Amino acid dipepetide frequency for Metallosphaera yellowstonensis MK1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.058AlaAla: 3.058 ± 0.091	0.518AlaCys: 0.518 ± 0.024	2.304AlaAsp: 2.304 ± 0.051	4.003AlaGlu: 4.003 ± 0.077	2.842AlaPhe: 2.842 ± 0.07	4.118AlaGly: 4.118 ± 0.076	0.864AlaHis: 0.864 ± 0.031	4.213AlaIle: 4.213 ± 0.071	3.74AlaLys: 3.74 ± 0.081	7.835AlaLeu: 7.835 ± 0.099	1.663AlaMet: 1.663 ± 0.046	1.795AlaAsn: 1.795 ± 0.052	1.935AlaPro: 1.935 ± 0.054	1.422AlaGln: 1.422 ± 0.051	3.588AlaArg: 3.588 ± 0.086	4.306AlaSer: 4.306 ± 0.074	2.896AlaThr: 2.896 ± 0.069	5.574AlaVal: 5.574 ± 0.107	0.771AlaTrp: 0.771 ± 0.034	2.392AlaTyr: 2.392 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.258CysAla: 0.258 ± 0.019	0.089CysCys: 0.089 ± 0.012	0.311CysAsp: 0.311 ± 0.02	0.459CysGlu: 0.459 ± 0.03	0.18CysPhe: 0.18 ± 0.017	0.775CysGly: 0.775 ± 0.036	0.2CysHis: 0.2 ± 0.015	0.308CysIle: 0.308 ± 0.023	0.354CysLys: 0.354 ± 0.021	0.551CysLeu: 0.551 ± 0.025	0.154CysMet: 0.154 ± 0.015	0.268CysAsn: 0.268 ± 0.02	0.599CysPro: 0.599 ± 0.031	0.198CysGln: 0.198 ± 0.016	0.39CysArg: 0.39 ± 0.024	0.498CysSer: 0.498 ± 0.027	0.295CysThr: 0.295 ± 0.023	0.451CysVal: 0.451 ± 0.025	0.069CysTrp: 0.069 ± 0.01	0.258CysTyr: 0.258 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.561AspAla: 2.561 ± 0.059	0.32AspCys: 0.32 ± 0.02	1.908AspAsp: 1.908 ± 0.057	3.355AspGlu: 3.355 ± 0.077	2.048AspPhe: 2.048 ± 0.052	3.113AspGly: 3.113 ± 0.077	0.774AspHis: 0.774 ± 0.031	2.611AspIle: 2.611 ± 0.059	2.574AspLys: 2.574 ± 0.067	5.443AspLeu: 5.443 ± 0.088	1.142AspMet: 1.142 ± 0.035	1.33AspAsn: 1.33 ± 0.042	2.655AspPro: 2.655 ± 0.063	1.011AspGln: 1.011 ± 0.033	2.546AspArg: 2.546 ± 0.061	2.81AspSer: 2.81 ± 0.065	1.718AspThr: 1.718 ± 0.047	5.006AspVal: 5.006 ± 0.082	0.617AspTrp: 0.617 ± 0.028	2.036AspTyr: 2.036 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	4.757GluAla: 4.757 ± 0.088	0.394GluCys: 0.394 ± 0.023	3.684GluAsp: 3.684 ± 0.074	6.92GluGlu: 6.92 ± 0.125	2.528GluPhe: 2.528 ± 0.063	5.251GluGly: 5.251 ± 0.094	0.868GluHis: 0.868 ± 0.038	5.269GluIle: 5.269 ± 0.087	4.518GluLys: 4.518 ± 0.107	7.782GluLeu: 7.782 ± 0.109	1.94GluMet: 1.94 ± 0.056	2.294GluAsn: 2.294 ± 0.055	1.994GluPro: 1.994 ± 0.047	1.415GluGln: 1.415 ± 0.055	4.978GluArg: 4.978 ± 0.097	3.504GluSer: 3.504 ± 0.067	2.974GluThr: 2.974 ± 0.059	7.305GluVal: 7.305 ± 0.113	0.719GluTrp: 