Amino acid dipepetide frequency for Sphingobacterium psychroaquaticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.927AlaAla: 5.927 ± 0.081	0.604AlaCys: 0.604 ± 0.024	4.136AlaAsp: 4.136 ± 0.062	4.412AlaGlu: 4.412 ± 0.066	3.524AlaPhe: 3.524 ± 0.055	5.119AlaGly: 5.119 ± 0.079	1.335AlaHis: 1.335 ± 0.031	5.352AlaIle: 5.352 ± 0.073	4.807AlaLys: 4.807 ± 0.065	7.262AlaLeu: 7.262 ± 0.081	1.734AlaMet: 1.734 ± 0.034	3.668AlaAsn: 3.668 ± 0.055	2.341AlaPro: 2.341 ± 0.048	3.181AlaGln: 3.181 ± 0.048	2.715AlaArg: 2.715 ± 0.043	4.721AlaSer: 4.721 ± 0.064	4.304AlaThr: 4.304 ± 0.069	5.125AlaVal: 5.125 ± 0.073	0.817AlaTrp: 0.817 ± 0.025	3.087AlaTyr: 3.087 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.475CysAla: 0.475 ± 0.019	0.128CysCys: 0.128 ± 0.011	0.347CysAsp: 0.347 ± 0.017	0.364CysGlu: 0.364 ± 0.018	0.381CysPhe: 0.381 ± 0.017	0.555CysGly: 0.555 ± 0.024	0.174CysHis: 0.174 ± 0.013	0.5CysIle: 0.5 ± 0.018	0.388CysLys: 0.388 ± 0.019	0.673CysLeu: 0.673 ± 0.023	0.175CysMet: 0.175 ± 0.012	0.332CysAsn: 0.332 ± 0.014	0.281CysPro: 0.281 ± 0.015	0.237CysGln: 0.237 ± 0.013	0.285CysArg: 0.285 ± 0.014	0.501CysSer: 0.501 ± 0.02	0.406CysThr: 0.406 ± 0.018	0.445CysVal: 0.445 ± 0.02	0.071CysTrp: 0.071 ± 0.007	0.294CysTyr: 0.294 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.062AspAla: 4.062 ± 0.06	0.328AspCys: 0.328 ± 0.015	2.476AspAsp: 2.476 ± 0.046	3.201AspGlu: 3.201 ± 0.049	3.28AspPhe: 3.28 ± 0.045	3.988AspGly: 3.988 ± 0.067	0.95AspHis: 0.95 ± 0.031	4.145AspIle: 4.145 ± 0.059	3.885AspLys: 3.885 ± 0.057	5.268AspLeu: 5.268 ± 0.065	1.293AspMet: 1.293 ± 0.032	2.807AspAsn: 2.807 ± 0.056	2.121AspPro: 2.121 ± 0.048	1.899AspGln: 1.899 ± 0.041	2.49AspArg: 2.49 ± 0.048	2.779AspSer: 2.779 ± 0.052	2.496AspThr: 2.496 ± 0.05	3.666AspVal: 3.666 ± 0.057	0.792AspTrp: 0.792 ± 0.026	2.623AspTyr: 2.623 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.519GluAla: 4.519 ± 0.072	0.271GluCys: 0.271 ± 0.015	3.029GluAsp: 3.029 ± 0.053	4.308GluGlu: 4.308 ± 0.076	2.294GluPhe: 2.294 ± 0.042	3.738GluGly: 3.738 ± 0.053	1.174GluHis: 1.174 ± 0.029	4.397GluIle: 4.397 ± 0.061	4.775GluLys: 4.775 ± 0.074	5.61GluLeu: 5.61 ± 0.079	1.477GluMet: 1.477 ± 0.035	3.464GluAsn: 3.464 ± 0.048	1.581GluPro: 1.581 ± 0.036	2.683GluGln: 2.683 ± 0.046	2.913GluArg: 2.913 ± 0.053	3.057GluSer: 3.057 ± 0.052	3.228GluThr: 3.228 ± 0.053	4.342GluVal: 4.342 ± 0.06	0.658GluTrp: 0.658 ± 0.023	2.013GluTyr: 2.013 ± 0.044	0.0GluXaa: 0.0 ± 0.0
Phe	3.357PheAla: 3.357 ± 0.055	0.403PheCys: 0.403 ± 0.016	2.992PheAsp: 2.992 ± 0.044	2.793PheGlu: 2.793 ± 0.042	2.668PhePhe: 2.668 ± 0.058	3.45PheGly: 3.45 ± 0.05	0.852PheHis: 0.852 ± 0.028	3.134PheIle: 3.134 ± 0.055	2.856PheLys: 2.856 ± 0.054	4.415PheLeu: 4.415 ± 0.064	1.249PheMet: 1.249 ± 0.028	2.741PheAsn: 2.741 ± 0.049	1.743PhePro: 1.743 ± 0.037	1.606PheGln: 1.606 ± 0.034	2.004PheArg: 2.004 ± 0.041	3.575PheSer: 3.575 ± 0.056	3.079PheThr: 3.079 ± 0.055	3.237PheVal: 3.237 ± 0.047	0.589PheTrp: 0.589 ± 0.024	2.075PheTyr: 2.075 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.111GlyAla: 5.111 ± 0.082	0.554GlyCys: 0.554 ± 0.023	3.497GlyAsp: 3.497 ± 0.061	3.664GlyGlu: 3.664 ± 0.047	3.553GlyPhe: 3.553 ± 0.052	5.022GlyGly: 5.022 ± 0.091	1.212GlyHis: 1.212 ± 0.031	5.091GlyIle: 5.091 ± 0.071	5.036GlyLys: 5.036 ± 0.077	6.333GlyLeu: 6.333 ± 0.074	1.773GlyMet: 1.773 ± 0.043	3.708GlyAsn: 3.708 ± 0.069	1.499GlyPro: 1.499 ± 0.039	2.546GlyGln: 2.546 ± 0.046	2.813GlyArg: 2.813 ± 0.053	4.366GlySer: 4.366 ± 0.071	4.432GlyThr: 4.432 ± 0.084	4.82GlyVal: 4.82 ± 0.075	0.947GlyTrp: 0.947 ± 0.025	3.23GlyTyr: 3.23 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.297HisAla: 1.297 ± 0.033	0.174HisCys: 0.174 ± 0.011	0.963HisAsp: 0.963 ± 0.025	0.985HisGlu: 0.985 ± 0.029	1.047HisPhe: 1.047 ± 0.028	1.174HisGly: 1.174 ± 0.034	0.511HisHis: 0.511 ± 0.021	1.52HisIle: 1.52 ± 0.035	0.989HisLys: 0.989 ± 0.027	1.829HisLeu: 1.829 ± 0.038	0.339HisMet: 0.339 ± 0.015	0.943HisAsn: 0.943 ± 0.027	0.908HisPro: 0.908 ± 0.028	0.782HisGln: 0.782 ± 0.027	0.836HisArg: 0.836 ± 0.026	0.964HisSer: 0.964 ± 0.029	1.057HisThr: 1.057 ± 0.028	1.162HisVal: 1.162 ± 0.031	0.261HisTrp: 0.261 ± 0.014	0.869HisTyr: 0.869 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.637IleAla: 5.637 ± 0.068	0.594IleCys: 0.594 ± 0.021	4.31IleAsp: 4.31 ± 0.055	4.306IleGlu: 4.306 ± 0.062	2.925IlePhe: 2.925 ± 0.054	5.02IleGly: 5.02 ± 0.062	1.337IleHis: 1.337 ± 0.035	4.453IleIle: 4.453 ± 0.072	4.355IleLys: 4.355 ± 0.06	6.047IleLeu: 6.047 ± 0.072	1.362IleMet: 1.362 ± 0.032	3.647IleAsn: 3.647 ± 0.059	3.023IlePro: 3.023 ± 0.048	2.663IleGln: 2.663 ± 0.046	3.065IleArg: 3.065 ± 0.055	4.651IleSer: 4.651 ± 0.059	4.082IleThr: 4.082 ± 0.062	4.557IleVal: 4.557 ± 0.068	0.68IleTrp: 0.68 ± 0.023	2.502IleTyr: 2.502 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.899LysAla: 4.899 ± 0.072	0.25LysCys: 0.25 ± 0.013	4.028LysAsp: 4.028 ± 0.057	5.009LysGlu: 5.009 ± 0.079	2.405LysPhe: 2.405 ± 0.044	4.476LysGly: 4.476 ± 0.064	1.242LysHis: 1.242 ± 0.03	4.551LysIle: 4.551 ± 0.069	5.076LysLys: 5.076 ± 0.084	5.73LysLeu: 5.73 ± 0.066	1.825LysMet: 1.825 ± 0.036	3.812LysAsn: 3.812 ± 0.055	2.416LysPro: 2.416 ± 0.043	2.737LysGln: 2.737 ± 0.047	2.945LysArg: 2.945 ± 0.045	3.874LysSer: 3.874 ± 0.055	3.864LysThr: 3.864 ± 0.059	4.464LysVal: 4.464 ± 0.062	0.755LysTrp: 0.755 ± 0.022	2.66LysTyr: 2.66 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	6.897LeuAla: 6.897 ± 0.082	0.782LeuCys: 0.782 ± 0.024	5.05LeuAsp: 5.05 ± 0.064	5.237LeuGlu: 5.237 ± 0.069	4.796LeuPhe: 4.796 ± 0.076	6.208LeuGly: 6.208 ± 0.082	1.811LeuHis: 1.811 ± 0.045	5.92LeuIle: 5.92 ± 0.076	6.315LeuLys: 6.315 ± 0.074	9.411LeuLeu: 9.411 ± 0.111	2.195LeuMet: 2.195 ± 0.045	4.974LeuAsn: 4.974 ± 0.063	3.873LeuPro: 3.873 ± 0.055	3.789LeuGln: 3.789 ± 0.061	4.171LeuArg: 4.171 ± 0.06	6.857LeuSer: 6.857 ± 0.082	5.536LeuThr: 5.536 ± 0.079	5.867LeuVal: 5.867 ± 0.071	0.911LeuTrp: 0.911 ± 0.028	3.525LeuTyr: 3.525 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.783MetAla: 1.783 ± 0.038	0.143MetCys: 0.143 ± 0.01	1.297MetAsp: 1.297 ± 0.032	1.52MetGlu: 1.52 ± 0.035	0.884MetPhe: 0.884 ± 0.028	1.617MetGly: 1.617 ± 0.03	0.415MetHis: 0.415 ± 0.017	1.343MetIle: 1.343 ± 0.032	1.883MetLys: 1.883 ± 0.036	2.251MetLeu: 2.251 ± 0.044	0.618MetMet: 0.618 ± 0.021	1.338MetAsn: 1.338 ± 0.028	0.98MetPro: 0.98 ± 0.028	0.989MetGln: 0.989 ± 0.028	1.137MetArg: 1.137 ± 0.032	1.403MetSer: 1.403 ± 0.033	1.242MetThr: 1.242 ± 0.034	1.491MetVal: 1.491 ± 0.031	0.214MetTrp: 0.214 ± 0.012	0.758MetTyr: 0.758 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.766AsnAla: 3.766 ± 0.05	0.288AsnCys: 0.288 ± 0.015	2.649AsnAsp: 2.649 ± 0.048	2.882AsnGlu: 2.882 ± 0.054	2.586AsnPhe: 2.586 ± 0.05	3.826AsnGly: 3.826 ± 0.069	0.919AsnHis: 0.919 ± 0.024	3.946AsnIle: 3.946 ± 0.062	3.727AsnLys: 3.727 ± 0.05	4.939AsnLeu: 4.939 ± 0.063	1.282AsnMet: 1.282 ± 0.029	3.184AsnAsn: 3.184 ± 0.059	2.632AsnPro: 2.632 ± 0.053	1.986AsnGln: 1.986 ± 0.038	2.46AsnArg: 2.46 ± 0.049	3.2AsnSer: 3.2 ± 0.062	3.323AsnThr: 3.323 ± 0.057	3.3AsnVal: 3.3 ± 0.06	0.721AsnTrp: 0.721 ± 0.024	2.519AsnTyr: 2.519 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	2.657ProAla: 2.657 ± 0.053	0.192ProCys: 0.192 ± 0.013	2.11ProAsp: 2.11 ± 0.04	2.657ProGlu: 2.657 ± 0.045	1.931ProPhe: 1.931 ± 0.041	2.372ProGly: 2.372 ± 0.05	0.678ProHis: 0.678 ± 0.025	2.595ProIle: 2.595 ± 0.047	2.258ProLys: 2.258 ± 0.04	3.209ProLeu: 3.209 ± 0.05	0.803ProMet: 0.803 ± 0.026	2.015ProAsn: 2.015 ± 0.038	0.853ProPro: 0.853 ± 0.03	1.449ProGln: 1.449 ± 0.037	1.218ProArg: 1.218 ± 0.032	2.339ProSer: 2.339 ± 0.038	2.405ProThr: 2.405 ± 0.046	2.644ProVal: 2.644 ± 0.054	0.439ProTrp: 0.439 ± 0.02	1.591ProTyr: 1.591 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.954GlnAla: 2.954 ± 0.05	0.202GlnCys: 0.202 ± 0.013	1.888GlnAsp: 1.888 ± 0.035	2.661GlnGlu: 2.661 ± 0.058	1.628GlnPhe: 1.628 ± 0.033	2.474GlnGly: 2.474 ± 0.048	0.924GlnHis: 0.924 ± 0.03	2.533GlnIle: 2.533 ± 0.048	2.627GlnLys: 2.627 ± 0.043	3.841GlnLeu: 3.841 ± 0.058	0.873GlnMet: 0.873 ± 0.022	1.962GlnAsn: 1.962 ± 0.041	1.33GlnPro: 1.33 ± 0.033	2.195GlnGln: 2.195 ± 0.056	1.768GlnArg: 1.768 ± 0.037	2.134GlnSer: 2.134 ± 0.039	2.131GlnThr: 2.131 ± 0.046	2.637GlnVal: 2.637 ± 0.039	0.473GlnTrp: 0.473 ± 0.019	1.664GlnTyr: 1.664 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.852ArgAla: 2.852 ± 0.057	0.22ArgCys: 0.22 ± 0.013	2.223ArgAsp: 2.223 ± 0.049	2.519ArgGlu: 2.519 ± 0.046	2.236ArgPhe: 2.236 ± 0.041	2.495ArgGly: 2.495 ± 0.046	0.744ArgHis: 0.744 ± 0.027	3.244ArgIle: 3.244 ± 0.048	2.935ArgLys: 2.935 ± 0.047	4.027ArgLeu: 4.027 ± 0.059	1.144ArgMet: 1.144 ± 0.03	2.409ArgAsn: 2.409 ± 0.048	1.464ArgPro: 1.464 ± 0.042	1.59ArgGln: 1.59 ± 0.032	1.762ArgArg: 1.762 ± 0.034	2.516ArgSer: 2.516 ± 0.052	2.438ArgThr: 2.438 ± 0.041	2.856ArgVal: 2.856 ± 0.047	0.613ArgTrp: 0.613 ± 0.022	2.188ArgTyr: 2.188 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.595SerAla: 4.595 ± 0.066	0.574SerCys: 0.574 ± 0.023	3.217SerAsp: 3.217 ± 0.053	3.105SerGlu: 3.105 ± 0.053	3.699SerPhe: 3.699 ± 0.054	4.654SerGly: 4.654 ± 0.069	1.039SerHis: 1.039 ± 0.028	4.551SerIle: 4.551 ± 0.051	3.815SerLys: 3.815 ± 0.054	6.187SerLeu: 6.187 ± 0.067	1.343SerMet: 1.343 ± 0.032	3.281SerAsn: 3.281 ± 0.061	2.3SerPro: 2.3 ± 0.043	1.99SerGln: 1.99 ± 0.036	2.467SerArg: 2.467 ± 0.048	4.217SerSer: 4.217 ± 0.07	3.888SerThr: 3.888 ± 0.061	4.189SerVal: 4.189 ± 0.061	0.789SerTrp: 0.789 ± 0.022	2.877SerTyr: 2.877 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	4.598ThrAla: 4.598 ± 0.065	0.337ThrCys: 0.337 ± 0.018	3.274ThrAsp: 3.274 ± 0.05	3.123ThrGlu: 3.123 ± 0.054	2.961ThrPhe: 2.961 ± 0.053	4.542ThrGly: 4.542 ± 0.077	1.066ThrHis: 1.066 ± 0.03	4.366ThrIle: 4.366 ± 0.058	3.537ThrLys: 3.537 ± 0.053	5.623ThrLeu: 5.623 ± 0.072	1.093ThrMet: 1.093 ± 0.027	2.963ThrAsn: 2.963 ± 0.059	2.552ThrPro: 2.552 ± 0.047	1.934ThrGln: 1.934 ± 0.039	1.966ThrArg: 1.966 ± 0.039	3.622ThrSer: 3.622 ± 0.061	3.553ThrThr: 3.553 ± 0.072	4.245ThrVal: 4.245 ± 0.069	0.654ThrTrp: 0.654 ± 0.021	2.547ThrTyr: 2.547 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	4.982ValAla: 4.982 ± 0.069	0.537ValCys: 0.537 ± 0.019	4.038ValAsp: 4.038 ± 0.054	3.93ValGlu: 3.93 ± 0.063	3.223ValPhe: 3.223 ± 0.045	4.531ValGly: 4.531 ± 0.073	1.187ValHis: 1.187 ± 0.031	4.271ValIle: 4.271 ± 0.064	4.274ValLys: 4.274 ± 0.058	6.53ValLeu: 6.53 ± 0.076	1.451ValMet: 1.451 ± 0.037	3.624ValAsn: 3.624 ± 0.059	2.562ValPro: 2.562 ± 0.046	2.413ValGln: 2.413 ± 0.04	2.876ValArg: 2.876 ± 0.049	4.576ValSer: 4.576 ± 0.063	3.841ValThr: 3.841 ± 0.072	4.954ValVal: 4.954 ± 0.069	0.753ValTrp: 0.753 ± 0.021	2.623ValTyr: 2.623 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.731TrpAla: 0.731 ± 0.022	0.112TrpCys: 0.112 ± 0.009	0.634TrpAsp: 0.634 ± 0.022	0.706TrpGlu: 0.706 ± 0.024	0.561TrpPhe: 0.561 ± 0.018	0.888TrpGly: 0.888 ± 0.029	0.24TrpHis: 0.24 ± 0.013	0.742TrpIle: 0.742 ± 0.024	0.825TrpLys: 0.825 ± 0.023	1.104TrpLeu: 1.104 ± 0.033	0.376TrpMet: 0.376 ± 0.017	0.721TrpAsn: 0.721 ± 0.024	0.295TrpPro: 0.295 ± 0.015	0.515TrpGln: 0.515 ± 0.018	0.575TrpArg: 0.575 ± 0.018	0.742TrpSer: 0.742 ± 0.025	0.664TrpThr: 0.664 ± 0.024	0.714TrpVal: 0.714 ± 0.024	0.171TrpTrp: 0.171 ± 0.013	0.52TrpTyr: 0.52 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.07TyrAla: 3.07 ± 0.047	0.318TyrCys: 0.318 ± 0.016	2.391TyrAsp: 2.391 ± 0.041	2.151TyrGlu: 2.151 ± 0.04	2.237TyrPhe: 2.237 ± 0.039	3.057TyrGly: 3.057 ± 0.051	0.8TyrHis: 0.8 ± 0.028	2.563TyrIle: 2.563 ± 0.043	2.655TyrLys: 2.655 ± 0.043	3.836TyrLeu: 3.836 ± 0.056	0.901TyrMet: 0.901 ± 0.029	2.541TyrAsn: 2.541 ± 0.055	1.66TyrPro: 1.66 ± 0.035	1.717TyrGln: 1.717 ± 0.04	2.008TyrArg: 2.008 ± 0.038	2.682TyrSer: 2.682 ± 0.046	2.585TyrThr: 2.585 ± 0.045	2.465TyrVal: 2.465 ± 0.044	0.525TyrTrp: 0.525 ± 0.02	2.006TyrTyr: 2.006 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3765 proteins (1360707 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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