Amino acid dipepetide frequency for Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.659AlaAla: 8.659 ± 0.13	1.058AlaCys: 1.058 ± 0.036	4.951AlaAsp: 4.951 ± 0.078	5.477AlaGlu: 5.477 ± 0.101	3.478AlaPhe: 3.478 ± 0.051	6.08AlaGly: 6.08 ± 0.092	1.864AlaHis: 1.864 ± 0.04	6.229AlaIle: 6.229 ± 0.09	5.683AlaLys: 5.683 ± 0.07	10.802AlaLeu: 10.802 ± 0.116	2.796AlaMet: 2.796 ± 0.052	4.261AlaAsn: 4.261 ± 0.077	3.206AlaPro: 3.206 ± 0.064	4.652AlaGln: 4.652 ± 0.069	3.597AlaArg: 3.597 ± 0.066	6.458AlaSer: 6.458 ± 0.091	4.476AlaThr: 4.476 ± 0.087	5.703AlaVal: 5.703 ± 0.079	0.967AlaTrp: 0.967 ± 0.03	2.494AlaTyr: 2.494 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.83CysAla: 0.83 ± 0.03	0.178CysCys: 0.178 ± 0.014	0.564CysAsp: 0.564 ± 0.022	0.556CysGlu: 0.556 ± 0.023	0.497CysPhe: 0.497 ± 0.021	0.805CysGly: 0.805 ± 0.026	0.361CysHis: 0.361 ± 0.017	0.582CysIle: 0.582 ± 0.023	0.409CysLys: 0.409 ± 0.02	1.036CysLeu: 1.036 ± 0.031	0.216CysMet: 0.216 ± 0.012	0.353CysAsn: 0.353 ± 0.017	0.43CysPro: 0.43 ± 0.022	0.555CysGln: 0.555 ± 0.022	0.468CysArg: 0.468 ± 0.022	0.702CysSer: 0.702 ± 0.023	0.444CysThr: 0.444 ± 0.021	0.652CysVal: 0.652 ± 0.024	0.121CysTrp: 0.121 ± 0.01	0.368CysTyr: 0.368 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	5.134AspAla: 5.134 ± 0.092	0.533AspCys: 0.533 ± 0.023	3.052AspAsp: 3.052 ± 0.069	3.759AspGlu: 3.759 ± 0.063	2.514AspPhe: 2.514 ± 0.048	3.774AspGly: 3.774 ± 0.079	0.934AspHis: 0.934 ± 0.028	4.084AspIle: 4.084 ± 0.06	3.5AspLys: 3.5 ± 0.053	5.054AspLeu: 5.054 ± 0.059	1.401AspMet: 1.401 ± 0.033	2.71AspAsn: 2.71 ± 0.056	2.002AspPro: 2.002 ± 0.042	1.517AspGln: 1.517 ± 0.036	1.962AspArg: 1.962 ± 0.047	3.58AspSer: 3.58 ± 0.066	2.942AspThr: 2.942 ± 0.072	3.576AspVal: 3.576 ± 0.058	0.768AspTrp: 0.768 ± 0.026	1.986AspTyr: 1.986 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.188GluAla: 5.188 ± 0.085	0.485GluCys: 0.485 ± 0.021	2.586GluAsp: 2.586 ± 0.057	2.624GluGlu: 2.624 ± 0.058	2.435GluPhe: 2.435 ± 0.043	3.134GluGly: 3.134 ± 0.051	1.563GluHis: 1.563 ± 0.039	3.446GluIle: 3.446 ± 0.061	2.931GluLys: 2.931 ± 0.058	7.219GluLeu: 7.219 ± 0.093	1.485GluMet: 1.485 ± 0.037	2.121GluAsn: 2.121 ± 0.043	1.963GluPro: 1.963 ± 0.047	4.049GluGln: 4.049 ± 0.064	2.994GluArg: 2.994 ± 0.057	3.123GluSer: 3.123 ± 0.053	2.904GluThr: 2.904 ± 0.059	3.923GluVal: 3.923 ± 0.065	0.582GluTrp: 0.582 ± 0.022	1.639GluTyr: 1.639 