0.719 ± 0.034	2.407GluTyr: 2.407 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.27PheAla: 2.27 ± 0.061	0.246PheCys: 0.246 ± 0.019	1.727PheAsp: 1.727 ± 0.05	1.88PheGlu: 1.88 ± 0.053	1.77PhePhe: 1.77 ± 0.057	2.71PheGly: 2.71 ± 0.063	0.724PheHis: 0.724 ± 0.03	2.423PheIle: 2.423 ± 0.064	2.571PheLys: 2.571 ± 0.055	5.123PheLeu: 5.123 ± 0.089	1.03PheMet: 1.03 ± 0.036	1.711PheAsn: 1.711 ± 0.049	2.147PhePro: 2.147 ± 0.052	1.14PheGln: 1.14 ± 0.04	2.397PheArg: 2.397 ± 0.051	3.638PheSer: 3.638 ± 0.085	2.452PheThr: 2.452 ± 0.058	3.283PheVal: 3.283 ± 0.07	0.526PheTrp: 0.526 ± 0.025	1.843PheTyr: 1.843 ± 0.048	0.001PheXaa: 0.001 ± 0.001
Gly	4.076GlyAla: 4.076 ± 0.093	0.46GlyCys: 0.46 ± 0.028	3.369GlyAsp: 3.369 ± 0.067	5.584GlyGlu: 5.584 ± 0.088	3.388GlyPhe: 3.388 ± 0.061	5.622GlyGly: 5.622 ± 0.101	1.217GlyHis: 1.217 ± 0.041	5.42GlyIle: 5.42 ± 0.089	5.422GlyLys: 5.422 ± 0.095	7.48GlyLeu: 7.48 ± 0.107	1.992GlyMet: 1.992 ± 0.046	2.619GlyAsn: 2.619 ± 0.066	2.155GlyPro: 2.155 ± 0.061	1.591GlyGln: 1.591 ± 0.056	4.832GlyArg: 4.832 ± 0.09	4.685GlySer: 4.685 ± 0.081	3.575GlyThr: 3.575 ± 0.081	6.887GlyVal: 6.887 ± 0.105	1.019GlyTrp: 1.019 ± 0.034	3.137GlyTyr: 3.137 ± 0.078	0.0GlyXaa: 0.0 ± 0.0
His	0.775HisAla: 0.775 ± 0.034	0.196HisCys: 0.196 ± 0.015	0.67HisAsp: 0.67 ± 0.029	0.986HisGlu: 0.986 ± 0.043	0.636HisPhe: 0.636 ± 0.032	1.366HisGly: 1.366 ± 0.045	0.35HisHis: 0.35 ± 0.021	0.722HisIle: 0.722 ± 0.033	0.767HisLys: 0.767 ± 0.032	1.599HisLeu: 1.599 ± 0.046	0.38HisMet: 0.38 ± 0.024	0.446HisAsn: 0.446 ± 0.022	0.819HisPro: 0.819 ± 0.033	0.363HisGln: 0.363 ± 0.022	0.937HisArg: 0.937 ± 0.035	0.972HisSer: 0.972 ± 0.034	0.679HisThr: 0.679 ± 0.03	1.405HisVal: 1.405 ± 0.047	0.176HisTrp: 0.176 ± 0.015	0.612HisTyr: 0.612 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	4.423IleAla: 4.423 ± 0.086	0.351IleCys: 0.351 ± 0.021	2.947IleAsp: 2.947 ± 0.063	3.995IleGlu: 3.995 ± 0.078	2.736IlePhe: 2.736 ± 0.072	4.217IleGly: 4.217 ± 0.084	1.059IleHis: 1.059 ± 0.037	4.306IleIle: 4.306 ± 0.103	3.756IleLys: 3.756 ± 0.07	6.914IleLeu: 6.914 ± 0.112	1.58IleMet: 1.58 ± 0.052	2.501IleAsn: 2.501 ± 0.066	3.507IlePro: 3.507 ± 0.079	1.529IleGln: 1.529 ± 0.044	3.66IleArg: 3.66 ± 0.087	5.328IleSer: 5.328 ± 0.093	3.54IleThr: 3.54 ± 0.069	5.101IleVal: 5.101 ± 0.078	0.547IleTrp: 0.547 ± 0.029	2.663IleTyr: 2.663 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	