Amino acid dipepetide frequency for Cryptosporangium phraense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.406AlaAla: 22.406 ± 0.183	0.926AlaCys: 0.926 ± 0.021	8.887AlaAsp: 8.887 ± 0.06	8.216AlaGlu: 8.216 ± 0.06	3.6AlaPhe: 3.6 ± 0.045	13.836AlaGly: 13.836 ± 0.111	2.48AlaHis: 2.48 ± 0.034	4.813AlaIle: 4.813 ± 0.05	2.395AlaLys: 2.395 ± 0.044	15.167AlaLeu: 15.167 ± 0.114	2.36AlaMet: 2.36 ± 0.032	2.144AlaAsn: 2.144 ± 0.032	7.119AlaPro: 7.119 ± 0.075	3.508AlaGln: 3.508 ± 0.04	10.179AlaArg: 10.179 ± 0.083	6.869AlaSer: 6.869 ± 0.05	7.651AlaThr: 7.651 ± 0.076	12.895AlaVal: 12.895 ± 0.091	1.909AlaTrp: 1.909 ± 0.024	2.518AlaTyr: 2.518 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.932CysAla: 0.932 ± 0.021	0.083CysCys: 0.083 ± 0.007	0.418CysAsp: 0.418 ± 0.013	0.306CysGlu: 0.306 ± 0.01	0.192CysPhe: 0.192 ± 0.01	0.806CysGly: 0.806 ± 0.02	0.152CysHis: 0.152 ± 0.009	0.164CysIle: 0.164 ± 0.009	0.077CysLys: 0.077 ± 0.006	0.653CysLeu: 0.653 ± 0.017	0.082CysMet: 0.082 ± 0.006	0.109CysAsn: 0.109 ± 0.007	0.408CysPro: 0.408 ± 0.015	0.151CysGln: 0.151 ± 0.008	0.538CysArg: 0.538 ± 0.017	0.395CysSer: 0.395 ± 0.014	0.411CysThr: 0.411 ± 0.015	0.562CysVal: 0.562 ± 0.016	0.114CysTrp: 0.114 ± 0.007	0.127CysTyr: 0.127 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	8.509AspAla: 8.509 ± 0.06	0.331AspCys: 0.331 ± 0.014	4.342AspAsp: 4.342 ± 0.044	4.022AspGlu: 4.022 ± 0.049	1.495AspPhe: 1.495 ± 0.03	6.311AspGly: 6.311 ± 0.064	1.258AspHis: 1.258 ± 0.026	1.536AspIle: 1.536 ± 0.029	0.847AspLys: 0.847 ± 0.022	6.798AspLeu: 6.798 ± 0.055	0.584AspMet: 0.584 ± 0.016	0.822AspAsn: 0.822 ± 0.021	4.81AspPro: 4.81 ± 0.057	1.644AspGln: 1.644 ± 0.032	5.251AspArg: 5.251 ± 0.052	2.411AspSer: 2.411 ± 0.032	2.737AspThr: 2.737 ± 0.036	5.893AspVal: 5.893 ± 0.057	0.899AspTrp: 0.899 ± 0.019	1.136AspTyr: 1.136 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.79GluAla: 6.79 ± 0.06	0.308GluCys: 0.308 ± 0.012	2.358GluAsp: 2.358 ± 0.037	2.569GluGlu: 2.569 ± 0.042	1.609GluPhe: 1.609 ± 0.027	3.272GluGly: 3.272 ± 0.04	1.339GluHis: 1.339 ± 0.023	2.346GluIle: 2.346 ± 0.032	1.214GluLys: 1.214 ± 0.026	6.156GluLeu: 6.156 ± 0.06	0.83GluMet: 0.83 ± 0.019	1.022GluAsn: 1.022 ± 0.024	3.356GluPro: 3.356 ± 0.044	1.98GluGln: 1.98 ± 0.027	4.877GluArg: 4.877 ± 0.057	2.589GluSer: 2.589 ± 0.036	2.765GluThr: 2.765 ± 0.042	4.462GluVal: 4.462 ± 0.047	0.785GluTrp: 0.785 ± 0.02	1.083GluTyr: 1.083 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.94PheAla: 3.94 ± 0.044	0.243PheCys: 0.243 ± 0.01	2.069PheAsp: 2.069 ± 0.034	1.318PheGlu: 1.318 ± 0.025	0.852PhePhe: 0.852 ± 0.021	3.2PheGly: 3.2 ± 0.043	0.507PheHis: 0.507 ± 0.015	0.693PheIle: 0.693 ± 0.018	0.409PheLys: 0.409 ± 0.013	2.746PheLeu: 2.746 ± 0.036	0.321PheMet: 0.321 ± 0.012	0.528PheAsn: 0.528 ± 0.018	1.369PhePro: 1.369 ± 0.025	0.599PheGln: 0.599 ± 0.017	1.996PheArg: 1.996 ± 0.028	1.566PheSer: 1.566 ± 0.027	1.819PheThr: 1.819 ± 0.025	2.642PheVal: 2.642 ± 0.034	0.466PheTrp: 0.466 ± 0.016	0.623PheTyr: 0.623 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.297GlyAla: 11.297 ± 0.091	0.712GlyCys: 0.712 ± 0.02	4.962GlyAsp: 4.962 ± 0.051	4.439GlyGlu: 4.439 ± 0.047	2.926GlyPhe: 2.926 ± 0.038	8.487GlyGly: 8.487 ± 0.096	1.984GlyHis: 1.984 ± 0.033	3.401GlyIle: 3.401 ± 0.044	1.91GlyLys: 1.91 ± 0.033	9.996GlyLeu: 9.996 ± 0.084	1.623GlyMet: 1.623 ± 0.031	1.708GlyAsn: 1.708 ± 0.025	5.441GlyPro: 5.441 ± 0.058	2.55GlyGln: 2.55 ± 0.037	7.831GlyArg: 7.831 ± 0.068	5.458GlySer: 5.458 ± 0.055	5.59GlyThr: 5.59 ± 0.064	8.244GlyVal: 8.244 ± 0.076	1.811GlyTrp: 1.811 ± 0.025	2.315GlyTyr: 2.315 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.322HisAla: 2.322 ± 0.033	0.179HisCys: 0.179 ± 0.008	1.277HisAsp: 1.277 ± 0.023	0.983HisGlu: 0.983 ± 0.022	0.56HisPhe: 0.56 ± 0.014	2.028HisGly: 2.028 ± 0.032	0.591HisHis: 0.591 ± 0.016	0.486HisIle: 0.486 ± 0.013	0.238HisLys: 0.238 ± 0.011	2.243HisLeu: 2.243 ± 0.032	0.225HisMet: 0.225 ± 0.009	0.325HisAsn: 0.325 ± 0.011	1.631HisPro: 1.631 ± 0.027	0.548HisGln: 0.548 ± 0.015	1.942HisArg: 1.942 ± 0.031	0.931HisSer: 0.931 ± 0.02	1.012HisThr: 1.012 ± 0.021	1.677HisVal: 1.677 ± 0.027	0.321HisTrp: 0.321 ± 0.011	0.458HisTyr: 0.458 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.456IleAla: 5.456 ± 0.047	0.273IleCys: 0.273 ± 0.011	2.532IleAsp: 2.532 ± 0.037	2.101IleGlu: 2.101 ± 0.03	0.788IlePhe: 0.788 ± 0.019	3.844IleGly: 3.844 ± 0.048	0.585IleHis: 0.585 ± 0.015	0.922IleIle: 0.922 ± 0.025	0.587IleLys: 0.587 ± 0.017	2.768IleLeu: 2.768 ± 0.035	0.392IleMet: 0.392 ± 0.012	0.727IleAsn: 0.727 ± 0.019	1.915IlePro: 1.915 ± 0.028	0.741IleGln: 0.741 ± 0.017	2.545IleArg: 2.545 ± 0.036	1.887IleSer: 1.887 ± 0.031	2.199IleThr: 2.199 ± 0.034	3.417IleVal: 3.417 ± 0.046	0.432IleTrp: 0.432 ± 0.013	0.641IleTyr: 0.641 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.385LysAla: 2.385 ± 0.046	0.089LysCys: 0.089 ± 0.006	0.932LysAsp: 0.932 ± 0.024	0.754LysGlu: 0.754 ± 0.02	0.436LysPhe: 0.436 ± 0.015	1.237LysGly: 1.237 ± 0.028	0.378LysHis: 0.378 ± 0.013	0.775LysIle: 0.775 ± 0.02	0.566LysLys: 0.566 ± 0.024	1.754LysLeu: 1.754 ± 0.031	0.306LysMet: 0.306 ± 0.012	0.448LysAsn: 0.448 ± 0.014	1.202LysPro: 1.202 ± 0.024	0.606LysGln: 0.606 ± 0.016	1.268LysArg: 1.268 ± 0.023	1.008LysSer: 1.008 ± 0.023	1.203LysThr: 1.203 ± 0.028	1.509LysVal: 1.509 ± 0.033	0.221LysTrp: 0.221 ± 0.009	0.438LysTyr: 0.438 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.089LeuAla: 16.089 ± 0.109	0.678LeuCys: 0.678 ± 0.015	7.096LeuAsp: 7.096 ± 0.064	4.574LeuGlu: 4.574 ± 0.051	2.786LeuPhe: 2.786 ± 0.037	9.679LeuGly: 9.679 ± 0.085	2.086LeuHis: 2.086 ± 0.03	3.798LeuIle: 3.798 ± 0.043	1.565LeuLys: 1.565 ± 0.031	11.247LeuLeu: 11.247 ± 0.092	1.388LeuMet: 1.388 ± 0.025	1.73LeuAsn: 1.73 ± 0.029	6.288LeuPro: 6.288 ± 0.053	2.222LeuGln: 2.222 ± 0.032	8.782LeuArg: 8.782 ± 0.071	5.688LeuSer: 5.688 ± 0.045	7.104LeuThr: 7.104 ± 0.061	9.902LeuVal: 9.902 ± 0.073	1.242LeuTrp: 1.242 ± 0.025	1.731LeuTyr: 1.731 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	1.974MetAla: 1.974 ± 0.029	0.099MetCys: 0.099 ± 0.007	0.739MetAsp: 0.739 ± 0.017	0.564MetGlu: 0.564 ± 0.017	0.467MetPhe: 0.467 ± 0.015	1.013MetGly: 1.013 ± 0.02	0.271MetHis: 0.271 ± 0.012	0.649MetIle: 0.649 ± 0.019	0.357MetLys: 0.357 ± 0.011	1.669MetLeu: 1.669 ± 0.029	0.248MetMet: 0.248 ± 0.011	0.353MetAsn: 0.353 ± 0.012	0.99MetPro: 0.99 ± 0.02	0.39MetGln: 0.39 ± 0.013	1.293MetArg: 1.293 ± 0.025	1.122MetSer: 1.122 ± 0.022	1.513MetThr: 1.513 ± 0.025	1.178MetVal: 1.178 ± 0.022	0.158MetTrp: 0.158 ± 0.008	0.228MetTyr: 0.228 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.287AsnAla: 2.287 ± 0.028	0.135AsnCys: 0.135 ± 0.008	1.043AsnAsp: 1.043 ± 0.024	0.774AsnGlu: 0.774 ± 0.017	0.491AsnPhe: 0.491 ± 0.017	1.792AsnGly: 1.792 ± 0.026	0.361AsnHis: 0.361 ± 0.011	0.584AsnIle: 0.584 ± 0.017	0.337AsnLys: 0.337 ± 0.014	1.775AsnLeu: 1.775 ± 0.029	0.256AsnMet: 0.256 ± 0.01	0.37AsnAsn: 0.37 ± 0.014	1.423AsnPro: 1.423 ± 0.026	0.525AsnGln: 0.525 ± 0.013	1.348AsnArg: 1.348 ± 0.027	0.868AsnSer: 0.868 ± 0.022	1.085AsnThr: 1.085 ± 0.023	1.546AsnVal: 1.546 ± 0.029	0.297AsnTrp: 0.297 ± 0.012	0.417AsnTyr: 0.417 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.993ProAla: 8.993 ± 0.088	0.266ProCys: 0.266 ± 0.012	4.842ProAsp: 4.842 ± 0.056	3.754ProGlu: 3.754 ± 0.044	1.618ProPhe: 1.618 ± 0.024	6.492ProGly: 6.492 ± 0.061	1.154ProHis: 1.154 ± 0.023	1.935ProIle: 1.935 ± 0.028	0.984ProLys: 0.984 ± 0.024	5.281ProLeu: 5.281 ± 0.052	0.946ProMet: 0.946 ± 0.021	1.062ProAsn: 1.062 ± 0.024	3.866ProPro: 3.866 ± 0.055	1.379ProGln: 1.379 ± 0.026	3.859ProArg: 3.859 ± 0.043	3.751ProSer: 3.751 ± 0.056	3.697ProThr: 3.697 ± 0.043	5.583ProVal: 5.583 ± 0.05	0.892ProTrp: 0.892 ± 0.021	1.2ProTyr: 1.2 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.414GlnAla: 3.414 ± 0.036	0.149GlnCys: 0.149 ± 0.008	1.094GlnAsp: 1.094 ± 0.022	1.065GlnGlu: 1.065 ± 0.021	0.8GlnPhe: 0.8 ± 0.021	1.721GlnGly: 1.721 ± 0.029	0.603GlnHis: 0.603 ± 0.016	1.208GlnIle: 1.208 ± 0.023	0.56GlnLys: 0.56 ± 0.017	3.064GlnLeu: 3.064 ± 0.037	0.439GlnMet: 0.439 ± 0.015	0.546GlnAsn: 0.546 ± 0.014	1.661GlnPro: 1.661 ± 0.035	1.079GlnGln: 1.079 ± 0.028	2.417GlnArg: 2.417 ± 0.04	1.181GlnSer: 1.181 ± 0.024	1.35GlnThr: 1.35 ± 0.027	2.465GlnVal: 2.465 ± 0.034	0.439GlnTrp: 0.439 ± 0.015	0.603GlnTyr: 0.603 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.29ArgAla: 10.29 ± 0.084	0.523ArgCys: 0.523 ± 0.017	4.3ArgAsp: 4.3 ± 0.045	4.256ArgGlu: 4.256 ± 0.051	2.379ArgPhe: 2.379 ± 0.034	5.783ArgGly: 5.783 ± 0.057	1.762ArgHis: 1.762 ± 0.026	3.247ArgIle: 3.247 ± 0.035	1.394ArgLys: 1.394 ± 0.027	8.658ArgLeu: 8.658 ± 0.069	1.653ArgMet: 1.653 ± 0.027	1.428ArgAsn: 1.428 ± 0.027	5.193ArgPro: 5.193 ± 0.052	2.237ArgGln: 2.237 ± 0.033	8.13ArgArg: 8.13 ± 0.076	4.437ArgSer: 4.437 ± 0.045	5.024ArgThr: 5.024 ± 0.05	6.292ArgVal: 6.292 ± 0.051	1.56ArgTrp: 1.56 ± 0.022	1.912ArgTyr: 1.912 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	7.482SerAla: 7.482 ± 0.063	0.349SerCys: 0.349 ± 0.013	3.18SerAsp: 3.18 ± 0.04	2.514SerGlu: 2.514 ± 0.034	1.526SerPhe: 1.526 ± 0.024	5.967SerGly: 5.967 ± 0.059	0.862SerHis: 0.862 ± 0.021	1.881SerIle: 1.881 ± 0.032	0.948SerLys: 0.948 ± 0.021	4.973SerLeu: 4.973 ± 0.042	1.073SerMet: 1.073 ± 0.023	0.941SerAsn: 0.941 ± 0.021	3.418SerPro: 3.418 ± 0.045	1.219SerGln: 1.219 ± 0.026	3.888SerArg: 3.888 ± 0.041	3.288SerSer: 3.288 ± 0.045	3.296SerThr: 3.296 ± 0.046	4.684SerVal: 4.684 ± 0.048	0.942SerTrp: 0.942 ± 0.019	1.165SerTyr: 1.165 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	8.371ThrAla: 8.371 ± 0.077	0.356ThrCys: 0.356 ± 0.013	3.59ThrAsp: 3.59 ± 0.044	2.847ThrGlu: 2.847 ± 0.032	1.744ThrPhe: 1.744 ± 0.028	6.187ThrGly: 6.187 ± 0.057	1.103ThrHis: 1.103 ± 0.021	2.302ThrIle: 2.302 ± 0.032	1.07ThrLys: 1.07 ± 0.024	6.143ThrLeu: 6.143 ± 0.055	0.938ThrMet: 0.938 ± 0.021	1.111ThrAsn: 1.111 ± 0.025	4.1ThrPro: 4.1 ± 0.047	1.266ThrGln: 1.266 ± 0.026	3.831ThrArg: 3.831 ± 0.047	3.298ThrSer: 3.298 ± 0.04	3.908ThrThr: 3.908 ± 0.058	6.012ThrVal: 6.012 ± 0.066	0.907ThrTrp: 0.907 ± 0.02	1.244ThrTyr: 1.244 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	12.602ValAla: 12.602 ± 0.083	0.667ValCys: 0.667 ± 0.017	5.813ValAsp: 5.813 ± 0.05	4.966ValGlu: 4.966 ± 0.049	2.521ValPhe: 2.521 ± 0.034	7.883ValGly: 7.883 ± 0.066	1.777ValHis: 1.777 ± 0.031	3.006ValIle: 3.006 ± 0.038	1.48ValLys: 1.48 ± 0.03	10.382ValLeu: 10.382 ± 0.083	1.177ValMet: 1.177 ± 0.024	1.641ValAsn: 1.641 ± 0.03	5.297ValPro: 5.297 ± 0.052	2.054ValGln: 2.054 ± 0.027	7.212ValArg: 7.212 ± 0.057	4.887ValSer: 4.887 ± 0.051	5.895ValThr: 5.895 ± 0.057	9.641ValVal: 9.641 ± 0.084	1.111ValTrp: 1.111 ± 0.023	1.491ValTyr: 1.491 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	1.751TrpAla: 1.751 ± 0.028	0.14TrpCys: 0.14 ± 0.008	0.82TrpAsp: 0.82 ± 0.02	0.654TrpGlu: 0.654 ± 0.017	0.495TrpPhe: 0.495 ± 0.015	1.064TrpGly: 1.064 ± 0.025	0.352TrpHis: 0.352 ± 0.013	0.604TrpIle: 0.604 ± 0.016	0.294TrpLys: 0.294 ± 0.012	1.84TrpLeu: 1.84 ± 0.033	0.258TrpMet: 0.258 ± 0.01	0.372TrpAsn: 0.372 ± 0.013	0.915TrpPro: 0.915 ± 0.021	0.521TrpGln: 0.521 ± 0.015	1.301TrpArg: 1.301 ± 0.023	0.977TrpSer: 0.977 ± 0.021	1.005TrpThr: 1.005 ± 0.021	1.157TrpVal: 1.157 ± 0.025	0.363TrpTrp: 0.363 ± 0.011	0.325TrpTyr: 0.325 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.589TyrAla: 2.589 ± 0.032	0.173TyrCys: 0.173 ± 0.008	1.343TyrAsp: 1.343 ± 0.026	1.034TyrGlu: 1.034 ± 0.019	0.621TyrPhe: 0.621 ± 0.017	2.082TyrGly: 2.082 ± 0.034	0.369TyrHis: 0.369 ± 0.013	0.4TyrIle: 0.4 ± 0.013	0.281TyrLys: 0.281 ± 0.013	2.363TyrLeu: 2.363 ± 0.035	0.177TyrMet: 0.177 ± 0.008	0.33TyrAsn: 0.33 ± 0.012	1.15TyrPro: 1.15 ± 0.026	0.641TyrGln: 0.641 ± 0.019	1.97TyrArg: 1.97 ± 0.033	0.984TyrSer: 0.984 ± 0.019	1.066TyrThr: 1.066 ± 0.024	1.743TyrVal: 1.743 ± 0.031	0.339TyrTrp: 0.339 ± 0.012	0.449TyrTyr: 0.449 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7680 proteins (2457430 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---