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.546PheAla: 3.546 ± 0.065	0.47PheCys: 0.47 ± 0.02	2.863PheAsp: 2.863 ± 0.044	2.531PheGlu: 2.531 ± 0.044	1.62PhePhe: 1.62 ± 0.039	2.971PheGly: 2.971 ± 0.053	0.776PheHis: 0.776 ± 0.022	2.814PheIle: 2.814 ± 0.053	1.962PheLys: 1.962 ± 0.05	3.14PheLeu: 3.14 ± 0.052	1.017PheMet: 1.017 ± 0.027	2.252PheAsn: 2.252 ± 0.037	1.38PhePro: 1.38 ± 0.034	1.167PheGln: 1.167 ± 0.029	1.358PheArg: 1.358 ± 0.033	3.571PheSer: 3.571 ± 0.065	2.26PheThr: 2.26 ± 0.046	2.595PheVal: 2.595 ± 0.046	0.499PheTrp: 0.499 ± 0.024	1.433PheTyr: 1.433 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.673GlyAla: 5.673 ± 0.093	0.817GlyCys: 0.817 ± 0.026	3.709GlyAsp: 3.709 ± 0.058	4.007GlyGlu: 4.007 ± 0.062	3.257GlyPhe: 3.257 ± 0.053	4.477GlyGly: 4.477 ± 0.082	1.575GlyHis: 1.575 ± 0.033	4.588GlyIle: 4.588 ± 0.061	3.812GlyLys: 3.812 ± 0.059	7.412GlyLeu: 7.412 ± 0.088	1.907GlyMet: 1.907 ± 0.049	2.693GlyAsn: 2.693 ± 0.063	1.764GlyPro: 1.764 ± 0.054	3.207GlyGln: 3.207 ± 0.085	3.093GlyArg: 3.093 ± 0.061	4.15GlySer: 4.15 ± 0.074	3.515GlyThr: 3.515 ± 0.128	5.008GlyVal: 5.008 ± 0.076	0.876GlyTrp: 0.876 ± 0.03	2.444GlyTyr: 2.444 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.616HisAla: 1.616 ± 0.034	0.336HisCys: 0.336 ± 0.017	1.11HisAsp: 1.11 ± 0.028	1.084HisGlu: 1.084 ± 0.032	1.129HisPhe: 1.129 ± 0.028	1.629HisGly: 1.629 ± 0.041	0.71HisHis: 0.71 ± 0.032	1.379HisIle: 1.379 ± 0.034	1.21HisLys: 1.21 ± 0.031	2.475HisLeu: 2.475 ± 0.053	0.485HisMet: 0.485 ± 0.019	0.953HisAsn: 0.953 ± 0.027	1.081HisPro: 1.081 ± 0.031	1.284HisGln: 1.284 ± 0.039	0.987HisArg: 0.987 ± 0.032	1.654HisSer: 1.654 ± 0.035	1.074HisThr: 1.074 ± 0.031	1.163HisVal: 1.163 ± 0.028	0.406HisTrp: 0.406 ± 0.021	0.937HisTyr: 0.937 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.496IleAla: 6.496 ± 0.089	0.683IleCys: 0.683 ± 0.023	4.17IleAsp: 4.17 ± 0.059	4.409IleGlu: 4.409 ± 0.061	2.053IlePhe: 2.053 ± 0.042	4.366IleGly: 4.366 ± 0.06	1.213IleHis: 1.213 ± 0.031	3.704IleIle: 3.704 ± 0.072	3.515IleLys: 3.515 ± 0.059	5.133IleLeu: 5.133 ± 0.078	1.296IleMet: 1.296 ± 0.033	3.357IleAsn: 3.357 ± 0.049	2.454IlePro: 2.454 ± 0.039	2.17IleGln: 2.17 ± 0.04	2.613IleArg: 2.613 ± 0.052	4.816IleSer: 4.816 ± 0.074	3.636IleThr: 3.636 ± 0.083	3.593IleVal: 3.593 ± 0.059	0.579IleTrp: 0.579 ± 0.02	1.677IleTyr: 1.677 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	5.332LysAla: 5.332 ± 0.082	0.329LysCys: 0.329 ± 0.018	2.708LysAsp: 2.708 ± 0.05	2.513LysGlu: 2.513 ± 0.053	1.55LysPhe: 1.55 ± 0.034	3.396LysGly: 3.396 ± 0.054	1.296LysHis: 1.296 ± 0.028	2.975LysIle: 2.975 ± 0.052	2.524LysLys: 2.524 ± 0.058	5.908LysLeu: 5.908 ± 0.069	1.357LysMet: 1.357 ± 0.037	2.038LysAsn: 2.038 ± 0.045	2.325LysPro: 2.325 ± 0.05	3.234LysGln: 3.234 ± 0.062	2.606LysArg: 2.606 ± 0.05	3.136LysSer: 3.136 ± 0.053	2.882LysThr: 2.882 ± 0.052	3.897LysVal: 3.897 ± 0.058	0.512LysTrp: 0.512 ± 0.018	1.32LysTyr: 1.32 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	11.598LeuAla: 11.598 ± 0.121	1.164LeuCys: 1.164 ± 0.032	6.088LeuAsp: 6.088 ± 0.074	5.794LeuGlu: 5.794 ± 0.081	4.191LeuPhe: 4.191 ± 0.078	7.534LeuGly: 7.534 ± 0.082	2.074LeuHis: 2.074 ± 0.044	6.251LeuIle: 6.251 ± 0.087	5.582LeuLys: 5.582 ± 0.084	11.467LeuLeu: 11.467 ± 0.157	2.859LeuMet: 2.859 ± 0.054	4.814LeuAsn: 4.814 ± 0.061	4.648LeuPro: 4.648 ± 0.072	4.004LeuGln: 4.004 ± 0.071	4.239LeuArg: 4.239 ± 0.061	8.889LeuSer: 8.889 ± 0.113	6.688LeuThr: 6.688 ± 0.09	7.461LeuVal: 7.461 ± 0.099	1.201LeuTrp: 1.201 ± 0.036	2.743LeuTyr: 2.743 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.769MetAla: 2.769 ± 0.052	0.189MetCys: 0.189 ± 0.012	1.297MetAsp: 1.297 ± 0.035	1.197MetGlu: 1.197 ± 0.032	0.798MetPhe: 0.798 ± 0.026	1.823MetGly: 1.823 ± 0.039	0.462MetHis: 0.462 ± 0.017	1.341MetIle: 1.341 ± 0.035	1.3MetLys: 1.3 ± 0.029	2.909MetLeu: 2.909 ± 0.055	0.772MetMet: 0.772 ± 0.025	1.048MetAsn: 1.048 ± 0.028	1.263MetPro: 1.263 ± 0.032	1.195MetGln: 1.195 ± 0.03	1.107MetArg: 1.107 ± 0.029	2.006MetSer: 2.006 ± 0.039	1.636MetThr: 1.636 ± 0.036	1.575MetVal: 1.575 ± 0.035	0.211MetTrp: 0.211 ± 0.013	0.504MetTyr: 0.504 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.722AsnAla: 3.722 ± 0.062	0.422AsnCys: 0.422 ± 0.018	2.322AsnAsp: 2.322 ± 0.066	2.309AsnGlu: 2.309 ± 0.047	1.587AsnPhe: 1.587 ± 0.033	3.09AsnGly: 3.09 ± 0.075	0.998AsnHis: 0.998 ± 0.028	2.759AsnIle: 2.759 ± 0.052	2.33AsnLys: 2.33 ± 0.041	4.369AsnLeu: 4.369 ± 0.066	0.991AsnMet: 0.991 ± 0.03	2.025AsnAsn: 2.025 ± 0.051	2.127AsnPro: 2.127 ± 0.039	2.303AsnGln: 2.303 ± 0.054	1.938AsnArg: 1.938 ± 0.045	2.884AsnSer: 2.884 ± 0.047	2.406AsnThr: 2.406 ± 0.046	2.496AsnVal: 2.496 ± 0.05	0.589AsnTrp: 0.589 ± 0.025	1.345AsnTyr: 1.345 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.323ProAla: 3.323 ± 0.057	0.317ProCys: 0.317 ± 0.017	2.101ProAsp: 2.101 ± 0.043	2.861ProGlu: 2.861 ± 0.056	1.631ProPhe: 1.631 ± 0.039	2.269ProGly: 2.269 ± 0.045	0.819ProHis: 0.819 ± 0.027	2.389ProIle: 2.389 ± 0.042	2.308ProLys: 2.308 ± 0.046	4.391ProLeu: 4.391 ± 0.066	1.101ProMet: 1.101 ± 0.033	1.732ProAsn: 1.732 ± 0.04	1.096ProPro: 1.096 ± 0.034	1.935ProGln: 1.935 ± 0.039	1.32ProArg: 1.32 ± 0.033	2.708ProSer: 2.708 ± 0.05	2.007ProThr: 2.007 ± 0.048	2.875ProVal: 2.875 ± 0.061	0.515ProTrp: 0.515 ± 0.021	1.126ProTyr: 1.126 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.614GlnAla: 5.614 ± 0.088	0.396GlnCys: 0.396 ± 0.02	2.401GlnAsp: 2.401 ± 0.051	2.26GlnGlu: 2.26 ± 0.046	1.791GlnPhe: 1.791 ± 0.04	3.932GlnGly: 3.932 ± 0.068	1.326GlnHis: 1.326 ± 0.035	2.737GlnIle: 2.737 ± 0.047	1.916GlnLys: 1.916 ± 0.042	6.181GlnLeu: 6.181 ± 0.096	1.155GlnMet: 1.155 ± 0.031	1.432GlnAsn: 1.432 ± 0.034	1.578GlnPro: 1.578 ± 0.041	3.549GlnGln: 3.549 ± 0.081	2.264GlnArg: 2.264 ± 0.046	3.033GlnSer: 3.033 ± 0.055	2.565GlnThr: 2.565 ± 0.051	3.766GlnVal: 3.766 ± 0.065	0.748GlnTrp: 0.748 ± 0.031	1.494GlnTyr: 1.494 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.372ArgAla: 3.372 ± 0.063	0.426ArgCys: 0.426 ± 0.018	2.279ArgAsp: 2.279 ± 0.042	2.486ArgGlu: 2.486 ± 0.052	2.148ArgPhe: 2.148 ± 0.042	2.532ArgGly: 2.532 ± 0.049	1.154ArgHis: 1.154 ± 0.035	2.751ArgIle: 2.751 ± 0.051	2.137ArgLys: 2.137 ± 0.043	5.106ArgLeu: 5.106 ± 0.082	1.073ArgMet: 1.073 ± 0.034	1.728ArgAsn: 1.728 ± 0.037	1.574ArgPro: 1.574 ± 0.038	2.346ArgGln: 2.346 ± 0.051	2.24ArgArg: 2.24 ± 0.048	2.565ArgSer: 2.565 ± 0.047	1.917ArgThr: 1.917 ± 0.041	3.004ArgVal: 3.004 ± 0.052	0.592ArgTrp: 0.592 ± 0.022	1.699ArgTyr: 1.699 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.17SerAla: 6.17 ± 0.092	0.686SerCys: 0.686 ± 0.025	3.499SerAsp: 3.499 ± 0.055	3.701SerGlu: 3.701 ± 0.054	2.978SerPhe: 2.978 ± 0.051	4.912SerGly: 4.912 ± 0.086	1.825SerHis: 1.825 ± 0.044	4.317SerIle: 4.317 ± 0.064	3.071SerLys: 3.071 ± 0.058	8.298SerLeu: 8.298 ± 0.098	1.674SerMet: 1.674 ± 0.039	2.719SerAsn: 2.719 ± 0.05	2.796SerPro: 2.796 ± 0.053	4.078SerGln: 4.078 ± 0.073	3.091SerArg: 3.091 ± 0.052	4.834SerSer: 4.834 ± 0.08	3.273SerThr: 3.273 ± 0.059	4.631SerVal: 4.631 ± 0.101	0.82SerTrp: 0.82 ± 0.029	2.279SerTyr: 2.279 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.847ThrAla: 4.847 ± 0.08	0.441ThrCys: 0.441 ± 0.018	2.925ThrAsp: 2.925 ± 0.061	3.084ThrGlu: 3.084 ± 0.057	1.871ThrPhe: 1.871 ± 0.05	4.238ThrGly: 4.238 ± 0.086	1.282ThrHis: 1.282 ± 0.03	2.809ThrIle: 2.809 ± 0.075	2.442ThrLys: 2.442 ± 0.05	6.3ThrLeu: 6.3 ± 0.1	1.112ThrMet: 1.112 ± 0.027	2.061ThrAsn: 2.061 ± 0.069	2.771ThrPro: 2.771 ± 0.067	3.161ThrGln: 3.161 ± 0.057	2.167ThrArg: 2.167 ± 0.053	3.642ThrSer: 3.642 ± 0.067	2.75ThrThr: 2.75 ± 0.065	3.486ThrVal: 3.486 ± 0.07	0.595ThrTrp: 0.595 ± 0.022	1.366ThrTyr: 1.366 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	5.913ValAla: 5.913 ± 0.077	0.667ValCys: 0.667 ± 0.027	3.93ValAsp: 3.93 ± 0.068	3.96ValGlu: 3.96 ± 0.074	2.701ValPhe: 2.701 ± 0.05	4.223ValGly: 4.223 ± 0.069	1.229ValHis: 1.229 ± 0.033	4.604ValIle: 4.604 ± 0.069	3.517ValLys: 3.517 ± 0.066	6.788ValLeu: 6.788 ± 0.084	1.818ValMet: 1.818 ± 0.043	3.224ValAsn: 3.224 ± 0.053	2.512ValPro: 2.512 ± 0.051	2.42ValGln: 2.42 ± 0.047	2.71ValArg: 2.71 ± 0.057	5.088ValSer: 5.088 ± 0.063	4.062ValThr: 4.062 ± 0.09	4.564ValVal: 4.564 ± 0.09	0.688ValTrp: 0.688 ± 0.025	1.781ValTyr: 1.781 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.794TrpAla: 0.794 ± 0.023	0.143TrpCys: 0.143 ± 0.01	0.595TrpAsp: 0.595 ± 0.022	0.498TrpGlu: 0.498 ± 0.021	0.569TrpPhe: 0.569 ± 0.022	0.731TrpGly: 0.731 ± 0.025	0.396TrpHis: 0.396 ± 0.016	0.562TrpIle: 0.562 ± 0.021	0.422TrpLys: 0.422 ± 0.02	1.668TrpLeu: 1.668 ± 0.04	0.286TrpMet: 0.286 ± 0.017	0.377TrpAsn: 0.377 ± 0.02	0.499TrpPro: 0.499 ± 0.022	1.126TrpGln: 1.126 ± 0.034	0.649TrpArg: 0.649 ± 0.025	0.74TrpSer: 0.74 ± 0.031	0.512TrpThr: 0.512 ± 0.033	0.768TrpVal: 0.768 ± 0.028	0.171TrpTrp: 0.171 ± 0.011	0.363TrpTyr: 0.363 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.297TyrAla: 2.297 ± 0.044	0.389TyrCys: 0.389 ± 0.019	1.634TyrAsp: 1.634 ± 0.107	1.284TyrGlu: 1.284 ± 0.038	1.427TyrPhe: 1.427 ± 0.037	2.067TyrGly: 2.067 ± 0.046	0.845TyrHis: 0.845 ± 0.027	1.614TyrIle: 1.614 ± 0.037	1.267TyrLys: 1.267 ± 0.037	3.636TyrLeu: 3.636 ± 0.059	0.599TyrMet: 0.599 ± 0.021	1.113TyrAsn: 1.113 ± 0.043	1.352TyrPro: 1.352 ± 0.035	2.185TyrGln: 2.185 ± 0.053	1.724TyrArg: 1.724 ± 0.039	2.074TyrSer: 2.074 ± 0.048	1.401TyrThr: 1.401 ± 0.041	1.667TyrVal: 1.667 ± 0.036	0.425TyrTrp: 0.425 ± 0.021	1.057TyrTyr: 1.057 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3727 proteins (1268806 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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