3.901LysAla: 3.901 ± 0.086	0.45LysCys: 0.45 ± 0.025	3.117LysAsp: 3.117 ± 0.066	5.617LysGlu: 5.617 ± 0.103	2.35LysPhe: 2.35 ± 0.061	5.067LysGly: 5.067 ± 0.088	0.618LysHis: 0.618 ± 0.029	4.091LysIle: 4.091 ± 0.086	3.452LysLys: 3.452 ± 0.086	6.398LysLeu: 6.398 ± 0.106	1.608LysMet: 1.608 ± 0.049	1.77LysAsn: 1.77 ± 0.056	1.976LysPro: 1.976 ± 0.054	0.984LysGln: 0.984 ± 0.031	4.111LysArg: 4.111 ± 0.1	3.402LysSer: 3.402 ± 0.068	2.504LysThr: 2.504 ± 0.06	6.517LysVal: 6.517 ± 0.109	0.63LysTrp: 0.63 ± 0.028	2.585LysTyr: 2.585 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	7.169LeuAla: 7.169 ± 0.111	0.491LeuCys: 0.491 ± 0.03	5.23LeuAsp: 5.23 ± 0.103	7.458LeuGlu: 7.458 ± 0.12	4.096LeuPhe: 4.096 ± 0.084	8.63LeuGly: 8.63 ± 0.13	1.568LeuHis: 1.568 ± 0.05	6.814LeuIle: 6.814 ± 0.112	6.868LeuLys: 6.868 ± 0.108	11.569LeuLeu: 11.569 ± 0.188	2.771LeuMet: 2.771 ± 0.069	4.409LeuAsn: 4.409 ± 0.082	4.442LeuPro: 4.442 ± 0.081	2.44LeuGln: 2.44 ± 0.056	7.616LeuArg: 7.616 ± 0.125	8.392LeuSer: 8.392 ± 0.125	5.628LeuThr: 5.628 ± 0.096	9.038LeuVal: 9.038 ± 0.112	1.129LeuTrp: 1.129 ± 0.041	3.835LeuTyr: 3.835 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	1.746MetAla: 1.746 ± 0.052	0.137MetCys: 0.137 ± 0.013	1.219MetAsp: 1.219 ± 0.044	1.922MetGlu: 1.922 ± 0.052	0.844MetPhe: 0.844 ± 0.032	2.141MetGly: 2.141 ± 0.056	0.26MetHis: 0.26 ± 0.017	1.926MetIle: 1.926 ± 0.044	1.86MetLys: 1.86 ± 0.053	2.123MetLeu: 2.123 ± 0.056	0.682MetMet: 0.682 ± 0.031	0.982MetAsn: 0.982 ± 0.035	0.829MetPro: 0.829 ± 0.034	0.406MetGln: 0.406 ± 0.022	2.04MetArg: 2.04 ± 0.055	1.768MetSer: 1.768 ± 0.047	1.348MetThr: 1.348 ± 0.042	1.914MetVal: 1.914 ± 0.048	0.302MetTrp: 0.302 ± 0.021	0.689MetTyr: 0.689 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.182AsnAla: 2.182 ± 0.053	0.27AsnCys: 0.27 ± 0.022	1.41AsnAsp: 1.41 ± 0.043	2.202AsnGlu: 2.202 ± 0.058	1.692AsnPhe: 1.692 ± 0.052	2.474AsnGly: 2.474 ± 0.085	0.446AsnHis: 0.446 ± 0.025	1.988AsnIle: 1.988 ± 0.058	1.807AsnLys: 1.807 ± 0.058	4.235AsnLeu: 4.235 ± 0.075	0.87AsnMet: 0.87 ± 0.037	1.356AsnAsn: 1.356 ± 0.06	2.107AsnPro: 2.107 ± 0.059	0.876AsnGln: 0.876 ± 0.033	1.812AsnArg: 1.812 ± 0.054	2.589AsnSer: 2.589 ± 0.069	1.556AsnThr: 1.556 ± 0.05	3.583AsnVal: 3.583 ± 0.089	0.435AsnTrp: 0.435 ± 0.024	1.866AsnTyr: 1.866 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	1.953ProAla: 1.953 ± 0.06	0.259ProCys: 0.259 ± 0.02	1.871ProAsp: 1.871 ± 0.05	2.96ProGlu: 2.96 ± 0.076	2.071ProPhe: 2.071 ± 0.053	2.968ProGly: 2.968 ± 0.07	0.831ProHis: 0.831 ± 0.035	2.461ProIle: 2.461 ± 0.065	2.487ProLys: 2.487 ± 0.053	4.738ProLeu: 4.738 ± 0.086	0.981ProMet: 0.981 ± 0.037	1.599ProAsn: 1.599 ± 0.052	2.285ProPro: 2.285 ± 0.061	1.27ProGln: 1.27 ± 0.044	2.15ProArg: 2.15 ± 0.057	3.459ProSer: 3.459 ± 0.062	2.189ProThr: 2.189 ± 0.057	3.717ProVal: 3.717 ± 0.076	0.666ProTrp: 0.666 ± 0.03	1.822ProTyr: 1.822 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	1.453GlnAla: 1.453 ± 0.046	0.127GlnCys: 0.127 ± 0.012	1.104GlnAsp: 1.104 ± 0.04	1.899GlnGlu: 1.899 ± 0.049	0.943GlnPhe: 0.943 ± 0.035	2.243GlnGly: 2.243 ± 0.068	0.263GlnHis: 0.263 ± 0.017	1.444GlnIle: 1.444 ± 0.044	1.034GlnLys: 1.034 ± 0.041	2.355GlnLeu: 2.355 ± 0.06	0.539GlnMet: 0.539 ± 0.024	0.745GlnAsn: 0.745 ± 0.033	0.8GlnPro: 0.8 ± 0.036	0.648GlnGln: 0.648 ± 0.031	1.291GlnArg: 1.291 ± 0.044	1.186GlnSer: 1.186 ± 0.041	1.059GlnThr: 1.059 ± 0.038	2.403GlnVal: 2.403 ± 0.059	0.257GlnTrp: 0.257 ± 0.02	0.86GlnTyr: 0.86 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	4.034ArgAla: 4.034 ± 0.078	0.474ArgCys: 0.474 ± 0.028	3.443ArgAsp: 3.443 ± 0.068	6.315ArgGlu: 6.315 ± 0.117	2.286ArgPhe: 2.286 ± 0.055	5.242ArgGly: 5.242 ± 0.099	0.884ArgHis: 0.884 ± 0.034	3.982ArgIle: 3.982 ± 0.083	4.317ArgLys: 4.317 ± 0.079	5.797ArgLeu: 5.797 ± 0.1	1.466ArgMet: 1.466 ± 0.038	2.153ArgAsn: 2.153 ± 0.054	2.178ArgPro: 2.178 ± 0.062	1.159ArgGln: 1.159 ± 0.038	5.194ArgArg: 5.194 ± 0.098	3.482ArgSer: 3.482 ± 0.063	2.75ArgThr: 2.75 ± 0.07	5.39ArgVal: 5.39 ± 0.103	0.741ArgTrp: 0.741 ± 0.035	2.119ArgTyr: 2.119 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	3.625SerAla: 3.625 ± 0.066	0.537SerCys: 0.537 ± 0.028	2.591SerAsp: 2.591 ± 0.056	3.678SerGlu: 3.678 ± 0.08	3.249SerPhe: 3.249 ± 0.066	4.843SerGly: 4.843 ± 0.088	1.168SerHis: 1.168 ± 0.043	4.196SerIle: 4.196 ± 0.085	4.137SerLys: 4.137 ± 0.085	8.952SerLeu: 8.952 ± 0.137	1.821SerMet: 1.821 ± 0.042	2.255SerAsn: 2.255 ± 0.059	3.822SerPro: 3.822 ± 0.076	1.874SerGln: 1.874 ± 0.052	4.34SerArg: 4.34 ± 0.083	5.916SerSer: 5.916 ± 0.102	3.81SerThr: 3.81 ± 0.084	5.322SerVal: 5.322 ± 0.09	0.999SerTrp: 0.999 ± 0.036	2.69SerTyr: 2.69 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.083ThrAla: 3.083 ± 0.065	0.442ThrCys: 0.442 ± 0.023	1.924ThrAsp: 1.924 ± 0.053	2.57ThrGlu: 2.57 ± 0.062	2.397ThrPhe: 2.397 ± 0.057	3.874ThrGly: 3.874 ± 0.07	0.746ThrHis: 0.746 ± 0.034	2.969ThrIle: 2.969 ± 0.07	2.493ThrLys: 2.493 ± 0.068	5.943ThrLeu: 5.943 ± 0.103	1.137ThrMet: 1.137 ± 0.039	1.712ThrAsn: 1.712 ± 0.052	2.663ThrPro: 2.663 ± 0.068	1.292ThrGln: 1.292 ± 0.042	2.384ThrArg: 2.384 ± 0.06	3.903ThrSer: 3.903 ± 0.084	2.741ThrThr: 2.741 ± 0.079	4.439ThrVal: 4.439 ± 0.093	0.601ThrTrp: 0.601 ± 0.027	1.873ThrTyr: 1.873 ± 0.063	0.0ThrXaa: 0.0 ± 0.0
Val	5.224ValAla: 5.224 ± 0.082	0.559ValCys: 0.559 ± 0.028	4.258ValAsp: 4.258 ± 0.084	6.753ValGlu: 6.753 ± 0.113	3.271ValPhe: 3.271 ± 0.075	6.143ValGly: 6.143 ± 0.1	1.222ValHis: 1.222 ± 0.04	6.64ValIle: 6.64 ± 0.083	6.463ValLys: 6.463 ± 0.102	8.965ValLeu: 8.965 ± 0.123	2.256ValMet: 2.256 ± 0.066	3.657ValAsn: 3.657 ± 0.095	3.66ValPro: 3.66 ± 0.085	1.787ValGln: 1.787 ± 0.053	5.982ValArg: 5.982 ± 0.102	6.114ValSer: 6.114 ± 0.104	4.773ValThr: 4.773 ± 0.093	8.291ValVal: 8.291 ± 0.125	0.768ValTrp: 0.768 ± 0.03	3.341ValTyr: 3.341 ± 0.077	0.0ValXaa: 0.0 ± 0.0
Trp	0.704TrpAla: 0.704 ± 0.031	0.062TrpCys: 0.062 ± 0.008	0.595TrpAsp: 0.595 ± 0.028	0.841TrpGlu: 0.841 ± 0.037	0.492TrpPhe: 0.492 ± 0.024	0.794TrpGly: 0.794 ± 0.035	0.179TrpHis: 0.179 ± 0.016	0.796TrpIle: 0.796 ± 0.035	0.67TrpLys: 0.67 ± 0.028	1.156TrpLeu: 1.156 ± 0.049	0.303TrpMet: 0.303 ± 0.021	0.543TrpAsn: 0.543 ± 0.03	0.347TrpPro: 0.347 ± 0.021	0.214TrpGln: 0.214 ± 0.017	1.125TrpArg: 1.125 ± 0.044	0.744TrpSer: 0.744 ± 0.028	0.591TrpThr: 0.591 ± 0.031	0.846TrpVal: 0.846 ± 0.035	0.166TrpTrp: 0.166 ± 0.015	0.565TrpTyr: 0.565 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.588TyrAla: 2.588 ± 0.061	0.283TyrCys: 0.283 ± 0.02	1.892TyrAsp: 1.892 ± 0.053	2.106TyrGlu: 2.106 ± 0.054	1.795TyrPhe: 1.795 ± 0.05	2.94TyrGly: 2.94 ± 0.061	0.614TyrHis: 0.614 ± 0.029	2.079TyrIle: 2.079 ± 0.058	1.86TyrLys: 1.86 ± 0.053	4.637TyrLeu: 4.637 ± 0.088	0.823TyrMet: 0.823 ± 0.032	1.612TyrAsn: 1.612 ± 0.053	1.813TyrPro: 1.813 ± 0.051	1.033TyrGln: 1.033 ± 0.048	2.032TyrArg: 2.032 ± 0.055	3.128TyrSer: 3.128 ± 0.061	2.107TyrThr: 2.107 ± 0.055	3.657TyrVal: 3.657 ± 0.075	0.595TyrTrp: 0.595 ± 0.036	1.869TyrTyr: 1.869 ± 0.063	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3340 proteins (771653 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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