0.402
3.561ValSer: 3.561 ± 0.495
3.989ValThr: 3.989 ± 0.528
4.274ValVal: 4.274 ± 0.58
0.997ValTrp: 0.997 ± 0.243
2.35ValTyr: 2.35 ± 0.527
0.0ValXaa: 0.0 ± 0.0
Trp
0.997TrpAla: 0.997 ± 0.329
0.142TrpCys: 0.142 ± 0.105
0.356TrpAsp: 0.356 ± 0.154
0.855TrpGlu: 0.855 ± 0.238
0.356TrpPhe: 0.356 ± 0.15
0.641TrpGly: 0.641 ± 0.333
0.285TrpHis: 0.285 ± 0.129
0.641TrpIle: 0.641 ± 0.177
0.783TrpLys: 0.783 ± 0.313
0.783TrpLeu: 0.783 ± 0.272
0.142TrpMet: 0.142 ± 0.097
1.496TrpAsn: 1.496 ± 0.881
0.142TrpPro: 0.142 ± 0.112
0.499TrpGln: 0.499 ± 0.193
0.214TrpArg: 0.214 ± 0.12
0.997TrpSer: 0.997 ± 0.264
0.997TrpThr: 0.997 ± 0.248
0.712TrpVal: 0.712 ± 0.242
0.0TrpTrp: 0.0 ± 0.0
0.712TrpTyr: 0.712 ± 0.28
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.781TyrAla: 1.781 ± 0.336
0.285TyrCys: 0.285 ± 0.151
2.564TyrAsp: 2.564 ± 0.456
4.487TyrGlu: 4.487 ± 0.619
1.994TyrPhe: 1.994 ± 0.407
3.063TyrGly: 3.063 ± 0.561
0.997TyrHis: 0.997 ± 0.331
3.063TyrIle: 3.063 ± 0.444
4.558TyrLys: 4.558 ± 0.6
2.92TyrLeu: 2.92 ± 0.483
1.211TyrMet: 1.211 ± 0.309
2.778TyrAsn: 2.778 ± 0.38
1.211TyrPro: 1.211 ± 0.322
1.638TyrGln: 1.638 ± 0.314
1.638TyrArg: 1.638 ± 0.399
2.35TyrSer: 2.35 ± 0.447
2.707TyrThr: 2.707 ± 0.471
2.279TyrVal: 2.279 ± 0.44
0.712TyrTrp: 0.712 ± 0.254
1.709TyrTyr: 1.709 ± 0.372
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (14041 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski