Amino acid dipepetide frequency for Williamsia sp. Leaf354

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.529AlaAla: 19.529 ± 0.19
0.901AlaCys: 0.901 ± 0.027
9.615AlaAsp: 9.615 ± 0.106
6.883AlaGlu: 6.883 ± 0.082
3.514AlaPhe: 3.514 ± 0.058
11.941AlaGly: 11.941 ± 0.148
2.934AlaHis: 2.934 ± 0.061
5.696AlaIle: 5.696 ± 0.071
2.452AlaLys: 2.452 ± 0.061
12.535AlaLeu: 12.535 ± 0.121
2.96AlaMet: 2.96 ± 0.046
2.23AlaAsn: 2.23 ± 0.049
6.542AlaPro: 6.542 ± 0.094
3.736AlaGln: 3.736 ± 0.053
9.238AlaArg: 9.238 ± 0.112
6.746AlaSer: 6.746 ± 0.081
8.468AlaThr: 8.468 ± 0.097
12.44AlaVal: 12.44 ± 0.13
1.523AlaTrp: 1.523 ± 0.035
2.125AlaTyr: 2.125 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
1.051CysAla: 1.051 ± 0.034
0.076CysCys: 0.076 ± 0.008
0.486CysAsp: 0.486 ± 0.022
0.323CysGlu: 0.323 ± 0.015
0.198CysPhe: 0.198 ± 0.012
0.833CysGly: 0.833 ± 0.029
0.158CysHis: 0.158 ± 0.012
0.26CysIle: 0.26 ± 0.014
0.098CysLys: 0.098 ± 0.009
0.583CysLeu: 0.583 ± 0.023
0.122CysMet: 0.122 ± 0.01
0.14CysAsn: 0.14 ± 0.01
0.388CysPro: 0.388 ± 0.017
0.136CysGln: 0.136 ± 0.01
0.541CysArg: 0.541 ± 0.023
0.461CysSer: 0.461 ± 0.02
0.439CysThr: 0.439 ± 0.019
0.618CysVal: 0.618 ± 0.022
0.082CysTrp: 0.082 ± 0.009
0.139CysTyr: 0.139 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
9.062AspAla: 9.062 ± 0.107
0.385AspCys: 0.385 ± 0.02
5.445AspAsp: 5.445 ± 0.076
3.919AspGlu: 3.919 ± 0.06
1.742AspPhe: 1.742 ± 0.039
6.324AspGly: 6.324 ± 0.077
1.898AspHis: 1.898 ± 0.039
2.916AspIle: 2.916 ± 0.047
1.143AspLys: 1.143 ± 0.042
7.231AspLeu: 7.231 ± 0.11
0.979AspMet: 0.979 ± 0.024
1.191AspAsn: 1.191 ± 0.033
4.904AspPro: 4.904 ± 0.07
1.566AspGln: 1.566 ± 0.035
5.571AspArg: 5.571 ± 0.074
3.18AspSer: 3.18 ± 0.05
4.172AspThr: 4.172 ± 0.056
5.632AspVal: 5.632 ± 0.092
0.862AspTrp: 0.862 ± 0.025
1.233AspTyr: 1.233 ± 0.033
0.001AspXaa: 0.001 ± 0.001
Glu
5.202GluAla: 5.202 ± 0.074
0.314GluCys: 0.314 ± 0.017
1.897GluAsp: 1.897 ± 0.045
2.004GluGlu: 2.004 ± 0.052
1.739GluPhe: 1.739 ± 0.04
3.004GluGly: 3.004 ± 0.06
1.35GluHis: 1.35 ± 0.031
2.885GluIle: 2.885 ± 0.052
1.41GluLys: 1.41 ± 0.048
5.466GluLeu: 5.466 ± 0.071
1.086GluMet: 1.086 ± 0.028
1.114GluAsn: 1.114 ± 0.031
2.631GluPro: 2.631 ± 0.053
1.878GluGln: 1.878 ± 0.041
4.218GluArg: 4.218 ± 0.06
2.981GluSer: 2.981 ± 0.044
2.756GluThr: 2.756 ± 0.044
4.441GluVal: 4.441 ± 0.058
0.726GluTrp: 0.726 ± 0.026
0.977GluTyr: 0.977 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.161PheAla: 4.161 ± 0.051
0.282PheCys: 0.282 ± 0.014
2.595PheAsp: 2.595 ± 0.059
1.371PheGlu: 1.371 ± 0.032
0.978PhePhe: 0.978 ± 0.029
3.443PheGly: 3.443 ± 0.054
0.587PheHis: 0.587 ± 0.023
1.009PheIle: 1.009 ± 0.03
0.393PheLys: 0.393 ± 0.019
2.418PheLeu: 2.418 ± 0.056
0.437PheMet: 0.437 ± 0.02
0.551PheAsn: 0.551 ± 0.023
1.336PhePro: 1.336 ± 0.032
0.543PheGln: 0.543 ± 0.022
1.671PheArg: 1.671 ± 0.039
1.643PheSer: 1.643 ± 0.038
2.151PheThr: 2.151 ± 0.042
2.753PheVal: 2.753 ± 0.049
0.388PheTrp: 0.388 ± 0.018
0.67PheTyr: 0.67 ± 0.023
0.0PheXaa: 0.0 ± 0.0
Gly
10.808GlyAla: 10.808 ± 0.157
0.754GlyCys: 0.754 ± 0.029
5.685GlyAsp: 5.685 ± 0.065
4.356GlyGlu: 4.356 ± 0.059
3.058GlyPhe: 3.058 ± 0.053
8.313GlyGly: 8.313 ± 0.239
2.037GlyHis: 2.037 ± 0.043
4.179GlyIle: 4.179 ± 0.074
2.074GlyLys: 2.074 ± 0.05
8.387GlyLeu: 8.387 ± 0.113
1.993GlyMet: 1.993 ± 0.043
1.787GlyAsn: 1.787 ± 0.059
4.468GlyPro: 4.468 ± 0.062
2.431GlyGln: 2.431 ± 0.057
6.632GlyArg: 6.632 ± 0.064
5.892GlySer: 5.892 ± 0.093
5.851GlyThr: 5.851 ± 0.091
8.46GlyVal: 8.46 ± 0.076
1.531GlyTrp: 1.531 ± 0.034
2.149GlyTyr: 2.149 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.449HisAla: 2.449 ± 0.054
0.188HisCys: 0.188 ± 0.013
1.579HisAsp: 1.579 ± 0.035
1.068HisGlu: 1.068 ± 0.03
0.595HisPhe: 0.595 ± 0.022
2.069HisGly: 2.069 ± 0.039
0.772HisHis: 0.772 ± 0.026
0.845HisIle: 0.845 ± 0.025
0.28HisLys: 0.28 ± 0.015
2.3HisLeu: 2.3 ± 0.044
0.351HisMet: 0.351 ± 0.017
0.414HisAsn: 0.414 ± 0.019
1.682HisPro: 1.682 ± 0.037
0.558HisGln: 0.558 ± 0.018
2.051HisArg: 2.051 ± 0.043
1.075HisSer: 1.075 ± 0.031
1.267HisThr: 1.267 ± 0.032
1.694HisVal: 1.694 ± 0.033
0.306HisTrp: 0.306 ± 0.014
0.404HisTyr: 0.404 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
7.109IleAla: 7.109 ± 0.081
0.382IleCys: 0.382 ± 0.016
4.121IleAsp: 4.121 ± 0.058
2.463IleGlu: 2.463 ± 0.04
0.956IlePhe: 0.956 ± 0.033
5.001IleGly: 5.001 ± 0.071
0.777IleHis: 0.777 ± 0.024
1.523IleIle: 1.523 ± 0.04
0.708IleLys: 0.708 ± 0.025
3.127IleLeu: 3.127 ± 0.048
0.564IleMet: 0.564 ± 0.019
0.995IleAsn: 0.995 ± 0.031
2.324IlePro: 2.324 ± 0.042
0.698IleGln: 0.698 ± 0.023
2.741IleArg: 2.741 ± 0.04
2.478IleSer: 2.478 ± 0.046
3.176IleThr: 3.176 ± 0.05
4.246IleVal: 4.246 ± 0.058
0.459IleTrp: 0.459 ± 0.019
0.74IleTyr: 0.74 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
2.291LysAla: 2.291 ± 0.064
0.114LysCys: 0.114 ± 0.01
0.971LysAsp: 0.971 ± 0.035
0.745LysGlu: 0.745 ± 0.03
0.501LysPhe: 0.501 ± 0.021
1.438LysGly: 1.438 ± 0.045
0.381LysHis: 0.381 ± 0.019
0.954LysIle: 0.954 ± 0.029
0.689LysLys: 0.689 ± 0.038
1.763LysLeu: 1.763 ± 0.048
0.389LysMet: 0.389 ± 0.018
0.501LysAsn: 0.501 ± 0.024
1.065LysPro: 1.065 ± 0.032
0.606LysGln: 0.606 ± 0.026
1.326LysArg: 1.326 ± 0.045
1.14LysSer: 1.14 ± 0.042
1.256LysThr: 1.256 ± 0.038
1.701LysVal: 1.701 ± 0.042
0.246LysTrp: 0.246 ± 0.016
0.46LysTyr: 0.46 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
13.291LeuAla: 13.291 ± 0.119
0.729LeuCys: 0.729 ± 0.025
6.944LeuAsp: 6.944 ± 0.098
3.958LeuGlu: 3.958 ± 0.066
2.626LeuPhe: 2.626 ± 0.051
8.623LeuGly: 8.623 ± 0.121
1.919LeuHis: 1.919 ± 0.039
4.03LeuIle: 4.03 ± 0.063
1.396LeuLys: 1.396 ± 0.05
8.61LeuLeu: 8.61 ± 0.101
1.637LeuMet: 1.637 ± 0.038
1.601LeuAsn: 1.601 ± 0.039
5.201LeuPro: 5.201 ± 0.079
2.125LeuGln: 2.125 ± 0.044
7.378LeuArg: 7.378 ± 0.088
5.534LeuSer: 5.534 ± 0.066
6.441LeuThr: 6.441 ± 0.09
8.725LeuVal: 8.725 ± 0.095
1.082LeuTrp: 1.082 ± 0.028
1.555LeuTyr: 1.555 ± 0.033
0.0LeuXaa: 0.0 ± 0.0
Met
2.476MetAla: 2.476 ± 0.044
0.148MetCys: 0.148 ± 0.011
0.884MetAsp: 0.884 ± 0.026
0.664MetGlu: 0.664 ± 0.027
0.626MetPhe: 0.626 ± 0.022
1.422MetGly: 1.422 ± 0.043
0.424MetHis: 0.424 ± 0.019
0.98MetIle: 0.98 ± 0.03
0.38MetLys: 0.38 ± 0.018
1.846MetLeu: 1.846 ± 0.042
0.425MetMet: 0.425 ± 0.019
0.464MetAsn: 0.464 ± 0.019
1.108MetPro: 1.108 ± 0.029
0.471MetGln: 0.471 ± 0.021
1.551MetArg: 1.551 ± 0.031
1.674MetSer: 1.674 ± 0.042
1.957MetThr: 1.957 ± 0.037
1.687MetVal: 1.687 ± 0.036
0.254MetTrp: 0.254 ± 0.017
0.319MetTyr: 0.319 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.353AsnAla: 2.353 ± 0.047
0.148AsnCys: 0.148 ± 0.012
1.115AsnAsp: 1.115 ± 0.032
0.777AsnGlu: 0.777 ± 0.029
0.538AsnPhe: 0.538 ± 0.021
2.08AsnGly: 2.08 ± 0.068
0.373AsnHis: 0.373 ± 0.016
0.828AsnIle: 0.828 ± 0.028
0.396AsnLys: 0.396 ± 0.02
1.816AsnLeu: 1.816 ± 0.042
0.331AsnMet: 0.331 ± 0.017
0.501AsnAsn: 0.501 ± 0.021
1.492AsnPro: 1.492 ± 0.039
0.518AsnGln: 0.518 ± 0.021
1.448AsnArg: 1.448 ± 0.036
1.083AsnSer: 1.083 ± 0.033
1.265AsnThr: 1.265 ± 0.034
1.521AsnVal: 1.521 ± 0.034
0.285AsnTrp: 0.285 ± 0.015
0.442AsnTyr: 0.442 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
6.997ProAla: 6.997 ± 0.101
0.263ProCys: 0.263 ± 0.014
4.649ProAsp: 4.649 ± 0.078
3.202ProGlu: 3.202 ± 0.059
1.558ProPhe: 1.558 ± 0.034
5.382ProGly: 5.382 ± 0.076
1.152ProHis: 1.152 ± 0.032
2.287ProIle: 2.287 ± 0.044
0.985ProLys: 0.985 ± 0.027
4.516ProLeu: 4.516 ± 0.069
1.098ProMet: 1.098 ± 0.025
1.039ProAsn: 1.039 ± 0.03
2.832ProPro: 2.832 ± 0.07
1.485ProGln: 1.485 ± 0.032
3.664ProArg: 3.664 ± 0.056
3.3ProSer: 3.3 ± 0.053
4.019ProThr: 4.019 ± 0.071
5.067ProVal: 5.067 ± 0.075
0.784ProTrp: 0.784 ± 0.028
1.009ProTyr: 1.009 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.016GlnAla: 3.016 ± 0.056
0.179GlnCys: 0.179 ± 0.012
0.944GlnAsp: 0.944 ± 0.031
0.876GlnGlu: 0.876 ± 0.027
0.867GlnPhe: 0.867 ± 0.026
1.86GlnGly: 1.86 ± 0.048
0.48GlnHis: 0.48 ± 0.018
1.528GlnIle: 1.528 ± 0.034
0.597GlnLys: 0.597 ± 0.025
2.637GlnLeu: 2.637 ± 0.052
0.614GlnMet: 0.614 ± 0.022
0.561GlnAsn: 0.561 ± 0.023
1.282GlnPro: 1.282 ± 0.029
0.978GlnGln: 0.978 ± 0.035
2.23GlnArg: 2.23 ± 0.042
1.415GlnSer: 1.415 ± 0.034
1.544GlnThr: 1.544 ± 0.033
2.287GlnVal: 2.287 ± 0.041
0.499GlnTrp: 0.499 ± 0.02
0.603GlnTyr: 0.603 ± 0.023
0.0GlnXaa: 0.0 ± 0.0
Arg
8.863ArgAla: 8.863 ± 0.091
0.515ArgCys: 0.515 ± 0.023
4.803ArgAsp: 4.803 ± 0.068
3.714ArgGlu: 3.714 ± 0.058
2.438ArgPhe: 2.438 ± 0.056
5.572ArgGly: 5.572 ± 0.073
1.793ArgHis: 1.793 ± 0.035
3.493ArgIle: 3.493 ± 0.046
1.305ArgLys: 1.305 ± 0.04
7.031ArgLeu: 7.031 ± 0.087
1.807ArgMet: 1.807 ± 0.037
1.433ArgAsn: 1.433 ± 0.034
4.108ArgPro: 4.108 ± 0.078
1.771ArgGln: 1.771 ± 0.04
6.992ArgArg: 6.992 ± 0.105
4.802ArgSer: 4.802 ± 0.064
4.817ArgThr: 4.817 ± 0.066
6.076ArgVal: 6.076 ± 0.071
1.416ArgTrp: 1.416 ± 0.042
1.644ArgTyr: 1.644 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
7.603SerAla: 7.603 ± 0.079
0.365SerCys: 0.365 ± 0.019
3.825SerAsp: 3.825 ± 0.057
2.545SerGlu: 2.545 ± 0.05
1.651SerPhe: 1.651 ± 0.036
6.166SerGly: 6.166 ± 0.09
1.053SerHis: 1.053 ± 0.03
2.589SerIle: 2.589 ± 0.05
1.071SerLys: 1.071 ± 0.035
5.01SerLeu: 5.01 ± 0.065
1.515SerMet: 1.515 ± 0.035
1.101SerAsn: 1.101 ± 0.032
3.306SerPro: 3.306 ± 0.046
1.39SerGln: 1.39 ± 0.036
3.951SerArg: 3.951 ± 0.059
3.778SerSer: 3.778 ± 0.068
4.251SerThr: 4.251 ± 0.065
5.451SerVal: 5.451 ± 0.073
0.86SerTrp: 0.86 ± 0.028
1.117SerTyr: 1.117 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
8.872ThrAla: 8.872 ± 0.101
0.386ThrCys: 0.386 ± 0.017
5.001ThrAsp: 5.001 ± 0.073
3.272ThrGlu: 3.272 ± 0.054
1.881ThrPhe: 1.881 ± 0.039
6.553ThrGly: 6.553 ± 0.088
1.308ThrHis: 1.308 ± 0.037
2.801ThrIle: 2.801 ± 0.045
1.15ThrLys: 1.15 ± 0.037
5.799ThrLeu: 5.799 ± 0.071
1.195ThrMet: 1.195 ± 0.031
1.114ThrAsn: 1.114 ± 0.037
4.425ThrPro: 4.425 ± 0.065
1.398ThrGln: 1.398 ± 0.034
4.294ThrArg: 4.294 ± 0.056
3.968ThrSer: 3.968 ± 0.063
4.938ThrThr: 4.938 ± 0.08
6.833ThrVal: 6.833 ± 0.087
0.851ThrTrp: 0.851 ± 0.025
1.239ThrTyr: 1.239 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
13.122ValAla: 13.122 ± 0.127
0.689ValCys: 0.689 ± 0.025
6.821ValAsp: 6.821 ± 0.081
4.431ValGlu: 4.431 ± 0.055
2.655ValPhe: 2.655 ± 0.044
7.96ValGly: 7.96 ± 0.083
1.909ValHis: 1.909 ± 0.048
4.458ValIle: 4.458 ± 0.057
1.389ValLys: 1.389 ± 0.038
8.837ValLeu: 8.837 ± 0.105
1.652ValMet: 1.652 ± 0.04
1.816ValAsn: 1.816 ± 0.045
4.475ValPro: 4.475 ± 0.075
1.702ValGln: 1.702 ± 0.039
6.046ValArg: 6.046 ± 0.068
5.357ValSer: 5.357 ± 0.066
6.4ValThr: 6.4 ± 0.094
10.119ValVal: 10.119 ± 0.124
1.035ValTrp: 1.035 ± 0.028
1.446ValTyr: 1.446 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.518TrpAla: 1.518 ± 0.036
0.132TrpCys: 0.132 ± 0.011
0.764TrpAsp: 0.764 ± 0.027
0.578TrpGlu: 0.578 ± 0.02
0.579TrpPhe: 0.579 ± 0.023
0.947TrpGly: 0.947 ± 0.032
0.294TrpHis: 0.294 ± 0.015
0.683TrpIle: 0.683 ± 0.024
0.289TrpLys: 0.289 ± 0.015
1.426TrpLeu: 1.426 ± 0.032
0.334TrpMet: 0.334 ± 0.017
0.356TrpAsn: 0.356 ± 0.016
0.694TrpPro: 0.694 ± 0.025
0.486TrpGln: 0.486 ± 0.02
1.131TrpArg: 1.131 ± 0.027
0.944TrpSer: 0.944 ± 0.022
0.978TrpThr: 0.978 ± 0.03
1.083TrpVal: 1.083 ± 0.028
0.328TrpTrp: 0.328 ± 0.016
0.279TrpTyr: 0.279 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.234TyrAla: 2.234 ± 0.043
0.181TyrCys: 0.181 ± 0.013
1.208TyrAsp: 1.208 ± 0.035
0.93TyrGlu: 0.93 ± 0.032
0.679TyrPhe: 0.679 ± 0.028
1.914TyrGly: 1.914 ± 0.044
0.348TyrHis: 0.348 ± 0.014
0.644TyrIle: 0.644 ± 0.022
0.331TyrLys: 0.331 ± 0.018
2.068TyrLeu: 2.068 ± 0.036
0.27TyrMet: 0.27 ± 0.015
0.399TyrAsn: 0.399 ± 0.018
1.026TyrPro: 1.026 ± 0.03
0.523TyrGln: 0.523 ± 0.018
1.722TyrArg: 1.722 ± 0.038
1.144TyrSer: 1.144 ± 0.033
1.134TyrThr: 1.134 ± 0.03
1.487TyrVal: 1.487 ± 0.038
0.309TyrTrp: 0.309 ± 0.016
0.4TyrTyr: 0.4 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4063 proteins (1352199 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski